Abstract: A vehicle seat sliding device includes: a lower rail configured to be fixed to a vehicle floor; an upper rail slidably engaging with the lower rail and configured to support a vehicle seat upward; a screw rod is rotatably supported by a first rail configuring one side of the lower and upper rails; a drive unit driving rotation of the screw rod; a nut member provided with a screw hole into which the screw rod is screwed; and a nut holding member fixed to a second rail configuring the other side of the lower and upper rails, and holding the nut member, in which one and the other of the nut and nut holding members are provided with a support shaft and an arcuate groove, respectively, and the nut holding member regulates integral rotation of the screw rod and the nut member, and allows the nut member to rotate around a second rotation axis.

Abstract: In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in Claim 1]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method cars dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3?-direction but also in the 5?-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

Abstract: A speed reducer includes: a case; an input shaft rotationally driven by an electric motor and having an eccentric shaft portion; an externally toothed gear wheel rotatably supported on the eccentric shaft portion; an output shaft rotatably supported on the case coaxially with the input shaft and having an internally toothed gear wheel; a guide plate formed with a guide recess recessed parallel to the input shaft, and disposed between the input shaft and the externally toothed gear wheel; a guide protrusion provided in the case to protrude parallel to the input shaft to guide sliding of the recess; and a guide portion provided between the externally toothed gear wheel and the guide plate to guide movement of the externally toothed gear wheel relative to the guide plate, thereby guiding the externally toothed gear wheel so as to be revolvable but non-rotatable in cooperation with the recess and the protrusion.

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (?-PGA-PAE) of poly(?-glutamic acid) (?-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.

Abstract: A vehicle seat sliding device includes: a lower rail configured to be fixed to a vehicle floor; an upper rail slidably engaging with the lower rail and configured to support a vehicle seat upward; a screw rod is rotatably supported by a first rail configuring one side of the lower and upper rails; a drive unit driving rotation of the screw rod; a nut member provided with a screw hole into which the screw rod is screwed; and a nut holding member fixed to a second rail configuring the other side of the lower and upper rails, and holding the nut member, in which one and the other of the nut and nut holding members are provided with a support shaft and an arcuate groove, respectively, and the nut holding member regulates integral rotation of the screw rod and the nut member, and allows the nut member to rotate around a second rotation axis.

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: A vehicle seat sliding device includes: a lower rail fixed to a vehicle floor; an upper rail slidably engaging with the lower rail and supports a vehicle seat upward; a nut member fixed to a first rail which configures one side of the lower rail and the upper rail; a screw rod screwed into the nut member; a drive unit rotating the screw rod; and a support supporting the screw rod on a second rail which configures the other side of the lower rail and the upper rail. The support includes a holding member that is provided with an insertion hole into which the screw rod is inserted and that is fixed to the second rail, and a holding nut that is provided with a through-hole into which the screw rod is inserted and that is screwed to a screwing portion provided on the screw rod or the holding member.

Abstract: A speed reducer includes: a case; an input shaft rotationally driven by an electric motor and having an eccentric shaft portion; an externally toothed gear wheel rotatably supported on the eccentric shaft portion; an output shaft rotatably supported on the case coaxially with the input shaft and having an internally toothed gear wheel; a guide plate formed with a guide recess recessed parallel to the input shaft, and disposed between the input shaft and the externally toothed gear wheel; a guide protrusion provided in the case to protrude parallel to the input shaft to guide sliding of the recess; and a guide portion provided between the externally toothed gear wheel and the guide plate to guide movement of the externally toothed gear wheel relative to the guide plate, thereby guiding the externally toothed gear wheel so as to be revolvable but non-rotatable in cooperation with the recess and the protrusion.

Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (?-PGA-PAE) of poly(?-glutamic acid) (?-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.

Abstract: A vehicular seat slide device, includes: a first rail fixed to one of a vehicular floor and a seat; a second rail fixed to the other one of the floor and the seat, and linked to be movable relative to the first rail; a screw rod supported by the second rail to be rotatable around an axial line which extends in a moving direction; a metal case fixed to the first rail, and through which the screw rod is inserted; a resin nut housed in the metal case in a state of being unmovable in the moving direction with respect to the metal case, and screwed to the screw rod; and a metal nut housed in the metal case in a state of not being in contact with the resin nut in the moving direction, and screwed to the screw rod.

Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (?-PGA-PAE) of poly(?-glutamic acid) (?-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: A vehicular seat slide device, includes: a first rail fixed to one of a vehicular floor and a seat; a second rail fixed to the other one of the floor and the seat, and linked to be movable relative to the first rail; a screw rod supported by the second rail to be rotatable around an axial line which extends in a moving direction; a metal case fixed to the first rail, and through which the screw rod is inserted; a resin nut housed in the metal case in a state of being unmovable in the moving direction with respect to the metal case, and screwed to the screw rod; and a metal nut housed in the metal case in a state of not being in contact with the resin nut in the moving direction, and screwed to the screw rod.

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: A seat adjusting apparatus for a vehicle includes a supporting member pivotally supported at a base member by a first bearing, a pinion gear driven by a driving device, a sector gear engageable with the pinion gear and a restriction mechanism formed at the sector gear for restricting a relative rotation between the pinion gear and the sector gear. The restriction mechanism includes a contact portion coming in contact with the pinion gear so that a component force of a reaction force, which works in a direction in which the first bearing is separated from the second bearing, acting on the pinion gear is reduced. A thickness of a first tooth root of a tooth included in the teeth formed at the sector gear is larger than a thickness of a second tooth root of the other teeth formed at the sector gear.

Abstract: A seat adjustment mechanism, which adjusts an angle formed between first and second seat members rotatably connected to each other, includes a first link member adapted to be connected to the first seat member and including a first end rotatably supported by the first seat member, a second link member adapted to be rotatably connected to the second seat member and including a first end rotatably supported by the second seat member and a second end rotatably connected to the first link member, a drive device, and an extending and retracting device driven by the drive device and extending and retracting linearly, wherein one of the drive device and the extending and retracting device is rotatably connected to a second end of the first link member and the other of the drive device and the extending and retracting device is rotatably connected to the second seat member.

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract: A seat adjusting apparatus for a vehicle includes a supporting member pivotally supported at a base member by means of a first bearing, a pinion gear driven by a driving device, a sector gear engageable with the pinion gear and a restriction mechanism formed at the sector gear for restricting a relative rotation between the pinion gear and the sector gear. The restriction mechanism includes a contact portion coming in contact with the pinion gear so that a component force of a reaction force, which works in a direction in which the first bearing is separated from the second bearing, acting on the pinion gear is reduced. A thickness of a first tooth root of a tooth included in the teeth formed at the sector gear is larger than a thickness of a second tooth root of the other teeth formed at the sector gear.

Abstract: In a seat cushion of a seat, a first actuator supplies air via inside of a communication tube to inside of a air bag in a state where an air valve has been opened by control of a second actuator, whereby air pressure inside the air bag is adjusted, hardness of a pad and in turn the seat cushion is adjusted. Further, after the hardness of the seat cushion has been adjusted, the air valve is closed by control of the second actuator. For this reason, the hardness of the seat cushion can be adjusted at an appropriate hardness with respect to a vehicle occupant.