Abstract: An aromatic fused ring compound which acts as a sodium channel blocker, and a use thereof. The aromatic fused ring compound has inhibitory activity on sodium ion channel Nav1.8, and may be used as a drug for a wide range of pain treatment.

Abstract: An electronic device is provided and includes a first conductive structure, a second conductive structure, a third conductive structure, a first insulating layer, a second insulating layer, a conductive element, an electronic component, and a plurality of passive components. The first insulating layer is disposed between the first conductive structure and the second conductive structure, and the second insulating layer is disposed between the second conductive structure and the third conductive structure. The second conductive structure is electrically connected to the first conductive structure at a first position, and the third conductive structure is electrically connected to the second conductive structure at a second position, wherein a center point of the first position and a center point of the second position is misaligned along a normal direction of a surface of the first insulating layer.

Abstract: A passivation layer is formed over an interconnect structure. An opening is etched at least partially through the passivation layer. A first conductive layer is deposited over the passivation layer. The first conductive layer partially fills the opening. An insulator layer is deposited over the first conductive layer. The insulator layer partially fills the opening. A second conductive layer is deposited over the insulator layer. The second conductive layer completely fills the opening. A first conductive structure is formed that is electrically coupled to the first conductive layer. A second conductive structure is formed that is electrically coupled to the second conductive layer.

Abstract: A radiotherapy system includes a neutron acceptor, an aerosolization device for aerosolizing the neutron acceptor, and an energy beam generator. A method for treating cancer, including: administering to a subject in need thereof an effective amount of an aerosolized neutron acceptor; and irradiating the subject with neutrons. A method for diagnosing cancer, including: administering to a subject in need thereof an effective amount of an aerosolized radioactive agent; and receiving an energy beam signal from the subject. A method for delivering a neutron receptor to a subject during radiation therapy, including aerosolizing the neutron receptor and administering to the subject an effective amount of the neutron receptor.

Abstract: A method for mask data synthesis and mask making includes calibrating an optical proximity correction (OPC) model by adjusting a plurality of parameters including a first parameter and a second parameter, wherein the first parameter indicates a long-range effect caused by an electron-beam lithography tool for making a mask used to manufacture a structure, and the second parameter indicates a geometric feature of a structure or a manufacturing process to make the structure, generating a device layout, calculating a first grid pattern density map of the device layout, generating a long-range correction map, at least based on the calibrated OPC model and the first grid pattern density map of the device layout, and performing an OPC to generate a corrected mask layout, at least based on the generated long-range correction map and the calibrated OPC model.

Abstract: A foldable electronic device includes a first body having an end and a first inclined surface, a second body having a second inclined surface, and a hinge module. The end includes an accommodating area. A virtual shaft line exists between sides of the first inclined surface and the second inclined surface that are closest to each other. The second body rotates relative to the first body through the virtual shaft line. The hinge module includes a first bracket adjacent to the first inclined surface, connected to the first body, and located in the accommodating area, a second bracket adjacent to the second inclined surface and connected to the second body, and a third bracket including a first end and a second end. The first bracket is connected to the first end through a first torsion assembly. The second bracket is connected to the second end through a second torsion assembly.

Abstract: Methods and systems for media trend detection and maintenance are provided herein. A set of media items each having common media characteristics is identified. A set of pose values is determined for each respective media item of the set of media items. Each pose value is associated with a particular predefined pose for objects depicted by the set of media items. A set of distance scores is calculated. Each distance score represents a distance between the respective set of pose values determined for a media item and a respective set of pose values determined for an additional media item. A coherence score is determined for the set of media items based on the calculated set of distance scores. Responsive to a determination that the coherence score satisfies one or more coherence criteria, a determination is made that the set of media items corresponds to a media trend of a platform.

Abstract: A socket of a testing tool is configured to provide testing signals. A device-under-test (DUT) board is configured to provide electrical routing. An integrated circuit (IC) die is disposed between the socket and the DUT board. The testing signals are electrically routed to the IC die through the DUT board. The IC die includes a substrate in which plurality of transistors is formed. A first structure contains a plurality of first metallization components. A second structure contains a plurality of second metallization components. The first structure is disposed over a first side of the substrate. The second structure is disposed over a second side of the substrate opposite the first side. A trench extends through the DUT board and extends partially into the IC die from the second side. A signal detection tool is configured to detect electrical or optical signals generated by the IC die.

Abstract: A circuit includes a voltage divider circuit configured to generate a feedback voltage according to an output voltage, an operational amplifier configured to output a driving signal according to the feedback voltage and a reference voltage and a pass gate circuit including multiple current paths. The current paths are controlled by the driving signal and connected in parallel between the voltage divider circuit and a power reference node.

Abstract: Disclosed in the present invention is a control method for water supply during loosening and conditioning based on a neural network model and a dual parameter correction. The method comprises: establishing a neural network-based model for predicting the amount of water supplied during loosening and conditioning; predicting and distributing the total water supplied; and correcting the model based on material balance calculation and deviation. In the present application, when there is a large deviation in outlet moisture, the dual correction control system combining the material balance calculation and the moisture deviation is used for correction to improve the stability and precise control of the outlet moisture during the loosening and conditioning process.

Abstract: A package-on-package (PoP) structure includes a first package structure and a second package structure stacked on the first package structure. The first package structure includes a die, conductive structures, an encapsulant, and a conductive pattern layer. The conductive structures surround the die. The encapsulant laterally encapsulates the die and the conductive structures. The conductive pattern layer is disposed over and in physical contact with a top surface of the encapsulant and top surfaces of the conductive structures. An entire bottom surface of the conductive pattern layer is located at a same level height, and an entirety of the top surface of the encapsulant and an entirety of the top surfaces of the conductive structures are located at the same level height.

Abstract: A method for manufacturing an electronic device includes the following steps: providing a carrier and a circuit substrate, wherein the carrier includes a plurality of spacers, the circuit substrate includes a plurality of electronic units, and the electronic units are detected and determined to be normal or defective; providing cover units on the carrier; disposing the circuit substrate on the cover units so that the spacers support the circuit substrate, wherein there is a gap between the circuit substrate and the cover units, and the cover units correspond to the electronic units determined to be normal; vacuuming the gap between the circuit substrate and the cover units; moving the spacers to make the cover units and the circuit substrate contact each other; and pressing the cover units and the circuit substrate to fix the cover units and the circuit substrate to each other.

Abstract: Provided in embodiments of the present application are an occlusion detection method for medical imaging, a medical imaging method, and a medical imaging system. The occlusion detection method for medical imaging includes: acquiring an image sequence, the image sequence including a plurality of images of an object in a time dimension; and according to at least one among confidence level change information and depth change information of a keypoint of the object in the plurality of images, determining an occlusion state of the keypoint.

Abstract: A nucleic acid detection device includes tube holders, an illumination module, a detection module and a driving module. The tube holders accommodates tubes, each containing a reagent and a magnetizable element. The illumination module includes light sources, a magnet and a casing, and the light sources and the magnet are installed on the casing. The driving module includes a motor, a lead screw and a slider. The lead screw is coupled to the motor and driven by the motor to rotate, and the slider is sleeved on the lead screw and has a reciprocating linear motion in response to a rotation of the lead screw. The illumination module is coupled to and moved together with the slider, so that the light sources and the magnet are synchronously driven by the motor and have reciprocating linear motions in a direction parallel to the lead screw.

Abstract: A semiconductor structure includes a semiconductor substrate; fin active regions protruded above the semiconductor substrate; and a gate stack disposed on the fin active regions; wherein the gate stack includes a high-k dielectric material layer, and various metal layers disposed on the high-k dielectric material layer. The gate stack has an uneven profile in a sectional view with a first dimension D1 at a top surface, a second dimension D2 at a bottom surface, and a third dimension D3 at a location between the top surface and the bottom surface, and wherein each of D1 and D2 is greater than D3.

Abstract: A data processing method includes acquiring Input/Output (I/O) data of plural storage apparatuses connected based on Redundant Arrays of Independent Disks (RAID), determining a stripe size for a data operation based on the I/O data, and storing the I/O data into the storage apparatuses based on the stripe size.

Abstract: Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed. The antibodies can be used to treat body weight loss, including cachexia, associated with the over-expression of human GDF15.

Abstract: An optical sensor includes a light source emitting signal light, a light sensing element on an optical path of the signal light, and a photoelectric conversion element on a side of the light sensing element away from the light source. The light sensing element is used to receive ambient light and the signal light on one side and transmit an incident light on another side, wherein a transmittance of the light sensing element changes according to an intensity of the ambient light to adjust an intensity of the incident light transmitted from the light sensing element. The photoelectric conversion element is configured to receive the incident light transmitted from the light sensing element, and to output a voltage modulation signal according to the incident light. A glasses is also provided.