Patents by Inventor Torsten Wuestefeld

Torsten Wuestefeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIVER CELL REGENERATION
    Publication number: 20260263504
    Abstract: There is provided a method of regenerating a liver cell in a subject having a liver cell degeneration, comprising administering an agent that modulates one or more gene or marker comprising C1ORF131 (2810004N23Rik), SLC45A4, NFKBIB, ARL6IP5, DBNL, GOLGA7B, FAM117B, MED28, TSC22D4, EIF4EBP1, PFN1, PNRC2, ZNF672 (Zfp672), IER5, ADAMTSL5, COL4A5, MYH15, and ILKAP, wherein the agent counteracts the liver cell degeneration and/or enhances a liver cell regeneration. Also disclosed are nucleic acid encoding an agent for inhibiting the one or more gene or marker, composition or a vector or a plasmid comprising the nucleic acids, a kit comprising the nucleic acids, and a composition or vector or plasmid for use in therapy.
    Type: Application
    Filed: May 31, 2024
    Publication date: September 10, 2026
    Inventors: Torsten Wuestefeld, Shainan Hora, Amanpreet Kaur
  • Method of stimulating proliferation of a cell
    Patent number: 12421515
    Abstract: Methods of treating and preventing diseases associated with fibrosis are disclosed, as well as agents for use in such methods. The methods comprise inhibiting at least one of ITFG1, MFAP4, GRHPR, ABCC4, PAK3, TRNP1, APLN, KIF20A, and/or LTB. In one embodiment, the disease is a liver disease or condition. Also disclosed are methods of promoting regeneration of cells, such as hepatocytes.
    Type: Grant
    Filed: April 27, 2022
    Date of Patent: September 23, 2025
    Assignee: Agency for Science, Technology and Research
    Inventors: Torsten Wuestefeld, Viktoriia Iakovleva
  • Medicament for liver regeneration and for treatment of liver failure
    Patent number: 11975032
    Abstract: The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: May 7, 2024
    Assignee: MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Lars Zender, Torsten Wuestefeld
  • METHOD OF STIMULATING PROLIFERATION OF A CELL
    Publication number: 20230167440
    Abstract: Methods of treating and preventing diseases associated with fibrosis are disclosed, as well as agents for use in such methods. The methods comprise inhibiting at least one of ITFG1, MFAP4, GRHPR, ABCC4, PAK3, TRNP1, APLN, KIF20A, and/or LTB. In one embodiment, the disease is a liver disease or condition. Also disclosed are methods of promoting regeneration of cells, such as hepatocytes.
    Type: Application
    Filed: August 31, 2022
    Publication date: June 1, 2023
    Inventors: Torsten WUESTEFELD, Viktoriia IAKOVLEVA
  • METHOD OF STIMULATING PROLIFERATION OF A CELL
    Publication number: 20220364089
    Abstract: Methods of treating and preventing diseases associated with fibrosis are disclosed, as well as agents for use in such methods. The methods comprise inhibiting at least one of ITFG1, MFAP4, GRHPR, ABCC4, PAK3, TRNP1, APLN, KIF20A, and† or LTB. In one embodiment, the disease is a liver disease or condition. Also disclosed are methods of promoting regeneration of cells, such as hepatocytes.
    Type: Application
    Filed: April 27, 2022
    Publication date: November 17, 2022
    Inventors: Torsten WUESTEFELD, Viktoriia IAKOVLEVA
  • MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE
    Publication number: 20190099453
    Abstract: The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
    Type: Application
    Filed: December 7, 2018
    Publication date: April 4, 2019
    Inventors: Lars Zender, Torsten Wuestefeld
  • MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE
    Publication number: 20190091265
    Abstract: The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
    Type: Application
    Filed: December 7, 2018
    Publication date: March 28, 2019
    Inventors: Lars Zender, Torsten Wuestefeld
  • Medicament for liver regeneration and for treatment of liver failure
    Patent number: 10188682
    Abstract: The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: January 29, 2019
    Assignees: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH, MEDIZINISCHE HOCHSCHULE HANNOVER
    Inventors: Lars Zender, Torsten Wuestefeld
  • MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE
    Publication number: 20160022742
    Abstract: The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
    Type: Application
    Filed: October 6, 2015
    Publication date: January 28, 2016
    Inventors: Lars Zender, Torsten Wuestefeld
  • Medicament for liver regeneration and for treatment of liver failure
    Patent number: 9186381
    Abstract: The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
    Type: Grant
    Filed: April 10, 2012
    Date of Patent: November 17, 2015
    Assignees: Helmholtz Zentrum Fuer Infektionsforschung GmbH, Medizinische Hochschule Hannover
    Inventors: Lars Zender, Torsten Wuestefeld
  • MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE
    Publication number: 20140141510
    Abstract: The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.
    Type: Application
    Filed: April 10, 2012
    Publication date: May 22, 2014
    Applicants: MEDIZINISCHE HOCHSCHULE HANNOVER, HELMHOLTZ ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH
    Inventors: Lars Zender, Torsten Wuestefeld