Abstract: A nucleic acid amplification reaction vessel includes a first inner wall, and a second inner wall that is arranged opposite to the first inner wall, in which a distance between the first inner wall and the second inner wall is a length in which a nucleic acid amplification reaction solution comes into contact with both the first inner wall and the second inner wall when the nucleic acid amplification reaction solution is poured.

Abstract: A substance purification device ensures that the interface between an aqueous liquid layer and an oil-based liquid layer is maintained in a stable manner.

Abstract: A biological substance extraction device includes an adsorption container that includes a first flow channel, and seal-tightly holds an adsorbent and a fluid within the first flow channel, and a washing container that includes a second flow channel, and seal-tightly holds a washing liquid and a fluid within the second flow channel, the adsorption container and the washing container being joined to form a flow channel through which a biological substance is moved. The first flow channel and the second flow channel communicate with each other in a state in which an insertion section is inserted into a reception section. The insertion section includes a guide member that extends from the first flow channel to the second flow channel. The guide member forms part of the flow channel between a first inner wall of the first flow channel and a second inner wall of the second flow channel.

Abstract: A nucleic acid amplification reaction container includes: a flow path which is formed between a first inner wall surface and a second inner wall surface that opposes the first inner wall surface, and has the longitudinal direction in the direction along the first inner wall surface, in which the distance between the first inner wall surface and the second inner wall surface is the distance by which nucleic acid amplification reaction liquid comes into contact with both of the first inner wall surface and the second inner wall surface in a case where the nucleic acid amplification reaction liquid is guided therein, and in which, in the section which is orthogonal to the longitudinal direction of the flow path, the length in the direction parallel to the first inner wall surface is 5 times or more the distance between the first inner wall surface and the second inner wall surface.

Abstract: A nucleic acid amplification reaction apparatus includes (A) a rotating body mounted with a nucleic acid amplification reaction container including reaction liquid in which nucleic acid is eluted and oil phase-separated from the reaction liquid, (B) a control section for rotating the rotating body and moving the reaction liquid back and forth between a first region and a second region, and (C) a fluorescence measuring device for performing fluorescence measurement of the reaction liquid in a position along a rotation track of the nucleic acid amplification reaction container at the time when the rotating body rotates.

Abstract: A biologically relevant material purification cartridge includes: a syringe which has a first portion and a second portion with a smaller inner diameter than that of the first portion; a plunger which has a cylindrical section capable of being fitted to an inner peripheral surface of the first portion and a rod-shaped section supported by the cylindrical section and capable of being fitted to an inner peripheral surface of the second portion, and can be inserted from the side of the first portion of the syringe, and can move in the insertion direction with respect to the syringe; and a cap which has a vent hole for communicating the internal space of the cylindrical section with the outside and a breathable sheet disposed to close the vent hole, and is connected to the cylindrical section.

Abstract: An elution container is a container that stores a liquid by sealing a first opening. The elution container includes: a first annular wall section having an annular wall surface formed around the first opening; and a first annular attachment surface which is formed on the inner side of the first annular wall section and to which a first film sealing the first opening is attached. The first annular wall section has a height higher than the first attachment surface. In addition, the elution container includes: a second annular wall section having an annular wall surface on a second end portion of the elution container; and a second annular attachment surface which is formed on the inner side of the second annular wall section and to which a second film sealing a second opening is attached. The second annular wall section has a height higher than the second attachment surface.

Abstract: In a nucleic acid purification device, a washing container in which a washing solution are sealed by in a first channel and an elution container in which an eluate are sealed by in a second channel are bonded to each other to form a channel for moving a nucleic acid, the washing container includes an outer peripheral wall which is arranged by being spaced apart from the first channel and accommodates a connection portion of the first channel and the second channel, and the elution container includes a first flange which has a gap in a portion between the outer peripheral wall and an inner wall and is in contact with the inner wall and a second flange which has a gap in a portion between the outer peripheral wall and the inner wall and is in contact with the inner wall.

Abstract: In a nucleic acid purification device, a washing container and an elution container are bonded to each other to form a channel for moving a nucleic acid, the washing container includes an outer peripheral wall which accommodates a connection portion of the first channel and a second channel, the elution container includes a plurality of flanges in the periphery of the second channel in contact with an inner wall of the outer peripheral wall, the plurality of flanges are arranged in a portion which is to be inserted into the inside of the outer peripheral wall of the elution container, and one space which is partitioned by two flanges adjacent to each other among the plurality of flanges and the outer peripheral wall communicates with another space adjacent to the one space in a state of being divided by one of the two flanges adjacent to each other.

Abstract: A thermal cycler includes: a first mounting unit and a second mounting unit which are cylindrical; a temperature gradient forming unit which forms a temperature gradient along mounting directions of the first mounting unit and the second mounting unit; and a driving mechanism which rotates the first mounting unit, the second mounting unit, and the temperature gradient forming unit around a rotating shaft having a component perpendicular to a direction in which gravity is applied and a component intersecting the mounting directions of the first mounting unit and the second mounting unit, wherein the first mounting unit and the second mounting unit are disposed on opposite sides to each other with the rotating shaft interposed therebetween, the mounting direction of the first mounting unit and the mounting direction of the second mounting unit are in the same direction.

Abstract: A substance amplification reaction apparatus includes a mounting section mountable with a substance amplification reaction container filled with reaction liquid and liquid and having a channel in which a first channel and a second channel are connected via a bent section and the reaction liquid moves, a first to third heating sections respectively capable of heating a first region, which is a region of an end portion on the first channel side of the channel, a second region, which is a region of the bent section, and a third region, which is a region at an end portion on the second channel side of the channel, and a driving mechanism configured to switch first arrangement, second arrangement, and third arrangement in this order. Each of the first to third arrangements is arrangement in which each of the first to third regions is below the other regions.

Abstract: A nucleic acid amplification reaction apparatus including a first heating section and a second heating section configured to heat a first region and a second region of a container respectively to a first temperature and a second temperature, higher than the first temperature, and a driving mechanism configured to switch the arrangement of the first and second regions in the order of first arrangement, second arrangement, and third arrangement. The first arrangement and the third arrangement are arrangement in which the first region is below the second region in a direction in which the gravity acts. The second arrangement is arrangement in which the second region is below the first region in the direction in which the gravity acts. The container includes a projecting section where an inner wall of the container projects outward and is configured to enable the reaction liquid to stay therein in the third arrangement.

Abstract: A nucleic acid amplification reaction apparatus including a first heating section to heat a first region of a container filled with reaction liquid and liquid and a second heating section to heat a second region of the container to temperature higher than the temperature of the first heating section, first arrangement is arrangement in which the first region is below the second region in a direction in which the gravity acts and the second arrangement is arrangement in which the second region is below the first region. Third arrangement is arrangement in which an axis in the longitudinal direction of the container is horizontal or arrangement in which the axis inclines with respect to the vertical line and the second region is below the first region. A driving mechanism switches the first arrangement, the second arrangement, and the third arrangement in this order.

Abstract: The present invention provides a method of manipulating a solid carrier and an apparatus of manipulating a solid carrier in which the solid carrier is passed through more regions in liquid in a vessel. More specifically, the method of manipulating the solid carrier is a method of manipulating a solid carrier in a liquid contained in a vessel, the solid carrier being magnetic and capable of carrying a substance, the method comprising: manipulating the solid carrier using a magnetic force application unit adapted to applying a magnetic force to the solid carrier in the vessel so that the relative position between the magnetic force application unit and the vessel is altered over a period of time by means of directing the solid carrier in a direction along either one or a combination of the vectors of the longitudinal direction of the vessel and the direction crossing the longitudinal direction of the vessel.

Abstract: A nucleic acid amplification reaction device includes a mounting portion, on which a cartridge is mountable, the cartridge including a tube having, in this order in the inside thereof, a first plug formed of oil, a fourth plug formed of an elution solution which causes the nucleic acid to be eluted from the nucleic acid-binding magnetic carriers bound to the nucleic acid, and a fifth plug formed of oil, a heating unit which heats the fourth plug and has a cylindrical groove, with which the tube is engaged when the cartridge is mounted on the mounting portion, and is exposed in a slit shape through an opening of the cylindrical groove, and a magnetic force applying mechanism which applies a magnetic force to the nucleic acid-binding magnetic carriers to move the nucleic acid-binding magnetic carriers in a longitudinal direction of the tube.

Abstract: A nucleic acid analysis device includes a mounting portion supporting a nucleic acid amplification reaction container, first and second heaters which heat first and second portions of the container, a rotating mechanism which collectively rotates the container and heaters, a heater controller, a rotating mechanism controller, a fluorescence measurer, and a nucleic acid melting curve analyzer. The container is repeatedly inverted while a nucleic acid amplification reaction cycle occurs therein. The first and second heaters heat the container such that the first portion reaches a first temperature and the second portion reaches a second temperature while the nucleic acid amplification reaction cycle occurs. After the nucleic acid amplification reaction cycle ends, the second heater increases the temperature of the second portion. The fluorescence emitted from the amplified nucleic acid is measured while the temperature of the second portion increases.

Abstract: A target substance purification device includes: a capillary that is elongated in a longitudinal direction and includes a first plug of oil, a plug of an elution liquid that undergoes phase separation from oil and elutes the target substance from a magnetic body detachably retaining the target substance, and a second plug of oil inside the capillary; a magnetic force applicator that applies a magnetic force to the capillary to retain and control the movement of the magnetic body along the longitudinal direction of the capillary; and a liquid sending mechanism that moves the elution liquid in the longitudinal direction of the capillary while the magnetic force applicator restricts movement of the magnetic body along the longitudinal direction of the capillary.

Abstract: A target substance purification device includes: a mount for installing a capillary containing a liquid plug and having a longitudinal direction; a magnetic force applying mechanism that applies a magnetic force to the capillary to retain a magnetic body detachably retaining the target substance; a control mechanism that restricts movement of the magnetic body along the longitudinal direction of the capillary; and a liquid sending mechanism that moves the liquid along the longitudinal direction of the capillary while the movement of the magnetic body is being restricted by the control mechanism.

Abstract: A nucleic acid amplification reaction apparatus includes a mounting section that mounts a nucleic acid amplification reaction vessel including a first side wall, and a second side wall that is arranged opposite to the first side wall, a distance between an inner surface of the first side wall and an inner surface of the second side wall is a length in which a nucleic acid amplification reaction solution comes into contact with both the first side wall and the second side wall, a first heating section that heats a first region of the nucleic acid amplification reaction vessel, a fluorescence measurement unit that measures fluorescence radiated by emitting excitation light to the side wall of the nucleic acid amplification reaction vessel, and a driving mechanism that switches arrangement of the mounting section, the first region, and the second region into a first arrangement or a second arrangement.

Abstract: A nucleic acid amplification reaction vessel includes a first inner wall, and a second inner wall that is arranged opposite to the first inner wall, in which a distance between the first inner wall and the second inner wall is a length in which a nucleic acid amplification reaction solution comes into contact with both the first inner wall and the second inner wall when the nucleic acid amplification reaction solution is poured.