Patents by Inventor Toshihiro Nakanishi

Toshihiro Nakanishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ailanthone derivatives
    Patent number: 4665201
    Abstract: Novel antineoplastic ailanthone derivatives (IIb) represented by the following formula wherein R.sub.2 is C.sub.5 -C.sub.18 .alpha.,.beta.-unsaturated acyl group and its related compounds are disclosed. ##STR1## Particularly, some of the above compounds are far more effective than mitomycin C against mouse lymphocytic leucemia p388.These compounds can be synthesized from known ailanthone via important intermediates, triacyloxy ailanthone, represented by the formula: ##STR2## wherein R.sub.1 is acyl group.
    Type: Grant
    Filed: January 15, 1985
    Date of Patent: May 12, 1987
    Assignee: Suntory, Limited
    Inventors: Tadashi Honda, Kayoko Imao, Nobuo Nakatsuka, Toshihiro Nakanishi
  • Polypeptide carcinostatic agent
    Patent number: 4497799
    Abstract: A carcinostatic agent containing a polypeptide of the formula ##SPC1##
    Type: Grant
    Filed: November 9, 1981
    Date of Patent: February 5, 1985
    Assignee: Suntory Ltd.
    Inventors: Hajime Yoshizumi, Kumao Toyoshima, Akira Hakura, Toshihiro Nakanishi
  • Method for treatment of transplanted tumors in mice
    Patent number: 4427657
    Abstract: Certain noval polypeptides and their use as carcinostatic agents and as agents for the detection and determination of viruses. The polypeptides contain forty-five amino acid residues and have a peculiar tetracyclic structure in that they are bridged with four disulfide bonds between each crysteine molecular pair, said pairs being present between the 3rd and 39th, 4th and 31st, 12th and 29th and 16th and 25th positions, respectively.
    Type: Grant
    Filed: June 17, 1981
    Date of Patent: January 24, 1984
    Assignee: Suntory Ltd.
    Inventors: Kumao Toyoshima, Akira Hakura, Toshihiro Nakanishi, Hajime Yoshizumi
  • Method for the detection of viruses
    Patent number: 4287185
    Abstract: Certain novel polypeptides and their use as carcinostatic agents and as agents for the detection and determination of viruses. The polypeptides contain forty-five amino acid residues and have a peculiar tetracyclic structure in that they are bridged with four disulfide bonds between each cysteine molecular pair, said pairs being present between the 3rd and the 39th, 4th and 31st, 12th and 29th and 16th and 25th positions, respectively.
    Type: Grant
    Filed: October 9, 1979
    Date of Patent: September 1, 1981
    Assignee: Suntory Ltd.
    Inventors: Kumao Toyoshima, Akira Hakura, Toshihiro Nakanishi, Hajime Yoshizumi