Patents by Inventor Toru Yoshimura

Toru Yoshimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160102339
    Abstract: Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting said sample, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide having locked nucleic acids at select positions sufficient to decrease non-specific background signal amplification. Also disclosed are methods for detecting a target nucleic acid in a sample in which said sample is contacted, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide and a signal amplifier oligonucleotide, both having locked nucleic acids at select positions sufficient to decrease non-specific background signal amplification. The disclosure also provides compositions and kits comprising such sequence conversion and signal amplifier oligonucleotides.
    Type: Application
    Filed: October 13, 2015
    Publication date: April 14, 2016
    Inventors: Ken KOMIYA, Makoto KOMORI, Toru YOSHIMURA
  • Publication number: 20160102345
    Abstract: Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting said sample, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide. Also disclosed are methods for detecting a target nucleic acid in a sample in which said sample is contacted, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide and a signal amplifier oligonucleotide. The disclosure also provides compositions and kits comprising such sequence conversion and signal amplifier oligonucleotides.
    Type: Application
    Filed: October 13, 2015
    Publication date: April 14, 2016
    Inventors: Ken KOMIYA, Makoto KOMORI, Toru YOSHIMURA
  • Patent number: 9120862
    Abstract: The present disclosure relates to antibodies and immunoassay methods for use in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: September 1, 2015
    Assignees: ABBOTT LABORATORIES, ABBOTT JAPAN
    Inventors: Toru Yoshimura, Barry Lee Dowell, Gangamani S. Beligere, Eisaku Yoshida
  • Publication number: 20150197823
    Abstract: Disclosed are methods for detecting a target nucleic acid in sample, which include contacting the sample with an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5? to 3? direction, an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to the target nucleic acid; a polymerase; and an endonuclease capable of nicking the endonuclease recognition site. The disclosure also provides compositions and kits comprising an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5? to 3? direction an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to a target nucleic acid.
    Type: Application
    Filed: January 15, 2015
    Publication date: July 16, 2015
    Inventors: KEN KOMIYA, MAKOTO KOMORI, TORU YOSHIMURA
  • Publication number: 20140287532
    Abstract: To provide a more convenient and more accurate method of assaying ProGRP by improving the stability of ProGRP which is known to be unstable in a biological sample. By using a blood sample in a condition in which a blood coagulation factor is not activated is used as a sample, the degradation of ProGRP is suppressed, whereby it is possible to store a sample for a long period of time and to improve the accuracy of an assay.
    Type: Application
    Filed: June 3, 2014
    Publication date: September 25, 2014
    Inventors: Toru Yoshimura, Kenju Fujita, Barry L. Dowell
  • Publication number: 20140045196
    Abstract: Provided are methods of diagnosing cancer in a patient by detecting the presence and/or amount of a biomarker of cancer in a sample from the patient. The methods and biomarkers may be used to develop an accurate prognosis for a patient having cancer or suspected of having cancer, or to accurately diagnose a patient having, or suspected of having cancer. The methods and biomarkers may be used to identify and/or classify a patient as a candidate for a cancer therapy.
    Type: Application
    Filed: August 8, 2013
    Publication date: February 13, 2014
    Applicants: University of Tokyo, Abbott Japan Co., Ltd
    Inventors: Noahiko Koshikawa, Masatoshi Nakagawa, Eisaku Yoshida, Toru Yoshimura, Motoharu Seiki
  • Publication number: 20140024050
    Abstract: The present invention relates to antibodies or binding proteins which bind to PIVKA II and may be used, for example, in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions.
    Type: Application
    Filed: February 14, 2013
    Publication date: January 23, 2014
    Applicant: ABBOTT LABORATORIES
    Inventors: TORU YOSHIMURA, Sharmila Manoj, Bailin Tu, Anthony S. Muerhoff
  • Publication number: 20130217145
    Abstract: The present invention relates to antibodies or binding proteins which bind to PIVKA II and may be used, for example, in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions.
    Type: Application
    Filed: September 6, 2012
    Publication date: August 22, 2013
    Applicant: ABBOTT LABORATORIES
    Inventors: Toru Yoshimura, Sharmila Manoj, Bailin Tu, Barry L. Dowell, Gangamani Beligere, Qiaoqiao Ruan, Anthony S. Muehoff
  • Publication number: 20130130275
    Abstract: Methods and kits for reducing non-specific binding in an immunoassay for PIVKA-II in a test sample are described, in which the test sample is reacted with an anti-prothrombin antibody in the presence of one or more of the following additives: skim milk, saponin, CaCl2, MgCl2, and a sulfobetaine zwitterionic detergent.
    Type: Application
    Filed: May 16, 2012
    Publication date: May 23, 2013
    Applicant: ABBOTT JAPAN CO., LTD.
    Inventors: Toru Yoshimura, Eisaku Yoshida, Ryotaro Chiba
  • Publication number: 20130011826
    Abstract: The present disclosure describes methods and kits for reducing interferences in immunoassays performed on solid phase and on samples containing serum or plasma, by adding an effective amount of a polycationic derivative of dextran to the assay.
    Type: Application
    Filed: July 8, 2011
    Publication date: January 10, 2013
    Applicant: ABBOTT LABORATORIES
    Inventors: Toru Yoshimura, Kenju Fujita
  • Patent number: 8283162
    Abstract: The present invention relates to antibodies that may be used, for example, in the diagnosis, treatment and prevention of haepatocellular carcinoma (HCC), liver cancer and related conditions.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: October 9, 2012
    Assignee: Abbott Laboratories
    Inventors: Toru Yoshimura, Barry L. Dowell, Gangamani S. Beligere, Qiaoqiao Ruan
  • Publication number: 20120020972
    Abstract: The present disclosure relates to antibodies and immunoassay methods for use in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions.
    Type: Application
    Filed: July 26, 2010
    Publication date: January 26, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Toru Yoshimura, Barry Lee Dowell, Gangamani S. Beligere, Eisaku Yoshida
  • Publication number: 20110256636
    Abstract: Methods for diagnosing rheumatoid arthritis (RA) are disclosed, using measurement of the CCL8 protein level in a test sample from a subject. Testing for CCL8 as an indicator of RA can be combined with testing for other indicators of RA, including clinical assessments, imaging or other RA markers such as Rheumatoid factor (RF). CCL8 testing can be used for discriminating RA from other diseases or conditions, evaluating the severity of RA. Related diagnostic reagents, kits, pharmaceutical compositions, and methods for identifying a candidate substance as a therapeutic agent for treating rheumatoid arthritis are also described.
    Type: Application
    Filed: April 14, 2011
    Publication date: October 20, 2011
    Applicant: ABBOTT JAPAN CO., LTD.
    Inventors: Toru Yoshimura, Ryotaro Chiba
  • Publication number: 20100233175
    Abstract: The present invention relates to antibodies that may be used, for example, in the diagnosis, treatment and prevention of haepatocellular carcinoma (HCC), liver cancer and related conditions.
    Type: Application
    Filed: March 10, 2009
    Publication date: September 16, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Toru Yoshimura, Barry L. Dowell, Gangamani S. Beligere, Qiaoqiao Ruan
  • Publication number: 20100136711
    Abstract: To provide a more convenient and more accurate method of assaying ProGRP by improving the stability of ProGRP which is known to be unstable in a biological sample. By using a blood sample in a condition in which a blood coagulation factor is not activated is used as a sample, the degradation of ProGRP is suppressed, whereby it is possible to store a sample for a long period of time and to improve the accuracy of an assay.
    Type: Application
    Filed: December 11, 2007
    Publication date: June 3, 2010
    Inventors: Toru Yoshimura, Kenju Fujita, Barry L. Dowell
  • Publication number: 20100022029
    Abstract: In immunoassays such as homocysteine immunoassays, it is known that the measured values can be dispersed due to the influence of inhibiting substances present in a biological sample on the immunoreaction. The present invention provides among other things a method whereby the influence of the immunoreaction inhibiting substances is easily and efficiently suppressed or eliminated, and also provides a kit used for such a method. The influence of the immunoreaction inhibiting substances is suppressed or eliminated when the analyte (e.g., homocysteine) contained in the biological sample is reacted with the antibody in the presence of extrinsic polyanion.
    Type: Application
    Filed: October 7, 2009
    Publication date: January 28, 2010
    Inventor: Toru Yoshimura
  • Publication number: 20070259376
    Abstract: In immunoassays such as homocysteine immunoassays, it is known that the measured values can be dispersed due to the influence of inhibiting substances present in a biological sample on the immunoreaction. The present invention provides among other things a method whereby the influence of the immunoreaction inhibiting substances is easily and efficiently suppressed or eliminated, and also provides a kit used for such a method. The influence of the immunoreaction inhibiting substances is suppressed or eliminated when the analyte (e.g., homocysteine) contained in the biological sample is reacted with the antibody in the presence of extrinsic polyanion.
    Type: Application
    Filed: December 28, 2006
    Publication date: November 8, 2007
    Inventor: Toru Yoshimura
  • Patent number: 6673629
    Abstract: A chromatography assay device and method for use with whole blood samples utilizing a red blood cell separating agent to aggregate red blood cells and permit plasma or serum to flow by capillary action and a neutralizing agent to neutralize any effects the red blood cell separating agent may have on the device and method.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: January 6, 2004
    Assignee: Abbott Laboratories
    Inventors: Toru Yoshimura, Toshihiro Ogasawara, Michihiro Saito, John P. Groff
  • Patent number: 5036420
    Abstract: A surge absorber utilizes a varistor electrically connected to a surge absorbing element. The varistor voltage and nonlinearity factor are chosen so that the varistor has a preselected voltage-current characteristic which prevents the varistor from breaking down and short circuiting and resulting in a thermal runaway.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: July 30, 1991
    Assignee: Mitsubishi Mining & Cement Co., Ltd.
    Inventors: Toru Yoshimura, Akio Uchida, Takaaki Ito, Nobuya Saruwatari
  • Patent number: 4928650
    Abstract: A first rocker arm is used to induce valve lift while a second one used to move the valve back to closed position. The rocker arms are arranged to engage the valve top or retainer surfaces at locations offset from the axis of the valve and to induce the valve to rotate during the lift and closing operations. Springs, hydraulic lifters or double adjust screw type arrangements are used to control clearances.
    Type: Grant
    Filed: May 28, 1989
    Date of Patent: May 29, 1990
    Assignee: Nissan Motor Co., Ltd.
    Inventors: Yutaka Matayoshi, Toru Yoshimura, Shigeru Kamegaya, Kyugo Hamai