Abstract: The purpose of the present invention is to provide a nucleic acid analyzer which prevents an increase in reagent consumption caused by a branched channel structure and on which multiple kinds of substrates having different channel numbers can be mounted. The nucleic acid analyzer according to the present invention is provided with a first substrate that comprises an inlet section connected to an introduction path, a first outlet section connected to a first discharge path, a second outlet section connected to a second discharge path, a first channel guiding a reagent from the inlet section to the first outlet section, a second channel guiding the reagent from the inlet section to the second outlet section, and a branching section branching, from the inlet section, into the first and second channels, wherein the first and second channels are connected to each other exclusively at the branching portion.

Abstract: The present invention provides a nucleic acid analysis device that, even when a plurality of flow cells is handled, does not require an increase in the required movement amount, and can be reduced in size by reducing the size of a stage mechanism. This nucleic acid analysis device is characterized by having a sample container containing a nucleic acid sample to be analyzed, an imaging means for observing the nucleic acid sample, and a stage mechanism for moving the sample container, and is characterized in that the stage mechanism has two translation means and at least one rotation means, one of the two translation means is disposed on the upper surface of the rotation means, and the other is disposed on the lower surface of the rotation means.

Abstract: An image capturing mechanism includes: an optical measurement unit for optically observing a sample; a temperature conditioning unit for heating or cooling the sample, the temperature conditioning unit being mounted on a table by means of a support member; and a moving mechanism for moving the table in order to photograph the sample. The temperature conditioning unit includes: a temperature conditioning part for heating or cooling the sample, abutted on one face of a Peltier device; a heat conducting member abutted on the other face of the Peltier device; and the support member for holding the temperature conditioning part and the heat conducting member and securing the temperature conditioning part and the heat conducting member on the table. At least the heat conducting member is connected to a cooling means, and the thermal conductivity of the support member is low relative to the thermal conductivity of the heat conducting member.

Abstract: An aluminum alloy includes: a core material made of an aluminum alloy including Si, Cu, and Mn, with the balance being Al and unavoidable impurities; a brazing material cladded onto one side surface of the core material, and made of an aluminum alloy including Si, with the balance being Al and unavoidable impurities; and a sacrificial anode material cladded onto the other side surface of the core material, and made of an aluminum alloy including Zn and Si, with the balance being Al and unavoidable impurities, wherein a total number density of single phase pure Si and a intermetallic compound existing in the sacrificial anode material and having a grain size of 0.1 ?m or more and 1.0 ?m or less is 1×103/mm2 or more and 1×106/mm2 or less.

Abstract: In order to reduce the cost of producing a spot array substrate and reduce the cost of nucleic acid polymer analysis, a spot array substrate is used which is produced by preparing a resin substrate 402 having a surface on which an uneven pattern is formed and a plurality of bead sitting positions set in a two-dimensional array within the uneven pattern, and loading surface-modified beads onto the bead sitting positions of the resin substrate.

Abstract: An aluminum alloy heat exchanger includes a core material formed of an aluminum alloy including Mn of 0.60 to 2.00 mass % and Cu of 1.00 mass % or less, with the balance being Al and inevitable impurities, and a sacrificial anode material formed of an aluminum alloy including Zn of 2.50 to 10.00 mass %, with the balance being Al and inevitable impurities. Pitting potential of a sacrificial anode material surface of a tube of the aluminum alloy heat exchanger in a 5% NaCl solution is ?800 (mV vs Ag/AgCl) or less, and pitting potential of an aluminum fin of the aluminum alloy heat exchanger in a 5% NaCl solution is equal to or more than the pitting potential of the sacrificial anode material surface of the tube of the aluminum alloy heat exchanger in a 5% NaCl solution.

Abstract: An aluminum alloy heat exchanger includes a core material formed of an aluminum alloy comprising Mn of 0.60 to 2.00 mass % and Cu of 1.00 mass % or less, with the balance being Al and inevitable impurities, and a sacrificial anode material formed of an aluminum alloy comprising Zn of 2.50 to 10.00 mass %, with the balance being Al and inevitable impurities. Pitting potential of a sacrificial anode material surface of a tube of the aluminum alloy heat exchanger in a 5% NaCl solution is ?800 (mV vs Ag/AgCl) or less, and pitting potential of an aluminum fin of the aluminum alloy heat exchanger in a 5% NaCl solution is less than the pitting potential of the sacrificial anode material surface of the tube of the aluminum alloy heat exchanger in a 5% NaCl solution.

Abstract: An aluminum alloy brazing sheet, a manufacturing method therefor, and a manufacturing method for an automotive heat exchanger. The aluminum alloy brazing sheet includes an aluminum alloy core material, a first brazing material that is clad to one surface of the core material, and a second brazing material that is clad to the other surface of the core material. The core material, the first brazing material, and the second brazing material each include a respective prescribed aluminum alloy. A count of an Al—Si—Fe intermetallic compound having an equivalent circle diameter of 0.5 to 80.0 ?m in the second brazing material is less than or equal to 2,000 particles per mm2.

Abstract: A three-layer clad material includes a core material, a cladding material 1, and a cladding material 2, the core material including an aluminum alloy that includes 0.5 to 1.8% of Mn, and either or both of more than 0.05% and less than 0.2% of Cu, and 0.05 to 0.30% of Ti, with the balance being Al and unavoidable impurities, the cladding material 1 including an aluminum alloy that includes 3 to 10% of Si, and 1 to 10% of Zn, with the balance being Al and unavoidable impurities, and the cladding material 2 including an aluminum alloy that includes 3 to 13% of Si, and 0.05% or less of Cu, with the balance being Al and unavoidable impurities, wherein the Si content X (%) in the cladding material 1 and the Si content Y (%) in the cladding material 2 satisfy the value (Y?X) is ?1.5 to 9%.

Abstract: An aluminum alloy heat exchanger for an exhaust gas recirculation system, obtained by brazing: a tube material comprising at least a core material made of aluminum alloy comprising 0.10 to 1.50% of Si, 0.05 to 3.00% of Cu, and 0.40 to 2.00% of Mn, and a sacrificial anticorrosion material made of aluminum alloy comprising 2.00 to 6.00% of Zn, with a Si content of less than 0.10%, clad on the inner side surface of the core material; and a fin material comprising a core material made of aluminum alloy comprising 0.10 to 1.50% of Si, and 0.40 to 2.00% of Mn, with a Zn content of less than 0.05%, and a brazing material clad on both surfaces of the core material, made of aluminum alloy comprising 3.00 to 13.00% of Si, with a Zn content of less than 0.05%.

Abstract: An aluminum alloy heat exchanger for an exhaust gas recirculation system, which is a heat exchanger installed in an exhaust gas recirculation system of an internal combustion engine to cool the exhaust gas comprises a tube provided with a sacrificial anticorrosion material on a side along which the exhaust gas passes, and a fin brazed to the surface side of the sacrificial anticorrosion material of the tube, the fin having a pitting potential higher than the pitting potential of the surface of the sacrificial anticorrosion material of the tube. According to the disclosure, an aluminum alloy heat exchanger for an exhaust gas recirculation system having a long service life with effective function of the sacrificial anticorrosion even under an acidic environment in which an oxide film is weakened as a whole and pitting corrosion is unlikely to occur can be provided.

Abstract: A multicolor fluorescence analysis device is provided. The device includes a first fiberoptic plate for guiding light including fluorescence emitted from a sample as a result of irradiation of excitation light and emitting the same from a first emission part. The device includes a second fiberoptic plate for receiving light emitted from the first emission part at a second incidence part, guiding the same, and emitting the same from a second emission part. The device includes a single multilayer dielectric interference film filter that is provided on an end surface of the second emission part, transmits at least a portion of the fluorescence, and transmits light of a plurality of transmission wavelength bands that do not include the excitation wavelength bands. The device includes a two-dimensional detection unit that is disposed so as to be adhered to the multilayer dielectric interference film filter.

Abstract: An aluminum alloy heat exchanger for an exhaust gas recirculation system, the heat exchanger obtained by brazing: a tube material comprising a core material comprising 0.05 mass % to 1.50 mass % of Si, 0.05 mass % to 3.00 mass % of Cu, and 0.40 mass % to 2.00 mass % of Mn, and a sacrificial anticorrosion material comprising 2.00 mass % to 6.00 mass % of Zn, clad on an inner side surface of the core material; and a fin material comprising a core material comprising 0.05 mass to 1.50 mass % of Si, and 0.40 mass % to 2.00 mass % of Mn, and a brazing material comprising 3.00 mass % to 13.00 mass % of Si, clad on both surfaces of the core material; the heat exchanger having a ratio of a surface area Sb (mm2) of the fin material to a surface area Sa (mm2) of the sacrificial anticorrosion material of less than 200%.

Abstract: An aluminum alloy clad material includes a core material, one side being clad with cladding material 1, the other side being clad with cladding material 2, the core material including an aluminum alloy that includes 0.5 to 1.8% of Mn, and limited to 0.05% or less of Cu, with the balance being Al and unavoidable impurities, the cladding material 1 including an aluminum alloy that includes 3 to 10% of Si, and 1 to 10% of Zn, with the balance being Al and unavoidable impurities, and the cladding material 2 including an aluminum alloy that includes 3 to 13% of Si, and limited to 0.05% or less of Cu, with the balance being Al and unavoidable impurities, wherein the Si content X (%) in the cladding material 1 and the Si content Y (%) in the cladding material 2 satisfy the value (Y?X) is ?1.5 to 9%.

Abstract: The substrate 100 for use in the analysis of a nucleic acid according to the present invention has multiple analysis areas 12 which are partitioned on a substrate 10, and enables the measurement of the analysis areas 12 while interchanging the analysis areas 12 in turn, said substrate 100 being characterized in that each of the analysis areas 12 consists of an adsorption part 13 onto which a DNA fragment or a carrier having the DNA fragment carried thereon can be adsorbed and a non-adsorption part 14 which is a part outside of the adsorption part 13, and the non-adsorption part 14 has, formed on at least a part thereof, a marker part 15 that has a specified shape and helps to identify the positions of the analysis areas 12.

Abstract: An aluminum alloy includes: a core material made of an aluminum alloy including Si, Cu, and Mn, with the balance being Al and unavoidable impurities; a brazing material cladded onto one side surface of the core material, and made of an aluminum alloy including Si, with the balance being Al and unavoidable impurities; and a sacrificial anode material cladded onto the other side surface of the core material, and made of an aluminum alloy including Zn and Si, with the balance being Al and unavoidable impurities, wherein a total number density of single phase pure Si and a intermetallic compound existing in the sacrificial anode material and having a grain size of 0.1 ?m or more and 1.0 ?m or less is 1×103/mm2 or more and 1×106/mm2 or less.

Abstract: A conventional solution exchanging method in a next-generation sequencer needs a reagent amount four or more times greater than an in-flow cell flow passage volume in order to efficiently promote a chemical reaction by replacing a reagent A in the flow cell with a new reagent B. Thus, the reagent consumption amount increases, and the cost is high. Meanwhile, an analysis apparatus according to the present invention is provided with: a flow cell used for analyzing samples; a sample container for containing a sample; a reagent container for containing a reagent; and a pressure generation mechanism for feeding the sample and the reagent to the flow cell through the flow passage, and also has an atmospheric opening in the flow passage of the flow cell on the upstream side.

Abstract: A multicolor fluorescence analysis device 11 is for detecting fluorescence emitted, as a result of excitation light irradiation, from a plurality of types of fluorophores included in a sample s, and is provided with an irradiation optical unit 520 for irradiating light emitted from a light source 510 onto a sample s as excitation light, a fluorescence condensation unit 530 having a fluorescence filter 531 that transmits light emitted from the sample s and transmits light of transmission wavelength bands different from the excitation wavelength bands, and a two-dimensional detector 554 that has a plurality of types of transmission filters 556 for transmitting prescribed wavelengths of light and detects the intensity of the light of the prescribed wavelength for each transmission filter 556, and the light emitted from at least two fluorophores from among the plurality of types of fluorophores is detected simultaneously and the fluorophore types are identified accordingly.

Abstract: By slowing down the passing velocity of a DNA molecule in a nanopore, the accuracy of the reading of a nucleotide sequence of DNA is improved. A small temperature difference is introduced between a DNA molecule having an asymmetric and periodic structure and a nanopore membrane that carries the DNA molecule, whereby the DNA molecule that passes through a nanopore can move in one direction and the passing velocity of the DNA molecule in the nanopore can be controlled and reduced. In this manner, the accuracy of the analysis of a nucleotide sequence can be improved. Furthermore, it becomes possible to dissociate double-stranded DNA into single-stranded DNA molecules by the action of temperature and subject the single-stranded DNA molecules to a measurement selectively. Furthermore, it also becomes possible to select the polarity of a DNA molecule and subject the DNA molecule to a measurement.

Abstract: Provided is a flow cell for nucleic acid analysis used for a sequence reaction with photocleavable nucleotides where an efficiency of the photocleaving reaction can be enhanced and noise upon florescence detection can be mitigated, thereby improving the accuracy of sequencing, shortening a runtime, and extending a read length. The flow cell for nucleic acid analysis includes a first substrate 101 provided with an optical filter 102 reflecting first light for changing a chemical structure of a substance in a flow passage, a hollow sheet 103 having a hollow portion for forming the flow passage, and a second substrate 105 transmitting the first light, in which the first substrate, the hollow sheet, and the second substrate are attached to each other.