Abstract: The present invention provides a prophylactic and/or therapeutic agent for inflammatory disease including a compound or a salt thereof, or a solvate thereof, the compound represented by a formula (1): [where each sign is defined as described in the description] as an active ingredient.

Abstract: The present invention provides a therapeutic agent for an immune/inflammatory disease comprising an anti-human TIGIT antibody, which activates a suppressive immune checkpoint molecule (TIGIT), as an active ingredient. Also, provided is an antibody having the following characteristics a) and b): a) the third CDR of heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 4 b) the third CDR of light chain variable region comprises the amino acid sequence of SEQ ID NO: 6.

Abstract: An antibody against spike protein of SARS-CoV-2 is provided, the antibody having a specific heavy chain variable region and a specific light chain variable region, or a fragment of the antibody, the antibody or fragment thereof inhibiting the binding between the spike protein of SARS-CoV-2 and ACE2, the antibody or fragment thereof inhibiting SARS-CoV-2 infection; and a pharmaceutical composition including the antibody or fragment thereof and a pharmaceutically acceptable carrier, the pharmaceutical composition including two or more kinds of the antibody or fragment thereof.

Abstract: [Problem to be Solved by the Invention] To predict the efficacy of a rheumatoid arthritis therapeutic agent, or find a simple and highly reproducible hiomarker that can be used to assess the activity of disease conditions and states of rheumatoid arthritis, and provide an effective method. [Solution] A method for predicting the efficacy of a rheumatoid arthritis therapeutic agent on a.

Abstract: The present invention provides a prophylactic and/or therapeutic agent for inflammatory disease including a compound or a salt thereof, or a solvate thereof, the compound represented by a formula (1): [where each sign is defined as described in the description] as an active ingredient.

Abstract: An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) as represented by SEQ ID: NO. 1 corresponding to the 134- to 146-positions in human BAFF (B cell activating factor belonging to the TNF family) protein which is preferably a monoclonal antibody; a method of producing the above antibody; a medicinal composition containing the antibody; utilization of the antibody; and a method of screening an inhibitory effect or an activating effect on BAFF with the use of the antibody.

Abstract: A method of evaluating disease activity of rheumatoid arthritis with good sensitivity by a simple method, and a kit for use in the method. It provides a Jacalin-binding O-linked oligosaccharide epitope as a negative marker for diagnosing rheumatoid arthritis, and enables more accurate assessment of disease condition by more objectively determining disease activity of rheumatoid arthritis using the amount of variation of a value obtained by multiplying the amount of MMP-3 in the blood or the amount of bound MMP-3 and ABA, ACA, or ACG in the blood by the reciprocal of the amount of bound MMP-3 and Jacalin in the blood. Through the discovery that an LEL or STL-reactive sugar chain on MMP-3 in the blood is a sugar chain marker for diagnosing polymyalgia rheumatica and relapsing polychondritis, the present invention also provides a method for accurate diagnosis of polymyalgia rheumatica and relapsing polychondritis.

Abstract: A vehicle seat structure allowing a reduction in the weight of a seat while ensuring cushioning performance. The seat includes a base plate member with an outer frame forming an outer periphery of the seat, and concave portions with seating positions and a seat back position on an inner peripheral side of the outer frame made concave in a direction of a seating load. In addition, the seat includes a fabric member that is provided in a tensioned state in such a manner so as to close open sides of the concave portions for supporting an occupant's weight. A first cushion member is provided in positions on the fabric member, at least corresponding to the outer frame.

Abstract: The object of the invention is to find a simple biomarker with high reproducibility with regard to a method for evaluating the activity of the condition and progression of rheumatoid arthritis disease and provide an effective evaluation method therefor. The invention is to provide a method for determining the value of a rheumatoid arthritis-linked indicator in a subject, the method being characterized by comprising a step for measuring the amount of expression of the FAM20A gene in blood collected from the subject, a step for analyzing the measured amount of expression using a gene expression profile that is prepared in advance and correlates with the indicator and a step for estimating the value of the indicator in the subject on the basis of the analysis results.

Abstract: A step unit that guides a sliding door of a vehicle includes a step member and a rail plate member. The step member includes first and second lower rails. The first lower rail has two ends that face toward each other to form a cutout portion in between. The rail plate member is arranged in the cutout portion. The step member includes an insertion hole and an extended portion. The insertion hole is located at a position corresponding to the cutout portion. The extended portion is extended from at least one of the two ends to support the rail plate member against a load received by the rail plate member from the roller. The rail plate member is inserted through the insertion hole from above the upper side of the step member and fixed by a fastening member to the step member.

Abstract: An antibody against a peptide having an amino acid sequence AVQGPEETVT QDC (expressed in single letter amino acid code) as represented by SEQ ID: NO. 1 corresponding to the 134- to 146-positions in human BAFF (B cell activating factor belonging to the TNF family) protein which is preferably a monoclonal antibody; a method of producing the above antibody; a medicinal composition containing the antibody; utilization of the antibody; and a method of screening an inhibitory effect or an activating effect on BAFF with the use of the antibody.

Abstract: A step unit comprises: a step member which is provided on the vehicle body side so as to be adjacent to a slide door of the vehicle and has a flat plate section on which an occupant's foot is placed; and a drive device which is affixed to the step member and drives the slide door to open and close the slide door. The step member is molded using a resin material and has a accommodation portion which is provided with a bottom formed below the upper surface of the flat plate section. The drive device is affixed while at least a part thereof is accommodated within the accommodation portion.

Abstract: A step unit that guides a sliding door of a vehicle includes a step member and a rail plate member. The step member includes first and second lower rails. The first lower rail has two ends that face toward each other to form a cutout portion in between. The rail plate member is arranged in the cutout portion. The step member includes an insertion hole and an extended portion. The insertion hole is located at a position corresponding to the cutout portion. The extended portion is extended from at least one of the two ends to support the rail plate member against a load received by the rail plate member from the roller. The rail plate member is inserted through the insertion hole from above the upper side of the step member and fixed by a fastening member to the step member.

Abstract: A drive device is provided with a housing 11 and an electromagnetic clutch mechanism 14 accommodated in the housing. The electromagnetic clutch mechanism 14 is provided with an armature 41 rotatably supported in the housing 11, a rotor 42 arranged to face the armature 41 and rotatably supported in the housing 11, and a coil 46. An annular magnet 44 is fixed on the outer circumference surface of the rotor 42. A sensor 15 arranged inside the housing 11 detects a polarity change of the magnet 44 in association with rotation of the rotor 42. The magnet 44 is provided with an annular wall portion 44b extending toward the armature 41 beyond a surface on which the armature 41 is in contact with the rotor 42 with respect to the axial direction. The annular wall portion 44b is spaced radially outward from the armature 41. The annular wall portion 44b prevents abrasion powder produced on actuation of the electromagnetic clutch mechanism 14 from being scattered.

Abstract: A driving device includes a first rotating member, an armature member being movable and rotatable together with, a second rotating member being rotatable relative to the armature member, a magnetic force generating portion for generating a magnetic force for attracting the armature member toward the second rotating member in order to establish a connection between the armature member and the second rotating member so as to be integrally rotatable, a sensor magnet fixed to the second rotating member, a sensor provided for detecting a change of the magnetic field and a fixing member formed with a first claw portion engaged with the second rotating member and a second claw portion engaged with the sensor magnet while being press-fitted thereto in a radial direction thereof, wherein the sensor magnet is fixed to the second rotating member by means of the fixing member.

Abstract: A step unit includes: a step member which is provided with a pair of lower rails extending in an opening and closing direction of a slide door of the vehicle; and a rail plate member which is provided to a cutout formed in a part of either of the lower rails and which continuously connects the lower rails in the opening and closing direction. The step member is molded using a resin material and is provided with an insertion hole which vertically penetrates through the step member at a position corresponding to the cutout; and a support extension section which is extended from a side end of the cutout of the lower rail. The rail plate member is mounted to the step member by being inserted so as to penetrate through the insertion hole from above the step member.

Abstract: A step unit comprises: a step member which is provided on the vehicle body side so as to be adjacent to a slide door of the vehicle and has a flat plate section on which an occupant's foot is placed; and a drive device which is affixed to the step member and drives the slide door to open and close the slide door. The step member is molded using a resin material and has a accommodation portion which is provided with a bottom formed below the upper surface of the flat plate section. The drive device is affixed while at least a part thereof is accommodated within the accommodation portion.

Abstract: A step unit includes: a step member which is provided with a pair of lower rails extending in an opening and closing direction of a slide door of the vehicle; and a rail plate member which is provided to a cutout formed in a part of either of the lower rails and which continuously connects the lower rails in the opening and closing direction. The step member is molded using a resin material and is provided with an insertion hole which vertically penetrates through the step member at a position corresponding to the cutout; and a support extension section which is extended from a side end of the cutout of the lower rail. The rail plate member is mounted to the step member by being inserted so as to penetrate through the insertion hole from above the step member.

Abstract: An electromagnetic clutch includes a motor, a worm wheel rotatably driven by a motor, a rotor having an electromagnetic coil and rotatable about a same rotational axis as the worm wheel, an armature that is mounted to the worm wheel and is pulled into contact with the rotor upon application of electric power to the electromagnetic coil, so that the armature is rotated with the rotor, a cover member configured to cover the rotor and the armature, and a power supply mechanism disposed between the cover member and the rotor and connected to a power source for supplying power to the electromagnetic coil.

Abstract: A vehicle seat structure allowing a reduction in the weight of a seat while ensuring cushioning performance. The seat includes a base plate member with an outer frame forming an outer periphery of the seat, and concave portions with seating positions and a seat back position on an inner peripheral side of the outer frame made concave in a direction of a seating load. In addition, the seat includes a fabric member that is provided in a tensioned state in such a manner so as to close open sides of the concave portions for supporting an occupant's weight. A first cushion member is provided in positions on the fabric member, at least corresponding to the outer frame.