Patents by Inventor Tobias William Barr Ost

Tobias William Barr Ost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for pair-wise sequencing a plurality of double stranded target polynucleotides
    Patent number: 7960120
    Abstract: The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of sequence information from each double-stranded template on a clustered array, rather than just a single sequencing read from one strand of the template.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: June 14, 2011
    Assignee: Illumina Cambridge Ltd.
    Inventors: Roberto Rigatti, Tobias William Barr Ost, Sarah J. Fashena
  • Method for sequencing a polynucleotide template
    Publication number: 20110014657
    Abstract: The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of sequence information from each double-stranded template on a clustered array, rather than just a single sequencing read from one strand of the template.
    Type: Application
    Filed: April 1, 2010
    Publication date: January 20, 2011
    Inventors: Roberto Rigatti, Tobias William Barr Ost, Sarah J. Fashena
  • Method for pair-wise sequencing a plurity of target polynucleotides
    Patent number: 7754429
    Abstract: The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of sequence information from each double-stranded template on a clustered array, rather than just a single sequencing read from one strand of the template.
    Type: Grant
    Filed: October 5, 2007
    Date of Patent: July 13, 2010
    Assignee: Illumina Cambridge Limited
    Inventors: Roberto Rigatti, Tobias William Barr Ost
  • Preparation of templates for nucleic acid sequencing
    Publication number: 20090118128
    Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.
    Type: Application
    Filed: July 20, 2006
    Publication date: May 7, 2009
    Inventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Barnes, Isabelle Marie Julia Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
  • Method for sequencing a polynucleotide template
    Publication number: 20090088327
    Abstract: The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of sequence information from each double-stranded template on a clustered array, rather than just a single sequencing read from one strand of the template.
    Type: Application
    Filed: October 5, 2007
    Publication date: April 2, 2009
    Inventors: Roberto Rigatti, Tobias William Barr Ost, Sarah Fashena