Patents by Inventor Todd Roswech
Todd Roswech has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11713235Abstract: A fluidic interconnect includes a first interface including a liquid port, a gas port, and a cradle; a second interface including a liquid port, a gas port, and a swing bar to engage the cradle, a weight of a container attached to one of the first or second interfaces to drive the liquid port of the first interface into connection with the liquid port of the second interface and the gas port of the first interface into connection with the gas port of the second interface.Type: GrantFiled: December 22, 2021Date of Patent: August 1, 2023Assignee: Life Technologies CorporationInventors: Todd Roswech, Jonathan Schultz, Chun Heen Ho
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Publication number: 20230188010Abstract: A rotor assembly includes a rotor plate to rotate around a first axis, a bucket attached to the rotor plate and to rotate around a second axis, and a stop plate to rotate around the first axis between an open position and a closed position. When in the closed position, the stop plate engages the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly. The rotor assembly further includes a housing for a sensor array component, the housing disposed in the bucket and including a solution inlet, a solution outlet, a transfer basin, a solution retainer disposed between the solution outlet and the transfer basin, and a collection reservoir in fluid communication with the transfer basin. The solution inlet and the solution outlet to engage ports of a flow cell of a sensor array.Type: ApplicationFiled: February 2, 2023Publication date: June 15, 2023Inventor: Todd ROSWECH
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Patent number: 11588381Abstract: A rotor assembly includes a rotor plate to rotate around a first axis, a bucket attached to the rotor plate and to rotate around a second axis, and a stop plate to rotate around the first axis between an open position and a closed position. When in the closed position, the stop plate engages the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly. The rotor assembly further includes a housing for a sensor array component, the housing disposed in the bucket and including a solution inlet, a solution outlet, a transfer basin, a solution retainer disposed between the solution outlet and the transfer basin, and a collection reservoir in fluid communication with the transfer basin. The solution inlet and the solution outlet to engage ports of a flow cell of a sensor array.Type: GrantFiled: September 3, 2020Date of Patent: February 21, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventor: Todd Roswech
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Publication number: 20230044160Abstract: An apparatus for preparing a reagent solution includes an enclosure and a container disposed within the enclosure. The container defines an internal cavity having a compressible volume and defines a passage providing fluidic communication between the internal cavity and the exterior of the container. Optionally, a compressible member is disposed within the internal cavity. A reagent is disposed within the internal cavity.Type: ApplicationFiled: October 20, 2022Publication date: February 9, 2023Inventors: Jonathan Schultz, Todd Roswech
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Patent number: 11478786Abstract: An apparatus for preparing a reagent solution includes an enclosure and a container disposed within the enclosure. The container defines an internal cavity having a compressible volume and defines a passage providing fluidic communication between the internal cavity and the exterior of the container. Optionally, a compressible member is disposed within the internal cavity. A reagent is disposed within the internal cavity.Type: GrantFiled: August 27, 2020Date of Patent: October 25, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Jonathan Schultz, Todd Roswech
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Publication number: 20220299508Abstract: Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. Further embodiments provide methods of detecting genetic abnormalities. Diagnostic tests comprising a sample-collecting component, one or more reagents (e.g., lysis reagents, nucleic acid amplification reagents), and a detection component (e.g., a component comprising a lateral flow assay strip) are provided.Type: ApplicationFiled: March 14, 2022Publication date: September 22, 2022Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Isaac Bean, Todd Roswech
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Publication number: 20220299509Abstract: A rapid diagnostic test apparatus includes: a housing; a sample chamber movably coupled to the housing; and a housing blister compartment arranged in the housing and configured to rupture when the housing is moved relative to the sample chamber from a first position to a second position. The sample chamber may include a vial portion. A vial blister compartment may seal an opening of the vial portion. The sample chamber may include a tube portion disposed in the housing. The vial portion may extend from the housing. The sample chamber may be rotatably coupled to the housing. The housing blister compartment may rupture when the housing is rotated relative to the sample chamber from the first position to the second position. The housing blister compartment may contain a fluid that may be released into the housing when in the second position.Type: ApplicationFiled: March 21, 2022Publication date: September 22, 2022Inventors: Matthew Dyer, Todd Roswech, Isaac Bean
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Publication number: 20220185653Abstract: A fluidic interconnect includes a first interface including a liquid port, a gas port, and a cradle; a second interface including a liquid port, a gas port, and a swing bar to engage the cradle, a weight of a container attached to one of the first or second interfaces to drive the liquid port of the first interface into connection with the liquid port of the second interface and the gas port of the first interface into connection with the gas port of the second interface.Type: ApplicationFiled: December 22, 2021Publication date: June 16, 2022Inventors: Todd ROSWECH, Jonathan SCHULTZ, Chun HO
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Publication number: 20220176371Abstract: Diagnostic devices for performing diagnostic tests are provided, as well as methods that utilize the diagnostic devices, methods for manufacturing the diagnostic devices, and test kits for performing the diagnostic tests. The diagnostic devices may include a sample chamber; a fluid chamber connected to the sample chamber by a conduit; and a test chamber separated from the sample chamber by a breakable seal. A movable liner may form a portion of an inner surface of the sample chamber. The sample chamber may be configured to receive a sample swab, which may move in a first direction when being inserted in the sample chamber to an inserted position, and which may to move in a second direction to cause the breakable seal to break. Movement of the sample swab in the second direction may cause the liner to move in the second direction to break the breakable seal.Type: ApplicationFiled: December 2, 2021Publication date: June 9, 2022Applicant: Detect, Inc.Inventors: Todd Roswech, Matthew Dyer
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Publication number: 20220155294Abstract: Diagnostic devices for performing diagnostic tests are provided, as well as methods that utilize the diagnostic devices, methods for manufacturing the diagnostic devices, and test kits for performing the diagnostic tests. The diagnostic devices include a sample chamber with an opening for receiving a sample; a fluid chamber containing a fluid; and a test and readout chamber containing a lateral-flow assay (LFA) strip. The fluid chamber and/or the test and readout chamber is/are burstable and is/are configured to be in fluid connection with the sample chamber upon bursting. The fluid chamber may be flexible and configured to burst at a seal separating the sample chamber from the fluid chamber. The seal maybe configured to break when a bursting force is applied to the fluid chamber.Type: ApplicationFiled: November 12, 2021Publication date: May 19, 2022Inventors: Todd Roswech, Matthew Dyer
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Publication number: 20220146508Abstract: Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. Further embodiments provide methods of detecting genetic abnormalities. Diagnostic tests comprising a sample-collecting component, one or more reagents (e.g., lysis reagents, nucleic acid amplification reagents), and a detection component (e.g., a component comprising a lateral flow assay strip and/or a colorimetric assay) are provided.Type: ApplicationFiled: November 4, 2021Publication date: May 12, 2022Applicant: Detect, Inc.Inventors: Todd Roswech, Jonathan M. Rothberg, Isaac Bean, Monica Florence Caravias, Matthew Dyer
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Publication number: 20220128555Abstract: Diagnostic devices for performing diagnostic tests are provided, as well as methods that utilize the diagnostic devices, methods for manufacturing the diagnostic devices, and test kits for performing the diagnostic tests. The diagnostic devices include a vial, a rupturable container disposed in an internal cavity of the vial and containing a fluid, and a test and readout device in fluid communication with the internal cavity of the vial. The rupturable container is configured to rupture during a test procedure of the diagnostic test to enable the fluid to flow into the internal cavity of the vial. The rupturable container may include a rupturable ampoule or a frangible seal. The rupturable container may be ruptured by deformation of the vial or by piercing caused by a sharp object in the vial or a sample swab inserted in the vial.Type: ApplicationFiled: October 26, 2021Publication date: April 28, 2022Applicant: Detect, Inc.Inventor: Todd Roswech
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Publication number: 20220120743Abstract: Described herein in an embodiment is a lateral flow assay strip for detecting the presence of one or more target nucleic acid sequences (e.g., one or more nucleic acid sequences of a pathogen, such as a coronavirus or an influenza virus). The lateral flow assay strip may comprise a first test line configured to detect a first target nucleic acid sequence and a flow control line configured to detect a liquid. In some cases, the first test line comprises a biological capture reagent (e.g., an immobilized antibody). In some cases, the flow control line comprises a non-biological fluid indicator (i.e., a non-antibody reagent). The non-biological fluid indicator may, for example, comprise a pH-sensitive material, a moisture-sensitive material, and/or a chemically-sensitive material. The flow control line may provide a visual indication of whether a fluidic sample was successfully transported from a first end of the lateral flow assay strip to the first test line.Type: ApplicationFiled: October 15, 2021Publication date: April 21, 2022Applicant: Detect, Inc.Inventors: Amy Cornell, Todd Roswech, John H. Leamon
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Publication number: 20220040699Abstract: Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In one embodiment, a diagnostic system is provided comprising a control device configured to control one or more parameters and/or actions of a diagnostic test, and a test kit component comprising a physical encoding of control information for the control device. In one embodiment, the control device is configured to receive the control information of the physical encoding and perform one or more actions based at least in part on the control information. In one embodiment, the control device can control one or more temperatures at which a biological sample is to be processed as part of the diagnostic test.Type: ApplicationFiled: August 9, 2021Publication date: February 10, 2022Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Benjamin Rosenbluth, Todd Roswech
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Patent number: 11214478Abstract: A fluidic interconnect includes a first interface including a liquid port, a gas port, and a cradle; a second interface including a liquid port, a gas port, and a swing bar to engage the cradle, a weight of a container attached to one of the first or second interfaces to drive the liquid port of the first interface into connection with the liquid port of the second interface and the gas port of the first interface into connection with the gas port of the second interface.Type: GrantFiled: February 2, 2021Date of Patent: January 4, 2022Assignee: Life Technologies CorporationInventors: Todd Roswech, Jonathan Schultz, Chun Ho
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Publication number: 20210378643Abstract: Provided herein, in some embodiments, are breakable swabs for sample collection. In some embodiments, the swabs may be used in rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. The swab may include a stem portion for handling and a head portion for collecting and/or holding a sample. After sample collection, the head portion may be inserted into a reaction tube or any other sample-receiving device. The stem portion of the swab may then be separated or detached from the head portion along a breakable portion.Type: ApplicationFiled: June 3, 2021Publication date: December 9, 2021Applicant: Detect, Inc.Inventors: Todd Roswech, Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth
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Publication number: 20210291165Abstract: Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. Further embodiments provide methods of detecting genetic abnormalities. Diagnostic tests comprising a sample-collecting component, one or more reagents (e.g., lysis reagents, nucleic acid amplification reagents), and a detection component (e.g., a component comprising a lateral flow assay strip and/or a colorimetric assay) are provided.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Todd Roswech, Matthew Dyer, Jose Camara, Eric Kauderer-Abrams, Jonathan C. Schultz
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Publication number: 20210291176Abstract: Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. Further embodiments provide methods of detecting genetic abnormalities. Diagnostic tests comprising a sample-collecting component, one or more reagents (e.g., lysis reagents, nucleic acid amplification reagents), and a detection component (e.g., a component comprising a lateral flow assay strip) are provided.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Todd Roswech, John H. Leamon, Jonathan M. Rothberg
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Publication number: 20210292825Abstract: Provided herein are rapid diagnostic tests, systems, and methods for detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens, such as SARS-CoV-2 or an influenza virus) using isothermal nucleic acid amplification. The tests, systems, and methods described herein may be performed in a point-of-care setting or a home setting without specialized equipment.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Matthew Dyer, Todd Roswech, Eric Kauderer-Abrams, Jose Camara
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Publication number: 20210291177Abstract: A reagent carrier includes: a cap configured to fit on an opening of a reaction vessel; and a reagent confined by the cap. The cap may be configured to release the reagent when a user manipulates the cap while the cap is fitted on the opening of the reaction vessel. For example, the reagent may be released when the user twists the cap from a first position to a second position or when the user pushes on a surface of the cap. The cap may be configured to seal the opening of the reaction vessel when the cap is fitted on the opening of the reaction vessel. In some implementations, the cap may be a blister cap containing the reagent. In some implementations, the cap may include a cage containing the reagent. In some implementations, the cap may include a deformable structure containing the reagent.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Todd Roswech, Eric Kauderer-Abrams, Matthew Dyer, Jose Camara, Owen Kaye-Kauderer, John H. Leamon