Patents by Inventor Toshihiko Nishiyama
Toshihiko Nishiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10836747Abstract: The present invention relates to an ethane-sulfonate salt of N-{5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl}-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydro-3-quinolinecarboxamide, which has an Axl-inhibiting activity and is useful as a prophylactic and/or therapeutic agent for immune diseases, cancer and the like, a crystal thereof, and a pharmaceutical composition thereof.Type: GrantFiled: January 25, 2018Date of Patent: November 17, 2020Assignee: ONO PHARMACEUTICAL CO., LTD.Inventors: Takahiro Nekado, Hideomi Kijima, Shizuka Ono, Toshihiko Nishiyama
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Publication number: 20190389837Abstract: The present invention relates to an ethane-sulfonate salt of N-{5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl}-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydro-3-quinolinecarboxamide, which has an Axl-inhibiting activity and is useful as a prophylactic and/or therapeutic agent for immune diseases, cancer and the like, a crystal thereof, and a pharmaceutical composition thereof.Type: ApplicationFiled: January 25, 2018Publication date: December 26, 2019Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Takahiro NEKADO, Hideomi KIJIMA, Shizuka ONO, Toshihiko NISHIYAMA
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Patent number: 9267442Abstract: A method of operating a generator arrangement includes selecting an operating mode as a function of at least one of: a speed of an engine, a temperature of at least a portion of the engine, a property of an exhaust fluid of the engine, and whether an engine braking command signal is received by the controller; controlling the flow of fluid from a first engine outlet to a first turbine by setting, based on the selected operating mode, an operating condition of a first flow control mechanism, the first turbine being part of a turbocharger having a compressor in fluid flow communication with an engine inlet; and controlling the flow of fluid from a second engine outlet to a second turbine by setting, based on the selected operating mode, an operating condition of a second flow control mechanism, the second turbine being parallel to the first turbine and being part of an electrical generator.Type: GrantFiled: March 6, 2013Date of Patent: February 23, 2016Assignee: Cummins LimitedInventors: Tim Denholm, Toshihiko Nishiyama, Owen Alistair Ryder
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Patent number: 8625254Abstract: A solid electrolytic capacitor includes an anode formed of a valve metal and having a roughened surface layer at a surface thereof, a dielectric layer formed of a valve metal oxide and formed on the anode, a cathode formed of a conductive polymer layer formed on the dielectric layer, an anode lead formed adjacent to and integrally with the anode, and a resist formed of an insulating material and delimiting the anode and the anode lead. The anode and the anode lead have a first stepped portion having both surfaces each cut in a thickness direction and covered with the resist, and the anode lead has a second stepped portion having both surfaces each cut deeper in the thickness direction than the first stepped portion.Type: GrantFiled: September 19, 2011Date of Patent: January 7, 2014Assignee: NEC Tokin CorporationInventors: Naoki Takahashi, Toshihiko Nishiyama, Satoshi Suzuki, Ryuta Kobayakawa, Tomoki Nobuta
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Publication number: 20130227944Abstract: A method of operating a generator arrangement comprises selecting an operating mode as a function of at least one of: a speed of an engine, a temperature of at least a portion of the engine, a property of an exhaust fluid of the engine, and whether an engine braking command signal is received by the controller; controlling the flow of fluid from a first engine outlet to a first turbine by setting, based on the selected operating mode, an operating condition of a first flow control mechanism, the first turbine being part of a turbocharger having a compressor in fluid flow communication with an engine inlet; and controlling the flow of fluid from a second engine outlet to a second turbine by setting, based on the selected operating mode, an operating condition of a second flow control mechanism, the second turbine being parallel to the first turbine and being part of an electrical generator.Type: ApplicationFiled: March 6, 2013Publication date: September 5, 2013Applicant: Cummins LtdInventors: Tim Denholm, Toshihiko Nishiyama, Owen Alistair Ryder
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Publication number: 20120276436Abstract: The present invention provides a stack-type lithium-ion polymer battery wherein: the battery capacity is not being degraded; the generation of the wrinkles and fracture of the separator is being suppressed; the battery has gas releasing paths; the displacement of an electrode stack hardly occurs; and the workability at the time of placing the electrode stack in a package body is improved by fixing the electrode stack. A stack-type lithium-ion polymer battery of the present invention comprises: a cathode 13; an anode 14; a separator 15; and a gel electrolyte; wherein an electrode stack 23 in which the cathode 13 and the anode 14 are stacked through the separator 15 is enclosed and fixed by insulating porous sheets 21 and 24, and is packaged with a laminate material.Type: ApplicationFiled: July 11, 2012Publication date: November 1, 2012Applicant: NEC TOKIN CORPORATIONInventors: Shinako Kaneko, Ryuichi Kasahara, Hiroshi Kobayashi, Yasutaka Kono, Toshihiko Nishiyama
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Patent number: 8289677Abstract: The present invention provides a conductive polymer suspension for providing a conductive polymer material having a high conductivity and a method for producing the same, and in particular, a solid electrolytic capacitor having a low ESR and a method for producing the same. The conductive polymer suspension is produced by: synthesizing a conductive polymer by chemical oxidative polymerization of a monomer giving the conductive polymer by using an oxidant in a solvent containing a dopant consisting of a low-molecular organic acid or a salt thereof; purifying the conductive polymer; and mixing the purified conductive polymer and an oxidant in an aqueous solvent containing a polyacid component.Type: GrantFiled: July 28, 2009Date of Patent: October 16, 2012Assignee: NEC Tokin CorporationInventors: Ryuta Kobayakawa, Tomoki Nobuta, Naoki Takahashi, Yasuhisa Sugawara, Satoshi Suzuki, Toshihiko Nishiyama
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Patent number: 8279582Abstract: The present invention provides a conductive polymer suspension for providing a conductive polymer material having a high conductivity and a method for producing the same, and in particular, a solid electrolytic capacitor having a low ESR and a method for producing the same. The conductive polymer suspension can be is produced by: synthesizing a conductive polymer by chemical oxidative polymerization of a monomer giving the conductive polymer by using an oxidant in an aqueous solvent containing a dopant consisting of a low-molecular organic acid or a salt thereof, or a polyacid having a weight average molecular weight of less than 2,000 or a salt thereof.Type: GrantFiled: July 28, 2009Date of Patent: October 2, 2012Assignee: NEC Tokin CorporationInventors: Tomoki Nobuta, Ryuta Kobayakawa, Naoki Takahashi, Yasuhisa Sugawara, Satoshi Suzuki, Toshihiko Nishiyama
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Patent number: 8251666Abstract: A blade of a hybrid type fan includes: a blade body 21 made of a synthetic resin; and a metallic insert 22 that is insert molded simultaneously with the blade body 21 and mounted to a mounting arm of a spider. At a corner on an outer side of a radial direction and a forward side of a rotary direction of the insert 22, a bulging portion 26 is provided to bulge toward the outer side of the radial direction and the forward side of the rotary direction. A bulging region 27 of the bulging portion 26 that the most prominently bulges toward the outer side of the radial direction is located to be forward in the rotary direction relative to a mounting center C of the insert 22 and the mounting arm along the radial direction.Type: GrantFiled: March 13, 2006Date of Patent: August 28, 2012Assignee: Komatsu Ltd.Inventors: Toshihiko Nishiyama, Keiichi Inaba, Kengo Koshimizu
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Patent number: 8202038Abstract: A hydraulic servo drive device for driving a swing mechanism of a variable geometry turbocharger includes a servo piston connected to a driveshaft of the swing mechanism and a pilot spool that is accommodated in a center hole of the servo piston and slides by pilot pressure. A first hydraulic chamber to and from which pressure oil flows are provided in a housing. The servo piston separately includes a pressure port for introducing pressure oil from an outside, a first piston port for intercommunicating the center hole and the first hydraulic chamber, a second piston port for intercommunicating the center hole and the second hydraulic chamber, and a return port for exiting pressure oil.Type: GrantFiled: September 26, 2007Date of Patent: June 19, 2012Assignee: Komatsu Ltd.Inventors: Toshihiko Nishiyama, Shuuji Hori, Takahisa Iino, Daisuke Kozuka
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Patent number: 8186158Abstract: A hydraulic servo drive device for driving a slide mechanism of a variable geometry turbocharger includes a servo piston connected to a driveshaft of the slide mechanism and a pilot spool that is accommodated in a center hole of the servo piton and slides by pilot pressure. A first hydraulic chamber and a second hydraulic chamber to and from which pressure oil flows are provided in a housing. The servo piston separately includes a pressure port for introducing pressure oil from an outside, a first piston port for intercommunicating the center hole and the first hydraulic chamber, a second piston port for intercommunicating the center hole and the second hydraulic chamber, and a return port for exiting pressure oil.Type: GrantFiled: September 26, 2007Date of Patent: May 29, 2012Assignee: Komatsu Ltd.Inventors: Toshihiko Nishiyama, Shuuji Hori, Takahisa Iino, Daisuke Kozuka
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Patent number: 8164884Abstract: In a solid electrolytic capacitor including a porous valve-acting metal, an anode conductor has a large number of pores having openings on the surface thereof according to the porosity of the valve-acting metal. A solid electrolyte layer is formed on the surface of the anode conductor so as to be filled in at least a portion of each of the pores and to close the openings thereof. Further, a cathode conductor is formed on the solid electrolyte layer. Preferably, the solid electrolyte layer has a two-layer structure with two layers having different particle sizes.Type: GrantFiled: October 28, 2008Date of Patent: April 24, 2012Assignee: NEC TOKIN CorporationInventors: Tomoki Nobuta, Naoki Takahashi, Ryuta Kobayakawa, Satoshi Suzuki, Toshihiko Nishiyama
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Patent number: 8109090Abstract: Provided are a variable geometry turbocharger in which a drain pipe from a hydraulic servo drive device can be omitted and in which a member for transmitting power of the hydraulic servo drive device can be efficiently lubricated, and a method of returning oil from the hydraulic servo drive device. The variable geometry turbocharger includes a slide mechanism for changing an opening degree of a nozzle, the hydraulic servo drive device for driving the slide mechanism by hydraulic pressure, and drain flow paths for delivering oil exhausted from the hydraulic servo drive device into an oil return chamber adjacent to a turbocharger body.Type: GrantFiled: October 25, 2007Date of Patent: February 7, 2012Assignee: Komatsu Ltd.Inventors: Toshihiko Nishiyama, Shuuji Hori, Takahisa Iino, Daisuke Kozuka
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Publication number: 20120002350Abstract: A solid electrolytic capacitor includes an anode formed of a valve metal and having a roughened surface layer at a surface thereof, a dielectric layer formed of a valve metal oxide and formed on the anode, a cathode formed of a conductive polymer layer formed on the dielectric layer, an anode lead formed adjacent to and integrally with the anode, and a resist formed of an insulating material and delimiting the anode and the anode lead. The anode and the anode lead have a first stepped portion having both surfaces each cut in a thickness direction and covered with the resist, and the anode lead has a second stepped portion having both surfaces each cut deeper in the thickness direction than the first stepped portion.Type: ApplicationFiled: September 19, 2011Publication date: January 5, 2012Applicant: NEC TOKlN CORPORATIONInventors: Naoki TAKAHASHI, Toshihiko Nishiyama, Satoshi Suzuki, Ryuta Kobayakawa, Tomoki Nobuta
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Patent number: 8038738Abstract: A solid electrolytic capacitor manufacturing method includes a process of removing a roughened surface layer (10a?) from a distal portion (13) of a metal member (10) and from part of an intermediate portion (12) adjacent to the distal portion (13), a process of forming a resist (40) on the distal portion (13) and the intermediate portion (12) of the metal member (10), a process of forming a conductive polymer layer (30) of a conductive polymer on a proximal portion (11) of the metal member (10), and a process of removing a resist (40?) and a surface layer portion (13?) of the metal member (10) from the distal portion (13) of the metal member (10).Type: GrantFiled: October 31, 2008Date of Patent: October 18, 2011Assignee: NEC Tokin CorporationInventors: Naoki Takahashi, Toshihiko Nishiyama, Satoshi Suzuki, Ryuta Kobayakawa, Tomoki Nobuta
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Patent number: 8015802Abstract: An inlet chamber 40 and outlet chamber 50 for exhaust gas are integrated as an inflow/outflow section 80, and a first post treatment device 10 equipped with a DPF 13 at its central portion and second post-treatment device 20 equipped with a urea DeNOx catalyst 23 on its outer periphery side are integrated as a catalyst installation section 70. The catalyst installation section 70, the inflow/outflow section 80, and a communication chamber forming section 30 are provided separately and detachably from one another, and the catalyst installation section 70 is made installable in a reversible manner. As a result, by reversing the catalyst installation section 70, it is possible to easily reverse the DPF 13 without having to extract it from the central part. Further, since the urea DeNOx catalyst 23 is reversed simultaneously, it is possible to change the direction in which the exhaust gas flows therein, thereby enabling to prevent unbalanced deterioration of the urea DeNOx catalyst 23.Type: GrantFiled: November 24, 2005Date of Patent: September 13, 2011Assignee: Komatsu Ltd.Inventors: Toshihiko Nishiyama, Koji Iijima
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Patent number: 8003642Abstract: The compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof specifically binds CCR5, so it is useful for preventing and/or treating CCR5-related diseases, for example, various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation, immunosuppression, psoriasis, multiple sclerosis, etc.), infectious diseases (infection with human immunodeficiency virus, acquired immunodeficiency syndrome, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacterial infection diabetes cancer metastasis and so on Wherein all symbols in formula are as defined in the specification.Type: GrantFiled: March 9, 2007Date of Patent: August 23, 2011Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Shinya Kusuda, Toshihiko Nishiyama, Kazuya Hashimura, Junya Ueda, Shiro Shibayama
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Publication number: 20110197435Abstract: The present invention provides a stack-type lithium-ion polymer battery wherein: the battery capacity is not being degraded; the generation of the wrinkles and fracture of the separator is being suppressed; the battery has gas releasing paths; the displacement of an electrode stack hardly occurs; and the workability at the time of placing the electrode stack in a package body is improved by fixing the electrode stack. A stack-type lithium-ion polymer battery of the present invention comprises: a cathode 13; an anode 14; a separator 15; and a gel electrolyte; wherein an electrode stack 23 in which the cathode 13 and the anode 14 are stacked through the separator 15 is enclosed and fixed by insulating porous sheets 21 and 24, and is packaged with a laminate material.Type: ApplicationFiled: April 26, 2011Publication date: August 18, 2011Applicant: NEC TOKIN CORPORATIONInventors: Shinako KANEKO, Ryuichi KASAHARA, Hiroshi KOBAYASHI, Yasutaka KONO, Toshihiko NISHIYAMA
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Turbo machine, compressor impeller used for turbo machine, and method of manufacturing turbo machine
Patent number: 7909578Abstract: A turbocharger as a turbo machine includes: a compressor impeller (13) having a projected portion (19) at a center of a rear surface; a drive shaft (15) connected to a bottomed coupling hole (20) provided in the projected portion (19) of the compressor impeller (13) through interference fit only; and a sleeve (30) with a cylindrical portion (33) connected to the outer peripheral portion of the projected portion (19) of the compressor impeller (13) by fitting only. The sleeve (30) is formed of a material whose coefficient of linear expansion is smaller than that of the compressor impeller (13). Accordingly, even when the coupling hole (20) in the projected portion (19) undergoes thermal expansion and the diameter of the coupling hole (20) increases, a connection between the drive shaft (15) and the coupling hole (20) can be prevented from being loosened since the radial increase thereof is suppressed by the cylindrical portion (33). Thus, the state of the connection thereof can be well maintained.Type: GrantFiled: October 18, 2005Date of Patent: March 22, 2011Assignee: Komatsu Ltd.Inventors: Toshihiko Nishiyama, Keiichi Inaba, Tetsuaki Ogawa, Hiroshi Sugito, Takahisa Iino -
Patent number: 7765793Abstract: To provide an exhaust emission control device of an internal combustion engine able to well atomize a reducing agent and ensure supply of combustion air. Since a controller of the exhaust emission control device also controls a nozzle opening degree of a variable geometry turbocharger for purpose of spraying a urea water, even in the state where the engine works in a low load range of T1 to T2 where supercharging pressure normally can not be increased, supercharging pressure P suitable to atomization of the urea water can be obtained by controlling the nozzle opening degree of the variable geometry turbocharger to be closer to a closing side compared to the conventional art (shown by the chain double-dashed line), while the urea water can be securely atomized by a part of the supercharged air.Type: GrantFiled: April 1, 2005Date of Patent: August 3, 2010Assignee: Komatsu Ltd.Inventors: Toshihiko Nishiyama, Hiroki Sato