Abstract: This disclosure relates to development of biocompatible and resorbable type II collagen fibers for medical applications. Its characteristics and methods of preparation are also disclosed.

Abstract: This disclosure describes implants for the repair and regeneration of articular cartilage that includes stratified multi-layered structure zones that simulate the extracellular matrix of the native articular cartilage. The various zones are physically and mechanically integrated for in vivo stability. Methods for fabricating the implants and methods of use thereof are also disclosed.

Abstract: A contact guiding device, which is adapted for being contacted with at least one electric contact, includes a mounting frame, a chip module, and a guiding structure. The chip module includes a substrate connected with the mounting frame, and at least one terminal mounted to the substrate. The guiding structure is provided at the mounting frame or the terminal for guiding the electric contact into contact with the terminal when the terminal approaches the electric contact. As a result, the contact guiding device can guide the electric contact to a correct position to ensure proper contact with the terminal, thereby preventing the electric contact from deformation and correcting the already deformed electric contact.

Abstract: A chip module of a toner cartridge is used to be coupled to an electronic image-forming apparatus including a reading head having communication conductive strips and a grounding conductive strip. The chip module includes a substrate, a memory mounted to the substrate, and terminals mounted to the substrate and electrically connected with the memory. Each terminal includes a sheet body parallel to an imaginary plane, two lateral sides respectively located at two opposite sides of the sheet body and parallel to the imaginary plane, and an arched contact edge located at a lateral edge of the sheet body and between the two lateral sides for being contacted with one of the communication conductive strips and the grounding conductive strip. As such, the chip module can be positively aligned and contacted with the reading head of the electronic image-forming apparatus.

Abstract: Disclosed are a bonding system and a bonding method. In one embodiment, the bonding system includes a chamber, first and second electrostatic chucks, a visible light sensor module and a nonvisible light module. The chamber is configured to provide a vacuum state. The first electrostatic chuck is configured to hold a first substrate having a first alignment mark in the chamber, wherein the first electrostatic chuck has a first window. The second electrostatic chuck is configured to hold a second substrate having a second alignment mark in the chamber, wherein the second electrostatic chuck has a second window. The visible light sensor module is configured to capture images of the first and the second alignment marks. The nonvisible light module is configured to capture a combined image of the first and second alignment marks via the first and second windows overlapping each other in the vacuum state.

Abstract: This disclosure provides a collagen fiber-based ink for bioprinting comprising a high solid content of collagen fiber particles that are suitable for manufacturing collagen-based scaffolds and tissue equivalent implants for regenerative medicine applications.

Abstract: Provided herein are pharmaceutical compositions comprising a lipid nanoparticle (LNP) and a therapeutic nucleic acid (TNA), wherein the LNP comprises a single-chain variable fragment (scFv) linked to the LNP, and at least one pharmaceutically acceptable excipient. The scFv is capable of binding an antigen present on the surface of a cell, advantageously providing LNP compositions that target only those cells or tissues expressing the receptor.

Abstract: A compression and kink resistant tubular implant for nerve repair. The implant includes a tubular biopolymeric membrane and a polymeric supporting filament. Also provided is a shaped compression resistant implant for ridge augmentation in dental surgery. Methods for producing the implants are also provided.

Abstract: A wafer bonding apparatus is provided. The wafer bonding apparatus includes a first wafer chuck, a second wafer chuck, and a plurality of bonding pins. The first wafer chuck is configured to hold a first wafer. The second wafer chuck is configured to hold a second wafer. The bonding pins are accommodated in the first wafer chuck and configured to be movable through the first wafer chuck to apply pressure to bend the first wafer, thereby causing bonding contact of the first wafer and the second wafer.

Abstract: The present invention relates to a glycosaminoglycan impregnated biopolymer-based scaffold implant for repair and regeneration of damaged and diseased human menisci. The biopolymer can be any suitable natural or genetically engineered biopolymers. This scaffold implant has several advantages over prior art implants including higher biomechanical strength and lower surface friction. A method of making the scaffold implant is also disclosed.

Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing silicate based glass. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.

Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.

Abstract: A method for filling toner into a toner cartridge includes the steps of (a) taking a container, which accommodates the toner therein and has opposite first and second ends, and then forming a toner outlet at the first end, (b) sleeving the toner cartridge, which is provided at an end thereof with an opening, onto the container from the first end to the second end via the opening, (c) forming an air permeable hole at the second end, (d) withdrawing the container from the toner cartridge to enable the toner to leave the container via the toner outlet and stay inside the toner cartridge, and (e) sealing the opening of the toner cartridge by a cover. The method is simple and convenient to operate. With the method, the toner can be effectively filled without leakage and with reduced amount of residual toner.

Abstract: An extreme ultra violet (EUV) lithography apparatus includes a light source that generates an EUV light beam, a scanner that receives the light from a junction with the light source and directs the light to a reticle stage, and a debris catcher disposed on a EUV beam path between the light source and the scanner. The debris catcher includes a network membrane including a plurality of nano-fibers.

Abstract: This disclosure provides a collagen fiber-based ink for bioprinting comprising a high solid content of collagen fiber particles that are suitable for manufacturing collagen-based scaffolds and tissue equivalent implants for regenerative medicine applications.

Abstract: An optical system is provided, including a fixed assembly, a plurality of movable members, and a plurality of driving assemblies respectively connected to the movable members. The movable members are connected to an optical element and movable relative to the fixed assembly. The driving assemblies respectively drive the movable members to move relative to the fixed assembly in different time intervals.

Abstract: Provided herein are lipid formulations comprising a lipid and a capsid free, non-viral vector (e.g. ceDNA). Lipid particles (e.g., lipid nanoparticles) of the invention include a lipid formulation that can be used to deliver a capsid-free, non-viral DNA vector to a target site of interest (e.g., cell, tissue, organ, and the like).

Abstract: The present invention relates to a glycosaminoglycan impregnated biopolymer-based scaffold implant for repairing and regeneration of damaged and diseased human menisci. The biopolymer can be any suitable natural or genetically engineered biopolymers. This scaffold implant has several advantages over prior art implants including higher biomechanical strength and lower surface friction. A method of making the scaffold implant is also disclosed.

Abstract: A grounding structure includes a flexible conductive webbing and a counterweight disposed on the flexible conductive webbing. The flexible conductive webbing is weaved from conductive wires, provided to be mounted on a carrier and electrically connected to the carrier. The counterweight is used to allow the flexible conductive webbing to contact a ground in a way of surface contact for electrostatic discharge.

Abstract: A method for producing a collagen meniscus implant by obtaining a freshly excised non-human meniscus, rinsing it in an aqueous solution, drying the rinsed meniscus, shaping it to approximate in dimension an average-sized human meniscus, extracting non-collagenous material from the shaped meniscus, and sterilizing it, yielding a collagen meniscus implant containing at least 90% by weight of type I collagen, less than 0.5% by weight of glycosaminoglycan, and less than 600 ppm DNA. Also disclosed is a collagen meniscus implant prepared by the above method. Further provided is a biocompatible and bioresorbable porous implant for meniscus repair. The implant includes a three-dimensional network of collagen fibers oriented in a direction approximating the collagen fiber orientation of a human meniscus. The implant has a size and a contour substantially equivalent to a human meniscus, and has a chemical composition similar to the above-described collagen meniscus implant.