Publication number: 20100272678
Abstract: Selenopheno triazene analogs, their compositions, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, and pharmaceutically acceptable salts and mixtures thereof are useful for the treatment of metastatic malignant melanoma and other cancers. The selenopheno triazene analogs have the general formulae (I) or (II): wherein the substituents R1, R2, R3, R6, and R7 are as described in the specification. Other cancers include which may be treated with these compounds include, but are not limited to, malignant melanoma, leukemia, lymphomas (Hodgkins and non-Hodgkins), sarcomas (Ewing's sarcoma), brain tumors, central nervous system (CNS) metastases, gliomas, carcinomas such as breast cancer, prostate cancer, lung cancer (small cell and non-small cell), colon cancer, pancreatic cancer, Head and Neck cancers and oropharyngeal squamous cell carcinoma.
Type:
Application
Filed:
April 26, 2010
Publication date:
October 28, 2010
Applicant:
KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LIMITE
Inventors:
Ganga Raju GOKARAJU, Sudhakar Kasina, Rama Raju Gokaraju, Venkata Kanaka Ranga Raju Gokaraju, Venkateswarlu Somepalli, Trimurtulu Golakoti, Kiran Bhupathiraju, Sengupta Krishanu, Venkata Krishna Raju Alluri
Publication number: 20090318551
Abstract: This invention relates to novel AKBA analogs of the formula I given below: Where in R1, R2, R3, R4 and R5 in each of the said analogs are: 1. R1?OCHO, R2?H, R3?COOH, R4 & R5?O 2. R1?OCOCH2Cl, R2?H, R3?COOH, R4 & R5?O 3. R1=5?-O-methylgalloyloxy, R2?H, R3?COOH, R4 & R5?O 4. R1?OCOCH2CH2COOH, R2?H, R3?COOH, R4 & R5?O 5. R1=8?,9?-Dihydro-4?-hydroxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 6. R1=4?-Hydroxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 7. R1=3?,4?-Dimethoxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 8. R1=3?,4?-Dihydroxy-5?-methoxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 9. R1?OCOCH2NH(tert-BOC), R2?H, R3?COOCH3, R4 & R5?O 10. R1?OCOCH2NH2HCl, R2?H, R3?COOH, R4 & R5?O 11. R1?OCOCH(CH3)NH2HCl, R2?H, R3?COOH, R4 & R5?O 12. R1?H, R2?OH, R3?COOCH3, R4 & R5?O 13. R1?H, R2?Br, R3?COOCH3, R4 & R5?O 14. R1?CN, R2?H, R3?COOCH3, R4 & R5?O 15. R1?SH, R2?H, R3?COOCH3, R4 & R5?O 16. R1 & R2?N(OH), R3?COOCH3, R4 & R5?O 17.
Type:
Application
Filed:
August 28, 2009
Publication date:
December 24, 2009
Inventors:
Ganga Raju Gokaraju, Rama Raju Gokaraju, Venkata Subbaraju Gottumukkala, Trimurtulu Golakoti
Patent number: 7625947
Abstract: This invention relates to novel AKBA analogs of the formula I given below: Where in R1, R2, R3, R4 and R5 in each of the said analogs are: 1. R1?OCHO, R2?H, R3?COOH, R4 & R5?O 2. R1?OCOCH2Cl, R2?H, R3?COOH, R4 & R5?O 3. R1?5?-O-methylgalloyloxy, R2?H, R3?COOH, R4 & R5?O 4. R1?OCOCH2CH2COOH, R2?H, R3?COOH, R4 & R5?O 5. R1?8?,9?-Dihydro-4?-hydroxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 6. R1?4?-Hydroxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 7. R1?3?,4?-Dimethoxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 8. R1?3?,4?-Dihydroxy-5?-methoxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 9. R1?OCOCH2NH(tert-BOC), R2?H, R3?COOCH3, R4 & R5?O 10. R1?OCOCH2NH2HCl, R2?H, R3—COOH, R4 & R5?O 11. R1?OCOCH(CH3)NH2HCl, R2?H, R3?COOH, R4 & R5?O 12. R1?H, R2?OH, R3?COOCH3, R4 & R5?O 13. R1?H, R2?Br, R3 COOCH3, R4 & R5?O 14. R1?CN, R2?H, R3?COOCH3, R4 & R5?O 15. R1?SH, R2?H, R3?COOCH3, R4& R5?O 16. R1 & R2?N(OH), R3?COOCH3, R4 & R5?O 17.
Type:
Grant
Filed:
June 18, 2004
Date of Patent:
December 1, 2009
Assignee:
Laila Nutraceuticals
Inventors:
Ganga Raju Gokaraju, Rama Raju Gokaraju, Venkata Subbaraju Gottumukkala, Trimurtulu Golakoti
Publication number: 20070167521
Abstract: This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are as indicated below in each of said analogs: 1. R1=COCH3, R2=R3=R4=H, R5=COOH or R1, =R3=R4=H, R2=COCH3, R5=COOH 2. R1=R2=COCH3, R3=R4=H, R5=COOH 3. R1=COC5H4N, R2=R3=R4=H, R5=COOH 4. R1=COCH2NH2.HC1, R2=R3=R4=H, R5=COOH 5. R1=COCH2(CH3)NH2.HC1, R2=R3=R4=H, R5=COOH 6. R1=COCH:CHC6H2(OCH3)3, R2=R3=R4=H, R5=COOCH3 7. R1 & R2=S02, R3=R4=H, R5=COOH 8. R1=R2=R3=R4=H, R5=CONH2 9. R1=R2=R3=R4=H, R5=CONHC6H5 10. R1=R2=R3=R4=H, R5=CONHCH2CH2NH2 11. R1=R2=R3=R4=H, R5=CON(CH2CH2)2NH 12. R1=R2=R3=R4=H, R5=CONHCH2CH20H 13. R1=R2=R3=R4=H, R5=COOCH3 14. R1=R2=COCH3, R3=R4=H, R5=COOCH3 15. R1=R2=H, R3 & R4=0, R5=COOCH3 16. R1=R2=COCH3, R3 & R4=0, R5=COOCH3 17. R1=R2=H, R3 & R4=0, R5=COOH 18. R1=R2=COCH3, R3 & R4=0, R5=COOH 19. R1 & R2=S02, R3 & R4=0, R5=COOH 20. R1=R2=H, R3 & R4=0, R5=CONH2 21. R1=R2=R3=H, R4=OH, R5=CONH2 22. R1=R2=R3=H, R4=OH, R5=COOCH3 23. R1=R2=R3=R4=H, R5=CH20H 24.
Type:
Application
Filed:
July 8, 2004
Publication date:
July 19, 2007
Inventors:
Ganga Gokaraju, Rama Gokaraju, Venkata Gottumukkala, Trimurtulu Golakoti, Venkateswarlu Somepalli, Venkateswara Chirravuri
Publication number: 20060089409
Abstract: This invention relates to novel AKBA analogs of the formula I given below: Where in R1, R2, R3, R4 and R5 in each of the said analogs are:— 1. R1?OCHO, R2?H, R3?COOH, R4 & R5?O 2. R1?OCOCH2Cl, R2?H, R3?COOH, R4 & R5?O 3. R1=5?-O-methylgalloyloxy, R2?H, R3?COOH, R4 & R5?O 4. R1?OCOCH2CH2COOH, R2?H, R3?COOH, R4 & R5?O 5. R1=8?,9?-Dihydro-4?-hydroxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 6. R1=4?-Hydroxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 7. R1=3?,4?-Dimethoxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 8. R1=3?,4?-Dihydroxy-5?-methoxycinnamoyloxy, R2?H, R3 COOH, R4 & R5?O 9. R1?OCOCH2NH(tert-BOC), R2?H, R3?COOCH3, R4 & R5?O 10. R1?OCOCH2NH2HCl, R2?H, R3—COOH, R4 & R5?O 11. R1?OCOCH(CH3)NH2HCl, R2?H, R3?COOH, R4 & R5?O 12. R1?H, R2?OH, R3?COOCH3, R4 & R5?O 13. R1?H, R2?Br, R3 COOCH3, R4 & R5?O 14. R1?CN, R2?H, R3?COOCH3, R4 & R5?O 15. R1?SH, R2?H, R3?COOCH3, R4& R5?O 16. R1 & R2?N(OH), R3?COOCH3, R4 & R5?O 17.
Type:
Application
Filed:
June 18, 2004
Publication date:
April 27, 2006
Applicant:
LAILA NUTRACEUTICALS
Inventors:
Ganga Gokaraju, Rama Gokaraju, Venkata Subbaraju, Trimurtulu Golakoti