Patents by Inventor Tina K. Van Dyk
Tina K. Van Dyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160326551Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of fermentation products from an engineered pyruvate utilizing pathway. The yeast host cells provided herein comprise an altered lipid profile, which confers resistance to butanol.Type: ApplicationFiled: December 22, 2014Publication date: November 10, 2016Inventors: Tina K. VAN DYK, Zhixiong XUE, Narendra S. YADAV, Hongxiang ZHANG
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Publication number: 20150203876Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding a polypeptide having sucrose transporter activity and a nucleotide sequence encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: ApplicationFiled: April 1, 2015Publication date: July 23, 2015Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Kristin RUEBLING-JASS, Jean-Francois TOMB, Tina K. VAN DYK, Zheng YOU
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Patent number: 9017961Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding a polypeptide having sucrose transporter activity and a nucleotide sequence encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: GrantFiled: March 5, 2012Date of Patent: April 28, 2015Assignee: E.I. du Pont de Nemours and CompanyInventors: Kristin Ruebling-Jass, Jean-Francois Tomb, Tina K Van Dyk, Zheng You
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Publication number: 20150064755Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding a polypeptide having sucrose transporter activity and a nucleotide sequence encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: ApplicationFiled: March 5, 2013Publication date: March 5, 2015Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: Kristin Ruebling-Jass, Jean-Francois Tomb, Tina K Van Dyk, Zheng You
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Publication number: 20140155578Abstract: Variant sucrose transporter polypeptides that enable bacterial growth over a wide range of gene expression levels and sucrose concentrations are described.Type: ApplicationFiled: February 6, 2014Publication date: June 5, 2014Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Dana Michelle Walters Pollak, Tina K. VAN DYK
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Publication number: 20140147899Abstract: Variant sucrose transporter polypeptides that enable bacterial growth over a wide range of gene expression levels and sucrose concentrations are described.Type: ApplicationFiled: February 6, 2014Publication date: May 29, 2014Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Dana Michelle Walters Pollak, Tina K. VAN DYK
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Patent number: 8686114Abstract: Variant sucrose transporter polypeptides that enable bacterial growth over a wide range of gene expression levels and sucrose concentrations are described. Additionally, recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided.Type: GrantFiled: March 5, 2012Date of Patent: April 1, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Dana Michelle Walters Pollak, Tina K Van Dyk
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Patent number: 8652823Abstract: Bacteria that are not natural butanol producers were found to have increased tolerance to butanol when the membrane content of unsaturated trans fatty acids was increased. Feeding cells with unsaturated trans fatty acids increased their concentration in the membrane, which may also be accomplished by expressing a fatty acid cistrans isomerase.Type: GrantFiled: November 25, 2009Date of Patent: February 18, 2014Assignee: Butamax(TM) Advanced Biofuels LLCInventors: Dennis Flint, Tina K. Van Dyk
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Patent number: 8614085Abstract: Increasing tolerance to butanol in yeast has been accomplished by decreasing activity of Pdr5p encoded by an endogenous PDR5 gene. A deletion mutation of the PDR5 gene led to improved growth yield in the presence of butanol. Yeast cells with reduced Pdr5p activity, or other multidrug resistance ATP-binding cassette transporter protein activity encoded by CDR1 or BFR1, and a butanol biosynthetic pathway may be used for improved butanol production.Type: GrantFiled: February 24, 2010Date of Patent: December 24, 2013Assignee: Butamax(TM) Advanced Biofuels LLCInventor: Tina K. Van Dyk
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Patent number: 8569036Abstract: TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.Type: GrantFiled: July 12, 2006Date of Patent: October 29, 2013Assignee: E I du Pont de Nemours and CompanyInventors: Robert Dicosimo, Sharon L. Haynie, Lixuan Lisa Huang, Fateme Sima Sariaslani, Tina K. Van Dyk, Robert J. Trotman
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Publication number: 20130230892Abstract: Variant sucrose transporter polypeptides that enable bacterial growth over a wide range of gene expression levels and sucrose concentrations are described.Type: ApplicationFiled: March 5, 2012Publication date: September 5, 2013Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: DANA MICHELLE WALTERS POLLAK, TINA K. VAN DYK
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Publication number: 20130230893Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding a polypeptide having sucrose transporter activity and a nucleotide sequence encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: ApplicationFiled: March 5, 2012Publication date: September 5, 2013Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: KRISTIN RUEBLING-JASS, Jean-Francois Tomb, Tina K. Van Dyk, Zheng You
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Patent number: 8518678Abstract: Screening of fatty acid fed bacteria which are not natural butanol producers identified increased membrane cyclopropane fatty acid as providing improved butanol tolerance. Increasing expression of cyclopropane fatty acid synthase in the presence of the enzyme substrate that is either endogenous to the cell or fed to the cell, increased butanol tolerance. Bacterial strains with increased cyclopropane fatty acid synthase and having a butanol biosynthetic pathway are useful for production of butanol.Type: GrantFiled: December 9, 2008Date of Patent: August 27, 2013Assignee: Butamax(TM) Advanced Biofuels LLCInventors: Dennis Flint, Robert A. Larossa, Vasantha Nagarajan, Tina K. Van Dyk, Rick W. Ye
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Patent number: 8426174Abstract: A method for the production of 2-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.Type: GrantFiled: April 28, 2008Date of Patent: April 23, 2013Assignee: Butamax(TM) Advanced Biofuels LLCInventors: Michael G. Bramucci, Dennis Flint, Edward S. Miller, Jr., Vasantha Nagarajan, Natalia Sedkova, Manjari Singh, Tina K. Van Dyk
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Patent number: 8426173Abstract: A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.Type: GrantFiled: April 28, 2008Date of Patent: April 23, 2013Assignee: Butamax (TM) Advanced Biofuels LLCInventors: Michael G. Bramucci, Dennis Flint, Edward S. Miller, Jr., Vasantha Nagarajan, Natalia Sedkova, Manjari Singh, Tina K. Van Dyk
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Patent number: 8222000Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct: a nucleotide sequence from Bacillus licheniformis ATCC® 14580 encoding a polypeptide having sucrose transporter activity and a nucleotide sequence from Bacillus licheniformis ATCC® 14580 encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: GrantFiled: December 6, 2010Date of Patent: July 17, 2012Assignee: E I du Pont de Nemours and CompanyInventor: Tina K. Van Dyk
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Publication number: 20120142064Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct: a nucleotide sequence from Bacillus licheniformis ATCC® 14580 encoding a polypeptide having sucrose transporter activity and a nucleotide sequence from Bacillus licheniformis ATCC® 14580 encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: ApplicationFiled: December 6, 2010Publication date: June 7, 2012Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventor: TINA K. VAN DYK
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Patent number: 8129170Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct: a nucleotide sequence from Pseudomonas fluorescens Pf5 (ATCC® BAA-477) encoding a polypeptide having sucrose transporter activity and a nucleotide sequence from Pseudomonas fluorescens Pf5 (ATCC® BAA-477) encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: GrantFiled: December 6, 2010Date of Patent: March 6, 2012Assignee: E.I. du Pont de Nemours and CompanyInventor: Tina K. Van Dyk
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Publication number: 20110195505Abstract: Bacteria that are not natural butanol producers were found to have increased tolerance to butanol when the saturated fatty acids content in bacterial cell membrane was increased. Methods for increasing the concentration of saturated fatty acids in the membranes of bacteria that are not natural butanol produces are described whereby tolerance of the bacterial cell to butanol is increased. Saturated fatty acids concentration in the bacterial cell membrane increased upon exogenously feeding saturated fatty acids to cells. Bacterial strains useful for production of butanol are described herein having modified unsaturated fatty acid biosynthetic pathway.Type: ApplicationFiled: October 7, 2010Publication date: August 11, 2011Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLCInventors: LORI JEAN EULER, DENNIS FLINT, BRIAN JAMES PAUL, TINA K. VAN DYK, RICK W. YE
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Publication number: 20110144377Abstract: The present invention provides a microorganism useful for biologically producing 3-hydroxypropionic acid from a fermentable carbon source. Further, the microorganism comprises disruptions in specified genes and alterations in the expression levels of specified genes that are useful in a higher yielding process to produce 3-hydroxypropionic acid, compositions comprising renewably sourced 3-hydroxypropionic acid provided by said microorganism, and industrial relevant products made using such renewably sourced 3-hydroxypropionic acid.Type: ApplicationFiled: June 15, 2010Publication date: June 16, 2011Applicant: E. I. DU PONT NEMOURS AND COMPANYInventors: Andrew C. Eliot, Tina K. Van Dyk