Patents by Inventor Toru Yakabe
Toru Yakabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11795427Abstract: A culture vessel that can suppress foaming in a culture medium when a common nozzle is used to supply a liquid culture medium and a gas together. This culture vessel includes: a vessel body having an opening portion that communicates with a housing space; a lid that closes the opening portion; and a nozzle that passes through the and extends to the housing space, and supplies a liquid culture medium and a gas together. The nozzle has a vent opening portion that is formed so as to open in a side of the nozzle and serves as a movement path of the gas from inside of the nozzle into the housing space.Type: GrantFiled: March 22, 2019Date of Patent: October 24, 2023Assignee: Sumitomo Bakelite Co., Ltd.Inventors: Ryohei Tsukada, Toru Yakabe, Haruo Okubo, Masaharu Kiyama, Midori Kato, Hikaru Saito
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Publication number: 20210002600Abstract: A culture vessel that can suppress foaming in a culture medium when a common nozzle is used to supply a liquid culture medium and a gas together. This culture vessel includes: a vessel body having an opening portion that communicates with a housing space; a lid that closes the opening portion; and a nozzle that passes through the and extends to the housing space, and supplies a liquid culture medium and a gas together. The nozzle has a vent opening portion that is formed so as to open in a side of the nozzle and serves as a movement path of the gas from inside of the nozzle into the housing space.Type: ApplicationFiled: March 22, 2019Publication date: January 7, 2021Inventors: Ryohei Tsukada, Toru Yakabe, Haruo Okubo, Masaharu Kiyama, Midori Kato, Hikaru Saito
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Patent number: 8822670Abstract: A method of synthesizing a cDNA chain using an insoluble carrier having on the surface thereof a polymer substance containing a first unit having a group derived from a phosphoric ester composing the hydrophilic portion of phospholipid, and a second unit having a group derived from carboxylic acid having an electron-attractive substituent bound to a carbonyl group, which includes immobilizing a polynucleotide for DNA elongation; bringing a solution containing an RNA fragment, nucleotide monomers, and a reverse transcriptase or an enzyme having polymerase activity into contact with the surface of the insoluble carrier; and allowing the polynucleotide for DNA elongation immobilized on the surface of the carrier to elongate using the RNA fragment contained in the solution as a template, to thereby form a single-strand cDNA.Type: GrantFiled: August 9, 2006Date of Patent: September 2, 2014Assignees: Sumitomo Bakelite Company, Ltd., Kenji KinoshitaInventors: Kenji Kinoshita, Toru Yakabe, Kentaro Fujimoto, Kanehisa Yokoyama, Kazuhiko Fujiwara
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Patent number: 8088580Abstract: The present invention provides an RNA detection method detecting, from a reaction system containing a target sample, a target RNA chain originated from the target sample, using a surface having on the surface thereof a polymer substance which contains a first unit having a group derived from a phosphate ester composing the hydrophilic portion of a phospholipid and a second unit having a carboxylic acid derivative group composed of an electron-attractive substitutional group bound to a carbonyl group, while being provided with at least one reaction space, the reaction space having an immobilized nucleic acid primer immobilized therein.Type: GrantFiled: June 1, 2007Date of Patent: January 3, 2012Assignee: Sumitomo Bakelite Company, Ltd.Inventors: Kenji Kinoshita, Kanehisa Yokoyama, Kentaro Fujimoto, Toru Yakabe, Shin Saito, Kazuhiko Fujiwara
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Patent number: 7968290Abstract: A method of detecting a gene including immobilizing a primer for DNA elongation onto an insoluble carrier having on the surface thereof a polymer substance containing a first unit having a phosphorylcholine group and a second unit having a carboxylic acid-derived group having an electron-attractive substituent bound to a carbonyl group; annealing the template DNA fragments or RNA fragments with the primer for DNA elongation, so as to elongate the DNA primer while incorporating therein an enzyme, thereby allowing coloration of a chromogenic reagent by its enzymatic action; and judging whether the DNA fragments or RNA fragments of the gene presents or not, based on the degree of coloration.Type: GrantFiled: May 16, 2006Date of Patent: June 28, 2011Assignee: Sumitomo Bakelite Co., Ltd.Inventors: Kenji Kinoshita, Kazuhiko Fujiwara, Kanehisa Yokoyama, Kentaro Fujimoto, Toru Yakabe
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Publication number: 20100016566Abstract: A method of synthesizing a cDNA chain using an insoluble carrier having on the surface thereof a polymer substance containing a first unit having a group derived from a phosphoric ester composing the hydrophilic portion of phospholipid, and a second unit having a group derived from carboxylic acid having an electron-attractive substituent bound to a carbonyl group, which includes immobilizing a polynucleotide for DNA elongation; bringing a solution containing an RNA fragment, nucleotide monomers, and a reverse transcriptase or an enzyme having polymerase activity into contact with the surface of the insoluble carrier; and allowing the polynucleotide for DNA elongation immobilized on the surface of the carrier to elongate using the RNA fragment contained in the solution as a template, to thereby form a single-strand cDNA.Type: ApplicationFiled: August 9, 2006Publication date: January 21, 2010Inventors: Kenji Kinoshita, Toru Yakabe, Kentaro Fujimoto, Kanehisa Yokoyama, Kazuhiko Fujiwara
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Publication number: 20090137406Abstract: The present invention provides an RNA detection method detecting, from a reaction system containing a target sample, a target RNA chain originated from the target sample, using a surface having on the surface thereof a polymer substance which contains a first unit having a group derived from a phosphate ester composing the hydrophilic portion of a phospholipid and a second unit having a carboxylic acid derivative group composed of an electron-attractive substitutional group bound to a carbonyl group, while being provided with at least one reaction space, the reaction space having an immobilized nucleic acid primer immobilized therein.Type: ApplicationFiled: June 1, 2007Publication date: May 28, 2009Inventors: Kenji Kinoshita, Kanehisa Yokoyama, Kentaro Fujimoto, Toru Yakabe, Shin Saito, Kazuhiko Fujiwara
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Publication number: 20090042190Abstract: A method of detecting a gene including immobilizing a primer for DNA elongation onto an insoluble carrier having on the surface thereof a polymer substance containing a first unit having a phosphorylcholine group and a second unit having a carboxylic acid-derived group having an electron-attractive substituent bound to a carbonyl group; annealing the template DNA fragments or RNA fragments with the primer for DNA elongation, so as to elongate the DNA primer while incorporating therein an enzyme, thereby allowing coloration of a chromogenic reagent by its enzymatic action; and judging whether the DNA fragments or RNA fragments of the gene presents or not, based on the degree of coloration.Type: ApplicationFiled: May 16, 2006Publication date: February 12, 2009Inventors: Kenji Kinoshita, Kazuhiko Fujiwara, Kanehisa Yokoyama, Kentaro Fujimoto, Toru Yakabe
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Patent number: 5762997Abstract: A method of forming a coating on an electron emitting cathode, in which (1) a black coating is formed on the inner surface of a cathode sleeve constituting the electron emitting cathode, (2) the cathode sleeve is filled with a suspension as a coating material, and (3) a porous absorbent member is brought into contact with or near an opening portion of the cathode sleeve at the same time or after the cathode sleeve is filled with the suspension, thereby causing the porous absorbent member to absorb an unnecessary portion of the suspension. Thereafter, the cathode sleeve to which the coating material is adhered is heat-treated. As a result, a black coating having a uniform thickness is formed, on the inner surface of the cathode sleeve, as a sintered layer obtained by mixing tungsten having an average particle diameter in a range of 0.5 .mu.m (inclusive) to 2 .mu.m (inclusive) with alumina having an average particle diameter in a range of 0.1 .mu.m (inclusive) to 1 .mu.Type: GrantFiled: March 22, 1996Date of Patent: June 9, 1998Assignee: Kabushiki Kaisha ToshibaInventors: Akihito Hara, Toshiharu Higuchi, Toru Yakabe, Shigeo Kanda, Eiji Yamamoto
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Patent number: 5543682Abstract: A black coating having a uniform thickness is formed, on the inner surface of the cathode sleeve, as a sintered layer obtained by mixing tungsten having an average particle diameter in a range of 0.5 .mu.m (inclusive) to 2 .mu.m (inclusive) with alumina having an average particle diameter in a range of 0.1 .mu.m (inclusive) to 1 .mu.m (exclusive) at a weight ratio of the tungsten to the alumina in a range of (90:10) to (65:35).Type: GrantFiled: March 17, 1994Date of Patent: August 6, 1996Assignee: Kabushiki Kaisha ToshibaInventors: Akihito Hara, Toshiharu Higuchi, Toru Yakabe, Shigeo Kanda, Eiji Yamamoto
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Patent number: 5027029Abstract: An indirectly heated type cathode assembly comprises a cathode sleeve having a heater within itself and having an emitter-impregnated type cathode disc fitted at one end, a plurality of straps connected at one end to a lower end portion of the cathode sleeve, and a cylinder holder whose upper end is connected to the other end of each strap, the holder being located outside the cathode sleeve such that it is spaced a predetermined distance apart from the cathode sleeve. A heat reflecting cylinder is located between the cathode sleeve and the holder of the indirectly heated type cathode assembly such that it is coaxial with the cathode sleeve and holder. The heat reflecting cylinder is supported by the holder and each strap extends such that it is not in contact with the heat reflecting cylinder. The strap is made of a Ta-W alloy or a Ta-W-Hf alloy.Type: GrantFiled: December 8, 1989Date of Patent: June 25, 1991Assignee: Kabushiki Kaisha ToshibaInventors: Toshiharu Higuchi, Sadao Matsumoto, Toru Yakabe, Sakae Kimura