Patents by Inventor Toru Yoshimura

Toru Yoshimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10641768
    Abstract: The present disclosure describes methods and kits for reducing interferences in immunoassays performed on solid phase and on samples containing serum or plasma, by adding an effective amount of a polycationic derivative of dextran to the assay.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: May 5, 2020
    Assignee: ABBOTT JAPAN CO. LTD.
    Inventors: Toru Yoshimura, Kenju Fujita
  • Patent number: 10604790
    Abstract: Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting the sample, in the presence of a polymerase and an endonuclease, with a first oligonucleotide comprising, in the 5? to 3? direction, a first signal DNA generation sequence, an endonuclease recognition site, and a sequence complementary to the 3? end of a target nucleic acid; a second oligonucleotide comprising, in the 5? to 3? direction, a second signal DNA generation sequence, an endonuclease recognition site, and a sequence that is homologous to the first signal DNA generation sequence of the first oligonucleotide; a third oligonucleotide comprising, in the 5? to 3? direction, a third signal DNA generation sequence, an endonuclease recognition site, and a sequence that is homologous to the second signal DNA generation sequence of the second oligonucleotide.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: March 31, 2020
    Assignee: ABBOTT LABORATORIES
    Inventors: Makoto Komori, Toru Yoshimura
  • Patent number: 10378922
    Abstract: A rotation angle detection apparatus includes a magnet that is provided to a rotating shaft of a rotating body and rotates with the rotating shaft to generate magnetic flux and a magnetic sensor that is provided at a distance from the magnet and detects a magnetic flux interlinked with the magnetic sensor. The rotation angle detection apparatus has a magnet magnetic flux detection circuit that detects a magnet magnetic flux generated from the magnet, a disturbance magnetic flux detection circuit that detects a disturbance magnetic flux, which is a magnetic flux other than the magnet magnetic flux and is interlinked with the magnetic sensor, and a correction circuit that corrects a result of detection of the magnetic sensor based on a result of detection of the magnet magnetic flux detection circuit and a result of detection of the disturbance magnetic flux detection circuit.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: August 13, 2019
    Assignee: DENSO CORPORATION
    Inventors: Takuya Kawamura, Hirofumi Kinjou, Toru Wakimoto, Hideaki Nakayama, Masataka Yoshimura
  • Publication number: 20190242899
    Abstract: Disclosed herein are biomarkers for hepatocellular carcinoma and pancreatic cancer. The biomarkers may be laminin gamma 2 monomer, PIVKA-II, AFP, CEA, CA19-9, or combinations thereof. Also disclosed herein are methods of diagnosing, prognosing, classifying risk, and monitoring progression of hepatocellular carcinoma or pancreatic cancer by the detecting the level of laminin gamma 2 monomer, PIVKA-II, AFP, CEA, CA19-9, or combinations thereof.
    Type: Application
    Filed: April 18, 2019
    Publication date: August 8, 2019
    Inventors: Toru Yoshimura, Eisaku Yoshida, Naohiko Koshikawa, Motoharu Seiki
  • Publication number: 20190245191
    Abstract: A current interrupt mechanism includes a partition wall defining a second space that is independent from a first space, and the partition wall includes a current path portion serving as a current path of a sealed battery. The current interrupt mechanism interrupts the current path in response to an internal pressure of the second space that is higher than a predetermined pressure. One conductive path passes through the current path of the current interrupt mechanism, and is in contact with the second electrolyte solution enclosed in the second space. Another conductive path includes a potential application line that is wired to the second electrolyte solution enclosed in the second space.
    Type: Application
    Filed: February 4, 2019
    Publication date: August 8, 2019
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Takayoshi DOI, Joji YOSHIMURA, Toru SUGIYAMA, Akinori EDA
  • Publication number: 20190176183
    Abstract: A dispenser can prevent leakage of contents from a nozzle tip when stopping discharging the contents. A dispenser includes: a syringe body that has a filled space of contents, and has a discharge hole at a tip thereof; a plunger that is slid in the syringe body by application of a pushing force, to discharge the contents in the filled space from the discharge hole; and a piston that is formed of an elastic material and located at a tip part of the plunger, wherein a gap is formed between an inner peripheral surface of the syringe body and an outer peripheral surface of the piston, when the plunger is pushed, the piston deforms to narrow the gap, and a back leakage risk (=(gap area/final discharge hole area)) after the deformation of the piston is 0 or more and less than 1.
    Type: Application
    Filed: June 30, 2017
    Publication date: June 13, 2019
    Applicants: KURARAY NORITAKE DENTAL INC., YOSHINO KOGYOSHO CO., LTD.
    Inventors: Hirotaka HORIGUCHI, Kazuhisa YOSHIMURA, Toru TOMA
  • Patent number: 10316353
    Abstract: Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting said sample, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide. Also disclosed are methods for detecting a target nucleic acid in a sample in which said sample is contacted, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide and a signal amplifier oligonucleotide. The disclosure also provides compositions and kits comprising such sequence conversion and signal amplifier oligonucleotides.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: June 11, 2019
    Assignees: Abbott Laboratories, Tokyo Institute of Technology
    Inventors: Ken Komiya, Makoto Komori, Toru Yoshimura
  • Publication number: 20190056384
    Abstract: This present invention relates generally to devices, systems, and methods for performing bioimaging at the microscopic scale and, more particularly, to devices and systems including a disposable testing device configured to perform bioimaging at the microscopic scale, and methods of performing the bioimaging using the disposable testing device. In some aspects, a testing device is provided for imaging assay beads. The testing device having a sample entry port for receiving the blood sample; a sample testing conduit fluidically connected to the sample entry port, the sample testing conduit including: (i) a planar member, (ii) a transparent planar member, and (iii) a plurality of wells having a predetermined average well height and disposed between the first planar member and the second planar member; and an imager chip forming at least a portion of the planar member.
    Type: Application
    Filed: August 17, 2018
    Publication date: February 21, 2019
    Applicant: Abbott Point of Care Inc.
    Inventors: Sergey Gershtein, Matt Bates, David Sabourin, Toru Yoshimura
  • Publication number: 20190056385
    Abstract: This present invention relates generally to devices, systems, and methods for performing bioimaging at the microscopic scale and, more particularly, to devices and systems including a disposable testing device configured to perform bioimaging at the microscopic scale, and methods of performing the bioimaging using the disposable testing device. In some aspects, a method is provided for imaging assay beads. The method includes moving a blood sample into a sample testing conduit having a first wall formed from at least a portion of an imager chip, a second wall formed from a transparent material layer, and a plurality of wells. The method further including driving a light emitter to project light through the wells, recording an output signal of at least one of absorbance and fluorescence, and converting the output signal to a value indicative of a reaction of a biological sample within each of the plurality of wells.
    Type: Application
    Filed: August 17, 2018
    Publication date: February 21, 2019
    Applicant: Abbott Point of Care Inc.
    Inventors: Sergey Gershtein, Matt Bates, David Sabourin, Toru Yoshimura
  • Patent number: 10208333
    Abstract: Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting said sample, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide having locked nucleic acids at select positions sufficient to decrease non-specific background signal amplification. Also disclosed are methods for detecting a target nucleic acid in a sample in which said sample is contacted, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide and a signal amplifier oligonucleotide, both having locked nucleic acids at select positions sufficient to decrease non-specific background signal amplification. The disclosure also provides compositions and kits comprising such sequence conversion and signal amplifier oligonucleotides.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: February 19, 2019
    Assignees: Abbott Laboratories, Tokyo Institute of Technology
    Inventors: Ken Komiya, Makoto Komori, Toru Yoshimura
  • Publication number: 20180347001
    Abstract: Disclosed are methods for detecting a target nucleic acid in sample, which include contacting the sample with an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5? to 3? direction, an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to the target nucleic acid; a polymerase; and an endonuclease capable of nicking the endonuclease recognition site. The disclosure also provides compositions and kits comprising an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5? to 3? direction an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to a target nucleic acid.
    Type: Application
    Filed: July 27, 2018
    Publication date: December 6, 2018
    Inventors: KEN KOMIYA, MAKOTO KOMORI, TORU YOSHIMURA
  • Patent number: 10107826
    Abstract: Methods and kits for reducing non-specific binding in an immunoassay for PIVKA-II in a test sample are described, in which the test sample is reacted with an anti-prothrombin antibody in the presence of one or more of the following additives: skim milk, saponin, CaCl2, MgCl2, and a sulfobetaine zwitterionic detergent.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: October 23, 2018
    Assignee: Abbott Japan Co. Ltd.
    Inventors: Toru Yoshimura, Eisaku Yoshida, Ryotaro Chiba
  • Patent number: 10067124
    Abstract: To provide a more convenient and more accurate method of assaying ProGRP by improving the stability of ProGRP which is known to be unstable in a biological sample. By using a blood sample in a condition in which a blood coagulation factor is not activated is used as a sample, the degradation of ProGRP is suppressed, whereby it is possible to store a sample for a long period of time and to improve the accuracy of an assay.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: September 4, 2018
    Assignees: Abbott Laboratories, Abbott Japan Co. Ltd.
    Inventors: Toru Yoshimura, Kenju Fujita, Barry L. Dowell
  • Patent number: 10036077
    Abstract: Disclosed are methods for detecting a target nucleic acid in sample, which include contacting the sample with an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5? to 3? direction, an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to the target nucleic acid; a polymerase; and an endonuclease capable of nicking the endonuclease recognition site. The disclosure also provides compositions and kits comprising an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5? to 3? direction an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to a target nucleic acid.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: July 31, 2018
    Assignees: Abbott Laboratories, Tokyo Institute of Technology
    Inventors: Ken Komiya, Makoto Komori, Toru Yoshimura
  • Publication number: 20170089889
    Abstract: To provide a more convenient and more accurate method of assaying ProGRP by improving the stability of ProGRP which is known to be unstable in a biological sample. By using a blood sample in a condition in which a blood coagulation factor is not activated is used as a sample, the degradation of ProGRP is suppressed, whereby it is possible to store a sample for a long period of time and to improve the accuracy of an assay.
    Type: Application
    Filed: October 3, 2016
    Publication date: March 30, 2017
    Inventors: Toru Yoshimura, Kenju Fujita, Barry L. Dowell
  • Publication number: 20170089905
    Abstract: Disclosed herein are biomarkers for hepatocellular carcinoma and pancreatic cancer. The biomarkers may be laminin gamma 2 monomer, PIVKA-II, AFP, CEA, CA19-9, or combinations thereof. Also disclosed herein are methods of diagnosing, prognosing, classifying risk, and monitoring progression of hepatocellular carcinoma or pancreatic cancer by the detecting the level of laminin gamma 2 monomer, PIVKA-II, AFP, CEA, CA19-9, or combinations thereof.
    Type: Application
    Filed: September 27, 2016
    Publication date: March 30, 2017
    Inventors: Toru Yoshimura, Eisaku Yoshida, Naohiko Koshikawa, Motoharu Seiki
  • Patent number: 9528998
    Abstract: Methods for diagnosing rheumatoid arthritis (RA) are disclosed, using measurement of the CCL8 protein level in a test sample from a subject. Testing for CCL8 as an indicator of RA can be combined with testing for other indicators of RA, including clinical assessments, imaging or other RA markers such as Rheumatoid factor (RF). CCL8 testing can be used for discriminating RA from other diseases or conditions, evaluating the severity of RA. Related diagnostic reagents, kits, pharmaceutical compositions, and methods for identifying a candidate substance as a therapeutic agent for treating rheumatoid arthritis are also described.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: December 27, 2016
    Assignee: ABBOTT LABORATORIES
    Inventors: Toru Yoshimura, Ryotaro Chiba
  • Publication number: 20160340710
    Abstract: Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting the sample, in the presence of a polymerase and an endonuclease, with a first oligonucleotide comprising, in the 5? to 3? direction, a first signal DNA generation sequence, an endonuclease recognition site, and a sequence complementary to the 3? end of a target nucleic acid; a second oligonucleotide comprising, in the 5? to 3? direction, a second signal DNA generation sequence, an endonuclease recognition site, and a sequence that is homologous to the first signal DNA generation sequence of the first oligonucleotide; a third oligonucleotide comprising, in the 5? to 3? direction, a third signal DNA generation sequence, an endonuclease recognition site, and a sequence that is homologous to the second signal DNA generation sequence of the second oligonucleotide.
    Type: Application
    Filed: December 24, 2015
    Publication date: November 24, 2016
    Inventors: Makoto Komori, Toru Yoshimura
  • Patent number: 9459248
    Abstract: To provide a more convenient and more accurate method of assaying ProGRP by improving the stability of ProGRP which is known to be unstable in a biological sample. By using a blood sample in a condition in which a blood coagulation factor is not activated is used as a sample, the degradation of ProGRP is suppressed, whereby it is possible to store a sample for a long period of time and to improve the accuracy of an assay.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: October 4, 2016
    Assignees: Abbott Laboratories, Abbott Japan Co. Ltd.
    Inventors: Toru Yoshimura, Kenju Fujita, Barry L. Dowell
  • Publication number: 20160102339
    Abstract: Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting said sample, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide having locked nucleic acids at select positions sufficient to decrease non-specific background signal amplification. Also disclosed are methods for detecting a target nucleic acid in a sample in which said sample is contacted, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide and a signal amplifier oligonucleotide, both having locked nucleic acids at select positions sufficient to decrease non-specific background signal amplification. The disclosure also provides compositions and kits comprising such sequence conversion and signal amplifier oligonucleotides.
    Type: Application
    Filed: October 13, 2015
    Publication date: April 14, 2016
    Inventors: Ken KOMIYA, Makoto KOMORI, Toru YOSHIMURA