Abstract: The present disclosure provides a method of generating induced neural progenitor cells from CD34+/CD45+ blood cells using a POU domain containing gene or protein and inhibitors of Smad and GSK-3?, without traversing the pluripotent state. Also provided are uses and assays of the cells produced by the methods of the disclosure.

Abstract: Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and methods for identifying subjects likely to be responsive to therapy with DR receptor antagonists. Methods for identifying cancer stem cells and chemotherapeutic compounds that are DR receptor antagonists as also provided. Also described are methods for the identification and validation of agents that target cancer stem cells.

Abstract: Described are compounds and methods useful for selectively targeting cancer stem cells. The compounds preferentially induce differentiation and/or reduce the proliferation of cancer stem cells relative to normal stem cells. Compounds useful for selectively targeting cancer stem cells include polyene macrolides such as Nystatin or Amphotericin B, analogs thereof and pharmaceutically acceptable salts thereof.

Abstract: Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and methods for identifying subjects likely to be responsive to therapy with DR receptor antagonists. Methods for identifying cancer stem cells and chemotherapeutic compounds that are DR receptor antagonists as also provided. Also described are methods for the identification and validation of agents that target cancer stem cells.

Abstract: The present invention describes a method to improve the properties of a dough and/or a baked product by adding a bread or dough-improving agent containing a enzyme with xylanolytic activity belonging to glycoside hydrolases family 8. Preferred enzymes are the psychrophilic xylanase from Pseudoalteromonas haloplanktis and the mesophilic xylanase Y from Bacillus halodurans C-125.

Abstract: The present invention describes a method to improve the properties of a dough and/or a baked product by adding a bread or dough-improving agent containing a enzyme with xylanolytic activity belonging to glycoside hydrolases family 8. Preferred enzymes are the psychrophilic xylanase from Pseudoalteromonas haloplanktis and the mesophilic xylanase Y from Bacillus halodurans C-125.

Abstract: The present invention describes a method to improve the properties of a dough and/or a baked product by adding a bread or dough-improving agent containing a enzyme with xylanolytic activity belonging to glycoside hydrolases family 8. Preferred enzymes are the psychrophilic xylanase from Pseudoalteromonas haloplanktis and the mesophilic xylanase Y from Bacillus halodurans C-125.

Abstract: The disclosed modular filter may include a filter medium and an external frame structure. The filter medium may form a chamber having a front side, a back side, and a periphery. The filter medium may also have a plurality of fibers. The external frame structure has at least one aperture mounted on at least one of the front side and back side of the chamber in which the external frame structure has a thickness greater than the lengths of the plurality of fibers.

Abstract: The present invention relates to novel enzymes with xylanolytic activity that belong to the glycoside hydrolase Family 8. The present invention in particular relates to enzymes isolated from bacterial psychrophilic strains that produce xylanases with an amino acid sequence as identified by any of SEQ ID NOs: 4, 6, 8, 10, 12, 14, 16, 35, 21, 23, 25, 27, 29, 31, 33, 37 or a variant thereof. Another aspect of the invention relates to the corresponding genes. These enzymes find many applications and are advantageously used for instance in feed and food applications such as baking. Compared to conventional xylanases, only small amounts of enzymes are needed to obtain a desired effect, such as an increase of the loaf volume and/or an increase in the width of cut on the surface of baked products.

Abstract: A method for manufacture and assembly of a structure includes manufacturing, at a first location, wall sections and floor/ceiling sections. The sections include structural portions and optionally external and interior finish features. The sections have self-aligning features, which may include rotatable attachments. At least some of the sections are attached to one another with rotatable attachments to define a structure segment. The structure segment may be placed in an assembled position, with the rotatable attachments fixed, and additional finish features are removably applied. The additional finish features are removed, and the structure segment is removed from the assembled position to a compact orientation for shipping. The structure segment may be placed in a shipping container for transport. The structure segment is transported in the folded position to a second location. The structure segment is moved to a final assembly position at the second location.

Abstract: The subject invention relates to automotive headlamp assemblies with a sign light shield. In an exemplary embodiment, the sign light shield can be raised or lowered by an actuator into or out of a reflecting position that allows the sign light shield to reflect light emitted from a light source through the upper portion of a lens. In another embodiment, the headlamp assembly can comprise two cutoff shields mounted to a rotatable shaft, where one of the cutoff shields has a sign light shield mounted directly to it and the other cutoff shield does not have a sign light shield. An actuator rotates the shaft until the sign light shield is in a position that will allow it to reflect light out of the upper portion of the lens or until the sign light shield is in a position where it cannot reflect any light.