Abstract: A system, computer program, and database for the accurate determination of consumer spend at the individual household level by category using a combination of census spend data at the neighborhood (Consumer Block Group) level and demographic data. The invention defines a set of detailed measures of consumer spend and computes values for those measures using unique combinations of data and machine learning generating a CBG spend model and a household spend model to iteratively refine the spend models and derive therefrom individual household dollar spend amounts to accurately identify target households or groups of households most likely to respond to advertisements or consumer communications.

Abstract: A system, computer program, and database for the accurate determination of consumer spend at the individual household level by category using a combination of census spend data at the neighborhood (Consumer Block Group) level and demographic data. The invention defines a set of detailed measures of consumer spend and computes values for those measures using unique combinations of data and machine learning generating a CBG spend model and a household spend model to iteratively refine the spend models and derive therefrom individual household dollar spend amounts to accurately identify target households or groups of households most likely to respond to advertisements or consumer communications.

Abstract: A method of forming a tissue equivalent is described. A length of polyester tube is threaded over a mandrel (H) and attached at either end by clips at A and D. A block (F) is then screwed into place. The polyester is then pre-soaked by injecting through Tap (2) an acidified collagen solution for approximately one hour. After a suitable period of time the excess solution is aspirated off. Following this stage, a second, alkaline solution is injected into the apparatus which contains smooth muscle cells (SMC). Thus, neutralisation of the collagen impregnated within the fabric of the tube occurs leading to spontaneous fibrillogenesis within the interstices of the cloth, eliminating the risk of delamination. The apparatus is then incubated. The collagen contracts down onto the fabric tube and the cell-impregnated gel becomes incorporated into the presoaked collagen. The pre-impregnated collagen and the collagen provided in the aqueous mixture contract down as one into a coherent whole with the SMC.