Abstract: An environmental control system includes a compression device including a compressor, a turbine, and an electric motor operably coupled by a shaft. The electric motor and the turbine are arranged in series relative to a flow of a first medium.

Abstract: An environmental control system of a vehicle includes a first compression device including a compressor, a first turbine, and a power turbine operably coupled by a shaft. The first turbine is configured to receive a first medium, the compressor is configured to receive a second medium, and the power turbine is configured to receive a third medium. A second compression device, separate from the first compression device, includes a second turbine. The environmental control system is operable in a first mode and a second mode. In the first mode, the second medium is provided to the compressor and the second turbine sequentially. In the second mode, the second medium bypasses the second turbine. In in both the first mode and the second mode, only the second medium is provided to an outlet of the environmental control system.

Abstract: Provided are methods of treating bladder cancer (e.g., urothelial carcinoma, UC) in a subject having bladder cancer, e.g., UC, with an effective dose regimen of an anti-PD-L1 antibody, e.g., durvalumab, or an antigen binding fragment thereof. Also provided are methods in which an anti-PD-L1 antibody is used in combination with another immunotherapeutic agent, e.g., tremelimumab to treat a bladder cancer, e.g., UC, in a subject having bladder cancer. In some cases, the subject undergoing treatment is identified as having a bladder cancer or tumor that is PD-L1-low/neg, or PD-L1-high. Methods are also provided in which anti-PD-L1 antibody treatment of bladder cancer is used following a standard of care or first-line therapy in subjects who have progressed following such therapies or who have relapsed after a prior treatment regimen.

Abstract: A method of operating an environmental control system of an aircraft includes providing a first medium to the environmental control system including a compressor and a turbine, wherein the first medium is provided to the compressor and the turbine sequentially and extracting work from a second medium provided to a power turbine operably coupled to the compressor to drive the compressor. In a first mode of operation, the first medium to be provided to a downstream load is output from the turbine, in a second mode of operation, at least a portion of the first medium to be provided to a downstream load bypasses the turbine, and in a third mode of operation, at least a portion of the first medium output from the compressor is provided to the power turbine.

Abstract: A method of operating an environmental control system of an aircraft includes providing a first medium to the environmental control system including a compressor and a turbine and extracting work from a second medium provided to a second turbine operably coupled to the compressor to drive the compressor. The first medium is provided to the compressor and the turbine sequentially. In a first mode of operation, the first medium to be provided to a downstream load is output from the turbine and in a second mode of operation, at least a portion of the first medium to be provided to the downstream load bypasses the turbine.

Abstract: A population of genetically engineered immune cells (e.g., T cells), which express a chimeric antigen receptor (CAR) specific to CD19 and contain a disrupted TRAC gene, a disrupted B2M gene, or both, for use in treating a B cell malignancy.

Abstract: An environmental control system includes a plurality of inlets for receiving a plurality of mediums including a first medium and a second medium and an outlet for delivering a conditioned flow of the second medium to one or more loads of the aircraft. A ram air circuit includes a ram air shell having at least one heat exchanger positioned therein and a compressing device is arranged in fluid communication with the ram air circuit and the outlet. The compressing device includes a compressor and at least one turbine operably coupled via a shaft. The environmental control system is operable in a first mode and a second mode. In the second mode, a pressure of the second medium output from the compressor is equal to the pressure of the second medium provided to the outlet.

Abstract: A population of genetically engineered immune cells (e.g., T cells), which express a chimeric antigen receptor (CAR) specific to CD19 and contain a disrupted TRAC gene, a disrupted B2M gene, or both, for use in treating a B cell malignancy.

Abstract: An environmental control system of an aircraft includes a compressing device including a compressor and a turbine configured to receive a flow of first medium sequentially and a second turbine arranged in fluid communication with an outlet of the compressor. The second turbine is configured to receive a flow of second medium distinct from the first medium. A dehumidification system is arranged in fluid communication with the turbine, a first bypass valve is configured to divert at least a portion of the flow of the first medium output from the compressor around the turbine, and a second bypass valve configured to divert at least a portion of the flow of first medium output from the compressor to the second turbine.

Abstract: An environmental control system of an aircraft includes a plurality of inlets for receiving a first medium, a second medium, and a third medium and an outlet for delivering a conditioned form of the first medium to at least one load of the aircraft. A compression device is arranged in fluid communication with the plurality of inlets and the outlet. The compression device includes a plurality of turbines including a first turbine and a second turbine configured to provide energy by expanding one or more mediums of the plurality of mediums and a compressor configured to receive energy from the one or more mediums expanded across at least one of the plurality of turbines. Energy derived from the second medium and/or the third medium within the second turbine is used to compress the first medium at the compressor.

Abstract: An environmental control system of an aircraft includes a compressing device including a compressor and a turbine configured to receive a flow of first medium sequentially. The compressing device additionally includes a second turbine configured to receive a flow of second medium distinct from the first medium. A dehumidification system is arranged in fluid communication with the turbine and a bypass valve is configured to divert the flow of the first medium output from the compressor around the turbine.

Abstract: An environmental control system includes a cooling circuit having at least one heat exchanger for cooling a first medium therein. At least one compressing device is operably coupled to the cooling circuit. The at least one compressing device includes a first compressor and a second compressor, wherein the first medium is provided to the first compressor and the second compressor in series, and a temperature of the first medium provided to an inlet of the second compressor is less than the temperature of the first medium at an outlet of the first compressor.

Abstract: A population of genetically engineered immune cells (e.g., T cells), which express a chimeric antigen receptor (CAR) specific to CD19 and contain a disrupted TRAC gene, a disrupted ?2M gene, or both, for use in treating a B cell malignancy.

Abstract: A thermal management system for one or more aircraft components includes a bleed airflow source at a gas turbine engine of the aircraft, one or more turbines configured to expand the bleed airflow, thus lowering a temperature of the bleed airflow, the bleed airflow driving rotation of the one or more turbines. One or more heat exchangers are in fluid communication with the one or more turbines. The one or more heat exchangers are configured to exchange thermal energy between the bleed airflow and a thermal load. One or more electrical generators are operably connected to the one or more turbines. The one or more electrical generators are configured to convert rotational energy of the one or more turbines to electrical energy.

Abstract: A method of monitoring aircraft including removing a conical collector through a cabin exhaust valve of the aircraft wherein ambient cabin air has been driven from the cabin over a reagent fluid within the conical collector in order to collect a representative sample of the cabin air within the reagent fluid.

Abstract: The disclosure provides systems (e.g., CRISPR/Cas systems) for introducing an edit in a genomic DNA molecule comprising the fatty acid amide hydrolase gene (FAAH) and/or the FAAH pseudogene (FAAH-OUT). Also provided are methods for use of the systems, nucleic acids, delivery systems, and/or compositions described for genome editing to modulate the expression and/or activity of FAAH, for example, in a method of treating chronic pain.

Abstract: An environmental control system of an aircraft includes a plurality of inlets for receiving a plurality of mediums including a first medium, a second medium, and a third medium and an outlet for delivering a conditioned flow of the second medium to one or more loads of the aircraft. At least one compressing device is arranged in in fluid communication with the plurality of inlets and the outlet. The at least one compressing device includes a four-wheel compressing device having a compressor and at least one turbine operably coupled via a shaft. In a first mode of operation, the compressor is driven by the first medium, and in a second mode of operation, the compressor is driven by the third medium.

Abstract: An environmental control system of an aircraft includes a ram air circuit including a ram air shell having at least one heat exchanger positioned therein and a divider arranged within the ram air shell to separate the ram air shell into a first region and a second region. The at least one heat exchanger is arranged within both the first region and the second region. A first medium is configured to flow through the first region and a second, distinct medium is configured to flow through the second region. The environmental control system additionally includes a dehumidification system arranged in fluid communication with the ram air circuit and a compression device arranged in fluid communication with the ram air circuit and the dehumidification system.

Abstract: A compressing device for use in an environmental control system includes at least one turbine configured to provide energy by expanding one or more mediums. The one or more mediums provided at an outlet of the at least one turbine form a heat sink within the environmental control system. A compressor is configured to receive energy from the one or more mediums expanded across the at least one turbine. During a first mode of the compressing device, energy derived from a first medium and a second medium of the one or more mediums is used to compress a second medium at the compressor. During a second mode of the compressing device, energy derived from the first medium, the second medium, and a third medium of the one or more mediums is used to compress the second medium at the compressor.

Abstract: An environmental control system of an aircraft including a plurality of inlets for receiving a plurality of mediums including a first medium, a second medium, and a third medium and an outlet for delivering a conditioned flow of the second medium to one or more loads of the aircraft. The environmental control system additionally includes a first compressing device and a second compressing device. The second compressing device is arranged in fluid communication with the first compressing device and the outlet. An inlet of the second compressing device is directly connected to an outlet of the first compressing device, and the first compressing device is driven by energy extracted from the first medium. The first medium is a flow of bleed air.