Patents by Inventor Toni-Jo Poel

Toni-Jo Poel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings
    Patent number: 6313307
    Abstract: A process for preparing a compound of the formula I: or pharmaceutical acceptable salts thereof wherein X is —NR1—, —S(O)g—, or —O—; R1 is —H, C1-6 alkyl optionally substituted with one or more —OH, —CN, or halo, or R1 is —(CH2)h-aryl, —COR1-1, —COOR1-2, —CO—(CH2)h—COR1-1, C1-6 alkyl sulfonyl, —SO2—(CH2)h-aryl, or —(CO)i-Het; R2 is —H, C1-6 alkyl, —(CH2)h-aryl, or halo; R3 and R4 are the same or different and are —H or halo; R6 is —H, C1-12 alkyl optionally substituted with one or more halo, C3-12 cycloalkyl, C1-6 alkoxy. The compounds are useful antimicrobial agents.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: November 6, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael Dalton Ennis, Robert Louis Hoffman, Douglas K. Hutchinson, David John Anderson, Toni-Jo Poel, Richard Charles Thomas
  • Oxazolidinone antibacterial agents having a thiocarbonyl functionality
    Patent number: 6255304
    Abstract: The present invention provides compounds of Formula 1 or pharmaceutical acceptable salts thereof wherein A, G and R, are as defined in the claims which are antibacterial agents.
    Type: Grant
    Filed: November 27, 1998
    Date of Patent: July 3, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Jackson B. Hester, Jr., Eldon George Nidy, Salvatore Charles Perricone, Toni-Jo Poel
  • Oxazolidinone antibacterial agents having a thiocarbonyl functionality
    Patent number: 6218413
    Abstract: The present invention provides compounds of Formula 1 or pharmaceutical acceptable salts thereof wherein A, G and R1 are as defined in the claims which are antibacterial agents.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: April 17, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Jackson B. Hester, Jr., Eldon George Nidy, Salvatore Charges Perricone, Toni-Jo Poel
  • Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings
    Patent number: 6166056
    Abstract: A compound of Formula (I): ##STR1## or pharmaceutical acceptable salts thereof wherein X is NR.sub.1 ; R.sub.1 is H, C.sub.1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R.sub.1 is --(CH.sub.2).sub.h -aryl, --COR.sub.1-1, --COOR.sub.1-2, --CO--(CH.sub.2).sub.h --COR.sub.1-1, C.sub.1-6 alkyl sulfonyl, --SO.sub.2 --(CH.sub.2).sub.h -aryl, or --(CO).sub.i --Het; R.sub.2 is H, C.sub.1-6 alkyl, --(CH.sub.2).sub.h -aryl, or halo; R.sub.3 and R.sub.4 are independently H or halo; R.sub.5 is H, C.sub.1-12 alkyl optionally substituted with one or more halo, C.sub.3-12 cycloalkyl, C.sub.1-6 alkoxy; m and n taken together are 1 or 2. The compounds are useful antimicrobial agents.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: December 26, 2000
    Assignees: Pharmacia, Upjohn Company
    Inventors: Richard C. Thomas, Toni-Jo Poel, Michael D. Ennis, David J. Anderson, Robert L. Hoffman
  • S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
    Patent number: 6083967
    Abstract: The present invention provides compounds of formula I and formula II useful as antimicrobial agents wherein R.sub.1 is methyl, ethyl, cyclopropyl, or dichloromethyl; R.sub.2 and R.sub.3 are independently hydrogen or fluoro; R.sub.4 is ethyl or dichloromethyl. The invention also relates to a novel assay for determining the inhibitory activity of oxazolidinones to human monoamine oxidase.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: July 4, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Toni-Jo Poel, Joseph Patrick Martin, Jr., Michael Robert Barbachyn
  • Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
    Patent number: 6051716
    Abstract: A process for preparing a compound of the formula I: ##STR1## or pharmaceutical acceptable salts thereof wherein X is --NR,--, --S(O).sub.g --, or --O--; R.sub.1 is --H, C.sub.1-6 alkyl optionally substituted with one or more --OH, --CN, or halo, or R.sub.1 is --(CH.sub.2).sub.h -aryl, --COR.sub.1-1, 13 COOR.sub.1-2, --CO--(CH.sub.2).sub.h --COR.sub.1-1, C.sub.1-6 alkyl sulfonyl, --SO.sub.2 --(CH.sub.2).sub.h -aryl, or --(CO).sub.i -Het; R.sub.2 is --H, C.sub.1-6 alkyl, --(CH.sub.2).sub.h -aryl, or halo; R.sub.3 and R.sub.4 are the same or different and are --H or halo; R.sub.5 is --H, C.sub.1-12 alkyl optionally substituted with one or more halo, C.sub.3-12 cycloalkyl, C.sub.1-6 alkoxy. The compounds are useful antimicrobial agents.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: April 18, 2000
    Assignee: Pharmacia & Upjohn, Inc.
    Inventors: Douglas K. Hutchinson, Toni-Jo Poel, Richard Charles Thomas
  • Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings
    Patent number: 5968962
    Abstract: A compound of the formula (I): ##STR1## or pharmaceutical acceptable salts thereof wherein X is NR.sub.1, S(O).sub.g, or O; R.sub.1 is H, C.sub.1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R.sub.1 is --(CH.sub.2).sub.h -- aryl, --COR.sub.1--1, --COOR.sub.1-2, --CO--(CH.sub.2).sub.h --COR.sub.1--1, C.sub.1-6 alkyl sulfonyl, --SO.sub.2 --(CH.sub.2).sub.h --aryl, or --(CO).sub.i --Het; R.sub.2 is H, C.sub.1-6 alkyl, --(CH.sub.2).sub.h --aryl, or halo; R.sub.3 and R.sub.4 are the same or different and are H or halo; R.sub.5 is H, C.sub.1-12 alkyl optionally substituted with one or more halo, C.sub.3-12 cycloalkyl, C.sub.1-6 alkoxy. The compounds are useful antimicrobial agents.
    Type: Grant
    Filed: August 13, 1996
    Date of Patent: October 19, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Richard C. Thomas, Toni-Jo Poel, Michael R. Barbachyn
  • Alkyl substituted piperadinyl and piperazinyl anti-AIDS compounds
    Patent number: 5866589
    Abstract: Anti-AIDS compounds of formula (I) ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are as defined in the specification and R.sub.8 is alkyl of substituted alkyl.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: February 2, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Donna L. Romero, Richard C. Thomas, Paul D. May, Toni-Jo Poel