Abstract: An antibody-drug conjugate represented by formula (I): (where Ab is an antibody, X is a group represented by formula (X-1), formula (X-2) or formula (X-3): (where at the left represents the binding site with NH and at the right represents the binding side with D), D is a group represented by formula (D-1) or formula (D-2): (where represents the binding site with X), and n is in the range of about 1 to about 8).

Abstract: For a vehicle interior compartment defined by a vehicle floor, opposing sidewalls, a forward end and a rearward end, and a vehicle ceiling covering at least part of the compartment, an end zone overhead display structure includes bulkhead forming attachment elements coupled to a roof strut spanning from sidewall to sidewall of the vehicle roof. The display structure includes an open box-like upper bracket and an open box-like lower bracket coupled together with the roof strut interposed to provide an assembly that reduces unwanted motion, rotation or vibration of the display assembly.

Abstract: Provided are a control method of an ultrasound diagnostic apparatus and an ultrasound diagnostic apparatus that enable a user to easily and accurately puncture a blood vessel of a subject.

Abstract: In an ultrasound diagnostic apparatus and a control method of the ultrasound diagnostic apparatus of the present invention, a posture sensor detects whether an orientation of a monitor is a vertically long posture or a laterally long posture, and a display control unit displays an ultrasound image on a display screen on the basis of the orientation of the monitor. A hidden region detection unit detects whether or not a hidden region that is not displayed on the display screen is present in the ultrasound image, and a blood vessel detection unit detects a blood vessel in the ultrasound image. Then, in a case where it is detected that the hidden region is present and it is detected that the blood vessel is present in the hidden region, an orientation suggestion unit suggests to change the orientation of the monitor. Accordingly, in a case where blood vessel puncture is performed, an appropriate orientation of the monitor for observing the blood vessel in the ultrasound image is suggested to the user.

Abstract: Systems and methods for automated ultrasound credentialing are described. In some embodiments, a credentialing system for issuing a sonographer credential to a sonography candidate includes an ultrasound probe coupled to a computing device and configured to generate ultrasound data. The computing device is configured to generate, based on the ultrasound data and as part of an automated review, an ultrasound examination score. The computing device is configured to transfer, based on the ultrasound examination score, the sonography candidate from the automated review to a manual review by a reviewer.

Abstract: Provided are a control method of an ultrasound diagnostic apparatus and an ultrasound diagnostic apparatus that enable a user to smoothly and appropriately perform an examination. An ultrasound diagnostic apparatus includes: an ultrasound probe; an image acquisition unit that acquires an ultrasound image of a blood vessel using the ultrasound probe; a blood vessel detection unit that detects the blood vessel from the ultrasound image; an examination site discrimination unit that discriminates an examination site; an examination mode setting unit that sets an examination mode corresponding to the discriminated examination site; a compression detection unit that detects a compression motion on a body surface of a subject by the ultrasound probe; a compression motion determination unit that determines whether or not the detected compression motion is proper for the set examination mode; and a notification unit that notifies a user of a determination result by the compression motion determination unit.

Abstract: The ultrasonography apparatus includes at least one processor, in which the processor acquires, from a detector that detects a posture of a palm of a subject in capturing an ultrasound image, information representing a posture of the palm at a first time point as a first detection result, acquires information representing a posture of the palm at a second time point, which is after the first time point and is a time point during capturing of the ultrasound image, as a second detection result, derives a difference between the posture of the palm at the first time point and the posture of the palm at the second time point based on the first detection result and the second detection result, and performs notification in a case in which the derived difference is equal to or greater than a threshold value.

Abstract: There is provided an information processing apparatus that enables a more effective reduction in a load imposed on a user, with the use of force applied to the user in relation to a tangible object. The information processing apparatus includes a control unit configured to estimate, on the basis of a state of a user, a first amount that is predicted by the user with regard to force applied to the user in relation to a tangible object, and control presentation of information to the user on the basis of the first amount and a second amount that is preliminarily registered with regard to the force.

Abstract: A semiconductor device, including: a semiconductor substrate formed of silicon carbide, components being formed at one surface of the semiconductor substrate; a periphery portion disposed at a pre-specified region of a periphery of the semiconductor substrate, the components not being formed at the periphery portion; and a plurality of trenches or portions of trenches formed at the periphery portion, an interior of each of the trenches being filled with a material with a different coefficient of thermal expansion from the silicon carbide.

Abstract: The present invention provides a graphene grid that can suppress or prevent uneven distribution, uneven orientation, and the like of a structural analysis target substance, and can capture the structural analysis target substance with high efficiency and analyze the structural analysis target substance with high resolution, in a structural analysis by cryo-electron microscopy. A graphene grid of the present invention has a graphene surface into which a functional group is introduced.

Abstract: The present invention provides a novel compound that can be used as a lactate dehydrogenase inhibitor or an active ingredient of a medicament such as an antiepileptic agent and an anti-cancer agent, and particularly, provides a novel compound excellent in metabolic stability. The novel compound according to the present invention is a compound represented by the following formula (1). In formula (1), R represents any substituent (for example, a monovalent substituent of an aromatic or non-aromatic 3 to 14-membered ring which may be unsubstituted or substituted and monocyclic or polycyclic), Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh and Ri each represent a hydrogen atom or any substituent (for example, Ra to Ri are all hydrogen atoms, or Re, Rf, Rg, Rh and Ri are hydrogen atoms and at least one of Ra, Rb, Rc and Rd is any substituent).

Abstract: The present invention provides an oral care agent suitable for removing oral deposits. An oral care agent of the present invention is a semi-solid oral care agent that is an agent for removing oral deposits.

Abstract: To provide a reducer supply device that can be made compact and has excellent maintainability. The reducer supply device includes a nozzle unit that adjusts a flow rate of a reducer which is to be supplied to a NOx purification catalyst device; and a pump unit that supplies the reducer to the nozzle unit. The nozzle unit and the pump unit are arranged at positions offset from each other in top view.

Abstract: Finding a protein of a minute amount present on a cell membrane to provide a method for producing an antibody against the protein. Producing an antibody using a protein identified by an identification method including: a labeling step of using a labeling agent comprising at least one selected from bis-iminobiotin compounds and bis-biotin compounds to obtain cells having a labeled protein; a degradation step of preparing a degradation product for an immobilization treatment, the degradation product containing the labeled protein; an immobilization step of immobilizing the labeled protein contained in the degradation product for an immobilization treatment on a stationary phase via a streptavidin mutant; a cleavage step of releasing an analysis sample from the stationary phase on which the labeled protein is immobilized; and an analysis step of analyzing the analysis sample to identify the labeled protein.

Abstract: The present invention provides a new method by which polymers can be modified. The present invention provides a method for modifying a polymer including the step of: irradiating a reaction system containing a polymer with light to react the reaction system in a presence of a compound radical, wherein the compound radical is a radical containing one element selected from the group consisting of Group 15 elements and Group 16 elements, and a Group 17 element.

Abstract: The present invention provides a method for producing a substance with a modified carbon allotrope surface that can suppress or prevent uneven distribution, uneven orientation, and the like of a structural analysis target substance in a structural analysis by cryo-electron microscopy. A method for producing a substance with a modified carbon allotrope surface of the present invention includes: the step of surface-treating by reacting a carbon allotrope surface with a halogen oxide radical, wherein the carbon allotrope surface is modified by the surface-treating.

Abstract: A three-dimensional display device configured to display a main image and an additional image on a screen includes a display region candidate decider that decides one candidate region from a plurality of region candidates for the additional image to be superimposed on the main image on the screen, a depth suitability determiner that determines whether a difference between a depth of the main image displayed at a boundary region and a depth of the additional image is within a predetermined tolerance range, and an image composer that, when the difference in depth between the depth of the main image displayed at the boundary region and the depth of the additional image is within the tolerance range, superimposes the additional image upon the main image at the candidate region, thereby composing a composite image of the main image and the additional image, and displays the composite image on the screen.

Abstract: The present invention provides a new method for modifying a polymer molded body and binding a target molecule. The method for selectively binding a target molecule to a polymer molded body of the present invention includes: a pretreatment step of irradiating a selected surface of a polymer molded body with light in the presence of a compound radical; and a binding step of reacting a target molecule with the polymer molded body after the pretreatments to bind the target molecule to the selected surface of the polymer molded body, wherein the compound radical is a radical containing one element selected from the group consisting of Group 15 elements and Group 16 elements, and a Group 17 element.

Abstract: A semiconductor device, including: a semiconductor substrate formed of silicon carbide, components being formed at one surface of the semiconductor substrate; a periphery portion disposed at a pre-specified region of a periphery of the semiconductor substrate, the components not being formed at the periphery portion; and a plurality of trenches or portions of trenches formed at the periphery portion, an interior of each of the trenches being filled with a material with a different coefficient of thermal expansion from the silicon carbide.

Abstract: An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, and usage of them.