Abstract: The present invention is directed to certain amides and heterocyclic compounds. The present invention also relates to uses of these compounds to treat several diseases including autoimmune disorders, cardiovascular disorders, inflammation, central nervous system disorders, arterial thrombotic disorders, fibrotic disorders, glaucoma, and neoplastic disorders.

Abstract: A power amplifier includes an output signal generator constructed to generate, on the basis of an input AC signal, an output signal including, in cycles, a first pulse being width higher in voltage than a first reference voltage and a second pulse being width lower in voltage than the first reference voltage and a feedback circuit constructed to generate a first bias signal corresponding to the output signal and feed back the first bias signal to an input side of the output signal generator to equalize a width of the first pulse and a width of the second pulse in the cycles of the output signal.

Abstract: A method of generating diffraction images based on wave equations includes generating a source wavefield and a receiver wavefield. Based on the source wavefield, a first source wavefield propagating in a first direction and a second source wavefield propagating in a second direction are generated. Based on the receiver wavefield, a first receiver wavefield propagating in the first direction and a second receiver wavefield propagating in the second direction are generated. A first seismic image is generated based on the first source wavefield and the first receiver wavefield. A second seismic image is generated based on the second source wavefield and the second receiver wavefield. A final seismic image is generated based on the first seismic image and the second seismic image.

Abstract: A method and reagent for constructing a nucleic acid double-linker single-strand cyclic library.

Abstract: An ultra-high sensitivity dual-gated biosensor based on an MOS transistor, which is applicable to detection of a series of early tumors. The sensor is prepared and processed by using SOI wafers, and a unique dual-gated structure is realized by ion implantation technique. The sensor is prepared by an ultraviolet lithography combined with an NLD etching method, realizing trace, instant and marker-free detection of tumor markers. The method detects a change in capacitance in the channel during binding of antigen antibodies. The detection method involved in the invention is more stable and strong in anti-interference, can meet the demands in the aspect of detection range and sensitivity, and especially has extremely outstanding detection sensitivity, and can detect a sample with a lowest concentration in the range of 1 fg/ml˜1 ng/ml.

Abstract: A personalized score for a place that a user may want to visit is computed and displayed to the user. The score is computed based on at least one of inferred or explicit parameters, using machine learning. The score may be displayed to the user in connection with the place, and in some examples explanations of the underlying factors that resulted in the score are also displayed. Because each user is unique, the score may be different for one person than for another. Accordingly, when a group of friends are deciding on a place to visit, such as a place to eat, the personalized score for a given restaurant may be higher for a first user than for a second user.

Abstract: This invention relates to a wax composition comprising one or more fatty acid diester compounds having the formula of R1 and R2 are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; and n1 is an integer from 2 to 10. This invention also relates to a wax composition comprising: a) one or more fatty acid monoester or diester compounds having the formula of: and b) one or more hydroxylated fatty acid diester compounds having the formula of In these formulae, R is H or COR1?; R1? and R2? are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; n2 is an integer from 2 to 24; m is an integer from 2 to 12; and .(OH)m represents 2 to 12 hydroxyl groups substituting for 2 to 12 hydrogen atoms in the alkyl groups R1? and/or R2?. Uses of the compositions are also disclosed.

Abstract: Multi-resolution encoded files are stored on a plurality of disk drives using systematic network coded storage. In some embodiments, the stored files are used to provide video streaming services for users.

Abstract: A method of enhancing seismic images includes receiving a seismic gather. The seismic gather includes a plurality of seismic traces. A feature trace is generated based on the plurality of seismic traces in the seismic gather. For each of the plurality of seismic traces in the seismic gather, a correlation trace is generated based on that seismic trace and the feature trace, the correlation trace is modified using an activation function, and an enhanced trace is generated by multiplying that seismic trace with the modified correlation trace.

Abstract: A Pushlet IM method for pushing a message from a first client device to a second client device includes the steps of: providing a Java-based web service; receiving a message from the first client device, the message including information of a recipient entity; verifying identity of a sender entity who intends to send the message to the recipient entity using the first client device; and creating a thread according to the information of the recipient entity for pushing the message to the second client device that is associated with the recipient entity.

Abstract: The present invention is directed to certain amides and heterocyclic compounds. The present invention also relates to uses of these compounds to treat several diseases including autoimmune disorders, cardiovascular disorders, inflammation, central nervous system disorders, arterial thrombotic disorders, fibrotic disorders, glaucoma, and neoplastic disorders.

Abstract: The present invention describes compositions, including pharmaceutical compositions, comprising an agent that binds members of the TNFRSF and a benzamide compound and methods for use thereof, for example in the treatment of cancer. In some implementations, the methods for use include methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.

Abstract: The present invention is directed to certain amides and heterocyclic compounds. The present invention also relates to uses of these compounds to treat several diseases including autoimmune disorders, cardiovascular disorders, inflammation, central nervous system disorders, arterial thrombotic disorders, fibrotic disorders, glaucoma, and neoplastic disorders.

Abstract: The present disclosure relates to certain amides and heterocyclic compounds. The present disclosure also relates to uses of these compounds to inhibit Rho-associated protein kinases and treat diseases including autoimmune disorders, graft versus host disease (GVHD), inflammation, cardiovascular disorders, central nervous system disorders, and neoplastic disorders.

Abstract: A power amplifier includes an output signal generator constructed to generate, on the basis of an input AC signal, an output signal including, in cycles, a first pulse being width higher in voltage than a first reference voltage and a second pulse being width lower in voltage than the first reference voltage and a feedback circuit constructed to generate a first bias signal corresponding to the output signal and feed back the first bias signal to an input side of the output signal generator to equalize a width of the first pulse and a width of the second pulse in the cycles of the output signal.

Abstract: This invention relates to a wax composition comprising one or more fatty acid diester compounds having the formula of R1 and R2 are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; and n1 is an integer from 2 to 10. This invention also relates to a wax composition comprising: a) one or more fatty acid monoester or diester compounds having the formula of: and b) one or more hydroxylated fatty acid diester compounds having the formula of In these formulae, R is H or COR1?; R1? and R2? are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; n2 is an integer from 2 to 24; m is an integer from 2 to 12; and .(OH)m represents 2 to 12 hydroxyl groups substituting for 2 to 12 hydrogen atoms in the alkyl groups R1? and/or R2?. Uses of the compositions are also disclosed.

Abstract: A lithium hydrogen titanate Li—H—Ti—O material includes Li, H, Ti, and O elements, wherein a mass percentage of Li is in a range from about 3% to about 12%, a mass percentage of H is in a range from about 0.1% to about 8%, a mass percentage of Ti is in a range from about 46% to about 56%, and a mass percentage of O is in a range from about 28% to about 50%. A lithium ion battery and a method for making the lithium hydrogen titanate Li—H—Ti—O material are also disclosed.

Abstract: A file processing method is provided. A file conversion logic based on a player plug-in, a software development kit (SDK), and a recording plug-in that are loaded and run in a designated three-dimensional (3D) operation environment is obtained. A first to-be-processed file and a second to-be-processed file obtained based on a source file are played. Audio/video decoding is performed on each of the first to-be-processed file and the second to-be-processed file based on the file conversion logic. Distortion processing is performed on a result of the audio/video decoding, and a result of the distortion processing is stored in an image file format in a video random access memory (RAM).

Abstract: The present disclosure describes methods and systems, including computer-implemented methods, computer program products, and computer systems, for generating Angle Domain Common Image Gathers (ADCIGs). One computer-implemented method includes receiving, at a data processing apparatus, a set of seismic data associated with a subsurface region wherein the set of seismic data includes receiver signal data at a plurality of time steps; for each time step in the plurality of time steps: calculating a receiver wavefield based on the receiver signal data at the respective time step; separating a first direction receiver wavefield and a second direction receiver wavefield of the receiver wavefield using Hilbert transformation of the receiver signal data at the respective time step; and applying an optical flow process on the first direction receiver wavefield to calculate wavefield directions; and generating an Angle Domain Common Image Gather (ADCIG) based on the wavefield directions.

Abstract: The present disclosure describes methods and systems, including computer-implemented methods, computer program products, and computer systems, for generating a velocity model for a subsurface structure. One computer-implemented method for determining velocity model for a subsurface structure includes generating, by at least one hardware processor, a first velocity model for the subsurface structure by performing a refraction traveltime tomography procedure based on an initial velocity model; and generating, by the at least one hardware processor, a first refined velocity model based on the first velocity model and a structure skeleton model, wherein the structure skeleton model is determined based on reflection seismic data of the subsurface structure.