Patents by Inventor Torben Halkier

Torben Halkier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease variants
    Patent number: 6087315
    Abstract: The present invention relates to protease variants, stabilized towards the inactivation caused by peroxidase systems, in which protease variants a naturally occurring tyrosine residue has been deleted or substituted with a different amino acid residue at one or more positions. The invention also relates to a method of stabilizing a protease towards the inactivation caused by peroxidase systems, and detergent compositions comprising a protease variant of the invention.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: July 11, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Grethe Rasmussen, Egon Nielsen, Torben Halkier
  • Enzyme with acetyl esterase activity
    Patent number: 6037161
    Abstract: The present invention provides an enzyme with acetyl esterase activity comprising the amino acid sequence IxFGDxYYT(SEQ ID NO: 1), in which x designates any amino acid residue. The enzyme exhibits activity towards acetylated xylan and acetylated mannan and may be used for modifying or degrading plant containing materials.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: March 14, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Stephan Christgau, Thomas Sandal, Markus Sakari Kauppinen, Torben Halkier, Henrik Dalb.o slashed.ge
  • Purified coprinus laccases and nucleic acids encoding the same
    Patent number: 6008029
    Abstract: The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: December 28, 1999
    Assignee: Novo Nordisk Biotech Inc.
    Inventors: Debbie Sue Yaver, Kimberley M. Brown, Sakari Kauppinen, Torben Halkier
  • Rhamnogalacturonase, corresponding DNA sequence, rhamnogalacturonase containing enzyme preparation and use of the enzyme preparation
    Patent number: 6001627
    Abstract: The present invention relates to rhamnogalacturonases derived from a strain of Aspergillus japonicus which (a) has a pH-optimum between 6.5 and 7.0; (b) retains at least 80% of the maximal activity throughout the pH range of 5.5-12; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 20-60.degree. C. The present invention relates to rhamnogalacturonases derived from a strain of Aspergillus aculeatus which (a) has a pH-optimum of about 5.0; (b) retains at least 80% of the maximal activity throughout the pH range of 3-6.5; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 5-50.degree. C.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: December 14, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Kurt Dorreich, Henrik Dalb.o slashed.ge, Jan M.o slashed.ller Mikkelsen, Flemming Mark Christensen, Torben Halkier
  • Enzymes with aminopeptidase activity
    Patent number: 5994113
    Abstract: The present invention relates to a enzyme exhibiting aminopeptidase activity, a method for producting said enzyme, and enzyme preparation containing said enzyme exhibithing aminopeptidase activity, and use of said enzyme for various industrial purposes.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: November 30, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Markus Sakari Kauppinen, Joan Qi Si, Tina Spendler, Claus Dambmann, Torben Halkier, Peter Rahbek stergaard, Shamkant Anant Patkar, Kim Hansen
  • Haloperoxidases from Curvularia verruculosa and nucleic acids encoding same
    Patent number: 5965418
    Abstract: The present invention relates to Curvularia verruculosa haloperoxidases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the haloperoxidases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods for recombinant production of the haloperoxidase. The invention further relates to compositions comprising the haloperoxidases and methods of using the compositions for killing microbial cells or inhibiting growth of microbial cells.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: October 12, 1999
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Claus Fuglsang, Karen Oxenb.o slashed.ll, Torben Halkier, Randy M. Berka, Joel Cherry
  • Enzymatic detergent composition
    Patent number: 5929017
    Abstract: A lipolytic enzyme with high activity at alkaline pH in the absence of Ca.sup.++ can be obtained from strains of filamentous fungi belonging to the genus Absidia. The lipolytic enzymes are effective for improving the effect of detergents towards fatty soiling.
    Type: Grant
    Filed: April 24, 1997
    Date of Patent: July 27, 1999
    Assignee: Novonordisk A/S
    Inventors: Erik Gormsen, Naoko Ikegami, Masanobu Abo, Shinobu Takagi, Noriko Tsutsumi, Torben Halkier
  • Enzyme with B-1, 3-glucanase activity
    Patent number: 5919688
    Abstract: A DNA construct exhibiting .beta.-1,3-glucanase activity, including an expression vectors, cells harbouring the DNA construct or expression vector, a method of producing the enzyme, as well as the enzyme and preparations containing the enzyme.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: July 6, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Pau Ferrer, Ivan Diers, Lisbeth Hedegaard, Torben Halkier, Juan A. Asenjo, Demitris Savva
  • .alpha.-galactosidase enzyme
    Patent number: 5919690
    Abstract: A DNA construct comprising a DNA sequence encoding a polypeptide having .alpha.-galactosidase activity, having the amino acid sequence of SEQ ID NO:3.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: July 6, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Inge Helmer Knap, Carsten M. Hjort, Torben Halkier, Lene Venke Kofod
  • Alkaline lipolytic enzyme
    Patent number: 5919746
    Abstract: The present invention relates to an alkaline lipolytic enzyme derivable from a strain of Botryosphaeria or Guignardia, to a lipolytic enzyme-producing microbial strain, to methods for the production of lipolytic enzyme and to a detergent composition comprising the lipolytic enzyme.
    Type: Grant
    Filed: August 28, 1997
    Date of Patent: July 6, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Satoshi Hirayama, Torben Halkier
  • Recombinant expression of a glucose oxidase from a cladosporium strain
    Patent number: 5879921
    Abstract: The invention is directed to alkaline glucose oxidases comprising novel peptide sequences. Furthermore, the invention relates to methods for producing and using said glucose oxidases.
    Type: Grant
    Filed: November 7, 1996
    Date of Patent: March 9, 1999
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Joel R. Cherry, Randy M. Berka, Torben Halkier
  • Polypeptides having mutanase activity and nucleic acids encoding same
    Patent number: 5874275
    Abstract: The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: February 23, 1999
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Randy M Berka, Stephan Christgau, Torben Halkier, Jeff Shuster, Claus Crone Fuglsang
  • Haloperoxidases from curvularia verruculosa and nucleic acids encoding same
    Patent number: 5866393
    Abstract: The present invention relates to Curvularia verruculosa haloperoxidases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the haloperoxidases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods for recombinant production of the haloperoxidase. The invention further relates to compositions comprising the haloperoxidases and methods of using the compositions for killing microbial cells or inhibiting growth of microbial cells.
    Type: Grant
    Filed: July 9, 1996
    Date of Patent: February 2, 1999
    Assignees: Novo Nordisk A/S, Novo Nordisk BioTech, Inc.
    Inventors: Claus Fuglsang, Karen Oxenb.o slashed.ll, Torben Halkier, Randy M. Berka, Joel Cherry
  • Lipases from hyphozyma
    Patent number: 5856163
    Abstract: A new species of the genus Hyphogyma is disclosed, as are new lipases obtainable therefrom, Also disclosed is a process for obtaining the enzymes.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: January 5, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Miyoko Hashida, Masanobu Abo, Yukiko Takamura, Ole Kirk, Torben Halkier, Sven Pedersen, Shamkant Anant Patkar, Mogens Trier Hansen
  • Penicillium purpurogenum mutanases and nucleic acids encoding same
    Patent number: 5853702
    Abstract: The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: December 29, 1998
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Randy M. Berka, Stephan Christgau, Torben Halkier, Jeff Shuster, Claus Crone Fuglsang
  • Enzyme with acetyl esterase activity
    Patent number: 5830734
    Abstract: An isolated and purified acetyl esterase with activity towards acetylated xylan and acetylated mannan obtained from Aspergillus aculeatus and having amino acid sequence that comprises Seq ID No 1. An enzyme can be used for the modification of plant cell wall components.
    Type: Grant
    Filed: January 4, 1996
    Date of Patent: November 3, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Stephen Christgau, Thomas Sandal, Markus Sakari Kauppinen, Torben Halkier, Henrik Dalb.o slashed.ge
  • Tripeptidyl aminopeptidase
    Patent number: 5821104
    Abstract: The present invention relates to a tripeptidyl aminopeptidase, a DNA construct encoding the tripeptidyl aminopeptidase, a method of producing tripeptidyl aminopeptidase and methods of reducing the tripeptidyl aminopeptidase production in cells in which tripeptidyl aminopeptidase activity is undesirable.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: October 13, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Kaj Andre Holm, Grethe Rasmussen, Torben Halkier, Jan Lehmbeck
  • Recombinant lipase and alpha-amylase variants
    Patent number: 5731280
    Abstract: The present invention relates to lipase and .alpha.-amylase variants, stabilized towards the inactiviation caused by peroxidase systems, in which variants a naturally occurring tryosine residue has been deleted, substituted with a different amino acid residue at one or more positions. The invention also relates to a method of stabilizing a lipase or an .alpha.-amylase towards the inactivation caused by the preoxidase systems, and detergent compositions comprising a lipase and/or .alpha.-amylase variant of the invention.
    Type: Grant
    Filed: June 15, 1995
    Date of Patent: March 24, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Egon Nielsen, Grethe Rasmussen, Torben Halkier
  • Xylanase, DNA sequences, coding for the xylanases and methods of use thereof
    Patent number: 5610048
    Abstract: The xylanase is characterized by several partial amino acid sequences and is immunoreactive with an antibody raised against a purified xylanase derived from Humicola insolens, DSM 1800. This xylanase preparation is practically free of cellulase xylanase and is well suited for treatment of paper pulp, as a baking agent and as an additive to fodder.
    Type: Grant
    Filed: September 21, 1993
    Date of Patent: March 11, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Martin Schulein, Torben Halkier, Hans P. Heldt-Hansen, Henrik Dalb.o slashed.ge, Lars S. Pedersen
  • Rhamnogalacturonase, corresponding DNA sequence, rhamnogalacturonase containing enzyme preparation and use of the enzyme preparation
    Patent number: 5538884
    Abstract: The present invention relates to rhamnogalacturonases derived from a strain of Aspergillus japonicus which (a) has a pH-optimum between 6.5 and 7.0; (b) retains at least 80% of the maximal activity throughout the pH range of 5.5-12; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 20.degree.-60.degree. C. The present invention relates to rhamnogalacturonases derived from a stain of Aspergillus aculeatus which (a) has a pH-optimum of about 5.0; (b) retains at least 80% of the maximal activity throughout the pH range of 3-6.5; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 5.degree.-50.degree. C.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: July 23, 1996
    Assignee: Novo Nordisk A/S
    Inventors: Kurt D orreich, Henrik Dalb.o slashed.ge, Jan M. Mikkelsen, Flemming M. Christensen, Torben Halkier