Patents by Inventor Toru Takeshita

Toru Takeshita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5551502
    Abstract: In a low-pressure casting in which molten metal is introduced into a cavity of a casting mold under a pressure applied to the surface of the molten metal according to a preset reference pressurizing pattern, the reference pressurizing pattern is corrected when that the cavity has been filled with molten metal is detected and the pressure applied to the molten metal surface is controlled according to the reference pressurizing pattern after the correction. The pressure difference between a set pressure at a predetermined time in the reference pressurizing pattern after the correction and a set pressure at the corresponding time in the reference pressurizing pattern before the correction, is calculated and a set pressure for the period up to the time the cavity is filled with molten metal in the reference pressurizing pattern for the next casting cycle is corrected on the basis of the calculated pressure difference.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: September 3, 1996
    Assignee: Mazda Motor Corporation
    Inventors: Nobuyuki Matsubayashi, Toru Takeshita
  • Patent number: 5275009
    Abstract: An air conditioning system including a refrigerant circulation route, a compressor, a condenser, an expansion valve, an evaporator and a pressure sensor for detecting pressure in the circulation route comprises a refrigerant phase detecter provided on the circulation route between the condenser and the evaporator where the refrigerant should be in a liquid phase for detecting whether the refrigerant is in a liquid phase or in a vapor phase and a control for determining whether the compressor is in a locked state in accordance with the signals from the refrigerant phase detecter and the pressure sensor. The air conditioning system can precisely determine and detect both compressor lock up and refrigerant leakage without providing a rotation detecting sensor for the compressor.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: January 4, 1994
    Assignees: Sanden Corporation, Japan Electronic Control Systems Company, Ltd.
    Inventors: Kazumitsu Kobayashi, Masaru Kuribara, Toru Takeshita
  • Patent number: 5197298
    Abstract: An air conditioning system including a refrigerant circulation route, a compressor, a condenser, an expansion valve, an evaporator and a pressure sensor for detecting pressure in the circulation route comprises a refrigerant phase detector provided on the circulation route between the condenser and the evaporator where the refrigerant should be in a liquid phase for detecting whether the refrigerant is in a liquid phase or in a vapor phase and a control for determining whether the compressor is in a locked state in accordance with the signals from the refrigerant phase detector and the pressure sensor. The air conditioning system can precisely determine and detect both compressor lock up and refrigerant leakage without providing a rotation detecting sensor for the compressor.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: March 30, 1993
    Assignees: Sanden Corporation, Japan Electronic Control Systems Company, Ltd.
    Inventors: Kazumitsu Kobayashi, Masaru Kuribara, Toru Takeshita
  • Patent number: 4456553
    Abstract: The present invention relates to novel vitamin D.sub.3 derivatives which have a carboxyl group or its ester group at the 22-position, processes for the preparation thereof, and antigens, which comprise said vitamin D.sub.3 derivative and an immunogenic carrier material, to be used for the preparation of antibodies for enzymeimmunoassay or radioimmunoassay and antibodies obtained therefrom.The determination of such activated vitamin D.sub.3 compounds as 25-hydroxy vitamin D.sub.3, 24, 25-dihydroxy vitamin D.sub.3, etc. can be made satisfactorily according to the present invention.
    Type: Grant
    Filed: May 18, 1983
    Date of Patent: June 26, 1984
    Assignee: Teijin Limited
    Inventors: Jun-ichi Oshida, Osamu Nishikawa, Hideki Tsuruta, Toru Takeshita, Itaru Yamamoto, Kenji Ishimaru
  • Patent number: 4402975
    Abstract: A compound represented by the following formula ##STR1## wherein R.sup.1 represents a hydrogen atom, an acyl group or an alkoxycarbonyl group; X.sup.1 represents an alkylene group having 3 to 6 carbon atoms, a 1,4-cyclohexylene group, or a 1,4-phenylene group, the alkylene group may be substituted by an alkyl group having 1 to 6 carbon atoms, and the 1,4-phenylene group may be substituted by 1 or 2 substituents selected from halogen atoms and alkoxy groups having 1 to 6 carbon atoms; R.sup.2 represents a hydrogen atom or a hydroxyl group and R.sup.3 represents hydrogen atom, or R.sup.2 and R.sup.3 together may form an oxo group (.dbd.O), and when X.sup.1 is other than the 1,4-phenylene group, R.sup.2 represents a hydrogen atom and R.sup.3 represents a bond between the carbon atoms to which R.sup.3 is bonded and that carbon atom of X.sup.1 which is adjacent to said carbon atom; X.sup.
    Type: Grant
    Filed: July 17, 1981
    Date of Patent: September 6, 1983
    Assignee: Teijin Limited
    Inventors: Toru Takeshita, Kenji Hoshina, Akira Ohtsu, Tatsuyuki Naruchi
  • Patent number: 4388243
    Abstract: The present invention relates to a novel process for the preparation of active-type vitamin D.sub.3 compounds and their intermediates. In accordance with the present invention, a large amount of an active-type vitamin D.sub.3 compounds, for example 1.alpha.-hydroxycholecalciferol, 1.alpha.,25-dihydroxycholecalciferol and the like, is efficiently prepared with high industrial advantages by a novel processes, which comprises (i) reacting hydroxycholesta-5-enes having the hydroxyl groups protected with lower alkoxycarbonyl group as a starting material with allylic brominating agent and dehydrobrominating agent to prepare the corresponding hydroxycholesta-5,7-dienes, (ii) exposing the hydroxycholesta-5,7-dienes to ultraviolet irradiation or to a combination of the irradiation with thermal isomerization to obtain a mixture of the unreacted hydroxycholesta-5,7-dienes and previtamin D.sub.3 compounds or a mixture of the unreacted hydroxycholesta-5,7-dienes and the protected active-type vitamin D.sub.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: June 14, 1983
    Assignee: Teijin Limited
    Inventors: Osamu Nishikawa, Kenji Ishimaru, Toru Takeshita, Hideki Tsuruta
  • Patent number: 4298537
    Abstract: A process for producing a steroid compound having an oxo group in the side chain, which comprises condensing an acid halide having a steroid skeleton with an organozinc compound at the halocarbonyl group of the acid halide in an inert organic medium in the presence of a catalytic amount of an ether capable of forming a complex with the organozinc compound, and if desired, hydrolyzing the product. The process produces the steroid compound at a high yield, and often at an almost quantitative yield. The steroid compound is an important intermediate for the production of vitamin D.sub.3 analogs such as active forms of vitamin D.sub.3. In one preferred embodiment, an industrially advantageous process from the standpoint of operation is provided.
    Type: Grant
    Filed: November 28, 1979
    Date of Patent: November 3, 1981
    Assignee: Teijin Limited
    Inventors: Osamu Nishikawa, Kenji Ishimaru, Toru Takeshita, Hideki Tsuruta
  • Patent number: 4292249
    Abstract: This invention relates to novel 25-hydroxy-24-oxocholestane derivatives and a process for preparing them.The novel 25-hydroxy-24-oxocholestane derivatives of this invention can easily be converted to 24,25-dihydroxycholecalciferol or 1.alpha.,24,25-trihydroxycholecalciferol which is known as useful for medicine controlling the calcium metabolism of warm-blooded animals. Moreover, 25-hydroxy-24-oxocholestane derivatives can be converted to novel 25-hydroxy-24-oxocholecalciferol expressed by the following formula ##STR1## and novel 1.alpha.,25-dihydroxy-24-oxocholecalciferol of the formula ##STR2## which are useful for medicine. The new 25-hydroxy-24-oxocholestane derivatives in the present invention are very useful as the intermediates for the synthesis of a variety of active vitamin D.sub.3.
    Type: Grant
    Filed: February 15, 1980
    Date of Patent: September 29, 1981
    Assignee: Teijin Limited
    Inventors: Osamu Nishikawa, Kenji Ishimaru, Toru Takeshita, Hideki Tsuruta
  • Patent number: 4199577
    Abstract: Novel 1.alpha.,3.beta.-dihydroxy-24-oxocholesta-5,7-diene and the hydroxyl group-protected derivatives thereof.Said novel 1.alpha.-hydroxy-24-oxovitamin D.sub.3 and said novel intermediates are also useful as the intermediates of 1.alpha.,24-dihydroxyvitamin D.sub.3.1.alpha.,3.beta.-Dihydroxy-24-oxocholesta-5,7-diene and the hydroxyl group-protected derivatives thereof are prepared from fucosterol via 1.alpha.,3.beta.-diprotected hydroxy-24(24)-ethylenedioxycholest-5-ene. 1.alpha.-hydroxy-24-oxovitamin D.sub.3 is prepared by irradiation with ultraviolet rays to 1.alpha.,3.beta.-dihydroxy-24-oxocholesta-5,7-diene or a hydroxyl group-protected derivatives thereof, isomerization using heat energy, and, when necessary, elimination of the protecting groups.
    Type: Grant
    Filed: September 1, 1978
    Date of Patent: April 22, 1980
    Assignee: Teijin Limited
    Inventors: Toru Takeshita, Takao Niki, Hiroyuki Kawashima, Kiyoshi Bannai
  • Patent number: 4022891
    Abstract: Novel 1.alpha., 24-dihydroxycholecalciferol and derivatives thereof which are useful with reduced side-effects for the treatment of abnormal metabolism of calcium and phosphorus caused by liver failure, renal failure, gastrointestinal tract failure and parathyroid failure, and related bone diseases. Preparation of the novel 1.alpha., 24-dihydroxycholecalciferol and their derivatives starts from 1.alpha., 24-dihydroxycholesterol prepared by reacting 1.alpha., 2.alpha.-epoxy-24-keto-cholesta-4,6-dien-3-one with an alkali metal and a proton donor in the presence of liquid ammonia or a liquid amine. Reaction of the 1.alpha., 24-dihydroxycholesterol with an allylic brominating agent, followed by contacting with a dehydrobrominating agent, affords 1.alpha.,3.beta., 24-trihydroxycholesta-5,7-diene derivative, which can then be converted to 1.alpha., 24-dihydroxycholocalciferol by ultraviolet irradiation in a organic solvent, followed by isomerization. Processes are also provided for separating 1.alpha.
    Type: Grant
    Filed: June 2, 1975
    Date of Patent: May 10, 1977
    Assignee: Teijin Limited
    Inventors: Toru Takeshita, Yoshinobu Hashimoto, Hiroyuki Kawashima, Sachio Ishimoto, Nobuo Ikekawa, Masuo Morisaki
  • Patent number: 3936478
    Abstract: A process for the preparation of desmosterol of which the hydroxyl group at the 3-position is protected, or bis-form derivatives thereof in high purity and with high yields, which comprises reacting 24-hydroxycholesterol of which the hydroxyl group at the 3-position is protected, or bis-form derivatives thereof, withA. phosphorus pentoxide or acid potassium sulfate, orB. phosphorus oxychloride, thionyl chloride, or sulfonyl chlorides, in the presence of tertiary amine.
    Type: Grant
    Filed: June 19, 1974
    Date of Patent: February 3, 1976
    Assignee: Teijin Limited
    Inventors: Toru Takeshita, Sachio Ishimoto