Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: Systems, methods, and kits useful for cleansing the eyelids and maintaining eyelid hygiene are disclosed. In one embodiment, a system for treating or cleansing an ocular region is disclosed. The system consists essentially of: (A) a tubular applicator, wherein the applicator comprises: (i) a first chamber and a second chamber; and (ii) a sealable element situated between the first chamber and the second chamber, wherein at least the second chamber is substantially pre-filled with an ocular composition, and (B) a dispenser, wherein the dispenser is bonded to an external surface of a first end of the applicator.

Abstract: Systems, methods, and kits useful for cleansing the eyelids and maintaining eyelid hygiene are disclosed. In one embodiment, a system for treating or cleansing an ocular region is disclosed. The system consists essentially of: (A) a tubular container, wherein the container comprises: (i) a first chamber and a second chamber; and (ii) a sealable element situated between the first chamber and the second chamber, wherein at least the second chamber is substantially pre-filled with an ocular composition, and (B) a dispenser, wherein the dispenser is bonded to an external surface of a first end of the container.

Abstract: The present disclosure relates to pinion assembly preloading systems and methods of operation. Disclosed are systems including a press actuator that applies an axial force against a pinion assembly; a force sensor that measures a reaction force at the pinion assembly; and a method of controlling the press actuator according to a change in the reaction force.

Abstract: The present disclosure relates to pinion assembly preloading systems. Disclosed are systems including a press actuator configured to apply an axial force against a pinion assembly; a force sensor configured to measure a reaction force at the pinion assembly; and a controller configured to control the press actuator according to a change in the reaction force.

Abstract: An assembly includes a rotatable member formed with a recess, a first component, a snap ring located in the recess for limiting axial displacement of the first component, and a bearing located between the first component and a second component, including a finger extending from a race of the bearing toward the bearing and able to limit radial movement of the snap ring.

Abstract: The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

Abstract: An assembly includes a rotatable member formed with a recess, a first component, a snap ring located in the recess for limiting axial displacement of the first component, and a bearing located between the first component and a second component, including a finger extending from a race of the bearing toward the bearing and able to limit radial movement of the snap ring.

Abstract: The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: The present disclosure relates to pinion assembly preloading systems. Disclosed are systems including a press actuator configured to apply an axial force against a pinion assembly; a force sensor configured to measure a reaction force at the pinion assembly; and a controller configured to control the press actuator according to a change in the reaction force.

Abstract: The present disclosure relates to XIAP inhibitor compounds of the formula I.

Abstract: The present disclosure relates to XIAP inhibitor compounds of the formula I.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: A golf accessory holder is made up of an oblong housing for a spring-loaded spool, a divot repair tool is slidable through a guideway on the housing, the tool being attached at one end to a flexible line which is wound upon the spool to enable extension of the tool when grasped by the golfer to repair a divot in the ground and to automatically retract the tool when released to slide upwardly into the groove; and other accessories, including a ball marker and golf tees may be releasably mounted on the housing.

Abstract: A method for reclaiming hydraulically dredged material from a dredge reclamation area (DRA) having particular application for reclaiming hydraulically dredged virgin/new cut earthen material. The method involves the construction of training dikes and weirs in the DRA for draining water from saturated silts within the DRA and drying clay in the DRA in either a separate processing area or within the confines of the DRA by windrowing and by mechanical manipulation of the clay. The silts are then dried in the same way and mixed with the dried clay, either in a separate processing area or within the DRA. The resulting reclaimed material can meet industry standard density tests of 95% standard Proctor along with removing the moisture content to a 2%± of optimum moisture or better for use as structural or regular fill.

Abstract: The present disclosure relates to XIAP inhibitor compounds of the formula I.

Abstract: A safety clip is designed for a vehicle emergency brake system having a stem extending from a braking mechanism and ending in a knob, and a releasable locking mechanism for maintaining the stem in an extended position during braking. The safety clip includes a resilient, generally C-shaped sleeve having an opening and a pair of circumferentially spaced wing members extending from said sleeve at a location approximately radially opposite from said sleeve opening. In a normally closed position, the sleeve is capable of frictionally engaging the stem when the stem is in its extended position. In a distended position, the sleeve is capable of removal from the stem. In operation, compressing the wing members urges the sleeve to a distended position.

Abstract: An improved data modem (IDM) and method includes a communication processor module, a mass storage module, a power converter module, and one or more DSP modules. The communication processor module utilizes commercial off-the-shelf components as well as electrically programmable logic devices (EPLD), which are programmed to provide a watchdog timer, programmable interrupt controller, flash page addressing, ISA bus decoder and controller, and various circuits and logic.