Abstract: The present invention relates generally to systems and methods and systems for generating polymer foams within body cavities to locate and/or control bleeding. The present invention further relates to methods and systems for generating polymer foams within non-compressible wounds to control or stop bleeding. The present invention further relates to the use of foams and gels for medical and cosmetic purposes.

Abstract: Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.

Abstract: According to one aspect of the invention, multicomponent fiber comprising (a) a polymeric core that comprises a core-forming polymer and (b) a polymeric sheath that comprises a hydrophilic polymer, wherein the core-forming fiber is more hydrophobic than the hydrophilic polymer and wherein the polymeric core, the polymeric sheath, or both, further comprises a hydrophilic excipient material. Other aspects of the present invention pertain to methods of forming such multicomponent fibers. Still other aspects of the present invention pertain to meshes and other articles that are formed using the multicomponent fibers.

Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).

Abstract: Systems and methods for the treatment of pelvic and junctional hemorrhage are provided, which utilize in situ forming polymer gels and foams to apply pressure to sites of hemorrhage due to penetrating or blunt injury, among other things.

Abstract: Systems and methods for electrospinning of core-sheath fibers are provided. The systems and methods achieve optimization of a shear stress that exists at a fluid boundary between core and sheath polymer solutions, by varying certain parameters of an electrospinning apparatus and/or the solutions used therewith.

Abstract: The present invention provides systems and methods for occluding and/or embolizing a cavity within a patient by delivering a prepolymer material into or onto a cavity and forming an expanding foam within the cavity. The inventions methods are applicable to occluding a variety of cavities, including blood vessels, aneurysms, left arterial appendages, vascular malformations and the like.

Abstract: Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.

Abstract: Systems and methods for electrospinning of core-sheath fibers are provided. The systems and methods achieve optimization of a shear stress that exists at a fluid boundary between core and sheath polymer solutions, by varying certain parameters of an electrospinning apparatus and/or the solutions used therewith.

Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).

Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).

Abstract: Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.

Abstract: Medical implants and methods useful in treating postpartum hemorrhage are disclosed. The implants, in some embodiments, comprise polyurethane foams having advantageous mechanical and other properties selected to promote hemostasis when brought in contact with an inner wall of a uterus. Methods of making and deploying such implants are also disclosed.

Abstract: Delivery catheters for in situ forming foams are provided. The catheters include, in various embodiments, coatings, valves, mixing structures, exit ports and combinations of the same.

Abstract: According to one aspect of the invention, multicomponent fiber are provided, which comprise (a) a polymeric core that comprises a core-forming polymer and (b) a polymeric sheath that comprises a sheath-forming polymer that is different than the core-forming polymer. Examples of core-forming polymers include, for instance, crosslinked polysiloxanes and thermoplastic polymers, among others. Examples of sheath-forming polymers include, for instance, solvent-soluble polymers, degradable polymers and hydrogel-forming polymers, among others. Other aspects of the present invention pertain to methods of forming such multicomponent fibers. For example, in certain preferred embodiments, the multicomponent fibers are formed using coaxial electrospinning techniques. Still other aspects of the present invention pertain to meshes and other articles that are formed using the multicomponent fibers.

Abstract: The present invention relates generally to systems and methods and systems for generating polymer foams within body cavities to locate and/or control bleeding. The present invention further relates to methods and systems for generating polymer foams within non-compressible wounds to control or stop bleeding. The present invention further relates to the use of foams and gels for medical and cosmetic purposes.

Abstract: The present invention provides systems and methods for occluding and/or embolizing a cavity within a patient by delivering a prepolymer material into or onto a cavity and forming an expanding foam within the cavity. The inventions methods are applicable to occluding a variety of cavities, including blood vessels, aneurysms, left arterial appendages, vascular malformations and the like.

Abstract: Systems and methods related to polymer foams for the treatment of blood vessel dissections are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to or within a dissection caused by an intimal tear in a blood vessel, sealing the dissection and preventing further perfusion thereof. In some embodiments, the polymer foam can be formed within a body cavity (i.e., in-situ foam formation). The foam may be used to fill the dissection as a thrombosing agent. In addition, the foam may be used in conjunction with medical devices such as stents, stent-grafts, balloons, and catheters.

Abstract: The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.

Abstract: Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.