Patents by Inventor Toshiro Sato

Toshiro Sato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230002724
    Abstract: A production method for an organoid, the production method including a step of culturing adult stem cells or a cell tissue piece including adult stem cells in a medium containing a chimeric Fibroblast Growth Factor (FGF) that includes a partial region of FGF1 and a partial region of FGF2; an organoid produced by the production method; a medium including a chimeric FGF and having a content of chimeric FGF of 50 ng/mL or less; and an evaluation method for a test substance are provided, and according to the chimeric FGF, a content of growth factors included in a medium can be reduced.
    Type: Application
    Filed: December 15, 2020
    Publication date: January 5, 2023
    Applicants: JSR Corporation, KEIO UNIVERSITY
    Inventors: Kentaro SHOJI, Toshiro SATO
  • Publication number: 20220298485
    Abstract: A production method for a proliferative liver organoid includes culturing liver stem cells or a tissue fragment including liver stem cells in a growth medium to obtain a proliferative liver organoid, in which the growth medium contains an interleukin-6 family cytokine. A production method for a metabolically activated liver organoid includes culturing the proliferative liver organoid produced by the production method for a proliferative liver organoid in a differentiation medium to obtain a metabolically activated liver organoid, in which the differentiation medium does not substantially contain an interleukin-6 family cytokine.
    Type: Application
    Filed: June 10, 2022
    Publication date: September 22, 2022
    Applicants: JSR Corporation, KEIO UNIVERSITY
    Inventors: Norio MASUDA, Toshiro SATO, Ryo IGARASHI
  • Patent number: 11435415
    Abstract: To provide a magnetic sensor element and a magnetic sensor device that can be easily manufactured and can reduce a loss of light to the extent possible. The above-described problem is solved by a magnetic sensor element comprising a planar lightwave circuit (11) provided with a light branching part (12), an input optical fiber (19) and an output optical fiber (20) connected to the planar lightwave circuit (11), a metal magnetic body type light transmitting film (30) that is provided on one end surface of the planar lightwave circuit (11) and transmits light entered from the input optical fiber (19), and a reflecting film (40) that is provided on the metal magnetic body type light transmitting film (30) and reflects the transmitted light. The output optical fiber (20) is a polarization-plane maintaining optical fiber, and the input optical fiber (19) and the output optical fiber (20) are aligned and connected to the planar lightwave circuit (11).
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: September 6, 2022
    Assignees: CITIZEN FINEDEVICE CO., LTD., CITIZEN WATCH CO., LTD., SHINSHU UNIVERSITY
    Inventors: Toshiya Kubo, Mitsunori Miyamoto, Toshiro Sato
  • Patent number: 11407980
    Abstract: A cell culture medium for culturing organoid containing at least two types of components selected from the group consisting of insulin-like growth factor 1 (IGF1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i) to iii): i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGF-?) inhibitor.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: August 9, 2022
    Assignee: KEIO UNIVERSITY
    Inventors: Toshiro Sato, Mami Matano
  • Publication number: 20220220427
    Abstract: A culture container for culturing epithelial cells, includes an upper container, a lid member configured to airtightly fit with an opening portion of the upper container, and a lower container configured to accommodate the upper container and a cell culture medium, in which at least a part of an area of the upper container in contact with the cell culture medium is formed of a membrane that is permeable to at least a part of components of the cell culture medium and impermeable to a cell, and a material of the lid member has an oxygen permeability coefficient of 1.0×10?6 cm3 cm/(cm2·sec·atm) or less.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 14, 2022
    Inventors: Toshiro SATO, Nobuo SASAKI
  • Publication number: 20220195534
    Abstract: There is provided a method for determining the risk of colorectal cancer, including a step of detecting a loss-of-function mutation of a gene involved in interleukin (IL)-17 signaling in a colorectal epithelial tissue sample derived from a subject, in which a presence of the loss-of-function mutation indicates that the subject has a high risk of colorectal cancer.
    Type: Application
    Filed: March 19, 2020
    Publication date: June 23, 2022
    Inventor: Toshiro SATO
  • Publication number: 20220062315
    Abstract: An object of the present invention is to provide an anti-human norovirus agent which can inhibit infection with and proliferation of human norovirus. The present inventors have found that the object can be attained through provision of an anti-human norovirus agent comprising, as an active ingredient, a fucose analog having an inhibitory action on glycosylation by fucosyltransferase (FUT). Examples of the active ingredient include a fucose analog represented by formula (III) or (IV) or a salt thereof. [In the formulas, each of formula (III) and formula (IV) represents an ?-anomer or a ?-anomer; each of R4, R3, and R4 is —OH or -OAc; R2 is a halogen atom, —OH, or -OAc; and R5 is —CH3, —C?CH, —C?CCH3, or —CH2C?CH.
    Type: Application
    Filed: December 27, 2019
    Publication date: March 3, 2022
    Applicants: KEIO UNIVERSITY, THE KITASATO INSTITUTE
    Inventors: Kazuhiko KATAYAMA, Akira FUJIMOTO, Kei HAGA, Reiko TODAKA, Toshiro SATO
  • Publication number: 20210123109
    Abstract: To identify a microorganism causing the development of primary sclerosing cholangitis associated with ulcerative colitis. A Klebsiella pneumoniae strain inducing inflammation in the liver.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 29, 2021
    Applicant: KEIO UNIVERSITY
    Inventors: Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Toshiro Sato, Takanori Kanai
  • Publication number: 20210123108
    Abstract: To identify a microorganism causing the development of primary sclerosing cholangitis associated with ulcerative colitis. A Klebsiella pneumoniae strain inducing inflammation in the liver.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 29, 2021
    Applicant: KEIO UNIVERSITY
    Inventors: Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Toshiro Sato, Takanori Kanai
  • Publication number: 20210102934
    Abstract: A human tissue stem cell in which a gene of interest is introduced into a gene locus of a stem cell marker gene.
    Type: Application
    Filed: March 27, 2018
    Publication date: April 8, 2021
    Inventors: Toshiro SATO, Mariko SHIMOKAWA
  • Patent number: 10947510
    Abstract: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising said epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem cells and isolated tissue fragments. The invention further relates to a cell culture medium comprising a BMP inhibitor, a mitogenic growth factor, and a Wnt agonist, to the use of said culture medium, and to crypt-villus organoids, gastric organoids and pancreatic organoids that are formed in said culture medium.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: March 16, 2021
    Assignee: Koninklijke Nederlandse Akademie Van Wetenschappen
    Inventors: Toshiro Sato, Johannes C. Clevers, Meritxell Huch Ortega
  • Publication number: 20200309869
    Abstract: To provide a magnetic sensor element and a magnetic sensor device that can be easily manufactured and can reduce a loss of light to the extent possible. The above-described problem is solved by a magnetic sensor element comprising a planar lightwave circuit (11) provided with a light branching part (12), an input optical fiber (19) and an output optical fiber (20) connected to the planar lightwave circuit (11), a metal magnetic body type light transmitting film (30) that is provided on one end surface of the planar lightwave circuit (11) and transmits light entered from the input optical fiber (19), and a reflecting film (40) that is provided on the metal magnetic body type light transmitting film (30) and reflects the transmitted light. The output optical fiber (20) is a polarization-plane maintaining optical fiber, and the input optical fiber (19) and the output optical fiber (20) are aligned and connected to the planar lightwave circuit (11).
    Type: Application
    Filed: September 28, 2018
    Publication date: October 1, 2020
    Applicants: CITIZEN FINEDEVICE CO., LTD., CITIZEN WATCH CO., LTD., SHINSHU UNIVERSITY
    Inventors: Toshiya KUBO, Mitsunori MIYAMOTO, Toshiro SATO
  • Publication number: 20200231937
    Abstract: A cell culture medium for culturing organoid containing at least two types of components selected from the group consisting of insulin-like growth factor 1 (IGH1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i (to III); i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGIF-?) inhibitor.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 23, 2020
    Applicant: KEIO UNIVERSITY
    Inventors: Toshiro SATO, Mami MATANO
  • Publication number: 20200216817
    Abstract: A cell culture medium for culturing organoid containing at lest two types of components selected from the group consisting of insulin-like growth factor 1 (IGH1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i (to III); i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGIF-?) inhibitor.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 9, 2020
    Applicant: KEIO UNIVERSITY
    Inventors: Toshiro SATO, Mami MATANO
  • Publication number: 20200087617
    Abstract: A 2D organoid for infection and growth culture of human diarrhea virus, obtained by: (1) obtaining a 3D organoid by three-dimensionally culturing a human intestinal epithelial stem cell, a human intestinal epithelial cell, or a tissue containing at least any of those cells on an extracellular matrix; and (2) dispersing the 3D organoid to prepare a single cell, and monolayer-culturing the single cell on an extracellular matrix to obtain the 2D organoid having a monolayer structure in which epithelial cells contain differentiated trophoblastic cells and goblet cells and configured as human intestinal lumen having a monolayer structure.
    Type: Application
    Filed: August 21, 2017
    Publication date: March 19, 2020
    Inventors: Toshiro Sato, Kazuhiko Katayama
  • Publication number: 20190390171
    Abstract: A cell culture medium for culturing organoid containing at least two types of components selected from the group consisting of insulin-like growth factor 1 (IGF1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i) to iii): i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGF-?) inhibitor.
    Type: Application
    Filed: May 10, 2017
    Publication date: December 26, 2019
    Applicant: KEIO UNIVERSITY
    Inventors: Toshiro SATO, Mami MATANO
  • Publication number: 20190338374
    Abstract: To identify a microorganism causing the development of primary sclerosing cholangitis associated with ulcerative colitis. A Klebsiella pneumoniae strain inducing inflammation in the liver.
    Type: Application
    Filed: April 19, 2019
    Publication date: November 7, 2019
    Applicant: KEIO UNIVERSITY
    Inventors: Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Toshiro Sato, Takanori Kanai
  • Publication number: 20190100724
    Abstract: The present invention provides a cell culture medium with which serum-free long-term culture of an epithelial stem cell, an epithelial cancer cell, or a tissue containing at least one thereof can be achieved. The cell culture medium of the present invention includes: a Wnt agonist composed of a complex of Wnt protein and afamin, which is a substance capable of stabilizing the Wnt protein, and R-spondin; and at least one selected from the group consisting of a mitogenic growth factor, a bone morphogenetic protein (BMP) inhibitor, a transforming growth factor-? (TGF-?) inhibitor, and a p38 inhibitor.
    Type: Application
    Filed: February 17, 2017
    Publication date: April 4, 2019
    Inventors: Toshiro SATO, Mami MATANO, Shinya SUGIMOTO, Junichi TAKAGI
  • Publication number: 20190100728
    Abstract: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising the epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem cells and isolated tissue fragments. The invention further relates to a cell culture medium comprising a BMP inhibitor, a mitogenic growth factor, and a Wnt agonist, to the use of the culture medium, and to crypt-villus organoids, gastric organoids and pancreatic organoids that are formed in the culture medium.
    Type: Application
    Filed: August 27, 2018
    Publication date: April 4, 2019
    Applicant: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Toshiro Sato, Johannes C. Clevers, Meritxell Huch Ortega
  • Patent number: 10039704
    Abstract: A composition that is useful in a skin function improving agent includes at least a sapogenol, and a collagen hydrolysate. This composition can be used in a skin function improving agent and is particularly useful in a skin function improving agent for inhibiting transdermal moisture loss and/or for retaining the moisture in the stratum corneum.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: August 7, 2018
    Assignee: J-OIL MILLS, INC.
    Inventors: Shuichi Kamo, Toshiro Sato, Rumi Kawahara, Shunsuke Suzuki