Abstract: The invention relates to a medicament for IBS, which comprises a dual antagonist for 5-HT2B and 5-HT7 receptors having selective binding affinities for 5-HT2B and 5-HT7 receptors. The pharmaceutical composition of the invention is useful as a drug which is excellent in the therapeutic effect on IBS and shows lessened side effects occurring in the existing remedies for IBS, because it showed good pharmacological actions in comparison with the case of independently using a 5-HT2B receptor antagonist having selective binding affinity for 5-HT2B receptor or a 5-HT7 receptor antagonist having selective binding affinity for 5-HT7 receptor.

Abstract: The present invention relates to prophylactic antimigraine agents comprising as an active ingredient a dual antagonist for the 5-HT2B and 5-HT7 receptors, the antagonist having a binding affinity selective for the 5-HT2B and 5-HT7 receptors. Since these prophylactic antimigraine agents show an excellent pharmacological effect in comparison with the cases in which a 5-HT2B receptor antagonist having a selective binding affinity to the 5-HT2B receptor or a 5-HT7 receptor antagonist having a selective binding affinity to the 5-HT7 receptor is used alone, they are useful as drugs which are excellent in prophylaxis of migraine and in which the side effects found in the existing prophylactic antimigraine agents are reduced.

Abstract: An image recognition apparatus, method and program capable of discriminatively recognizing an object at an enhanced recognition rate despite an increase in the total number of reference images registered in image databases. When any individual person or public corporation for example is to be specified from the object image obtained by shooting the person or the like, one image database of the attribute corresponding to various situations, or familiarity to the object image is selected automatically, and then the person or corporation is specified from the shot image while referring to the reference images stored in the image database of the selected attribute.

Abstract: The piperidine derivative of the present invention in which the 4-position of the piperidine ring is bonded, via vinylene, to a mono-substituted (—R1) or unsubstituted benzene ring and the 1-position of the piperidine ring has an acyl group [—C(?O)—R4], or a pharmaceutically acceptable salt thereof has an excellent sodium channel inhibition action and an excellent analgesic action and shows a high analgesic effect particularly to neurogenic pain.

Abstract: An image recognition apparatus, method and program capable of discriminatively recognizing an object at an enhanced recognition rate despite an increase in the total number of reference images registered in image databases. When any individual person or public corporation for example is to be specified from the object image obtained by shooting the person or the like, one image database of the attribute corresponding to various situations, or familiarity to the object image is selected automatically, and then the person or corporation is specified from the shot image while referring to the reference images stored in the image database of the selected attribute.

Abstract: This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R1: an oxygen-containing saturated hetero ring or the like, Alk1: a lower alkylene, m: 0 or 1, Alk2: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR5, R3: H or the like, and R2, R4, R5, R6 and R7: the same or different from one another and each represents H or the like. Provided that R3 does not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, R4 represents a group other than Me when m is 1, R1 is OH or OMe and Alk1 is a C1-3 alkylene, and further 1) when X is a bond, n is 1 and R3 is H, or 2) when X is a bond, n is 0 and R3 is cyclohexane.

Abstract: There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder, and the like. A benzamide derivative or a salt thereof wherein a benzene ring is attached to a D ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring) through an amide bond, the benzene ring is directly bonded to an E ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is further bonded to A (an amino moiety, a monocyclic or bicyclic heterocycle) through L (a lower alkylene).

Abstract: There are provided novel crystals of (?)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide monophosphate.

Abstract: According to the present invention, an SMTP server sending a mail having a predetermined mail address as a recipient to a server that receives and manages the mail having the predetermined mail address, includes: an advertisement information memory operable to store advertisement information to be added to the mail; an advertisement information detector operable to detect the advertisement information to be added to the mail from the advertisement information memory based on at least one of user information about a user having the mail address of the recipient of the mail, user information about a user having a mail address of a sender of the mail and a sentence included in the mail; an advertisement information adding portion operable to add the advertisement information to the mail; and a sending portion operable to send the mail to the server.

Abstract: There are provided a novel process for the production of an isoquinoline derivative having an inhibitory action for If current; a novel benzamide derivative or a salt thereof used for the production process; and a process for the production of the benzamide derivative or a salt thereof.

Abstract: This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R1: an oxygen-containing saturated hetero ring or the like, Alk1: a lower alkylene, m: 0 or 1, Alk2: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR5, R3: H or the like, and R2, R4, R5, R6 and R7: the same or different from one another and each represents H or the like. Provided that R3 does not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, R4 represents a group other than Me when m is 1, R1 is OH or OMe and Alk1 is a C1-3 alkylene, and further 1) when X is a bond, n is 1 and R3 is H, or 2) when X is a bond, n is 0 and R3 is cyclohexane.

Abstract: An image recognition apparatus, method and program capable of discriminatively recognizing an object at an enhanced recognition rate despite an increase in the total number of reference images registered in image databases. When any individual person or public corporation for example is to be specified from the object image obtained by shooting the person or the like, one image database of the attribute corresponding to various situations, or familiarity to the object image is selected automatically, and then the person or corporation is specified from the shot image while referring to the reference images stored in the image database of the selected attribute.

Abstract: A flexible printed circuit board including a component mount section, which an electronic component is mounted on, and a cable section, which connects to the component mount section; circuit patterns being provided on the cable section, and covered by a soft laminated adhesive.

Abstract: The compound of the present invention relates to a drug, particularly to a novel isoquinoline derivative or its salt having an If current inhibitory effect without serious side effects such as convulsion and also to a drug, particularly a cardiac rate lowering agent, containing the compound as the active ingredient. Namely, the compound has a current If inhibitory effect and is particularly useful as a cardiac rate lowering agent for preventing ischemic heart diseases such as angina and cardiac infarction and circulatory diseases such as congestive cardiac insufficiency and arrhythmia (supraventricular arrhythmia). The present invention relates to dialkoxy-1,2,3,4-tetrahydroquinoline-2-carbonylpiperidino-3,4-dialkoxypropaneanilide derivatives, etc.

Abstract: A bolt press fit apparatus comprising; a bolt press fit press machine, a hardware mounting members which can move between a press position of the bolt press fit press machine and a retracted position separated from this press position, and which has a predetermined number of bolt-insertion holes into which bolts are press fitted, bolt transfer mechanisms, and bolt temporarily-press fit mechanisms which insert and temporarily press fit the bolts from the bolt transfer mechanism in a corresponding manner with respect to the predetermined number of bolt-insertion holes.

Abstract: A system for drawing an outer cylinder of a rubber bush comprising an inner cylinder serving as a shaft member, the outer cylinder disposed around the inner cylinder and a rubber elastic body interposed between the inner cylinder and the outer cylinder, comprising first and second turning tables each having at least two piling portions on which the rubber bushes to be drawn are piled up in a vertical direction; first and driving apparatuses for bringing up the rubber bushes piled up on the piling portion of the first and second turning tables to a predetermined robot grasping position; a drawing apparatus having a die for drawing the outer cylinder of the rubber bush; a robot apparatus for grasping and transferring the rubber bush located at the robot grasping position to set the same to a predetermined position of the die; a control apparatus for controlling the robot apparatus such that the rubber bushes from the piling portion of one of the first and second turning tables are sequentially transferred to th

Abstract: A flexible printed circuit board including a component mount section, which an electronic component is mounted on, and a cable section, which connects to the component mount section; circuit patterns being provided on the cable section, and covered by a soft laminated adhesive.

Abstract: A bolt press fit apparatus comprising; a bolt press fit press machine, a hardware mounting members which can move between a press position of the bolt press fit press machine and a retracted position separated from this press position, and which has a predetermined number of bolt-insertion holes into which bolts are press fitted, bolt transfer mechanisms, and bolt temporarily-press fit mechanisms which insert and temporarily press fit the bolts from the bolt transfer mechanism in a corresponding manner with respect to the predetermined number of bolt-insertion holes.

Abstract: A system for drawing an outer cylinder of a rubber bush comprising an inner cylinder serving as a shaft member, the outer cylinder disposed around the inner cylinder and a rubber elastic body interposed between the inner cylinder and the outer cylinder, comprising first and second turning tables each having at least two piling portions on which the rubber bushes to be drawn are piled up in a vertical direction; first and driving apparatuses f or bringing up the rubber bushes piled up on the piling portion of the first and second turning tables to a predetermined robot grasping position; a drawing apparatus having a die for drawing the outer cylinder of the rubber bush; a robot apparatus for grasping and transferring the rubber bush located at the robot grasping position to set the same to a predetermined position of the die; a control apparatus for controlling the robot apparatus such that the rubber bushes from the piling portion of one of the first and second turning tables are sequentially transferred to t

Abstract: In a method of forming vibration isolating rubber bushes, a metal part attaching jig is first prepared. The metal part attaching jig includes: a guide member having a plurality of guide holes which droppingly guide a plurality of metal parts to a plurality of metal part receiving recesses of a lower mold half, respectively; and a guide hole opening and closing member which can open the guide holes by one action in a state where the metal parts inserted into the guide holes are received. The metal parts are inserted into the guide holes, respectively, after the guide hole opening and closing member is switched to a closing side. The guide hole opening and closing member is then switched to an opening side to cause the metal parts to be dropped and accommodated into the metal part receiving recesses.