Abstract: Crankshaft and connecting rod assemblies for hydraulic fracturing pumps and related methods may enhance the flow of fracturing fluid into a wellhead during a high-pressure fracturing operation. The assemblies and methods may include a crankshaft having a crankpin between first and second journals. The crankpin may include first and second longitudinally spaced ridges at least partially extending circumferentially around the crankpin. The assemblies and methods further may include first and second connecting rods connected to the crankpin. The first connecting rod may include first and second crankpin connectors connected to the crankpin and at least partially defining therebetween a connecting rod clearance between and positioned to at least partially receive therein an end of a second connecting rod. The assemblies and methods also may include first and second rod clamps connected to the first crankpin connector, thereby to rotatably connect the first and second connecting rods to the crankpin.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Some embodiments of the present disclosure relate to a battery containment assembly for powering an electronic device. The battery containment assembly including at least one lithium-ion battery. The battery containment assembly includes a battery casing enclosing the at least one lithium-ion battery and having a cooling channel extending from a vent of the battery casing to the at least one lithium-ion battery, the cooling channel configured to vent any gas exhausted by the at least one lithium-ion battery to mix with air outside of the battery casing and to lower a temperature of the gas exhausted from the at least one lithium-ion battery during a thermal runaway condition of the at least one lithium-ion battery before the gas exits the vent.

Abstract: A wearable infusion pump allows a user to insert a program key into a housing of the pump to select a continuous dosage rate. Program keys are shaped to close contacts on a printed circuit board within the housing to communicate the selected dosage rate to a microprocessor. In this way, a single disposable pump, sold with one Stock keeping unit (SKU), can be used to deliver a plurality of dosage rates. The disposable pump is provided with an on-board display and a one-button on-board user operable control. In preferred embodiments, the infusion pump according to the invention may be used for continuous delivery of insulin in management of Type II diabetes.

Abstract: Systems, apparatuses, and methods are described for synchronizing output of a plurality of user devices. An immersive experience for users may be provided by mapping what the users are watching into functionalities of the user devices. Manifest files may comprise information determined for audio and/or video features of segments of audiovisual content. The manifest files may be used by secondary user devices to output visual effects in synchronization with output of audiovisual content by a primary user device.

Abstract: A vehicle door assembly includes a door module and a door panel. The door module has a back plate with a periphery bearing attachment orifices defining a base plane. At least one guide rail extends in a rail direction in a rail plane offset from the base plane and has a connected edge and a free edge. The connected edge is attached to the back plate, and the free edge is shaped for slidably attaching a carrier plate for a window. The guide rail vertically protrudes beyond the periphery of the back platen. A void in the rail plane intersects a trajectory of the connected edge. The void provides access through the rail plane to the periphery of the back plate, wherein an attachment orifice is disposed in the void. The door panel has a central hole and attachment openings aligned with the attachment orifices of the door module.

Abstract: A vehicle door assembly includes a door module and a door panel. The door module has a back plate with a periphery bearing attachment orifices defining a base plane. At least one guide rail extends in a rail direction in a rail plane offset from the base plane and has a connected edge and a free edge. The connected edge is attached to the back plate, and the free edge is shaped for slidably attaching a carrier plate for a window. The guide rail vertically protrudes beyond the periphery of the back platen. A void in the rail plane intersects a trajectory of the connected edge. The void provides access through the rail plane to the periphery of the back plate, wherein an attachment orifice is disposed in the void. The door panel has a central hole and attachment openings aligned with the attachment orifices of the door module.

Abstract: A multi-tape dispenser, for dispensing reversed-conjoined and non-reversed-conjoined adhesive tape end portions from adhesive tape rolls, includes a housing structure configured with at least two rotatable tape-roll hubs installed perpendicularly to the front wall panel and rear wall panel so that at least one of the tape rolls installed on the rotatable tape-roll hubs is reversed and at least one adhesive edge of at least one tape roll is conjoined partially and longitudinally to a reversed adhesive edge of at least one rear tape roll when the reversed-conjoined tape end portions are being dispensed simultaneously on the same path. The multi-tape dispenser may be manufactured for use with a combination of two tape-roll hubs or three tape-roll hubs with tape rolls mounted thereto to produce reversed-conjoined tape end portions. The dispenser can also be used for dispensing at least one tape roll without being conjoined.

Abstract: A method of treating connective tissue by applying a DC current to the tissue in the absence of intentionally heating the tissue.

Abstract: An architecture allows individual system components to be developed and tested individually, i.e., as distinct modules, and to be subsequently combined through standardized electrical and communication interfaces. Any combination of these modules can be implemented to form different products that provide any number of functions, such as an integrated system for monitoring a health condition and/or delivering a medication. The architecture also provides an approach for dynamically updating the product and offering its users the latest generation of technology even after the users have already purchased the product. In particular, the embodiments employ the communication interfaces to also provide connection to a remote network that can update or upgrade the product's software when the product is out in the field.

Abstract: An architecture allows individual system components to be developed and tested individually, i.e., as distinct modules, and to be subsequently combined through standardized electrical and communication interfaces. Any combination of these modules can be implemented to form different products that provide any number of functions, such as an integrated system for monitoring a health condition and/or delivering a medication. The architecture also provides an approach for dynamically updating the product and offering its users the latest generation of technology even after the users have already purchased the product. In particular, the embodiments employ the communication interfaces to also provide connection to a remote network that can update or upgrade the product's software when the product is out in the field.

Abstract: A switch according to the present invention can have a number of ports in an ASIC greater than the ASIC clock speed divided by the network protocol rate. The switch ASIC contains multiple blocks, each block having a number of ports equal to the ASIC clock speed divided the packet rate of the protocol. Each block has a number of queues equal to the total number of ports on the ASIC to receive packets. The queues are scheduled from each block into a number of outputs equal to the number of blocks. The outputs of each block are received by a scheduler which evaluates the packets available at the outputs of each block to determine the combination of outputs which provides the most connections that are ready for transmission. The combination with the most connections is then utilized to provide packets to the egress section of each block.

Abstract: A service cart for storing components of a substrate processing system includes a first side configured to store a transfer plate removed from the substrate processing system. The first side includes a first mount and a second mount that are spaced apart to retain respective upper portions of the transfer plate. Each of the first mount and the second mount includes a respective groove arranged to retain the upper portions of the transfer plate. The first side further includes a first bumper and a second bumper that are spaced apart to abut respective lower portions of the transfer plate. Each of the first bumper and the second bumper are arranged to retain a desired distance between the first side and the lower portions of the transfer plate. A second side of the service cart includes a drawer or an opening to provide access to an interior of the service cart.

Abstract: A service cart for storing components of a substrate processing system includes a first side configured to store a transfer plate removed from the substrate processing system. The first side includes a first mount and a second mount that are spaced apart to retain respective upper portions of the transfer plate. Each of the first mount and the second mount includes a respective groove arranged to retain the upper portions of the transfer plate. The first side further includes a first bumper and a second bumper that are spaced apart to abut respective lower portions of the transfer plate. Each of the first bumper and the second bumper are arranged to retain a desired distance between the first side and the lower portions of the transfer plate. A second side of the service cart includes a drawer or an opening to provide access to an interior of the service cart.

Abstract: Systems and methods for coordinating home automation activity may include accessing event data from a storage database communicatively coupled with an electronic device. Each item of event data may include a time and date at which the event data was collected. The methods may include generating a graphical, perspective depiction identifying the number of events occurring during discrete time intervals for a period of time. The depiction may include the discrete time intervals in perspective view. The methods may also include outputting the graphical, perspective depiction from the electronic device for display on a display device.

Abstract: A wearable infusion pump allows a user to insert a program key into the device housing to select a continuous dosage rate. The program keys are shaped to close contacts on a printed circuit board within the housing to communicate the selected dosage to a microprocessor. In this way, a single disposable pump, sold with one SKU, can be used to deliver a plurality of dosage rates. The disposable pump is provided with on-board display and one-button on-board user operable control. In preferred embodiments, the infusion pump according to the invention may be used for the continuous delivery of insulin in the management of Type II diabetes.

Abstract: An architecture allows individual system components to be developed and tested individually, i.e., as distinct modules, and to be subsequently combined through standardized electrical and communication interfaces. Any combination of these modules can be implemented to form different products that provide any number of functions, such as an integrated system for monitoring a health condition and/or delivering a medication. The architecture also provides an approach for dynamically updating the product and offering its users the latest generation of technology even after the users have already purchased the product. In particular, the embodiments employ the communication interfaces to also provide connection to a remote network that can update or upgrade the product's software when the product is out in the field.

Abstract: An architecture allows individual system components to be developed and tested individually, i.e., as distinct modules, and to be subsequently combined through standardized electrical and communication interfaces. Any combination of these modules can be implemented to form different products that provide any number of functions, such as an integrated system for monitoring a health condition and/or delivering a medication. The architecture also provides an approach for dynamically updating the product and offering its users the latest generation of technology even after the users have already purchased the product. In particular, the embodiments employ the communication interfaces to also provide connection to a remote network that can update or upgrade the product's software when the product is out in the field.

Abstract: A multi-tape dispenser, for dispensing reversed-conjoined and non-reversed-conjoined adhesive tape end portions from adhesive tape rolls, includes a housing structure configured with at least two rotatable tape-roll hubs installed perpendicularly to the front wall panel and rear wall panel so that at least one of the tape rolls installed on the rotatable tape-roll hubs is reversed and at least one adhesive edge of at least one tape roll is conjoined partially and longitudinally to a reversed adhesive edge of at least one rear tape roll when the reversed-conjoined tape end portions are being dispensed simultaneously on the same path. The multi-tape dispenser may be manufactured for use with a combination of two tape-roll hubs or three tape-roll hubs with tape rolls mounted thereto to produce reversed-conjoined tape end portions. The dispenser can also be used for dispensing at least one tape roll without being conjoined.

Abstract: A switch according to the present invention can have a number of ports in an ASIC greater than the ASIC clock speed divided by the network protocol rate. The switch ASIC contains multiple blocks, each block having a number of ports equal to the ASIC clock speed divided the packet rate of the protocol. Each block has a number of queues equal to the total number of ports on the ASIC to receive packets. The queues are scheduled from each block into a number of outputs equal to the number of blocks. The outputs of each block are received by a scheduler which evaluates the packets available at the outputs of each block to determine the combination of outputs which provides the most connections that are ready for transmission. The combination with the most connections is then utilized to provide packets to the egress section of each block.