Patents by Inventor Tomikazu Sasaki

Tomikazu Sasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CGAS in systemic lupus erythematosus (SLE)
    Patent number: 10329258
    Abstract: The present invention provides therapeutic strategies for treatment of severe debilitating diseases associated with IFN-I due to cGAS activation. In one aspect, the invention provides compounds of Formula (I): [Formula should be inserted here] and pharmaceutical uses thereof. In another aspect, the invention provides methods for treating an autoimmune disease or a monogenic disorder by administering an effective amount of a compound of Formula (I).
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: June 25, 2019
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Keith Elkon, Jie An, Mark Minie, Tomikazu Sasaki, Joshua J. Woodward
  • CGAS IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
    Publication number: 20180086713
    Abstract: The present invention provides therapeutic strategies for treatment of severe debilitating diseases associated with IFN-I due to cGAS activation. In one aspect, the invention provides compounds of Formula (I): [Formula should be inserted here] and pharmaceutical uses thereof. In another aspect, the invention provides methods for treating an autoimmune disease or a monogenic disorder by administering an effective amount of a compound of Formula (I).
    Type: Application
    Filed: April 26, 2016
    Publication date: March 29, 2018
    Inventors: Keith ELKON, Jie AN, Mark MINIE, Tomikazu SASAKI, Joshua J. WOODWARD
  • Artemisinin compounds and synthesis and use thereof
    Patent number: 9422306
    Abstract: The present disclosure describes artemisinin compounds. The compounds can be synthesized using an Ugi synthesis reaction and can be used in the treatment of cancers, parasitic infections and yeast infections.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: August 23, 2016
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Tomikazu Sasaki, Shusheng Wang
  • ARTEMISININ COMPOUNDS AND SYNTHESIS AND USE THEREOF
    Publication number: 20150344493
    Abstract: The present disclosure describes artemisinin compounds. The compounds can be synthesized using an Ugi synthesis reaction and can be used in the treatment of cancers, parasitic infections and yeast infections.
    Type: Application
    Filed: December 19, 2013
    Publication date: December 3, 2015
    Inventors: Tomikazu Sasaki, Shusheng Wang
  • Covalent conjugates between endoperoxides and transferrin and lactoferrin receptor-binding agents
    Patent number: 9169291
    Abstract: The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: October 27, 2015
    Assignee: University of Washington
    Inventors: Tomikazu Sasaki, Henry Chiu-Yuen Lai, Narendra Pal Singh, Steve J. Oh
  • Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use
    Patent number: 8048850
    Abstract: In one aspect, the invention provides covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and holotransferrin. In another aspect, the invention provides methods for administering the covalent conjugates of the invention to treat cancer and infections by pathogens that bind iron-carrying proteins.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: November 1, 2011
    Assignee: University of Washington
    Inventors: Henry C. Lai, Tomikazu Sasaki, Narendra P. Singh
  • COVALENT CONJUGATES BETWEEN ENDOPEROXIDES AND TRANSFERRIN AND LACTOFERRIN RECEPTOR-BINDING AGENTS
    Publication number: 20110150830
    Abstract: The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections.
    Type: Application
    Filed: February 14, 2011
    Publication date: June 23, 2011
    Applicant: WASHINGTON, UNIVERSITY OF
    Inventors: Tomikazu Sasaki, Henry Chiu-Yuen Lai, Narendra Pal Singh, Steve J. Oh
  • Conjugates of artemisinin-related endoperoxides and hydrazone derivatives for the treatment of cancer
    Patent number: 7692030
    Abstract: Compounds having an artemisinin-related endoperoxide moiety covalently coupled to a hydrazone moiety through a linker. Compositions and methods for treating cancer using the compounds.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: April 6, 2010
    Assignee: University of Washington
    Inventors: Tomikazu Sasaki, Henry Lai, Narendra P. Singh
  • CONJUGATES OF ARTEMISININ-RELATED ENDOPEROXIDES AND HYDRAZONE DERIVATIVES FOR THE TREATMENT OF CANCER
    Publication number: 20080103192
    Abstract: Compounds having an artemisinin-related endoperoxide moiety covalently coupled to a hydrazone moiety through a linker. Compositions and methods for treating cancer using the compounds.
    Type: Application
    Filed: October 15, 2007
    Publication date: May 1, 2008
    Applicant: Washington, University of
    Inventors: Tomikazu Sasaki, Henry Lai, Narendra Singh
  • COVALENT CONJUGATES BETWEEN ENDOPEROXIDES AND TRANSFERRIN AND LACTOFERRIN RECEPTOR-BINDING AGENTS
    Publication number: 20070231300
    Abstract: The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections.
    Type: Application
    Filed: March 28, 2007
    Publication date: October 4, 2007
    Applicant: WASHINGTON, UNIVERSITY OF
    Inventors: Tomikazu Sasaki, Henry Chiu-Yuen Lai, Narendra Pal Singh, Steve J. Oh
  • Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use
    Publication number: 20040067875
    Abstract: In one aspect, the invention provides covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and holotransferrin. In another aspect, the invention provides methods for administering the covalent conjugates of the invention to treat cancer and infections by pathogens that bind iron-carrying proteins.
    Type: Application
    Filed: June 6, 2003
    Publication date: April 8, 2004
    Applicant: University of Washington
    Inventors: Henry C. Lai, Tomikazu Sasaki, Narendra P. Singh
  • Derivatized calcitonins
    Patent number: 5710244
    Abstract: Derivatized calcitonin molecules, pharmaceutical compositions comprising derivatized calcitonins, and methods of reducing serum calcium in a patient using the derivatized calcitonins are disclosed. The molecules are characterized by a derivatized amino terminus formed by combining a calcitonin with a cyclic, polycyclic or heterocyclic moiety. Multimeric forms of the molecules are also disclosed.
    Type: Grant
    Filed: December 30, 1993
    Date of Patent: January 20, 1998
    Inventors: Virender M. Labroo, Tomikazu Sasaki