Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: A deceleration device according to an embodiment includes a driven gear configured to rotate about a rotational axis by driving power of a drive mechanism; a deceleration unit including a plurality of gears including a first gear and a second gear, the first gear that rotates by the driven gear, the second gear that rotates about the rotational axis, the deceleration unit configured to rotate the second gear at a reduced speed with respect to the driven gear; a first contact included in the second gear; and a second contact provided separately from the driven gear and the plurality of gears and configured to come into contact with the first contact to stop the rotation of the second gear.

Abstract: A slide device includes a lower rail; an upper rail disposed movably with respect to the lower rail; a screw provided on one of the lower rail and the upper rail; and a nut provided on the other one of the lower rail and the upper rail, and engaging the screw, wherein: the upper rail moves relatively with respect to the lower rail in accordance with rotation of at least one of the screw and the nut; the lower rail includes a bottom wall, a side wall extending upward from the bottom wall, and an upper wall extending toward the center in a width direction from the side wall; and the screw or the nut provided on the lower rail has a central axis line which is disposed in a space enclosed by the bottom wall, the side wall, and the upper wall of the lower rail.

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: In this method, an oligonucleotide represented by formula (II) [wherein Y1, Q, Base, r and r? are each as defined in claim 1] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in claim 1]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3?-direction but also in the 5?-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

Abstract: A slide device includes a lower rail; an upper rail disposed movably with respect to the lower rail; a screw provided on one of the lower rail and the upper rail; and a nut provided on the other one of the lower rail and the upper rail, and engaging the screw, wherein: the upper rail moves relatively with respect to the lower rail in accordance with rotation of at least one of the screw and the nut; the lower rail includes a bottom wall, a side wall extending upward from the bottom wall, and an upper wall extending toward the center in a width direction from the side wall; and the screw or the nut provided on the lower rail has a central axis line which is disposed in a space enclosed by the bottom wall, the side wall, and the upper wall of the lower rail.

Abstract: A seat rotating device for a vehicle includes: a plate used to support a seat; and a pair of guide rails arranged side by side in a vehicle width direction and supporting the plate. The guide rails each have a fixed rail and a sliding member that supports the plate and is slidable along the fixed rail. The plate includes guides that guide each of the sliding members. The guides are configured such that the plate rotates while causing the sliding members to move in directions opposite to each other or the plate rotates based on movement of the sliding members in directions opposite to each other.

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: A gear device includes a housing, a cover, and a gear. The cover covers an opening of the housing. The gear is accommodated in the housing. One of the housing and the cover includes a projection projected toward the gear and having a center axis that extends along a rotation axis of the gear. The gear includes a recess that receives the projection.

Abstract: A deceleration device according to an embodiment includes a driven gear configured to rotate about a rotational axis by driving power of a drive mechanism; a deceleration unit including a plurality of gears including a first gear and a second gear, the first gear that rotates by the driven gear, the second gear that rotates about the rotational axis, the deceleration unit configured to rotate the second gear at a reduced speed with respect to the driven gear; a first contact included in the second gear; and a second contact provided separately from the driven gear and the plurality of gears and configured to come into contact with the first contact to stop the rotation of the second gear.

Abstract: A vehicle seat sliding device includes: a lower rail fixed to a vehicle floor; an upper rail slidably engaging with the lower rail and supports a vehicle seat upward; a nut member fixed to a first rail which configures one side of the lower rail and the upper rail; a screw rod screwed into the nut member; a drive unit rotating the screw rod; and a support supporting the screw rod on a second rail which configures the other side of the lower rail and the upper rail. The support includes a holding member that is provided with an insertion hole into which the screw rod is inserted and that is fixed to the second rail, and a holding nut that is provided with a through-hole into which the screw rod is inserted and that is screwed to a screwing portion provided on the screw rod or the holding member.

Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (?-PGA-PAE) of poly(?-glutamic acid) (?-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.

Abstract: A vehicle seat device lifts and lowers a seat. The vehicle seat device includes a base, a lifter link, and a drive device. The lifter link includes a plurality of members that move a seat cushion of the seat vertically relative to the base. The drive device is coupled to the lifter link. The drive device relatively moves the lifter link. The drive device is attached to the base, a vehicle floor, or a seat-mounting device fixed to the vehicle floor.

Abstract: A seat rotating device for a vehicle includes: a plate used to support a seat; and a pair of guide rails arranged side by side in a vehicle width direction and supporting the plate. The guide rails each have a fixed rail and a sliding member that supports the plate and is slidable along the fixed rail. The plate includes guides that guide each of the sliding members. The guides are configured such that the plate rotates while causing the sliding members to move in directions opposite to each other or the plate rotates based on movement of the sliding members in directions opposite to each other.

Abstract: In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in Claim 1]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3?-direction but also in the 5?-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: A vehicle seat sliding device includes: a lower rail configured to be fixed to a vehicle floor; an upper rail slidably engaging with the lower rail and configured to support a vehicle seat upward; a screw rod is rotatably supported by a first rail configuring one side of the lower and upper rails; a drive unit driving rotation of the screw rod; a nut member provided with a screw hole into which the screw rod is screwed; and a nut holding member fixed to a second rail configuring the other side of the lower and upper rails, and holding the nut member, in which one and the other of the nut and nut holding members are provided with a support shaft and an arcuate groove, respectively, and the nut holding member regulates integral rotation of the screw rod and the nut member, and allows the nut member to rotate around a second rotation axis.

Abstract: In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in Claim 1]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method cars dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3?-direction but also in the 5?-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.