Abstract: A method includes assessing tumor margins and discriminating between tumor and non-tumor tissues by analyzing the compositional make-up of smoke produced during cautery resection of tissues.

Abstract: The present invention pertains to an apparatus and method for adaptive exposure in imaging systems. An x-ray source for producing x-ray radiation and an x-ray detector for measuring amount of x-ray radiation passing through the human patient and striking the detector can be used. A tomographic image of the human patient or a tomosynthetic image of the human patient can be generated. Region of interest filtering and equalization filtering can be utilized. Filtering can be accomplished with a mechanical shield or shutter or with electronic control of the x-ray source.

Abstract: A method includes assessing tumor margins and discriminating between tumor and non-tumor tissues by analyzing the compositional make-up of smoke produced during cautery resection of tissues.

Abstract: Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

Abstract: The present invention pertains to an apparatus and method for X-ray imaging wherein a radiation source comprising rows of discrete emissive locations can be positioned such that these rows are angularly offset relative to rows of sensing elements on a radiation sensor. A processor can process and allocate responses of the sensing elements in appropriate memory locations given the angular offset between source and sensor. This manner of allocation can include allocating the responses into data rows associated with unique positions along a direction of columns of discrete emissive locations on the source. Mapping coefficients can be determined that map allocated responses into an image plane.

Abstract: The present invention pertains to a method and apparatus for generating a beam of charged particles, accelerating the charged particles toward a first side of a layer of X-ray target material configured to emit Bremsstrahlung radiation through a second side, receiving the Bremsstrahlung radiation on a first face of an additional layer of a different X-ray target material configured to emit characteristic fluorescence X-rays with energy above 20 keV through a second face, wherein the additional layer of X-ray target material is located within 3 mm of the second side of the first layer of material. The first X-ray target material can have an atomic number greater than 21.

Abstract: The present invention pertains to a system and method for X-ray imaging wherein a targeted fluence at the detector for projection images can be achieved at a plurality of projection angles around the imaging subject by control of exposure times implemented during image acquisition. Exposure time for a second projection image may be determined by the fluence in a first projection image, and in a third projection image by the fluence in a second projection image, where projection images are acquired within two degrees of one another. An acquisition parameter calculation can be configured to calculate acquisition parameters, such as said exposure times, to achieve the targeted fluence in projection images and can be coupled to a rotation controller that implements the acquisition parameters by controlling a relative angle between the imaging subject and X-ray image acquisition device.

Abstract: The present invention pertains to a system for electronic brachytherapy wherein a layer of target material can produce reflection and transmission X-rays when struck by electrons from a cathode. An alternative system can have a fixed-size containment structure around a miniature X-ray source, with X-ray attenuating coolant fluid between the source and containment structure. A balloon can be around the fixed-size containment structure and can be inflated with an X-ray inert gas.

Abstract: A method includes assessing tumor margins and discriminating between tumor and non-tumor tissues by analyzing the compositional make-up of smoke produced during cautery resection of tissues.

Abstract: The present invention pertains to a system and method for adaptive X-ray filtration comprising a volume of X-ray attenuating material with a central less attenuating three-dimensional region. The volume of X-ray attenuating material can be positioned within 10 cm from an X-ray source and rotated around an internal axis of rotation. The volume of X-ray attenuating material can be symmetric around the internal axis while the central less attenuating region can be asymmetric around the internal axis. Rotating the volume by a predetermined angle around the internal axis can change the amount of attenuation of an X-ray beam through the filter. The volume can be rotated by the same predetermined angle as an imaging subject or X-ray source and detector are rotated during X-ray image acquisition.

Abstract: The present invention pertains to a system and method for X-ray imaging wherein a targeted fluence at the detector for projection images can be achieved at a plurality of projection angles around the imaging subject by control of exposure times implemented during image acquisition. Exposure time for a second projection image may be determined by the fluence in a first projection image, and in a third projection image by the fluence in a second projection image, where projection images are acquired within two degrees of one another. An acquisition parameter calculation can be configured to calculate acquisition parameters, such as said exposure times, to achieve the targeted fluence in projection images and can be coupled to a rotation controller that implements the acquisition parameters by controlling a relative angle between the imaging subject and X-ray image acquisition device.

Abstract: The present invention pertains to an apparatus and method for inverse geometry volume computed tomography medical imaging of a human patient. A plurality of stationary x-ray sources for producing x-ray radiation are used. A rotating collimator located between the plurality of x-ray sources and the human patient is also used. A rotating detector can also be used.

Abstract: The present invention pertains to an apparatus and method for X-ray imaging a human patient. A vacuum bell bonded to an X-ray radiation-permeable window that can emit X-ray radiation from a plurality of spots located 1 cm from its edge, a collimator, and a detector are used. A ring of stationary X-ray sources can also be used with a stationary collimator and a rotating slot collimator and detector. An X-ray beam can be aligned in an X-ray system by establishing a position of the beam with respect to a moving collimator at a number of points in time, monitoring the velocity of the collimator, navigating the beam to a calculated position of a hole in the collimator, and correcting the alignment of the beam based on the location of the beam on the detector.

Abstract: The present invention pertains to a system and method for X-ray imaging wherein a targeted fluence at the detector for projection images can be achieved at a plurality of projection angles around the imaging subject by control of exposure times implemented during image acquisition. Exposure time for a second projection image may be determined by the fluence in a first projection image, and in a third projection image by the fluence in a second projection image, where projection images are acquired within two degrees of one another. An acquisition parameter calculation can be configured to calculate acquisition parameters, such as said exposure times, to achieve the targeted fluence in projection images and can be coupled to a rotation controller that implements the acquisition parameters by controlling a relative angle between the imaging subject and X-ray image acquisition device.

Abstract: The present invention pertains to an apparatus and method for X-ray imaging a human patient. A vacuum bell bonded to an X-ray radiation-permeable window that can emit X-ray radiation from a plurality of spots located 1 cm from its edge, a collimator, and a detector are used. A ring of stationary X-ray sources can also be used with a stationary collimator and a rotating slot collimator and detector. An X-ray beam can be aligned in an X-ray system by establishing a position of the beam with respect to a moving collimator at a number of points in time, monitoring the velocity of the collimator, navigating the beam to a calculated position of a hole in the collimator, and correcting the alignment of the beam based on the location of the beam on the detector.

Abstract: A method includes assessing tumor margins and discriminating between tumor and non-tumor tissues by analyzing the compositional make-up of smoke produced during cautery resection of tissues.

Abstract: The present invention pertains to an apparatus and method for medical imaging comprising rotating two X-ray source-detector pairs around an axis of rotation simultaneously to quickly acquire image data and form a computed tomography (CT) dataset. The sources can be configured to emit radiation from a plurality of discrete locations. The CT dataset can be utilized as a prior to reconstruct a three-dimensional image from subsequent bi-planar imaging with these source-detector pairs.

Abstract: The present invention pertains to an apparatus and method for adaptive exposure in imaging systems. An x-ray source for producing x-ray radiation and an x-ray detector for measuring amount of x-ray radiation passing through the human patient and striking the detector can be used. A tomographic image of the human patient or a tomosynthetic image of the human patient can be generated. Region of interest filtering and equalization filtering can be utilized. Filtering can be accomplished with a mechanical shield or shutter or with electronic control of the x-ray source.

Abstract: The present invention pertains to an apparatus and method for inverse geometry volume computed tomography medical imaging of a human patient. A plurality of stationary x-ray sources for producing x-ray radiation are used. A rotating collimator located between the plurality of x-ray sources and the human patient is also used. A rotating detector can also be used.

Abstract: The present invention pertains to an apparatus and method for X-ray imaging a human patient. A vacuum bell bonded to an X-ray radiation-permeable window that can emit X-ray radiation from a plurality of spots located 1 cm from its edge, a collimator, and a detector are used. A ring of stationary X-ray sources can also be used with a stationary collimator and a rotating slot collimator and detector. An X-ray beam can be aligned in an X-ray system by establishing a position of the beam with respect to a moving collimator at a number of points in time, monitoring the velocity of the collimator, navigating the beam to a calculated position of a hole in the collimator, and correcting the alignment of the beam based on the location of the beam on the detector.