Abstract: An adeno-associated virus (AAV) vector for inserting a desired nucleic acid into a nucleic acid in a cell, wherein the nucleic acid in the cell comprises a region consisting of a first nucleotide sequence and a region consisting of a second nucleotide sequence in order in a direction from a 5? end to a 3? end, wherein the vector comprises a first gRNA target sequence, a region consisting of a first nucleotide sequence, the desired nucleic acid, a region consisting of a second nucleotide sequence, a second gRNA target sequence, a cell-specific promoter, a sequence encoding a Cas9 nuclease, an RNA polymerase III promoter, a sequence encoding a first gRNA recognizing the first gRNA target sequence and a sequence encoding a second gRNA recognizing the second gRNA target sequence, wherein the vector yields a nucleic acid fragment comprising a region consisting of a first nucleotide sequence, the desired nucleic acid and the region consisting of the second nucleotide sequence by the Cas9 nuclease, wherein a first n

Abstract: A supply device configured to supply a medium to a processing unit configured to perform processing on the medium, the supply device including an accommodating unit configured to accommodate a plurality of the media in a state of being stacked therein and a vibration imparting unit configured to contact ends of the plurality of media accommodated in the accommodating unit to impart vibration to the medium.

Abstract: A composition for optic nerve cell protection, for preventing or treating glaucoma, for suppressing retinal ganglion cell death, or for delaying a progression of visual acuity loss of human contains at least one selected from the group consisting of products obtained by steaming and drying wheat, defatted wheat germ, defatted rice germ, defatted soybean, fermented grape, hesperidin, lactic acid bacterium Lactobacillus salivarius, wild grape, Tamarind, Haskap, pomegranate seeds, licorice powder, and cinnamon powder.

Abstract: An ophthalmic information processing system according to an embodiment includes a receiver and a processor. The receiver receives morphological data of an eye fundus of a subject. In addition, the receiver receives background data of the subject. The processor executes optic nerve head shape classification based on the morphological data and the background data received by the receiver.

Abstract: A perimeter 2 capable of acquiring, as a threshold SV, a value corresponding to a response result of a subject 22 to an optotype presented with various brightness, for measurement points set across an entire measurement field of view of the ocular fundus, displaying the threshold SV as a threshold inspection result SHR and storing the same in a memory 13, comprises: a portion 15 for obtaining a pattern deviation PDV of the threshold SV relating to each measurement point RG, from the threshold inspection result SHR; a portion for 15 for obtaining a P value representing the obtained pattern deviation PDV for each measurement point RG as a probability variable, and generating a probability map image MAP4 indicating the measurement points RG separately for each P value; a portion 16 for selecting, from an abnormal measurement point group RG of points in the probability map image MAP4 in which at least a prescribed number of measurement points having a P value at most equal to 5% are continuous, and, of those, for

Abstract: An information presentation system includes: an overload preventing device that derives a load factor which is an index of a load applied to a rope; a data logger that accumulates data on the load factor derived by the overload preventing device and data on a time length for which a load corresponding to the derived load factor has been applied to the rope, the data on the load factor and the data on the time length being associated with one another, and generates lifting rope statistical information and raising rope statistical information indicating a relationship between the load factor and the cumulative time for each rope; and a presenting unit that presents the lifting rope statistical information and the raising rope statistical information generated by the data logger.

Abstract: The present invention addresses the problem of providing an intraocular irrigating solution that allows the intraocular tissue to be sufficiently protected during ophthalmic surgery and further has high safety. The problem is solved by an intraocular irrigating solution containing at least one of active sulfur molecules of which examples include cysteine persulfide and glutathione persulfide.

Abstract: A fundus analysis apparatus includes a storage, an area setting unit, and a morphological information generating unit. The storage is configured to store OCT information acquired by applying optical coherence tomography to the fundus of an eye. The area setting unit is configured to set a front area corresponding to a front surface of the lamina cribrosa and a rear area corresponding to a rear surface of the lamina cribrosa in the OCT information. The morphological information generating unit is configured to generate morphological information indicating the morphology of the lamina cribrosa based on at least the front area and the rear area.

Abstract: An image display apparatus includes: a light source part generating a plurality of light rays corresponding to respective pixels in an image that changes over time; a projecting part defining an optical path from the light source part to an eye, and forming the image on a retina of the eye by projecting the generated light rays directly on the retina through the optical path; a splitting part splitting a plurality of reflection light rays from positions in a certain site of the eye on the optical path, the positions corresponding to the respective pixels; a detecting part detecting intensities of the reflection light rays that have been split; and a processing part obtaining parameters indicative of conditions of the site at the positions corresponding to the respective pixels, based on intensities of the generated light rays and the intensities of the reflection light rays, for the respective pixels.

Abstract: [Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity. [Solution] A compound represented by the following general formula (I) or a salt thereof.

Abstract: An object of the present invention is to provide a composite material that may be easily delivered and mounted in the living body. The object can be solved by a coated composite material characterized in that a composite material, in which a porous body is bounded to a substrate, is coated with at least one soluble component selected from a group consisting of a water-soluble compound, a temperature-sensitive soluble compound, and a pH sensitive soluble compound.

Abstract: An ophthalmic information processing system according to an embodiment includes a receiver and a processor. The receiver receives morphological data of an eye fundus of a subject. In addition, the receiver receives background data of the subject. The processor executes optic nerve head shape classification based on the morphological data and the background data received by the receiver.

Abstract: A liquid jet apparatus comprises a liquid jet head, a carriage carrying the liquid jet head in a side-to-side direction, a liquid flow channel, and a liquid container in fluid communication with the liquid jet head through the liquid flow channel. The liquid container includes a liquid containing chamber arranged along a front/back direction orthogonal to the side-to-side direction; a liquid outlet port, from which the liquid contained in the liquid containing chamber flows to the liquid flow channel; and a liquid inlet port, through which the liquid is injected into the liquid containing chamber. The liquid inlet port has an end surface that does not face in a vertical direction relative to a normal posture of the apparatus.

Abstract: The invention provides a method of preserving ocular cells in a patient having or at risk of developing glaucoma. In particular, microglial cell activation can be decreased, oligodendrocyte loss can be reduced, and/or the viability of retinal ganglion cells can be preserved by administering a selective TNFR2 antagonist to an individual having or at risk of developing glaucoma.

Abstract: The present invention addresses the problem of providing an intraocular irrigating solution that allows the intraocular tissue to be sufficiently protected during ophthalmic surgery and further has high safety. The problem is solved by an intraocular irrigating solution containing at least one of active sulfur molecules of which examples include cysteine persulfide and glutathione persulfide.

Abstract: A composition for optic nerve cell protection, for preventing or treating glaucoma, for suppressing retinal ganglion cell death, or for delaying a progression of visual acuity loss of human contains at least one selected from the group consisting of products obtained by steaming and drying wheat, defatted wheat germ, defatted rice germ, defatted soybean, fermented grape, hesperidin, lactic acid bacterium Lactobacillus salivarius, wild grape, Tamarind, Haskap, pomegranate seeds, licorice powder, and cinnamon powder.

Abstract: [Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity. [Solution] A compound represented by the following general formula (I) or a salt thereof.

Abstract: The invention provides a method of preserving ocular cells in a patient having or at risk of developing glaucoma. In particular, microglial cell activation can be decreased, oligodendrocyte loss can be reduced, and/or the viability of retinal ganglion cells can be preserved by administering a selective TNFR2 antagonist to an individual having or at risk of developing glaucoma.

Abstract: An information presentation system includes: an overload preventing device that derives a load factor which is an index of a load applied to a rope; a data logger that accumulates data on the load factor derived by the overload preventing device and data on a time length for which a load corresponding to the derived load factor has been applied to the rope, the data on the load factor and the data on the time length being associated with one another, and generates lifting rope statistical information and raising rope statistical information indicating a relationship between the load factor and the cumulative time for each rope; and a presenting unit that presents the lifting rope statistical information and the raising rope statistical information generated by the data logger.

Abstract: An image display apparatus includes: a light source part generating a plurality of light rays corresponding to respective pixels in an image that changes over time; a projecting part defining an optical path from the light source part to an eye, and forming the image on a retina of the eye by projecting the generated light rays directly on the retina through the optical path; a splitting part splitting a plurality of reflection light rays from positions in a certain site of the eye on the optical path, the positions corresponding to the respective pixels; a detecting part detecting intensities of the reflection light rays that have been split; and a processing part obtaining parameters indicative of conditions of the site at the positions corresponding to the respective pixels, based on intensities of the generated light rays and the intensities of the reflection light rays, for the respective pixels.