Patents by Inventor Tsvee Lapidot

Tsvee Lapidot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SHORT BETA-DEFENSIN-DERIVED PEPTIDES
    Publication number: 20170119847
    Abstract: The invention is directed to ?-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem cells and progenitor cells. Specifically, the invention provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. The invention further provides compositions and methods useful in the treatment of cancer.
    Type: Application
    Filed: December 28, 2016
    Publication date: May 4, 2017
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Tsvee LAPIDOT, Alexander KALINKOVICH, Matityahu FRIDKIN
  • Short beta-defensin-derived peptides
    Patent number: 9567371
    Abstract: The invention is directed to ?-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem cells and progenitor cells. Specifically, the invention provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. The invention further provides compositions and methods useful in the treatment of cancer.
    Type: Grant
    Filed: October 11, 2015
    Date of Patent: February 14, 2017
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Tsvee Lapidot, Alexander Kalinkovich, Matityahu Fridkin
  • SHORT BETA-DEFENSIN-DERIVED PEPTIDES
    Publication number: 20160122391
    Abstract: The invention is directed to ?-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem cells and progenitor cells. Specifically, the invention provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells. The invention further provides compositions and methods useful in the treatment of cancer.
    Type: Application
    Filed: October 11, 2015
    Publication date: May 5, 2016
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Tsvee LAPIDOT, Alexander KALINKOVICH, Matityahu FRIDKIN
  • Short beta-defensin-derived peptides
    Patent number: 9155780
    Abstract: The invention is directed to beta-defensin-derived peptides and their use in modulating the activity of hematopoietic cells and other CXCR4-expressing cells. Specifically, the invention provides compositions and methods useful in the treatment of cancer. The invention further provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: October 13, 2015
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Tsvee Lapidot, Alexander Kalinkovich, Matityahu Fridkin
  • Stem cells suitable for transplantation, their preparation and pharmaceutical compositions comprising them
    Patent number: 8367057
    Abstract: The present invention relates to stem cells suitable for transplantation and to methods for their preparation.
    Type: Grant
    Filed: February 21, 2011
    Date of Patent: February 5, 2013
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Tsvee Lapidot, Joy Kahn
  • Stem cells having increased sensitivity to SDF-1 and methods of generating and using same
    Patent number: 8252588
    Abstract: The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: August 28, 2012
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Orit Kollet, Tsvee Lapidot
  • Catecholamine receptor modulation
    Patent number: 8241903
    Abstract: The invention relates to receptors of catecholamines and their role in stem cell development and function.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: August 14, 2012
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Tsvee Lapidot, Asaf Spiegel, Menachem Rubinstein, Alexander Kalinkovich, Shoham Shivtiel
  • SHORT BETA-DEFENSIN-DERIVED PEPTIDES
    Publication number: 20120045411
    Abstract: The invention is directed to beta-defensin-derived peptides and their use in modulating the activity of hematopoietic cells and other CXCR4-expressing cells. Specifically, the invention provides compositions and methods useful in the treatment of cancer. The invention further provides compositions and methods useful for promoting mobilization and transplantation of hematopoietic stem cells and progenitor cells.
    Type: Application
    Filed: February 10, 2010
    Publication date: February 23, 2012
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Tsvee Lapidot, Alexander Kalinkovich, Matityahu Fridkin
  • Stem Cells Suitable for Transplantation, Their Preparation and Pharmaceutical Compositions Comprising Them
    Publication number: 20110268712
    Abstract: The present invention relates to stem cells suitable for transplantation and to methods for their preparation.
    Type: Application
    Filed: February 21, 2011
    Publication date: November 3, 2011
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Tsvee Lapidot, Joy Kahn
  • Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same
    Patent number: 8029780
    Abstract: The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: October 4, 2011
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Orit Kollet, Tsvee Lapidot
  • Elastase inhibitor and acute leukemia
    Publication number: 20090232793
    Abstract: The invention relates to the use of an elastase inhibitor in the manufacture of a medicament for the treatment of leukemia, preferably acute leukemia and more preferably for the treatment of AML
    Type: Application
    Filed: August 4, 2005
    Publication date: September 17, 2009
    Applicant: YEDA RESEARCH AND DEVELOPEMENT CO., LTD.
    Inventors: Tsvee Lapidot, Sigal Tavor, Isabelle Petit
  • Catecholamine Receptor Modulation
    Publication number: 20090191162
    Abstract: The invention relates to receptors of catecholamines and their role in stem cell development and function.
    Type: Application
    Filed: June 19, 2007
    Publication date: July 30, 2009
    Applicant: Yeda Research And Development Co., Ltd.
    Inventors: Tsvee Lapidot, Asaf Spiegel, Menachem Rubinstein, Alexander Kalinkovich, Shoham Shivtiel
  • Use of Protease or a Protease Inhibitor for the Manufacture of Medicaments
    Publication number: 20080305097
    Abstract: The invention relates to the use of a cathepsin K inhibitor (CTKI) or CTK, a mutein, isoform, fused protein, functional derivative, active fraction, circularly permutated derivative, a salt or inducer thereof in the manufacture of a medicament for treating a disease in which SDF-1 activity and/or concentration is involved with the development and/or course of the disease.
    Type: Application
    Filed: October 27, 2005
    Publication date: December 11, 2008
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Tsvee Lapidot, Orit Kollet
  • MIGRATION OF HEMATOPOIETIC STEM CELLS AND PROGENITOR CELLS TO THE LIVER
    Publication number: 20080193426
    Abstract: The invention relates to transplantation of hematopoietic stem cells (HSC) and/or progenitor cells (HPC) into the liver. More specifically the invention relates to the use of chemokines, preferably SDF-1, for enhancing homing of HSC/HPC to the liver.
    Type: Application
    Filed: November 30, 2007
    Publication date: August 14, 2008
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Orit KOLLET, Tsvee Lapidot
  • Nucleic acids encoding chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
    Patent number: 7374912
    Abstract: Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: May 20, 2008
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Michel Revel, Judith Chebath, Tsvee Lapidot, Orit Kollet
  • Stem Cells Suitable for Transplantation, their Preparation and Pharmaceutical Compositions Comprising Them
    Publication number: 20080025957
    Abstract: The present invention relates to stem cells suitable for transplantation and to methods for their preparation.
    Type: Application
    Filed: November 8, 2004
    Publication date: January 31, 2008
    Applicant: Yeda Research and Development Co. Ltd. P. O. Box 95
    Inventors: Tsvee Lapidot, Joy Kahn
  • Chimeric Interleukin-6 Soluble Receptor/Ligand Protein, Analogs Thereof and Uses Thereof
    Publication number: 20070172455
    Abstract: Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.
    Type: Application
    Filed: March 20, 2007
    Publication date: July 26, 2007
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Michel Revel, Judith Chebath, Tsvee Lapidot, Orit Kollet
  • Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same
    Publication number: 20070172464
    Abstract: The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.
    Type: Application
    Filed: April 7, 2004
    Publication date: July 26, 2007
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Orit Kollet, Tsvee Lapidot
  • Chimeric interleukin-6 soluble receptor/ligand proteins
    Patent number: 7198781
    Abstract: Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: April 3, 2007
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Michel Revel, Judith Chebath, Tsvee Lapidot, Orit Kollet
  • Stem cells having increased sensitivity to sdf-1 and methods of generating and using same
    Publication number: 20070003540
    Abstract: The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.
    Type: Application
    Filed: April 7, 2004
    Publication date: January 4, 2007
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Orit Kollet, Tsvee Lapidot