Abstract: A developing device for an image forming apparatus of a non-magnetic one-component type. The developing device has a developing roller having a body and a shaft. Bearings for supporting the shaft have a groove made in a contact surface that is in contact with the shaft, and grease is pooled in the groove. The contact surface of the shaft has a surface roughness from 0.2 to 0.5, and the grease has consistency from 265 to 385 ( 1/10 mm·20° C.).

Abstract: A hydraulic unit is switched among a first region A where a flow rate is adjusted by controlling a rotational speed of an electric motor while maintaining a displacement of a variable displacement pump at a maximum value, a second region B where the flow rate is adjusted by changing the displacement of the variable displacement pump while maintaining the rotational speed of the electric motor at a minimum value lower than the rotational speed in the first region A, and a third region C where, in a range where a discharge pressure of the variable displacement pump is larger than that in the first region A, the flow rate is adjusted by changing the rotational speed of the electric motor in a range larger than the minimum rotational speed, while maintaining the displacement of the variable displacement pump at an allowable maximum value that is derived from the discharge pressure and a maximum shaft torque of the electric motor.

Abstract: A manufacturing method of an electro optical device includes drawing a seal material in adjacent substrate forming areas on a first large size substrate and bonding a second large size substrate to the first large size substrate via the seal material. During drawing of the seal material, the seal material is continuously drawn in the substrate forming areas by a going stroke, a return point, and a returning stroke. In the going stroke, the seal material is continuously drawn through a portion of each of the substrate forming areas to the return point. In the returning stroke, the seal material is continuously drawn from the return point and through a different portion of each of the substrate forming areas.

Abstract: The inventors discovered for the first time the nucleotide sequence of the human DR5 gene promoter, the nucleotide sequence of the human Siah-1 gene promoter and what appear to be the core promoter regions thereof. The present invention further provides a screening method for substances which regulate promoter activity, comprising a step of bringing a test substance into contact with cells holding a vector which comprises this DNA together with a reporter gene ligated expressibly to this DNA, and a step of detecting changes in the expressed amount of the reporter gene due to contact with the test substance. This screening method is a method of very efficiently selecting anti-cancer drugs and the like.

Abstract: A mono-component developing apparatus including a developing roller which transports toner supported on an outer circumferential face of a center portion toward a developing area by rotating while frictionally sliding on a sealing member on each of two end portions. The developing roller includes surface processing areas having a spiral shape, placed on each of outer circumferential faces of the two end portions. An angle, made by a spiral direction of each surface processing area and the rotation direction, is an acute angle. The developing roller inhibits toner leakage, with the driving torque of the developing roller being only slightly increased.

Abstract: The inventors discovered for the first time the nucleotide sequence of the human DR5 gene promoter, the nucleotide sequence of the human Siah-1 gene promoter and what appear to be the core promoter regions thereof. The present invention further provides a screening method for substances which regulate promoter activity, comprising a step of bringing a test substance into contact with cells holding a vector which comprises this DNA together with a reporter gene ligated expressibly to this DNA, and a step of detecting changes in the expressed amount of the reporter gene due to contact with the test substance. This screening method is a method of very efficiently selecting anti-cancer drugs and the like.

Abstract: There is provided a cleaning device capable of maintaining a sufficient cleaning effect by preventing creep deformation of a cleaning member. The cleaning device of the present invention for cleaning a transfer body in an image forming apparatus includes a first cleaning member whose top end is brought into pressure contact with the transfer body, and a second cleaning member which is placed downstream from the first cleaning member with respect to a moving direction of the transfer body and whose top end is brought into pressure contact with the transfer body, wherein the second cleaning member is provided rotatably with respect to the first cleaning member.

Abstract: The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from —N? etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from —CH2— etc., and R2 is selected from C1-6 alkyl etc.

Abstract: A stabilizer control device for a vehicle includes a first and second stabilizer bars, a housing fixed to an end portion of the second stabilizer bar so as to arrange an end portion of the first stabilizer bar adjacent to the end portion of the second stabilizer bar, a rotational torque reducing mechanism having an input portion fixed to the first stabilizer bar and the housing and reducing a relative rotational torque between the housing and the first stabilizer bar and outputting, a hollow member including the first stabilizer bar so as to rotatably support the first stabilizer bar within the housing and fixed with an output portion of the rotational torque reducing mechanism so as to rotatably support the output portion within the housing, and a clutch mechanism arranged between the hollow member and the housing for engaging and disengaging therebetween.

Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

Abstract: A hydraulic excavator includes a rotation motor (31) for rotating an upper rotating structure. The rotation motor (31) includes an electric motor (32), a hydraulic motor (40), and a reduction gearbox (33). The hydraulic motor (40) includes a motor mechanism (50) and a clutch mechanism (70). The motor mechanism (50), which is a vane-type hydraulic motor, is engaged with/disengaged from a motor shaft (37) by the clutch mechanism (70). When rotation speed of the upper rotating structure is low, and a required value of output torque of the rotation motor (31) is high, an operation of driving the output shaft (35) by the hydraulic motor (40) is performed in the rotation motor (31).

Abstract: A hydraulic unit is switched among a first region A where a flow rate is adjusted by controlling a rotational speed of an electric motor while maintaining a displacement of a variable displacement pump at a maximum value, a second region B where the flow rate is adjusted by changing the displacement of the variable displacement pump while maintaining the rotational speed of the electric motor at a minimum value lower than the rotational speed in the first region A, and a third region C where, in a range where a discharge pressure of the variable displacement pump is larger than that in the first region A, the flow rate is adjusted by changing the rotational speed of the electric motor in a range larger than the minimum rotational speed, while maintaining the displacement of the variable displacement pump at an allowable maximum value that is derived from the discharge pressure and a maximum shaft torque of the electric motor.

Abstract: A developing device for an image forming apparatus of a non-magnetic one-component type. The developing device has a developing roller having a body and a shaft. Bearings for supporting the shaft have a groove made in a contact surface that is in contact with the shaft, and grease is pooled in the groove. The contact surface of the shaft has a surface roughness from 0.2 to 0.5, and the grease has consistency from 265 to 385 ( 1/10 mm·20° C.).

Abstract: A water processing method for providing a gettering sink effect to a wafer having a plurality of streets which are formed in a lattice pattern on the front surface of a substrate and devices which are formed in a plurality of areas sectioned by the plurality of streets, comprising the steps of removing distortion produced on the rear surface of the substrate of the wafer whose rear surface of the substrate has been ground to a predetermined thickness; forming a gettering sink effect layer by applying a laser beam of a wavelength having permeability for the substrate of the wafer which has undergone the distortion removing step, with its focal point set to the inside of the substrate to form a deteriorated layer in the inside of the substrate; and dividing the wafer which has undergone the gettering sink effect layer forming step, into individual chips along the streets.

Abstract: The present invention relates to a more accurate method of diagnosing cancer in a tissue or a cell by measuring the expression and activity of cell cycle related proteins and analyzing a cell cycle profile. In a cell cycle profile, at least two values of expression or activity of cell cycle related proteins are concurrently measured. The measurement of the cell cycle related protein is not limited as to the measurement method.

Abstract: A manufacturing method of an electro optical device includes drawing a seal material in adjacent substrate forming areas on a first large size substrate and bonding a second large size substrate to the first large size substrate via the seal material. During drawing of the seal material, the seal material is continuously drawn in the substrate forming areas by a going stroke, a return point, and a returning stroke. In the going stroke, the seal material is continuously drawn through a portion of each of the substrate forming areas to the return point. In the returning stroke, the seal material is continuously drawn from the return point and through a different portion of each of the substrate forming areas.

Abstract: To provide a developing roller which makes it possible to sufficiently prevent toner leakage, with the driving torque of the developing roller being scarcely increased, and a mono-component developing apparatus having such a developing roller. A developing roller for a mono-component developing apparatus, which transports toner supported on an outer circumferential face of a center portion 12 toward a developing area by rotating while frictionally sliding on a sealing member on each of two end portions 11a, 11b, comprising: surface processing areas 13 having a spiral shape, placed on each of outer circumferential faces of the two end portions, wherein an angle ?, made by a spiral direction y of each surface processing area and the rotation direction x, is allowed to have an acute angle, and a mono-component developing apparatus having such a developing roller.

Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

Abstract: A 44-bp region that confers vitamin D3-responsiveness to the human p27Kip1 promoter in the human p27Kip1 transcriptional regulatory mechanism was revealed. This region also conferred vitamin D3-responsiveness to a heterogenous promoter. Moreover, it was found that vitamin D3 enhances the binding between the CCAAT box existing in the region and the NF-Y protein and also the binding between the Sp1 sequence (also existing in the region) and the Sp1 protein, thus inducing human p27Kip1 transcription. Also revealed were methods of screening for pharmaceutical agents that regulate the expression of the p27Kip1 gene using these molecular mechanisms.

Abstract: A scribing head 1 of this invention raises and lowers a scribing cutter by rotation of a servomotor 3. As a scribe pressure, a rotational torque of the servomotor 3 is transmitted to the scribing cutter. To form a scribe line across another scribe line which is formed earlier, the scribe pressure is raised temporarily when the scribing head passes the scribe line which is formed earlier. The rotational torque of the servomotor 3 is controlled at any of preset limits while the position of a cutter 6 of the scribing head shifts on the brittle substrate. The servomotor 3 is driven under position-control mode.