Abstract: The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases. A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

Abstract: The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases. A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

Abstract: A fluid containing bag according to the invention includes a bag main body which is constituted by front and rear two sheets and an entire periphery of which is hermetically sealed except one portion, an inlet/outlet spout one end side of which is connected to the one portion and other end side of which is extended to outside of the bag main body, means for closing an inlet/outlet port of the inlet/outlet spout, and a reinforcing tape attached to a portion or an entire periphery of an inner peripheral face of the bag main body connecting side base portion of the inlet/outlet spout.

Abstract: An endoscope bending control apparatus includes: an image feature value calculating section for calculating, based on an endoscopic image, an image feature value related to a luminal dark part; a bending control section for performing bending control on a bending portion in either one of a first bending operation mode in which a position of the luminal dark part is set as an insertion target and a distal end of the insertion portion is directed to the position and a second bending operation mode in which the distal end of the insertion portion is directed in a direction of the position of the luminal dark part; an operation mode switching section for switching an operation mode from one bending operation mode to the other according to a first switching condition based on the calculated image feature value; and a switching condition changing section for changing the first switching condition.

Abstract: An endoscope system of the invention includes: an endoscope including an insertion portion, a distal end portion provided on a distal end side of the insertion portion, and a bending portion which is capable of changing a position and an orientation of the distal end portion; a position detecting section for acquiring position information on a position where the distal end portion is located; a passing target position setting section for setting a passing target position for the distal end portion; a path estimating section for estimating a path through which the distal end portion is to be passed; a bending control target position setting section for setting a bending control target position such that the distal end portion reaches the passing target position along the path; and a bending control information calculating section for calculating an amount of bending and a bending direction of the bending portion.

Abstract: A novel pyrazole derivative of the following formula having a histamine H3 receptor antagonistic effect: or a pharmaceutically acceptable salt thereof or a pharmaceutical preparation comprising the same as an active ingredient is effective for prevention or treatment of dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.

Abstract: An endoscope system includes: an endoscope for picking up an image in a body cavity by an image pickup apparatus provided in a distal end of an insertion portion; a position detecting apparatus for detecting, based on luminal information acquired by the image pickup apparatus, position information used for inserting the distal end of the insertion portion; a recording apparatus for recording, in a time-sequential manner, the position information detected by the position detecting apparatus; a determining apparatus for determining whether or not the detecting operation of the position information performed by the position detecting apparatus satisfies a set condition; and a direction calculating apparatus for, when the determination result shows that the set condition is not satisfied, reading out the position information recorded in the recording apparatus and outputting information on a direction in which the distal end of the insertion portion is to be inserted.

Abstract: A surgical instrument having a surgical unit which operates on an operating portion in a body cavity, an accommodation portion capable of accommodating the surgical unit. The surgical instrument having movement manipulation mechanism connected to the surgical unit for moving the surgical unit to a position at which the surgical unit is accommodated in the accommodation portion and to a position at which the surgical unit is exposed from the accommodation portion along the inside of the accommodation portion.

Abstract: A multijointed bending mechanism having a first bending piece, a second bending piece connected to the first bending piece so as to be rotatable around a first rotation shaft, a third bending piece connected to the second bending piece so as to be rotatable around a second rotation shaft, at least two first wires connected to the first bending piece to rotate the first bending piece and at least two second wires connected to the second bending piece to rotate the second bending piece. The first wires are disposed inwards of the second wires with respect to a vertical direction of the first and second rotation shafts.

Abstract: A multijointed bending mechanism having a first bending piece, a second bending piece connected to the first bending piece so as to be rotatable around a first rotation shaft, a third bending piece connected to the second bending piece so as to be rotatable around a second rotation shaft, at least two first wires connected to the first bending piece to rotate the first bending piece and at least two second wires connected to the second bending piece to rotate the second bending piece. The first wires and the second wires are disposed concentrically with respect to a vertical direction of the first rotation shaft and the second rotation shaft.

Abstract: An endoscope apparatus includes an accessory including an actuation portion configured to be actuated, an operating unit for operating the actuation portion, an endoscope including an accessory insertion pass wherein the accessory is adapted to be inserted through the accessory insertion pass from a proximal end portion of the accessory insertion pass to a distal end portion of the accessory insertion pass, and projected from and retracted into the distal end portion of the accessory insertion pass, a detecting unit configured to detect a condition of a part of the accessory, which is projected from the distal end portion of the accessory insertion pass, and a control unit configured to control an actuation of the actuation portion by an operation to the operating detecting unit.

Abstract: A multijointed bending mechanism having a first bending piece, a second bending piece connected to the first bending piece so as to be rotatable around a first rotation shaft, a third bending piece connected to the second bending piece so as to be rotatable around a second rotation shaft, at least two first wires connected to the first bending piece to rotate the first bending piece and at least two second wires connected to the second bending piece to rotate the second bending piece. The second wires are disposed inwards of the first wires with respect to a vertical direction of the first and second rotation shafts.

Abstract: Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MC4 receptor antagonistic effect.

Abstract: An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of ?2C-adrenoceptor and is useful in preventing and treating disorders attributable to ?2C-adrenoceptor. The above-described object is solved by the following cyclic amine compound, etc., wherein X is O, S, SO, SO2 or NR2, etc.; R1 is a hydrogen atom, a cyano group, a carboxyl group, a C2-C13 alkoxycarbonyl group, a carbamoyl group, etc.; Ar1 and Ar2 are the same or different and each represent an aryl or heteroaryl group which may be substituted by 1 to 3 substituents and so on; ring B is a benzene ring may be substituted by 1 to 3 substituents and so on; n is an integer from 1 to 10; and p and q are the same or different and each represent an integer of 1 or 2.

Abstract: An energy surgical device is provided with a treatment section which treats a subject, an energy supply section which supplies energy to the treatment section, a state-change detecting section which detects a state change of the treatment section, an energy instruction input section which inputs an instruction for the energy supply, and a regulation section which regulates the energy supply by the energy supply section based on the input of the energy supply instruction through the energy instruction input section and a result of detection in the state-change detecting section.

Abstract: A method of manufacturing a retainer for a roller bearing made of a metal plate and has a tubular main portion, pockets formed in the main portion intermittently concerning a circumferential direction and capable of retaining rollers rollably, and an outwardly oriented flange-like collar portion. An annular intermediate material is formed by die cutting the metal plate, and after a second intermediate material is formed by forming through holes in the intermediate material intermittently, a portion of the second intermediate material excluding a radially outer end portion is plastically deformed into a tubular shape. The portion plastically deformed tubular shape is formed as the main portion, a portion corresponding to the radially outer end portion of the second intermediate material is formed as the collar portion or a collar portion element for forming the collar portion, and portions corresponding to the through holes are formed as the pockets.

Abstract: An endoscope system includes an endoscope with a bending portion installed on a distal side of an insertion portion; a bending drive unit which drives and bends the bending portion electrically; a map information storage unit which stores map information digitized by associating an amount of bending and a corresponding three-dimensional position and direction of a distal end of the insertion portion with each other, with a position near a rear end of the bending portion being designated as a reference position; a position and direction detecting unit which detects the position and direction of the distal end of the insertion portion; and a bending control unit which controls the bending drive unit to orient the distal end of the insertion portion into a target direction using the map information.

Abstract: A therapeutic device system is provided with a control parameter section for calculating a control parameter for adjusting a drive amount of a manipulator with respect to a manipulation signal on the basis of curved state information on an endoscope insertion section, and changing the old control parameter, and when a state of a curve of the endoscope insertion section has changed, a control parameter conforming to the change is calculated to change the old one, whereby the same manipulation operation of the operator enables the same operation of the manipulator to be performed at all times.

Abstract: An endoscopic therapeutic device includes an elongated insertion section which is inserted into a living body through a therapeutic device channel of an endoscope, a tubular puncture needle which is disposed at a distal end portion of the insertion section and is made to pierce a living body tissue, a syringe for sampling the living body tissue in a state in which the puncture needle pierces the living body tissue, and a freezing device for subjecting the living body tissue, which is collected by the syringe, to a process for analysis.

Abstract: An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of ?2C-adrenoceptor and is useful in preventing and treating disorders attributable to ?2C-adrenoceptor. The above-described object is solved by the following cyclic amine compound, etc., wherein X is O, S, SO, SO2 or NR2, etc.; R1 is a hydrogen atom, a cyano group, a carboxyl group, a C2-C13 alkoxycarbonyl group, a carbamoyl group, etc.; Ar1 and Ar2 are the same or different and each represent an aryl or heteroaryl group which may be substituted by 1 to 3 substituents and so on; ring B is a benzene ring may be substituted by 1 to 3 substituents and so on; n is an integer from 1 to 10; and p and q are the same or different and each represent an integer of 1 or 2.