Abstract: The present invention provides a method of inhibiting tumor progression in an individual in need of such treatment, comprising the step of administering to said individual a pharmacologically effective dose of a phospholipase C inhibitor. Also provided is a method of inhibiting metastasis in an individual in need of such treatment, comprising the step of administering to said individual a pharmacologically effective dose of a phospholipase C inhibitor. Further provided are pharmaceutical compositions, comprising a phospholipase C inhibitor of tumor invasiveness and metastasis and a pharmaceutically acceptable carrier and a pharmaceutical composition, comprising a phospholipase C inhibitor of tumor invasiveness and metastasis, a antineoplastic agent and a pharmaceutically acceptable carrier.

Abstract: The present invention is a reformed container end and a method of forming the container end. The container end includes a center panel surrounded by a countersink having an inner wall, an outer wall, and a countersink bottom. The countersink bottom includes a first arcuate segment having a small radius and a second arcuate segment having a larger radius. The container end may also include a portion wherein the center panel is slightly expanded and the inner wall is further reformed to direct potential buckling away from the nose of a pour opening panel.