Abstract: The present disclosure provides, for example, a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X1, X2, X3 and X4 are each independently —CR2? or N?, R2 is, for example, a halogen atom, R1 is, for example, —S(?O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.

Abstract: There are provided a washout processor and a washing method that prevent solid contents from being attached to a developed flexographic printing plate precursor again.

Abstract: Provided are a treatment device and a treatment method capable of easily reusing a used rinsing liquid, and reducing the amount of waste liquid.

Abstract: The present invention automatically switches edges of a multi-edge tool. This numerical value control device controls a machine tool in which a multi-edge tool for turning is used to turn a workpiece, and said numerical value control device comprises: an NC command decoder unit that decodes a command of a processing program; a storage unit that stores tool information and edge information pertaining to the multi-edge tool; a tool information generation unit that generates geometric information pertaining to the multi-edge tool on the basis of the tool information and the edge information.

Abstract: A programming device includes an information storage unit that stores, in association with identification information assigned to a tool, coordinate conversion information used to convert a coordinate value in a rotating coordinate system into a coordinate value in a reference coordinate system, an execution command generation unit that generates a coordinate conversion execution command based on the coordinate conversion information stored in association with the identification information, and a programming unit that creates a coordinate conversion program including the coordinate conversion execution command generated by the execution command generation unit.

Abstract: A numerical controller includes an information storage unit that stores, in association with identification information assigned to a tool, coordinate conversion information used to convert a coordinate value in a rotating coordinate system into a coordinate value in a reference coordinate system, an information acquisition unit that acquires, from a machining program, a coordinate value that indicates a movement path of the tool to which the identification information is assigned, and a coordinate conversion unit that performs coordinate conversion of the coordinate value indicating the movement path acquired by the information acquisition unit, based on the coordinate conversion information stored in the information storage unit.

Abstract: A numerical control device includes an NC command decoding unit and a tool information storage/generation unit. The NC command decoding unit has a cut amount decoding unit for decoding the cut amount for rough machining, a machining shape generation unit for generating a finishing shape, a machining pathway generation unit for generating a path for rough machining, a tool direction provisional determining unit for provisionally determining the direction of the tool, a path joining assessment unit for assessing whether or not to omit a round-up operation, a machining path joining unit for generating a new path for directly moving to the end point of the next operation after the round-up operation if the round-up operation is to be omitted, and a tool direction determining unit for determining the direction of the tool at each machining shape change point on a path for rough machining including the new path.

Abstract: Provided are a treatment device and a treatment method capable of easily reusing a used rinsing liquid, and reducing the amount of waste liquid.

Abstract: A travel management device detects that a moving body is traveling in a wrong direction on a travel path on which the moving body is currently traveling, based on at least one of a front recognition result and a rear recognition result, the front recognition result indicating display content displayed by a sign appearing in a front captured image, the front captured image being obtained by capturing an image to front of the moving body, the rear recognition result indicating display content displayed by a sign appearing in a rear captured image, the rear captured image being obtained by capturing an image to rear of the moving body. Furthermore, the travel management device detects a possibility of the moving body traveling in a wrong direction in future on a travel path located ahead in a travel direction of the moving body than the travel path on which the moving body is currently traveling, based on at least one of the front recognition result and the rear recognition result.

Abstract: A numerical control device according to an embodiment of the present disclosure is a numerical control device for controlling at least two oscillating drive axes which linearly drive so as to cause mutually differing targets to change speed regularly at a fixed period, based on a machining program, in which the numerical control device controls the at least two oscillating drive axes so as to keep fixed a phase difference of periodic variable components of the at least two oscillating drive axes.

Abstract: Disclosed is a method for producing an antibody reagent for detecting a test substance in a sample by an immune complex transfer method. The method comprises the steps of: bringing an antibody solution comprising a labeled antibody capable of binding to the test substance into contact with a solid phase used in the immune complex transfer method; and separating the solid phase and the antibody solution to prepare the antibody reagent from the antibody solution.

Abstract: A numerical control device according to an aspect of the present disclosure controls, in accordance with a machining program, a machine tool that includes a plurality of machining systems performing machining by each causing a tool to act on a workpiece, and can perform tool oscillation that causes a relative speed of the tool in relation to the workpiece to periodically change in at least one of the machining systems, the numerical control device including: a condition change unit which, upon newly starting machining by one of the machining systems, in a case of another of the machining systems performing machining for which a presence/absence of the tool oscillation differs from the newly starting machining, changes a condition of the newly starting machining or the machining for which the presence/absence of the tool oscillation differs, from a condition derived from the machining program.

Abstract: Provided is a method for detecting a test substance, the method including the steps of: forming an immune complex on a first solid phase by bringing a test substance, a labeled antibody, a capture antibody and the first solid phase into contact with one another; transferring the immune complex onto a second solid phase by breaking the binding between the capture antibody and the first solid phase to liberate the immune complex, and bringing the second solid phase and the immune complex into contact with each other, where the second solid phase is bound to the capture antibody; and detecting the test substance by measuring a label contained in the complex on the second solid phase. The test substance detected by the method is a multimeric antigen, particularly amyloid ? or tau protein.

Abstract: Disclosed is a method for obtaining information of a test substance, the method including: forming a complex by causing a capture substance to bind to a test substance in a specimen; selectively collecting at least the complex from the specimen; immobilizing the complex collected from the specimen, onto a base plate; and obtaining information regarding a structure of the test substance from the complex immobilized on the base plate.

Abstract: Disclosed is a method for detecting an analyte in a sample, including the steps of: (A) forming a first complex comprising: an analyte; a first trapping body which specifically binds to the analyte; a second trapping body which specifically binds to a site of the analyte, the site being different from a site to which the first trapping body specifically binds; and a third trapping body which specifically binds to the second trapping body; (B) separating a part comprising the analyte and the first trapping body from the third trapping body; (C) allowing a fourth trapping body to trap the part to form a second complex; and (D) detecting the analyte of the second complex, wherein the second trapping body comprises a binding substance which binds to the analyte, a support, and a linker which links the binding substance and the support with each other.

Abstract: Provided is a conveying type washing device capable of achieving both maintainability and productivity. This conveying type washing device develops a flexographic printing plate precursor after imagewise exposure using a washing solution. The conveying type washing device has a conveying unit that conveys the flexographic printing plate precursor through a conveying path including a curved conveying path, and a development unit that develops the flexographic printing plate precursor in a state in which the flexographic printing plate precursor is immersed in the washing solution by the conveying unit and conveyed.

Abstract: A numerical control device according to an aspect of the present disclosure controls, in accordance with a machining program, a machine tool that includes a plurality of machining systems performing machining by each causing a tool to act on a workpiece, and can perform tool oscillation that causes a relative speed of the tool in relation to the workpiece to periodically change in at least one of the machining systems, the numerical control device including: a condition change unit which, upon newly starting machining by one of the machining systems, in a case of another of the machining systems performing machining for which a presence/absence of the tool oscillation differs from the newly starting machining, changes a condition of the newly starting machining or the machining for which the presence/absence of the tool oscillation differs, from a condition derived from the machining program.

Abstract: A numerical control device according to an embodiment of the present disclosure is a numerical control device for controlling at least two oscillating drive axes which linearly drive so as to cause mutually differing targets to change speed regularly at a fixed period, based on a machining program, in which the numerical control device controls the at least two oscillating drive axes so as to keep fixed a phase difference of periodic variable components of the at least two oscillating drive axes.

Abstract: A numerical controller includes a position instruction generating unit configured to generate the position instruction; an oscillation instruction generating unit configured to generate the oscillation instruction; a position speed control unit configured to add the position instruction and the oscillation instruction to generate a synthesized instruction; and a current control unit configured to control movement of a tool or rotation of a spindle. The oscillation instruction generating unit includes a tracking error calculating unit configured to obtain and calculate an actual angle and an ideal angle of the spindle, and a frequency recalculating unit configured to recalculate the oscillation frequency or a rotational speed of the spindle based on the actual angle and the ideal angle. The current control unit controls the movement of the tool or the rotation of the spindle according to the recalculated oscillation frequency or rotational speed of the spindle.

Abstract: A numerical controller performs machine learning to calculate tailstock pressing force to stabilize behavior of a workpiece during lathe machining and acquires, as state information, current tailstock pressing force. Then, the numerical controller acquires, as determination data, current vibration or displacement of the workpiece, or power consumption by tailstock pressing force, updates a value function based on the acquired determination data, and outputs an adjustment value of the state information based on the updated value function.