Abstract: An implantable drug-delivery device for repairing a crushed peripheral nerve. The drug-delivery device includes a matrix formed of a biopolymer and an erythropoietin (EPO) entrapped in the matrix. After in vivo implantation of the drug-delivery device, the EPO elutes over a period of 1 day to 12 weeks. Also disclosed is a method for repairing a crushed peripheral nerve using the implantable drug-delivery device.

Abstract: An implantable drug-delivery device for repairing a severed peripheral nerve. The drug-delivery device includes a matrix formed of a biopolymer and an erythropoietin (EPO) entrapped in the matrix. After in vivo implantation of the drug-delivery device, the EPO elutes over a period of 1 day to 12 weeks. Also disclosed is a method for repairing a severed peripheral nerve using the implantable drug-delivery device.

Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.

Abstract: A calibration method of an optical system is provided, wherein the optical system includes a movable element that can move within an operation interval. The calibration method includes the step of establishing a relationship between the operation interval and an electrical signal coding sequence. The calibration method further includes the step of establishing a relationship between the operation interval and a sensing signal coding sequence.

Abstract: A waste toner detection device includes a stirring shaft for stirring waste toners, a transmission member moveable in response to a rotational load of the stirring shaft between an engaged position and a disengaged position where the transmission member does not transmit rotation to the stirring shaft, a rotary arm drivenable by the transmission member when the transmission member is located at the disengaged position, and an indication member. The indication member is restricted by the rotary arm at a retracted position when the rotary arm is located at a locked position, and the indication member is driven by a biasing force to move to an extended position when the rotary arm is located at a released position. As a result, the waste toner detection device can accurately detects whether the amount of the waste toners stored in a waste toner container has reached a predetermined amount.

Abstract: An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.

Abstract: A compression and kink resistant tubular implant for nerve repair. The implant includes a tubular biopolymeric membrane and a polymeric supporting filament. Also provided is a shaped compression resistant implant for ridge augmentation in dental surgery. Methods for producing the implants are also provided.

Abstract: A calibration method of an optical system is provided, wherein the optical system includes a movable element that can move within an operation interval. The calibration method includes the step of establishing a relationship between the operation interval and an electrical signal coding sequence. The calibration method further includes the step of establishing a relationship between the operation interval and a sensing signal coding sequence.

Abstract: An optical system is provided, including a fixed assembly, a plurality of movable members, and a plurality of driving assemblies respectively connected to the movable members. The movable members are connected to an optical element and movable relative to the fixed assembly. The driving assemblies respectively drive the movable members to move relative to the fixed assembly in different time intervals.

Abstract: A toner detection device of a waste toner container having a housing includes a rotational wheel, a transmission member and a resilient member. The rotational wheel is rotatably disposed to the housing and provided with a first abutment portion. The transmission member including a second abutment position is connected with the rotational wheel in a way that the transmission member is rotatable with the rotational wheel and moveable relative to the rotational wheel between a first position and a second position. Two ends of the resilient member are respectively abutted against the first and second abutment portions in a way that the second abutment portion approaches the first abutment portion and the transmission member is rotatable relative to the rotational wheel with the transmission member moving from the first position to the second position.

Abstract: A method for producing a collagen meniscus implant by obtaining a freshly excised non-human meniscus, rinsing it in an aqueous solution, drying the rinsed meniscus, shaping it to approximate in dimension an average-sized human meniscus, extracting non-collagenous material from the shaped meniscus, cross-linking, and sterilizing it, yielding a collagen meniscus implant containing at least 90% by weight of type I collagen, less than 0.5% by weight of native glycosaminoglycan, and less than 600 ppm DNA. Also disclosed is a collagen meniscus implant prepared by the above method. Further provided is a biocompatible and bioresorbable porous implant for meniscus repair. The implant includes a three-dimensional network of collagen fibers oriented in a direction approximating the collagen fiber orientation of a human meniscus. The implant has a size and a contour substantially equivalent to a human meniscus, and has a chemical composition similar to the above-described collagen meniscus implant.

Abstract: A density gradient biopolymeric matrix implant is disclosed. The implant includes a first homogeneous matrix layer and a second homogeneous matrix layer having a density different from that of the first homogeneous matrix layer. Biopolymeric fibers at the surface of the first homogeneous matrix layer are physically in contact with and cross-linked to the biopolymeric fibers at the surface of the second homogeneous matrix layer. Also disclosed is a three-dimensional density gradient biopolymeric matrix implant that includes a first homogeneous matrix surrounding a second homogeneous matrix having a different density. Biopolymeric fibers at an inner surface of the first homogeneous matrix are physically in contact with and cross-linked to biopolymeric fibers at an outer surface of the second homogeneous matrix. Furthermore, methods for preparing the density gradient biopolymeric matrix implant and the three-dimensional density gradient biopolymeric matrix implant are provided.

Abstract: An implantable drug-delivery device for repairing a severed peripheral nerve. The drug-delivery device includes a matrix formed of a biopolymer and an erythropoietin (EPO) entrapped in the matrix. After in vivo implantation of the drug-delivery device, the EPO elutes over a period of 1 day to 12 weeks. Also disclosed is a method for repairing a severed peripheral nerve using the implantable drug-delivery device.

Abstract: A carbonate apatite prepared from natural bone. The carbonate apatite has a protein content of 2000-8000 parts per million and a surface area of 15 to 70 m2/g. Also provided is a method for preparing the carbonate apatite from cancellous bone particles.

Abstract: A collagen-coated tissue based membrane that is smooth on both sides so as to inhibit cell and tissue adhesion. Also disclosed are methods for making a collagen-coated tissue-based membrane.

Abstract: A method for producing a collagen meniscus implant by obtaining a freshly excised non-human meniscus, rinsing it in an aqueous solution, drying the rinsed meniscus, shaping it to approximate in dimension an average-sized human meniscus, extracting non-collagenous material from the shaped meniscus, and sterilizing it, yielding a collagen meniscus implant containing at least 90% by weight of type I collagen, less than 0.5% by weight of glycosaminoglycan, and less than 600 ppm DNA. Also disclosed is a collagen meniscus implant prepared by the above method. Further provided is a biocompatible and bioresorbable porous implant for meniscus repair. The implant includes a three-dimensional network of collagen fibers oriented in a direction approximating the collagen fiber orientation of a human meniscus. The implant has a size and a contour substantially equivalent to a human meniscus, and has a chemical composition similar to the above-described collagen meniscus implant.

Abstract: A collagen-coated tissue based membrane that is smooth on both sides so as to inhibit cell and tissue adhesion. Also disclosed are methods for making a collagen-coated tissue-based membrane.

Abstract: A collagen-coated tissue-based membrane that is smooth on both sides so as to inhibit cell and tissue adhesion. The tissue-based membrane is a serous membrane having a fibrous surface and a smooth surface and the collagen is coated on the fibrous surface. Also provided are methods for making the collagen-coated tissue-based membrane.

Abstract: A density gradient biopolymeric matrix implant is disclosed. The implant includes a first homogeneous matrix layer and a second homogeneous matrix layer having a density different from that of the first homogeneous matrix layer. Biopolymeric fibers at the surface of the first homogeneous matrix layer are physically in contact with and cross-linked to the biopolymeric fibers at the surface of the second homogeneous matrix layer. Also disclosed is a three-dimensional density gradient biopolymeric matrix implant that includes a first homogeneous matrix surrounding a second homogeneous matrix having a different density. Biopolymeric fibers at an inner surface of the first homogeneous matrix are physically in contact with and cross-linked to biopolymeric fibers at an outer surface of the second homogeneous matrix. Furthermore, methods for preparing the density gradient biopolymeric matrix implant and the three-dimensional density gradient biopolymeric matrix implant are provided.

Abstract: A lithography apparatus includes a plurality reticle edge masking assemblies (REMAs), wherein each REMA of the plurality of REMAs is positioned to receive one of a plurality of light beams, and each REMA of the plurality of REMAs comprises a movable slit for passing the received light beam therethrough. The lithography apparatus includes a controller for controlling a speed of the movable slit based on a size of the movable slit, an intensity of the one or more collimated light beams, or a material to be patterned. The lithography apparatus further includes a single mask having a single pattern, wherein the mask is configured to receive light from every REMA of the plurality of REMAs. The lithography apparatus includes a projection lens configured to receive light transmitted through the single mask, wherein the lithography apparatus is configured to introduce an immersion liquid into a space adjacent to the projection lens.