Abstract: An air cycle machine for an environmental control system for an aircraft includes at least one turbine configured to receive and extract work from a first medium and a third medium. A compressor is configured to compress a second medium and a shaft mechanically couples the at least one turbine and the compressor. A mixing point is located downstream of at least one turbine. A mixture of the first medium and the third medium generated at the mixing point is provided to another component of the environmental control system.

Abstract: An environmental control system of an aircraft includes a plurality of inlets for receiving a plurality of mediums including a first medium and a second medium and an outlet for delivering a conditioned flow of the second medium to one or more loads of the aircraft. A ram air circuit includes a ram air shell having at least one heat exchanger positioned therein. A compressing device is arranged in fluid communication with the ram air circuit and the outlet. The compressing device including a first compressor, a second compressor, and at least one turbine operably coupled via a shaft. The first compressor and the second compressor are arranged in parallel with respect to a flow of the second medium and the first medium is used as a heat sink by another component within the environmental control system.

Abstract: A compressing device for use in an environmental control system includes at least one turbine configured to provide energy by expanding one or more medium. The one or more mediums provided at an outlet of the at least one turbine form a heat sink within the environmental control system. A compressor is configured to receive energy from the one or more mediums expanded across the at least one turbine. During a first mode of the compressing device, energy derived from a first medium of the one or more mediums is used to compress a second medium at the compressor and during a second mode of the compressing device, energy derived from both the first medium and a third medium of the one or more mediums is used to compress a second medium at the compressor.

Abstract: An environmental control system includes a plurality of inlets for receiving a plurality of mediums including a first medium and a second medium and an outlet for delivering a conditioned form of the second medium to at least one load of the aircraft. A ram air circuit includes a ram air shell having at least one heat exchanger positioned therein and a dehumidification system is arranged in fluid communication with the ram air circuit. A compression device is arranged in fluid communication with the ram air circuit and the dehumidification system. The compression device includes a compressor and a plurality of turbines including a first turbine and a second turbine operably coupled by a shaft. An outlet of the first turbine is directly coupled to an inlet of the second turbine, such that the first medium is provided to the first turbine and the second turbine in series.

Abstract: An environmental control system of an aircraft includes a plurality of inlets for receiving a plurality of mediums including a first medium, a second medium, and a third medium and an outlet for delivering a conditioned flow of the second medium to one or more loads of the aircraft. A ram air circuit includes a ram air shell having at least one heat exchanger positioned therein. At least one compressing device is arranged in fluid communication with the ram air circuit and the outlet. The at least one compressing device includes at least one compressor and at least one turbine operably coupled via a shaft. A heat exchanger is arranged in fluid communication with the at least one compressing device. The second medium output from the at least one compressing device is cooled by the third medium. The second medium is fresh air.

Abstract: An environmental control system for providing a conditioned medium to one or more loads of an aircraft includes a compressing device including a compressor and a turbine operably coupled to the compressor. The turbine is arranged downstream from the compressor relative to a flow of first medium. At least one power turbine is operably coupled to the compressor. The at least one power turbine is configured to receive a flow of a second medium, and the flow of second medium includes a cabin discharge air.

Abstract: Methods comprising repeating cycles of administration of a composition comprising cediranib according to a fixed intermittent dosing regimen comprising administration of an effective amount of the composition comprising cediranib on one or more consecutive days of a cycle followed by one or more consecutive days of rest on which said composition is not administered are disclosed herein, and may be used as monotherapy or may comprise administration of one or more partner drugs or therapies and may be used in combination therapy.

Abstract: An environmental control system of a vehicle includes a ram air circuit including a ram air shell having a ram air heat exchanger positioned therein, a dehumidification system arranged in fluid communication with the ram air circuit, a first compression device arranged in fluid communication with the dehumidification system, the first compression device including a first compressor, and a second compression device arranged in fluid communication with the ram air circuit. The second compression device includes a second compressor. A first medium is provided to the first compressor and to the second compressor in series.

Abstract: A medium supply system for delivering one or more mediums to an environmental control system of a vehicle includes a manifold arranged in fluid communication with an inlet of the environmental control system, a first medium source for delivering a first medium to the manifold via a first port; a second medium source for delivering a second medium to the manifold via a second port, and a third medium source for delivering a third medium to the manifold via a third port. At least one of a temperature and pressure of each of the first medium, the second medium, and the third medium varies.

Abstract: A population of genetically engineered immune cells (e.g., T cells), which express a chimeric antigen receptor (CAR) specific to CD19 and contain a disrupted TRAC gene, a disrupted B2M gene, or both, for use in treating a B cell malignancy.

Abstract: A fuel tank inerting system of an aircraft includes a first air flow provided from a first source having a first temperature and a second air flow including cabin outflow air having a second temperature. The first temperature is greater than the second temperature. A fuel tank inerting heat exchanger is arranged in fluid communication with both the first air flow and the second air flow. At least one air separating module is configured to separate an inert gas from the first air flow output from the fuel tank inerting heat exchanger.

Abstract: Disclosed is a cooling circuit for cooling a heat load in an aircraft system, having: a compressor; a turbine connected to the compressor by a shaft, the turbine configured to drive the compressor via the shaft when RAM air pressure into a turbine inlet is above a first threshold; and a motor connected to the shaft configured to drive the compressor when RAM air pressure at the turbine inlet is below the first threshold to cause the compressor to draw air into the turbine inlet, through the turbine, a heat exchanger in fluid communication with the heat load, the compressor, and out of a compressor outlet.

Abstract: A bleed air control system and method include first and second flow paths, first and second flow control valves, and a controller. The first flow path is configured to carry a first bleed air flow and includes a heat transfer device configured to transfer heat to or from the first bleed air flow. The second flow path is configured to carry a second bleed air flow. The first and second flow paths merge downstream to provide a combined bleed air flow. The first flow control valve is positioned to control the first bleed air flow, and the second flow control valve is positioned to control the second bleed air flow. The controller is configured to control the first and second flow control valves to control a temperature and flow of the combined bleed air flow.

Abstract: An environmental control system includes an ambient air conduit and a bleed air conduit, an electric compressor connected to the ambient air conduit and a mechanical compressor connected to the electric compressor. The electric compressor is supported for rotation independent of the mechanical compressor. A turbine is operatively connected to the mechanical compressor, the turbine connected to both the ambient air conduit and the bleed air conduit to provide conditioned air to a conditioned air conduit. Computer program products and methods of providing conditioned air to conditioned air loads are also described.

Abstract: An environmental control system (ECS) for an aircraft includes at least one cooling turbine, and a turbine bypass valve disposed fluidly upstream of the at least one cooling turbine. The turbine bypass valve is configured to direct a first portion of an ECS output airflow to a first air load at a first pressure via a first outlet passage, and direct a second portion of the ECS output airflow across a cooling turbine of the at least one cooling turbine and to a second air load at a second pressure lower than the first pressure for cooling thereof.

Abstract: An environmental control system for providing a conditioned medium to one or more loads of an aircraft includes an air conditioning system including a compressor for regulating a pressure of a first medium and a turbine operably coupled to the compressor and a pressurized volume containing a second medium. The pressurized volume is arranged in fluid communication with a component of the air conditioning system. At least one valve of the air conditioning system is operable to control a flow of second medium to the turbine, wherein the at least one valve is adjustable to maintain a minimum pressure within the pressurized volume.

Abstract: An environmental control system for providing a conditioned medium to one or more loads of an aircraft includes a compressing device including a compressor and a turbine operably coupled to the compressor. The turbine is arranged downstream from the compressor relative to a flow of first medium. At least one power turbine is operably coupled to the compressor. The at least one power turbine is configured to receive a flow of a second medium, and the flow of second medium includes a cabin discharge air.

Abstract: An environmental control system of an aircraft includes a compressing device including a compressor and a turbine configured to receive a flow of first medium sequentially. The compressing device additionally includes a second turbine configured to receive a flow of second medium distinct from the first medium. A dehumidification system is arranged in fluid communication with the turbine and a bypass valve is configured to divert the flow of the first medium output from the compressor around the turbine.

Abstract: An environmental control system of an aircraft includes a compressing device including a compressor and a turbine configured to receive a flow of first medium sequentially and a second turbine arranged in fluid communication with an outlet of the compressor. The second turbine is configured to receive a flow of second medium distinct from the first medium. A dehumidification system is arranged in fluid communication with the turbine, a first bypass valve is configured to divert at least a portion of the flow of the first medium output from the compressor around the turbine, and a second bypass valve configured to divert at least a portion of the flow of first medium output from the compressor to the second turbine.

Abstract: Provided herein, in some embodiments, are methods and compositions for treatment of subjects with ?-thalassemia and subjects with severe sickle cell disease using autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells.