Patents by Inventor Toshio Fujiwara
Toshio Fujiwara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20250034098Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-II crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).Type: ApplicationFiled: October 17, 2024Publication date: January 30, 2025Applicant: NIPPON SHINYAKU CO., LTD.Inventor: Toshio FUJIWARA
-
Patent number: 12152009Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-{5, 6-diphenylpyrazin-2-yl}-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-II crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).Type: GrantFiled: April 12, 2023Date of Patent: November 26, 2024Assignee: NIPPON SHINYAKU CO., LTD.Inventor: Toshio Fujiwara
-
Publication number: 20230303500Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5, 6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 Å) . A form-II crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 Å) .Type: ApplicationFiled: April 12, 2023Publication date: September 28, 2023Applicant: NIPPON SHINYAKU CO., LTD.Inventor: Toshio FUJIWARA
-
Publication number: 20230250083Abstract: A main object of the present invention is to provide new crystals of (S)-N2-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate (hereinafter, referred to as “compound A”). A Form-I crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.4 degrees, 12.5 degrees, 15.1 degrees, 16.4 degrees, 18.3 degrees, 19.0 degrees, 24.9 degrees, 25.4 degrees, 27.3 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.54 ?). A Form-II crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.2 degrees, 12.4 degrees, 14.8 degrees, 16.5 degrees, 18.1 degrees, 18.5 degrees, 19.8 degrees, 23.6 degrees, 24.9 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.Type: ApplicationFiled: April 13, 2023Publication date: August 10, 2023Applicant: NIPPON SHINYAKU CO., LTD.Inventors: Toshio FUJIWARA, Joanna BIS, Senthil Kumar Kusalakumari SUKUMAR
-
Patent number: 11680055Abstract: A main object of the present invention is to provide new crystals of (S)-N2-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate (hereinafter, referred to as “compound A”). A Form-I crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.4 degrees, 12.5 degrees, 15.1 degrees, 16.4 degrees, 18.3 degrees, 19.0 degrees, 24.9 degrees, 25.4 degrees, 27.3 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.54 ?). A Form-II crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.2 degrees, 12.4 degrees, 14.8 degrees, 16.5 degrees, 18.1 degrees, 18.5 degrees, 19.8 degrees, 23.6 degrees, 24.9 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.Type: GrantFiled: September 27, 2018Date of Patent: June 20, 2023Assignee: NIPPON SHINYAKU CO., LTD.Inventors: Toshio Fujiwara, Joanna Bis, Senthil Kumar Kusalakumari Sukumar
-
Patent number: 11655218Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-II crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).Type: GrantFiled: December 28, 2020Date of Patent: May 23, 2023Assignee: NIPPON SHINYAKU CO., LTD.Inventor: Toshio Fujiwara
-
Publication number: 20210114995Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-II crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).Type: ApplicationFiled: December 28, 2020Publication date: April 22, 2021Applicant: NIPPON SHINYAKU CO., LTD.Inventor: Toshio FUJIWARA
-
Patent number: 10906879Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-III crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).Type: GrantFiled: September 27, 2018Date of Patent: February 2, 2021Assignee: NIPPON SHINYAKU CO., LTD.Inventor: Toshio Fujiwara
-
Publication number: 20200223804Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-III crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).Type: ApplicationFiled: September 27, 2018Publication date: July 16, 2020Applicant: NIPPON SHINYAKU CO., LTD.Inventor: Toshio FUJIWARA
-
Publication number: 20200223823Abstract: A main object of the present invention is to provide new crystals of (S)-N2-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate (hereinafter, referred to as “compound A”). A Form-I crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.4 degrees, 12.5 degrees, 15.1 degrees, 16.4 degrees, 18.3 degrees, 19.0 degrees, 24.9 degrees, 25.4 degrees, 27.3 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.54 ?). A Form-II crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.2 degrees, 12.4 degrees, 14.8 degrees, 16.5 degrees, 18.1 degrees, 18.5 degrees, 19.8 degrees, 23.6 degrees, 24.9 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.Type: ApplicationFiled: September 27, 2018Publication date: July 16, 2020Applicant: NIPPON SHINYAKU CO., LTD.Inventors: Toshio FUJIWARA, Joanna BIS, Senthil Kumar Kusalakumari SUKUMAR
-
Patent number: 7785705Abstract: The flower thinning agent of the present invention comprises a preparation of a mixture of an inorganic compound of poor water solubility with an additive, satisfying the following relationships of (a) 0.03?P?30, (b) 3?Q?800, and (c) 0.5?Q/P?1000, wherein P: average particle diameter (?m) measured by SALD-2000A laser type particle size distribution meter, Q: BET specific surface area (m2/g) measured according to the nitrogen adsorption method. The flower thinning agent of the present invention is not harmful to a human body and has not only high adaptability to the deflection of spread timing, but also high flower thinning effect.Type: GrantFiled: August 1, 2003Date of Patent: August 31, 2010Assignee: Maruo Calcium Company LimitedInventors: Hisakazu Hojo, Hiroshi Shibata, Naoki Kubota, Nariatsu Uto, Toshio Fujiwara
-
Patent number: 7714595Abstract: A foreign object detection sensor applied to an electric sliding door apparatus is provided. The sensor includes a contact detecting section, a change detecting section, and a determination section. The contact detection section has a pressure sensitive portion which is capable of elastically changing in form through contact with a foreign object. The contact detecting section outputs a contact detection signal. The change detecting section measures the time required for the oscillation signal for a predetermined number of cycles to be outputted within a measurement period, which is set shorter than the response time it takes from when the object makes contact with the pressure sensitive portion to when the contact detecting section outputs the contact detection signal in the case where the movable body is in the closing operation at a predetermined maximum moving speed.Type: GrantFiled: January 31, 2008Date of Patent: May 11, 2010Assignee: ASMO Co., Ltd.Inventors: Toshio Fujiwara, Masaaki Shimizu
-
Publication number: 20080180114Abstract: A foreign object detection sensor applied to an electric sliding door apparatus is provided. The sensor includes a contact detecting section, a change detecting section, and a determination section. The contact detection section has a pressure sensitive portion which is capable of elastically changing in form through contact with a foreign object. The contact detecting section outputs a contact detection signal. The change detecting section measures the time required for the oscillation signal for a predetermined number of cycles to be outputted within a measurement period, which is set shorter than the response time it takes from when the object makes contact with the pressure sensitive portion to when the contact detecting section outputs the contact detection signal in the case where the movable body is in the closing operation at a predetermined maximum moving speed.Type: ApplicationFiled: January 31, 2008Publication date: July 31, 2008Applicant: ASMO CO., LTD.Inventors: TOSHIO FUJIWARA, MASAAKI SHIMIZU
-
Patent number: 6965308Abstract: A system for operating a plurality of power generation stations. The system comprises: a general control device for monitoring a plurality of power generation stations, each of the stations including at least one electric power generation unit; a plurality of unit control devices, each of which monitoring each of the generation units, the unit control devices producing alarm data; and communication means for exchanging data between the general control device and each of the unit control devices. Only part of the alarm data produced in the unit control devices are displayed at the general control device.Type: GrantFiled: March 23, 2001Date of Patent: November 15, 2005Assignee: Kabushiki Kaisha ToshibaInventors: Hiroshi Fukuda, Toshihiko Tanaka, Toshio Fujiwara, Kanetoshi Nara, Jin Murata, Toshihiro Yamada
-
Publication number: 20050245396Abstract: The flower thinning agent of the present invention comprises a preparation of a mixture of an inorganic compound of poor water solubility with an additive, satisfying the following relationships of (a) 0.03?P?30, (b) 3?Q?800, and (c) 0.5?Q/P?1000, wherein P: average particle diameter (?m) measured by SALD-2000A laser type particle size distribution meter, Q: BET specific surface area (m2/g) measured according to the nitrogen adsorption method. The flower thinning agent of the present invention is not harmful to a human body and has not only high adaptability to the deflection of spread timing, but also high flower thinning effect.Type: ApplicationFiled: August 1, 2003Publication date: November 3, 2005Applicant: MARUO CLACIUM COMPANY LIMITEDInventors: Hisakazu Hojo, Hiroshi Shiabata, Naoki Kubota, Nariatsu Uto, Toshio Fujiwara
-
Publication number: 20040169653Abstract: In a navigation system using a bird's-eye view display mode, map data on a plan view map are subjected to a perspective projection conversion to obtain drawing data on a bird's-eye view map. In this case, an input of the position of a view point is accepted, and a projection plane for a bird's-eye view is determined on the basis of the coordinates of a current position and a destination and the position of the view point so that the display positions of the two points which have been subjected to perspective-projection conversion are coincident with predetermined positions. Alternatively, an input of a scale is accepted, and the position of the view point and the projection plane are determined on the basis of the coordinates of the two points and the scale so that the display positions of the two points after the perspective projection conversion are coincident with predetermined positions and the drawing scale is coincident with the input scale.Type: ApplicationFiled: March 9, 2004Publication date: September 2, 2004Inventors: Yoshinori Endo, Toshio Fujiwara, Hiroyuki Satake, Hiroshi Shojima, Norimasa Kishi, Masaki Watanabe, Motoki Hirano
-
Patent number: 6760027Abstract: In a navigation system using a bird's-eye view display mode, map data on a plan view map are subjected to a perspective projection conversion to obtain drawing data on a bird's-eye view map. An input of the position of a view point is accepted, and a projection plane for a bird's-eye view is determined so that the display positions of the two points which have been subjected to perspective-projection conversion are coincident with predetermined positions. Alternatively, an input of a scale is accepted, so that the display positions of the two points after the perspective projection conversion are coincident with predetermined positions and the drawing scale is coincident with the input scale. In a further alternative, an input of the projection angle is accepted, and the projection plane is determined on the basis of the projection angle and the position of the view point.Type: GrantFiled: June 9, 2003Date of Patent: July 6, 2004Assignees: Hitachi, Ltd., Nissan Motor Co., Ltd., Xanavi Informatics CorporationInventors: Yoshinori Endo, Toshio Fujiwara, Hiroyuki Satake, Hiroshi Shojima, Norimasa Kishi, Masaki Watanabe, Motoki Hirano
-
Patent number: 6756919Abstract: A map display apparatus includes a map data memory which stores map data necessary for plotting a map of a predetermined region; a map display which reads map data out of the map data memory and plots a bird's-eye view display by projecting the map data read out from the map data memory onto a projection plane which makes a projection angle with a plane of the map data read out from the map data memory, the projection angle being greater than 0° and less than 90°, the bird's-eye view display including identifying marks which identify items in the bird's-eye view display; and an identifying mark overlap preventer which prevents identifying marks from overlapping one another in the bird's-eye view display.Type: GrantFiled: May 19, 2003Date of Patent: June 29, 2004Assignees: Hitachi, Ltd., Xanavi Informatics CorporationInventors: Yoshinori Endo, Toshio Fujiwara, Hiroshi Shojima, Motoki Hirano, Kaoru Harada, Tetsumori Aikawa
-
Publication number: 20040012506Abstract: In order to provide a navigation system intelligibly providing various information which contains information to vary with time and is expected by the user, without increasing quantity of the information to be transmitted to a terminal mounted on a car, a navigation system is constituted with an information offering equipment and an information display system, and said information offering equipment has an individual information reception means to obtain individual information through a network and a data transmission means to transmit the received information to the information display system, and said information display system has a data receiver receiving the data from the information offering equipment, a map display means, an icon display means displaying the receive data on a map, an icon select means, and a detailed information display means which displays the detailed information of an icon selected.Type: ApplicationFiled: July 7, 2003Publication date: January 22, 2004Inventors: Toshio Fujiwara, Yasushi Fukunaga, Kozo Nakamura, Ken?apos; ichirou Kurata, Yasuhiro Gunji, Yoshinori Endo, Mariko Okude
-
Patent number: 6654014Abstract: In a navigation system using a bird's-eye view display mode, map data on a plan view map are subjected to a perspective projection conversion to obtain drawing data on a bird's-eye view map. In this case, an input of the position of a view point is accepted, and a projection plane for a bird's-eye view is determined on the basis of the coordinates of a current position and a destination and the position of the view point so that the display positions of the two points which have been subjected to perspective-projection conversion are coincident with predetermined positions. Alternatively, an input of a scale is accepted, and the position of the view point and the projection plane are determined on the basis of the coordinates of the two points and the scale so that the display positions of the two points after the perspective projection conversion are coincident with predetermined positions and the drawing scale is coincident with the input scale.Type: GrantFiled: May 11, 2001Date of Patent: November 25, 2003Inventors: Yoshinori Endo, Toshio Fujiwara, Hiroyuki Satake, Hiroshi Shojima, Norimasa Kishi, Masaki Watanabe, Motoki Hirano