Abstract: A sensor communications system provides for the secure transfer of sensor measurement data from sensor devices to a remote, network connected server system. The sensor devices include processor to encrypt a sensor measurement data stream using the public key of an asymmetric key pair and to transmit the encrypted sensor measurement data stream through the local network interface. The remote server system includes a network gateway and a compute server with the compute server being couplable to the network gateway and an authorization server storing the private key of the asymmetric key pair. The compute server operates to decrypt the encrypted sensor measurement data stream using the private key and to process the decrypted sensor measurement data stream for presentation a user of the remote server system.

Abstract: A computerized efficient data processing management method for imaging applications first performs a data flow graph generation by computing means using at least one image data and at least one requested task to generate a data flow graph. The method then applies a task execution scheduling using the data flow graph generated, a caching system configuration, the at least one image data and at least one requested task to schedule execution of the at least one requested task to generate task execution output. In addition, an adaptive data processing method performs caching system update and an optimal data processing method further performs data flow graph update.

Abstract: A networked computer system providing an automated control system that enables a sensor client to securely communicate with a heterogeneous set of unique sensors. The system enables autonomous secure identification of specific sensors capable of system inter-operation. Recognized sensors are autonomously paired and the connection secured using a password unique to the sensor and autonomously managed by the system. Measurement data is source encrypted using a well-defined public key, thereby providing data security that extends uninterrupted from the sensor itself to an appropriately authorized subsystem of the control system.

Abstract: A sweat sensor includes a first conductor and a second conductor that are parallel with one another. The sweat sensor also includes a channel disposed between the first and second conductors. The channel is configured to receive a sample of sweat. A measure of capacitance between the first and second conductors changes based at least partially upon a volume of the sweat in the channel.

Abstract: The present invention relates to conjugates comprising (a) an antisense oligonucleotide (ASO) and (b) at least one G-quadruplex structure, wherein the ASO and the at least one G-quadruplex structure are heterologous to each other. The G-quadruplex of the conjugate may be further conjugated with ligands or functional moieties for addressable delivery and enhanced properties including potency and therapeutic index. Further encompassed are such conjugates for use as a medicament, a method of modulating the stability, translation, splicing, cleavage, or activity of a target nucleic acid molecule using such conjugates, and use of G-quadruplex in stabilizing antisense oligonucleotides.

Abstract: A computerized efficient data processing management method for imaging applications first performs a data flow graph generation by computing means using at least one image data and at least one requested task to generate a data flow graph. The method then applies a task execution scheduling using the data flow graph generated, a caching system configuration, the at least one image data and at least one requested task to schedule execution of the at least one requested task to generate task execution output. In addition, an adaptive data processing method performs caching system update and an optimal data processing method further performs data flow graph update.

Abstract: The present invention relates to conjugates comprising (a) an antisense oligonucleotide (ASO) and (b) at least one G-quadruplex structure, wherein the ASO and the at least one G-quadruplex structure are heterologous to each other. The G-quadruplex of the conjugate may be further conjugated with ligands or functional moieties for addressable delivery and enhanced properties including potency and therapeutic index. Further encompassed are such conjugates for use as a medicament, a method of modulating the stability, translation, splicing, cleavage, or activity of a target nucleic acid molecule using such conjugates, and use of G-quadruplex in stabilizing antisense oligonucleotides.

Abstract: A method for the generation of a G-quadruplex structure on a target nucleic acid sequence is presented. The approach combines the specificity of Watson-Crick base pair with the stability associated with a robust G-quadruplex scaffold. The induction of such bimolecular quadruplex-duplex hybrids can be applied within the antigene or antisense context for enhanced steric blockage to the transcriptional or translational machinery. In addition, such structures provide unique features for ligand design. This approach also allows the site-specific generation of G-quadruplex structures within nucleic acid nanoarchitectures.

Abstract: A peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a derivative thereof is provided. Also provided are conjugates of such a peptide, the use of the peptide or the conjugates as a medicament, and methods for the detection of parallel-stranded G-quadruplexes.

Abstract: This invention relates to a nucleic acid nanoparticle comprising at least one G-quadruplex structure wherein at least one guanine base comprises a modification in the N2-position and the use of said nucleic acid nanoparticle as a medicament, molecular sensor, or tag. Further this invention relates to methods of stabilizing a nucleic acid nanoparticle comprising at least one G-quadruplex structure.

Abstract: This invention relates to a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a derivative thereof. The present invention also relates to conjugates of said peptide, the use of the peptide or the conjugate as a medicament and to methods for the detection of parallel-stranded G-quadruplexes.

Abstract: A method for the generation of a G-quadruplex structure on a target nucleic acid sequence is presented. The approach combines the specificity of Watson-Crick base pair with the stability associated with a robust G-quadruplex scaffold. The induction of such bimolecular quadruplex-duplex hybrids can be applied within the antigene or antisense context for enhanced steric blockage to the transcriptional or translational machinery. In addition, such structures provide unique features for ligand design. This approach also allows the site-specific generation of G-quadruplex structures within nucleic acid nanoarchitectures.

Abstract: A Recognition Frame presents multi-level application elements to the user simultaneously through a computer graphical user interface. The interface consists of an image display panel for displaying image channels; a data display panel for displaying object measurements and summary statistics; a configuration display panel for displaying recipe content; a master tab for selecting the panels. It also consists of a processing toolbar for context dependent processing tool display. The Recognition Frame further comprises a second side frame for data object display and charting. The second side frame has a tabular arrangement consisting of properties tab, controls tab, and charts tab. The Recognition Frame links application elements through a complex data model wherein interface display is automatically updated when one element is changed.

Abstract: An adaptive dilation method receives an image and performs an adaptive background distance transform to create an adaptive background distance transform image. A threshold is applied to the adaptive background distance transform image to generate adaptive dilation image output. An adaptive erosion method receives an image and performs an adaptive foreground distance transform to create an adaptive foreground distance transform image. A threshold is applied to the adaptive foreground distance transform image to generate adaptive erosion image output.

Abstract: A two pass Zone Of Influence (ZOI) creation method creates a Zone Of Influence (ZOI) image. The two pass ZOI creation method performs a first pass scan to create a first pass intermediate distance image and a shortest distance component label image. It then performs a second pass scan using the first pass intermediate distance image and the shortest distance component label image to create a background distance transform image and a updated shortest distance component label image. An adaptive image region partition method allows distance lengths of the two pass adaptive ZOI creation method depend on their associated component labels.

Abstract: A region-guided boundary refinement method for object segmentation in digital images receives an initial object regions of interest and performs directional boundary decomposition using the initial object regions of interest to generate a plurality of directional object boundaries output. A directional border search is performed using the plurality of directional object boundaries to generate base border points output. A base border integration is performed using the base border points to generate base borders output. In addition, a boundary completion is performed using the base borders having boundary refined object regions of interest output. A region-guided boundary completion method for object segmentation in digital images receives an initial object regions of interest and base borders. It performs boundary completion using the initial object regions of interest and the base borders to generate boundary refined object regions of interest output.

Abstract: The present invention provides to the isolation of a small cysteine rich secretory protein from a haematopoietic macrophage cell line, which is capable of elevating cytosolic calcium levels. In particular, the present invention provides a method of treating or preventing bone disorders or diseases comprising the step of administering a composition comprising caltrin or functionally active fragment thereof to an individual in a need thereof.

Abstract: A Recognition Frame presents multi-level application elements to the user simultaneously through a computer graphical user interface. The interface consists of an image display panel for displaying image channels; a data display panel for displaying object measurements and summary statistics; a configuration display panel for displaying recipe content; a master tab for selecting the panels. It also consists of a processing toolbar for context dependent processing tool display. The Recognition Frame further comprises a second side frame for data object display and charting. The second side frame has a tabular arrangement consisting of properties tab, controls tab, and charts tab. The Recognition Frame links application elements through a complex data model wherein interface display is automatically updated when one element is changed.

Abstract: An adaptive dilation method receives an image and performs an adaptive background distance transform to create an adaptive background distance transform image. A threshold is applied to the adaptive background distance transform image to generate adaptive dilation image output. An adaptive erosion method receives an image and performs an adaptive foreground distance transform to create an adaptive foreground distance transform image. A threshold is applied to the adaptive foreground distance transform image to generate adaptive erosion image output.

Abstract: A region-guided boundary refinement method for object segmentation in digital images receives an initial object regions of interest and performs directional boundary decomposition using the initial object regions of interest to generate a plurality of directional object boundaries output. A directional border search is performed using the plurality of directional object boundaries to generate base border points output. A base border integration is performed using the base border points to generate base borders output. In addition, a boundary completion is performed using the base borders having boundary refined object regions of interest output. A region-guided boundary completion method for object segmentation in digital images receives an initial object regions of interest and base borders. It performs boundary completion using the initial object regions of interest and the base borders to generate boundary refined object regions of interest output.