Patents by Inventor Tohru Yasukohchi

Tohru Yasukohchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8828373
    Abstract: A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn?1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: September 9, 2014
    Assignee: NOF Corporation
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Patent number: 8034981
    Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: October 11, 2011
    Assignee: NOF Corporation
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Patent number: 8003117
    Abstract: A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA2 is an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn?1.07 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: August 23, 2011
    Assignee: NOF Corporation
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Publication number: 20110082277
    Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
    Type: Application
    Filed: November 9, 2010
    Publication date: April 7, 2011
    Applicant: NOF CORPORATION
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yammamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Patent number: 7851491
    Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: December 14, 2010
    Assignee: NOF Corporation
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Publication number: 20090192320
    Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
    Type: Application
    Filed: March 6, 2009
    Publication date: July 30, 2009
    Applicant: NOF CORPORATION
    Inventors: Ken-ichiro NAKAMOTO, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Patent number: 7531604
    Abstract: A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4?m?100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: May 12, 2009
    Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.
    Inventors: Syunsuke Ohhashi, Kazuhiro Kubo, Chika Itoh, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Kurosawa, Hitoshi Yamauchi
  • Patent number: 7524981
    Abstract: A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1?k1?(k+2)/2, 0?k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: April 28, 2009
    Assignees: NOF Corporation, DAIICHI Pharmaceutical Co., Ltd.
    Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi, Yusuke Ohkawa, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Patent number: 7524875
    Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: April 28, 2009
    Assignee: NOF Corporation
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Patent number: 7495116
    Abstract: A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3?m?200, 9?m×(k1+k2+k3)?1000, 1?k1?2, 0?k2?9 and 0?k3?9, and 3?k1+k2+k3?10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: February 24, 2009
    Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.
    Inventors: Chika Itoh, Kazuhiro Kubo, Syunsuke Ohhashi, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Patent number: 7399877
    Abstract: A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5?m?600, 1?n?45, 0?q?200, 10?m+n+q?600, 0.04?n/(m+n+q), and q/(m+n+q)?0.
    Type: Grant
    Filed: March 19, 2004
    Date of Patent: July 15, 2008
    Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.
    Inventors: Chika Itoh, Syunsuke Ohhashi, Kazuhiro Kubo, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Patent number: 7198945
    Abstract: A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features: (1) having one or more aliphatic hydrocarbon groups at one end; (2) having one or more portions containing a hydrophilic group in a molecule; and (3) having one or more reactive functional groups which are capable of covalently binding with the substance to be modified at an end different from the end in the above (1).
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: April 3, 2007
    Assignees: Teruyuki Nagamune, NOF Corporation
    Inventors: Teruyuki Nagamune, Chika Itoh, Tohru Yasukohchi, Syunsuke Ohhashi, Kazuhiro Kubo
  • Publication number: 20070031481
    Abstract: A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5?m?600, 1?n?45, 0?q?200, 10?m+n+q?600, 0.04?n/(m+n+q), and q/(m+n+q)?0.
    Type: Application
    Filed: March 19, 2004
    Publication date: February 8, 2007
    Inventors: Chika Itoh, Syunsuke Ohhashi, Kazuhiro Kubo, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Publication number: 20060210618
    Abstract: A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1?k1?(k+2)/2, 0?k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
    Type: Application
    Filed: December 12, 2003
    Publication date: September 21, 2006
    Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi, Yusuke Ohkawa, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Publication number: 20060115450
    Abstract: A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn?1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
    Type: Application
    Filed: June 2, 2005
    Publication date: June 1, 2006
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Publication number: 20060110436
    Abstract: A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4?m?100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium
    Type: Application
    Filed: September 30, 2003
    Publication date: May 25, 2006
    Inventors: Syunsuke Ohhashi, Kazuhiro Kubo, Chika Itoh, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Kurosawa, Hitoshi Yamauchi
  • Publication number: 20060073113
    Abstract: A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA2 is an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance, polydispersity Mw/Mu of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn?1.07 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.
    Type: Application
    Filed: June 2, 2005
    Publication date: April 6, 2006
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Publication number: 20050288490
    Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.
    Type: Application
    Filed: June 2, 2005
    Publication date: December 29, 2005
    Inventors: Ken-ichiro Nakamoto, Syunsuke Ohashi, Yuji Yamamoto, Kenji Sakanoue, Chika Itoh, Tohru Yasukohchi
  • Publication number: 20050220856
    Abstract: A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3?m?200, 9?m×(k1+k2+k3)?1000, 1?k1?2, 0?k2?9 and 0?k3?9, and 3?k1+k2+k3?10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.
    Type: Application
    Filed: March 28, 2003
    Publication date: October 6, 2005
    Inventors: Chika Itoh, Kazuhiro Kubo, Syunsuke Ohhashi, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Kurosawa, Hitoshi Yamauchi
  • Publication number: 20050079188
    Abstract: A base for a skin external composition comprises, as a main ingredient, an alkylene oxide derivative represented by the following formula (I): R1O—[(AO)m(EO)n]—R2??(I) wherein AO is an oxyalkylene group having a carbon number of 3 to 4; EO is an oxyethylene group; and R1 and R2 may be the same or different, and are a hydrocarbon group having a carbon number of 1 to 4, or a hydrogen atom. The base is a water-soluble base that can exert both of the smooth feeling and the moist feeling.
    Type: Application
    Filed: September 27, 2002
    Publication date: April 14, 2005
    Inventors: Takashi Ohmori, Hiroyuki Kakoki, Reiji Miyahara, Tomiyuki Nanba, Toshihiko Nakane, Kei-chi Maruyama, Takeshi Sakoda, Tohru Yasukohchi, Yoji Tezuka