Abstract: A method of constructing a data architecture for use in identifying connections between perturbagens and genes associated with skin tone. The method includes providing a gene expression profile for a control cell, generating a gene expression profile for a cell exposed to a perturbagen, identifying genes differentially expressed in response to the perturbagen, creating an ordered list of identifiers, storing the ordered list as an instance on a computer readable medium, and constructing a data architecture of stored instances.

Abstract: Embodiments of screening methods for determining test agents effective for modifying the appearance of pigmented skin are provided. The screening method may comprise the steps of contacting a cell, a cell culture, or bulk cells with the test agent, wherein the cell, the cell culture, or the bulk cells comprise ADR?1 receptors, and determining based on the binding interaction of the test agent with the ADR?1 receptors whether the test agent is an effective ADR?1 receptor antagonist suitable for modifying the appearance of pigmented skin, wherein a test agent is considered to be an effective ADR?1 receptor antagonist when it defines a half maximal inhibitory concentration of less than about 1000 ppm.

Abstract: An electronic device having a function of identifying a lane on which a vehicle is traveling based on imaging data includes a white line recognition unit for recognizing a white line based on imaging data taken by a rear camera, a lane width detection unit for detecting a lane width by measuring distances from the vehicle to the right white line and to the left white line, a lane change detection unit for detecting a lane change based on the detection result by the lane width detection unit, a lane number increase detection unit for detection an increase in the number of lanes based on the detection result by the lane width detection unit, and a traveling lane identifying unit for identifying a lane on which the vehicle is traveling based on the detection results of the lane width detection unit and the lane number increase detection unit.

Abstract: Low pH cosmetic compositions and methods for improving the appearance of skin. The low pH cosmetic compositions herein include a saccharide and, optionally, one or more additional skin care actives to improve the appearance of skin. The lower pH reduces or even eliminates some of the skin health and appearance drawbacks associated with saccharide induced glycation.

Abstract: A method of identifying a test agent as a skin tone agent. The method includes determining the level of high-mobility group protein B1 (HMGB1), messenger RNA associated with the expression and/or regulation of HMGB1 (HMGB1 mRNA), and/or micro-RNA associated with the expression and/or regulation of HMGB1 (HMGB1 miRNA) present in the test sample, and identifying the test agent as a skin tone agent when there is no increase in HMGB1 level, a downregulation in transcription of HMGB1 mRNA, and/or an upregulation of HMGB1 miRNA. The method also includes identifying a test agent as a skin tone agent when the test agent inhibits or prevents an increase in melanocyte dendricity and/or body size caused by HMGB1.

Abstract: A method of making a skin composition that includes an effective amount of skin care agent selected to inhibit HMGB1 stimulation of human melanocytes. The method includes determining the level of high-mobility group protein B1 (HMGB1), messenger RNA associated with the expression and/or regulation of HMGB1 (HMGB1 mRNA), and/or micro-RNA associated with the expression and/or regulation of HMGB1 (HMGB1 miRNA) present in the test sample, and identifying the test agent as a skin tone agent when there is no increase in HMGB1 level, a downregulation in transcription of HMGB1 mRNA, and/or an upregulation of HMGB1 miRNA. The method also includes identifying a test agent as a skin tone agent when the test agent inhibits or prevents an increase in melanocyte dendricity and/or body size caused by HMGB1, and incorporating the skin tone agent in a dermatologically acceptable carrier.

Abstract: Cosmetic methods and compositions for improving the appearance and barrier function of skin. The methods and compositions utilize a combination of niacinamide and a suitable saccharide at low pH to decrease trans-epidermal water loss in skin, reduce the size of hyperpigmented spots, and improve the appearance of skin better than their high pH counterparts.

Abstract: A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis (2-ethylhexyl) sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.

Abstract: Cosmetic methods and compositions for improving the appearance and barrier function of skin. The methods and compositions utilize a combination of niacinamide and a suitable saccharide at low pH to decrease trans-epidermal water loss in skin, reduce the size of hyperpigmented spots, and improve the appearance of skin better than their high pH counterparts.

Abstract: Personal care compositions containing an active selected from the group consisting of phlorogine, phlorgine BG, deoxyArbutin, sucrose dilaurate, bakuchiol, pyrenoine, millet, arlatone dioic acid, cinnamic acid, ferulic acid, achromaxyl, methyl nicotinamide, oil soluble licorice extract, folic acid, undecylenic acid, zinc undecylenate, L-tryptophan, thiamine HCl, hexylresorcinol, lipidami red vine, dragosine, methyl gentisate, inositol, symdiol 68, laminaine, their salts, their derivatives, their precursors, and/or combinations thereof. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.

Abstract: A cosmetic composition for topical application to skin is provided. The cosmetic composition includes vitamin B3 compound, a ricinoleate compound and a dermatologically acceptable carrier. The vitamin B3 compound and the ricinoleate beneficially or even synergistically up-regulate proteasomal protease activity as evidenced by a higher observed net luminescence value relative to the calculated net luminescence value in B16 melanoma cells.

Abstract: A skin care product is provided. The skin care product includes a multi-component skin care composition disposed in a multi-chamber container. The multi-component skin care composition includes an aqueous carrier component and a nicotinamide riboside component disposed in separate chambers, which prevents these components from contacting one another prior to use. The aqueous carrier component and the nicotinamide riboside component can be separated from one another by one or more fluid impermeable dividing members and/or activatable elements, which upon activation enable contact between the aqueous carrier component and nicotinamide riboside component.

Abstract: A stable cosmetic agent in the form of a plurality of encapsulated particles in a core-shell configuration. The encapsulated particles are formed by coating nicotinamide riboside powder or a nicotinamide riboside containing material with one or more water-insoluble encapsulating agents. The stable encapsulated nicotinamide riboside particles exhibit less than 20% hydrolysis when incorporated into an aqueous skin care composition.

Abstract: A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include batyl alcohol, undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.

Abstract: A method of inhibiting PAR2 activation of keratinocytes by boosting the PAR2 inhibition ability of a vitamin B3 compound and an N-acyl amino acid compound with a Laminaria Saccharina extract. The method may be used to improve the appearance of hyperpigmented spots on skin. By determining the amount of Laminaria Saccharina extract needed to boost PAR2 inhibition ability of a vitamin B3 compound and an N-acyl amino acid compound, improved skin care composition can be formulated for the treatment of hyperpigmented skin.

Abstract: An electronic device having a function of identifying a lane on which a vehicle is traveling based on imaging data includes a white line recognition unit for recognizing a white line based on imaging data taken by a rear camera, a lane width detection unit for detecting a lane width by measuring distances from the vehicle to the right white line and to the left white line, a lane change detection unit for detecting a lane change based on the detection result by the lane width detection unit, a lane number increase detection unit for detection an increase in the number of lanes based on the detection result by the lane width detection unit, and a traveling lane identifying unit for identifying a lane on which the vehicle is traveling based on the detection results of the lane width detection unit and the lane number increase detection unit.

Abstract: A method of identifying a test agent as a skin tone agent. The method includes determining the level of high-mobility group protein B1 (HMGB1), messenger RNA associated with the expression and/or regulation of HMGB1 (HMGB1 mRNA), and/or micro-RNA associated with the expression and/or regulation of HMGB1 (HMGB1 miRNA) present in the test sample, and identifying the test agent as a skin tone agent when there is no increase in HMGB1 level, a downregulation in transcription of HMGB1 mRNA, and/or an upregulation of HMGB1 miRNA. The method also includes identifying a test agent as a skin tone agent when the test agent inhibits or prevents an increase in melanocyte dendricity and/or body size caused by HMGB1.

Abstract: A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis(2-ethylhexyl)adipate, bis(2-ethylhexyl)maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis(2-ethylhexyl)sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.

Abstract: A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using said cosmetic compositions is also disclosed herein.

Abstract: Human skin tissue sample methods and models for identifying and screening test agents as effective for providing skin tone benefits, methods for validating hypotheses for mechanisms driving skin pigmentation as well as methods for driving skin pigment levels in ex-vivo skin tissue. The method includes contacting a cultured human skin tissue sample with a test agent, generating a transcriptional profile from the sample, and comparing the results to a control to determine if the test agent is effective for providing a skin tone benefit.