Patents by Inventor Toshio Fujiwara

Toshio Fujiwara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230303500
    Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5, 6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 Å) . A form-II crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 Å) .
    Type: Application
    Filed: April 12, 2023
    Publication date: September 28, 2023
    Applicant: NIPPON SHINYAKU CO., LTD.
    Inventor: Toshio FUJIWARA
  • Publication number: 20230250083
    Abstract: A main object of the present invention is to provide new crystals of (S)-N2-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate (hereinafter, referred to as “compound A”). A Form-I crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.4 degrees, 12.5 degrees, 15.1 degrees, 16.4 degrees, 18.3 degrees, 19.0 degrees, 24.9 degrees, 25.4 degrees, 27.3 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.54 ?). A Form-II crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.2 degrees, 12.4 degrees, 14.8 degrees, 16.5 degrees, 18.1 degrees, 18.5 degrees, 19.8 degrees, 23.6 degrees, 24.9 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.
    Type: Application
    Filed: April 13, 2023
    Publication date: August 10, 2023
    Applicant: NIPPON SHINYAKU CO., LTD.
    Inventors: Toshio FUJIWARA, Joanna BIS, Senthil Kumar Kusalakumari SUKUMAR
  • Patent number: 11680055
    Abstract: A main object of the present invention is to provide new crystals of (S)-N2-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate (hereinafter, referred to as “compound A”). A Form-I crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.4 degrees, 12.5 degrees, 15.1 degrees, 16.4 degrees, 18.3 degrees, 19.0 degrees, 24.9 degrees, 25.4 degrees, 27.3 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.54 ?). A Form-II crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.2 degrees, 12.4 degrees, 14.8 degrees, 16.5 degrees, 18.1 degrees, 18.5 degrees, 19.8 degrees, 23.6 degrees, 24.9 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: June 20, 2023
    Assignee: NIPPON SHINYAKU CO., LTD.
    Inventors: Toshio Fujiwara, Joanna Bis, Senthil Kumar Kusalakumari Sukumar
  • Patent number: 11655218
    Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-II crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: May 23, 2023
    Assignee: NIPPON SHINYAKU CO., LTD.
    Inventor: Toshio Fujiwara
  • Publication number: 20210114995
    Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-II crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).
    Type: Application
    Filed: December 28, 2020
    Publication date: April 22, 2021
    Applicant: NIPPON SHINYAKU CO., LTD.
    Inventor: Toshio FUJIWARA
  • Patent number: 10906879
    Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-III crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: February 2, 2021
    Assignee: NIPPON SHINYAKU CO., LTD.
    Inventor: Toshio Fujiwara
  • Publication number: 20200223823
    Abstract: A main object of the present invention is to provide new crystals of (S)-N2-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate (hereinafter, referred to as “compound A”). A Form-I crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.4 degrees, 12.5 degrees, 15.1 degrees, 16.4 degrees, 18.3 degrees, 19.0 degrees, 24.9 degrees, 25.4 degrees, 27.3 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.54 ?). A Form-II crystal of the compound A, showing diffraction peaks in its X-ray powder diffraction spectrum at least at the following angles of diffraction 2?: 6.9 degrees, 9.2 degrees, 12.4 degrees, 14.8 degrees, 16.5 degrees, 18.1 degrees, 18.5 degrees, 19.8 degrees, 23.6 degrees, 24.9 degrees, and 27.7 degrees, wherein X-ray powder diffraction spectrum is obtained by using Cu K? radiation (?=1.
    Type: Application
    Filed: September 27, 2018
    Publication date: July 16, 2020
    Applicant: NIPPON SHINYAKU CO., LTD.
    Inventors: Toshio FUJIWARA, Joanna BIS, Senthil Kumar Kusalakumari SUKUMAR
  • Publication number: 20200223804
    Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2?) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?). A form-III crystal of Compound B, which shows peaks at diffraction angles (2?) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-K? radiation (?=1.54 ?).
    Type: Application
    Filed: September 27, 2018
    Publication date: July 16, 2020
    Applicant: NIPPON SHINYAKU CO., LTD.
    Inventor: Toshio FUJIWARA
  • Patent number: 7785705
    Abstract: The flower thinning agent of the present invention comprises a preparation of a mixture of an inorganic compound of poor water solubility with an additive, satisfying the following relationships of (a) 0.03?P?30, (b) 3?Q?800, and (c) 0.5?Q/P?1000, wherein P: average particle diameter (?m) measured by SALD-2000A laser type particle size distribution meter, Q: BET specific surface area (m2/g) measured according to the nitrogen adsorption method. The flower thinning agent of the present invention is not harmful to a human body and has not only high adaptability to the deflection of spread timing, but also high flower thinning effect.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: August 31, 2010
    Assignee: Maruo Calcium Company Limited
    Inventors: Hisakazu Hojo, Hiroshi Shibata, Naoki Kubota, Nariatsu Uto, Toshio Fujiwara
  • Patent number: 7714595
    Abstract: A foreign object detection sensor applied to an electric sliding door apparatus is provided. The sensor includes a contact detecting section, a change detecting section, and a determination section. The contact detection section has a pressure sensitive portion which is capable of elastically changing in form through contact with a foreign object. The contact detecting section outputs a contact detection signal. The change detecting section measures the time required for the oscillation signal for a predetermined number of cycles to be outputted within a measurement period, which is set shorter than the response time it takes from when the object makes contact with the pressure sensitive portion to when the contact detecting section outputs the contact detection signal in the case where the movable body is in the closing operation at a predetermined maximum moving speed.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: May 11, 2010
    Assignee: ASMO Co., Ltd.
    Inventors: Toshio Fujiwara, Masaaki Shimizu
  • Publication number: 20080180114
    Abstract: A foreign object detection sensor applied to an electric sliding door apparatus is provided. The sensor includes a contact detecting section, a change detecting section, and a determination section. The contact detection section has a pressure sensitive portion which is capable of elastically changing in form through contact with a foreign object. The contact detecting section outputs a contact detection signal. The change detecting section measures the time required for the oscillation signal for a predetermined number of cycles to be outputted within a measurement period, which is set shorter than the response time it takes from when the object makes contact with the pressure sensitive portion to when the contact detecting section outputs the contact detection signal in the case where the movable body is in the closing operation at a predetermined maximum moving speed.
    Type: Application
    Filed: January 31, 2008
    Publication date: July 31, 2008
    Applicant: ASMO CO., LTD.
    Inventors: TOSHIO FUJIWARA, MASAAKI SHIMIZU
  • Patent number: 6965308
    Abstract: A system for operating a plurality of power generation stations. The system comprises: a general control device for monitoring a plurality of power generation stations, each of the stations including at least one electric power generation unit; a plurality of unit control devices, each of which monitoring each of the generation units, the unit control devices producing alarm data; and communication means for exchanging data between the general control device and each of the unit control devices. Only part of the alarm data produced in the unit control devices are displayed at the general control device.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: November 15, 2005
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Hiroshi Fukuda, Toshihiko Tanaka, Toshio Fujiwara, Kanetoshi Nara, Jin Murata, Toshihiro Yamada
  • Publication number: 20050245396
    Abstract: The flower thinning agent of the present invention comprises a preparation of a mixture of an inorganic compound of poor water solubility with an additive, satisfying the following relationships of (a) 0.03?P?30, (b) 3?Q?800, and (c) 0.5?Q/P?1000, wherein P: average particle diameter (?m) measured by SALD-2000A laser type particle size distribution meter, Q: BET specific surface area (m2/g) measured according to the nitrogen adsorption method. The flower thinning agent of the present invention is not harmful to a human body and has not only high adaptability to the deflection of spread timing, but also high flower thinning effect.
    Type: Application
    Filed: August 1, 2003
    Publication date: November 3, 2005
    Applicant: MARUO CLACIUM COMPANY LIMITED
    Inventors: Hisakazu Hojo, Hiroshi Shiabata, Naoki Kubota, Nariatsu Uto, Toshio Fujiwara
  • Publication number: 20040169653
    Abstract: In a navigation system using a bird's-eye view display mode, map data on a plan view map are subjected to a perspective projection conversion to obtain drawing data on a bird's-eye view map. In this case, an input of the position of a view point is accepted, and a projection plane for a bird's-eye view is determined on the basis of the coordinates of a current position and a destination and the position of the view point so that the display positions of the two points which have been subjected to perspective-projection conversion are coincident with predetermined positions. Alternatively, an input of a scale is accepted, and the position of the view point and the projection plane are determined on the basis of the coordinates of the two points and the scale so that the display positions of the two points after the perspective projection conversion are coincident with predetermined positions and the drawing scale is coincident with the input scale.
    Type: Application
    Filed: March 9, 2004
    Publication date: September 2, 2004
    Inventors: Yoshinori Endo, Toshio Fujiwara, Hiroyuki Satake, Hiroshi Shojima, Norimasa Kishi, Masaki Watanabe, Motoki Hirano
  • Patent number: 6760027
    Abstract: In a navigation system using a bird's-eye view display mode, map data on a plan view map are subjected to a perspective projection conversion to obtain drawing data on a bird's-eye view map. An input of the position of a view point is accepted, and a projection plane for a bird's-eye view is determined so that the display positions of the two points which have been subjected to perspective-projection conversion are coincident with predetermined positions. Alternatively, an input of a scale is accepted, so that the display positions of the two points after the perspective projection conversion are coincident with predetermined positions and the drawing scale is coincident with the input scale. In a further alternative, an input of the projection angle is accepted, and the projection plane is determined on the basis of the projection angle and the position of the view point.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: July 6, 2004
    Assignees: Hitachi, Ltd., Nissan Motor Co., Ltd., Xanavi Informatics Corporation
    Inventors: Yoshinori Endo, Toshio Fujiwara, Hiroyuki Satake, Hiroshi Shojima, Norimasa Kishi, Masaki Watanabe, Motoki Hirano
  • Patent number: 6756919
    Abstract: A map display apparatus includes a map data memory which stores map data necessary for plotting a map of a predetermined region; a map display which reads map data out of the map data memory and plots a bird's-eye view display by projecting the map data read out from the map data memory onto a projection plane which makes a projection angle with a plane of the map data read out from the map data memory, the projection angle being greater than 0° and less than 90°, the bird's-eye view display including identifying marks which identify items in the bird's-eye view display; and an identifying mark overlap preventer which prevents identifying marks from overlapping one another in the bird's-eye view display.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: June 29, 2004
    Assignees: Hitachi, Ltd., Xanavi Informatics Corporation
    Inventors: Yoshinori Endo, Toshio Fujiwara, Hiroshi Shojima, Motoki Hirano, Kaoru Harada, Tetsumori Aikawa
  • Publication number: 20040012506
    Abstract: In order to provide a navigation system intelligibly providing various information which contains information to vary with time and is expected by the user, without increasing quantity of the information to be transmitted to a terminal mounted on a car, a navigation system is constituted with an information offering equipment and an information display system, and said information offering equipment has an individual information reception means to obtain individual information through a network and a data transmission means to transmit the received information to the information display system, and said information display system has a data receiver receiving the data from the information offering equipment, a map display means, an icon display means displaying the receive data on a map, an icon select means, and a detailed information display means which displays the detailed information of an icon selected.
    Type: Application
    Filed: July 7, 2003
    Publication date: January 22, 2004
    Inventors: Toshio Fujiwara, Yasushi Fukunaga, Kozo Nakamura, Ken?apos; ichirou Kurata, Yasuhiro Gunji, Yoshinori Endo, Mariko Okude
  • Patent number: 6654014
    Abstract: In a navigation system using a bird's-eye view display mode, map data on a plan view map are subjected to a perspective projection conversion to obtain drawing data on a bird's-eye view map. In this case, an input of the position of a view point is accepted, and a projection plane for a bird's-eye view is determined on the basis of the coordinates of a current position and a destination and the position of the view point so that the display positions of the two points which have been subjected to perspective-projection conversion are coincident with predetermined positions. Alternatively, an input of a scale is accepted, and the position of the view point and the projection plane are determined on the basis of the coordinates of the two points and the scale so that the display positions of the two points after the perspective projection conversion are coincident with predetermined positions and the drawing scale is coincident with the input scale.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: November 25, 2003
    Inventors: Yoshinori Endo, Toshio Fujiwara, Hiroyuki Satake, Hiroshi Shojima, Norimasa Kishi, Masaki Watanabe, Motoki Hirano
  • Publication number: 20030208316
    Abstract: In a navigation system using a bird's-eye view display mode, map data on a plan view map are subjected to a perspective projection conversion to obtain drawing data on a bird's-eye view map. In this case, an input of the position of a view point is accepted, and a projection plane for a bird's-eye view is determined on the basis of the coordinates of a current position and a destination and the position of the view point so that the display positions of the two points which have been subjected to perspective-projection conversion are coincident with predetermined positions. Alternatively, an input of a scale is accepted, and the position of the view point and the projection plane are determined on the basis of the coordinates of the two points and the scale so that the display positions of the two points after the perspective projection conversion are coincident with predetermined positions and the drawing scale is coincident with the input scale.
    Type: Application
    Filed: June 9, 2003
    Publication date: November 6, 2003
    Applicants: Hitachi Ltd., Nissan Motor Co., Ltd., Xanavi Informatics Corporation
    Inventors: Yoshinori Endo, Toshio Fujiwara, Hiroyuki Satake, Hiroshi Shojima, Norimasa Kishi, Masaki Watanabe, Motoki Hirano
  • Publication number: 20030201914
    Abstract: In order to provide a navigation system intelligibly providing various information which contains information to vary with time and is expected by the user, without increasing quantity of the information to be transmitted to a terminal mounted on a car, a navigation system is constituted with an information offering equipment and an information display system, and said information offering equipment has an individual information reception means to obtain individual information through a network and a data transmission means to transmit the received information to the information display system, and said information display system has a data receiver receiving the data from the information offering equipment, a map display means, an icon display means displaying the receive data on a map, an icon select means, and a detailed information display means which displays the detailed information of an icon selected.
    Type: Application
    Filed: May 7, 2003
    Publication date: October 30, 2003
    Inventors: Toshio Fujiwara, Yasushi Fukunaga, Kozo Nakamura, Ken?apos;ichirou Kurata, Yasuhiro Gunji, Yoshinori Endo, Mariko Okude