Abstract: Taselisib (GDC-0032) induces the degradation of mutant-p110 alpha protein. Methods for selecting patients with mutant PI3K tumors for treatment with taselisib are described.

Abstract: A data integration pipeline is configured to receive and integrate raw data into a data processing system. Raw data may be defined as an electronic collection of data composed of information from multiple records, whose primary relationship to each other is their shared origin from a single or multiple databases. In integrating the raw data, the data integration pipeline may split the integration into two phases, more specifically: an ingest phase, and an import phase.

Abstract: Disclosed herein is an assembly for selectively aerating a liquid including a base member a reservoir adapted to receive the liquid. The assembly also includes a support member non-rotatably coupled to the base member and a diverter member coupled to the support member and rotatable between a first diverter position and a second diverter position. The diverter member has at least one primary aperture and at least one secondary aperture. The assembly additionally includes an aerator member non-rotatably secured to the diverter member, the aerator member having an aeration aperture. In the first diverter position, a portion of the liquid in the reservoir flows through the primary aperture. In the second diverter position, a portion of the liquid in the reservoir flows through the secondary aperture, and though the aeration aperture.

Abstract: A system and method for providing and executing a domain-specific programming language for cloud services infrastructure is provided. The system may be used to integrate references to external entities, such as cloud service compute instances, directly into a domain-specific programming language, allowing developers to easily integrate cloud services directly using the domain-specific programming language. Using a domain-specific programming language, references to external entities (not in memory) as variables may be used. Using the domain-specific programming language described herein, lexical scoping may be mapped onto collections of entities that aren't a native part of the language. In order to facilitate these and other benefits, the system may maintain state information of all references and shared variables across program boundaries. The system may make the state information accessible via a state information service that understands the language features of the domain-specific programming language.

Abstract: A method for drying a wet semiconductor substrate includes immersing the wet substrate in a rinsing liquid in a sealed drying chamber, producing a volume of vaporized drying fluid in a vapor generator, establishing fluid communication between the vapor generator and the drying chamber, transferring the vaporized drying fluid to the drying chamber by removing the rinsing liquid from the drying chamber, and allowing the vaporized drying fluid to condense on the wet substrate. The method further includes providing vacuum pressure within the drying chamber and backfilling the drying chamber with an inert gas to substantially achieve atmospheric pressure.

Abstract: In various embodiments, cylinder assemblies are coupled in series pneumatically, thereby reducing a range of force produced by or acting on the cylinder assemblies during expansion or compression of a gas.

Abstract: In various embodiments, cylinder assemblies are coupled in series pneumatically, thereby reducing a range of force produced by or acting on the cylinder assemblies during expansion or compression of a gas.

Abstract: In various embodiments, cylinder assemblies are coupled in series pneumatically, thereby reducing a range of force produced by or acting on the cylinder assemblies during expansion or compression of a gas.

Abstract: In various embodiments, pneumatic cylinder assemblies are coupled in series pneumatically, thereby reducing a range of force produced by or acting on the pneumatic cylinder assemblies during expansion or compression of a gas.

Abstract: In various embodiments, pneumatic cylinder assemblies are coupled in series pneumatically, thereby reducing a range of force produced by or acting on the pneumatic cylinder assemblies during expansion or compression of a gas.

Abstract: In various embodiments, pneumatic cylinder assemblies are coupled in series pneumatically, thereby reducing a range of force produced by or acting on the pneumatic cylinder assemblies during expansion or compression of a gas.

Abstract: In various embodiments, pneumatic cylinder assemblies are coupled in series pneumatically, thereby reducing a range of force produced by or acting on the pneumatic cylinder assemblies during expansion or compression of a gas.

Abstract: A method of reducing tunneling in a wireless packet network. The method includes defining a home access point for a client station, determining that the client station is being serviced by an access point different from the home access point, deciding if the client station should change its home access point to the access point from which the client station receives service and initiating a change of the home access point of the client station, if so decided.

Abstract: A spray application system for applying material to a surface of a rotating body such as a beverage can includes a detector that detects the actual speed of rotation of the surface during a spraying operation. This allows a controller to adjust trigger signals for the application device to be adjusted based on speed of rotation to minimize overcoat. A laser sensor may be used as an example. The use of the speed detector also allows for partial wraps as well as full wraps of applying material to the rotating surface.

Abstract: A spray application system for applying material to a surface of a rotating body such as a beverage can includes a detector that detects the actual speed of rotation of the surface during a spraying operation. This allows a controller to adjust trigger signals for the application device to be adjusted based on speed of rotation to minimize overcoat. A laser sensor may be used as an example. The use of the speed detector also allows for partial wraps as well as full wraps of applying material to the rotating surface.

Abstract: A method and apparatus for conducting business via the worldwide Web in which business programming is isolated from Web user interface programming. In accordance with the invention, a gateway servlet interfaces between a consumer's browser's software, a plurality of Java beans, Java Server Pages, and a e-business retailer's back-end business software running, for instance, on a separate mainframe. The gateway servlet receives input information from the consumer and instantiates and populates a Java bean that confirms that the input data has been entered correctly. It then forwards the verified input data the back-end software for business processing. The back-end software returns a user interface record object to the gateway which then instantiates and populates another Java bean to format the data.

Abstract: A method for preventing co-channel operation with a radar system includes the steps of setting a state of a first communication channel to active, connecting to a first wireless access point on the first communication channel, passively scanning at least a second communication channel for communication from a second wireless access point, setting a state of the second channel to active if frames are received on the second channel, determining whether an elapsed time since frames were received on at least one of the first channel and the second channel has exceed a predefined value, and in response to the predefined value being exceeded for at least one of the first channel and the second channel, setting the state of a corresponding one of the first channel and the second channel to passive.

Abstract: A soft plastic articulating fishing lure includes a head and a plurality of body sections integrally molded with hinge sections. The hinge sections are preferably smaller in height than the respective body sections they join to promote increased swimming action at lower pull speed. Central body sections are preferably molded with relatively rounded back and relatively flatter front to promote water flow to effect swim-like movement of the lure. When fished, the lure articulates at the hinge joints only. In one embodiment, the head portion includes a molded slot, and a weighted insert is provided therein defining eyes for fishing line and hook, and a weights for lure control. In another embodiment, an insert with hook is provided within a slot in the head of the head and the hook is caused to rotate upwards out of the recess and into the mouth of the fish to hook the fish.

Abstract: A disc brake assembly for a vehicle having a caliper mounted to a non-rotating structure of the vehicle and a housing mounted to a rotating structure of the vehicle fixedly connected to a rotor within the housing. A pressure plate and a pair of annular brake discs on each side of the rotor and extending parallel to the rotor are disposed within the housing and mounted to the caliper for axial movement into the pressure plate. At least one annular brake disc is axially moveable by a hydraulically or pneumatically urged annular piston disposed in caliper.

Abstract: The invention relates to an apparatus for measuring the relative difficulty in donning of a glove. The apparatus contains a glove mount for holding a glove to be tested in an open donnable position and a device for measuring the effort associated with donning the glove. The invention also relates to a method for measuring the effort associated with donning a glove by providing a testing apparatus having a glove mount and a device for measuring effort associated with donning of a glove, mounting a glove for testing on the glove mount so the glove is open and donnable, initializing the testing apparatus, and acquiring data from the device relating to the effort associated with donning of the glove.