Patents by Inventor Tung Yuan Shih

Tung Yuan Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230082397
    Abstract: A new compound composition that is free of a side effect to a liver and used for alleviating the toxicity of an acetaminophen (APAP) medicament to the liver. The compound composition comprises (a) a pharmaceutically effective amount of acetaminophen and (b) a frequently-used safe and pharmaceutically acceptable excipient that can be combined with one or more than two medicaments that can reduce the toxicity of a drug via liver enzyme CYP2E1 metabolism to the liver.
    Type: Application
    Filed: November 23, 2022
    Publication date: March 16, 2023
    Applicant: NATIONAL DEFENSE EDUCATION AND RESEARCH FOUNDATION
    Inventors: Oliver Yoa-Pu HU, Tung-Yuan SHIH
  • Patent number: 11534416
    Abstract: A new compound composition that is free of a side effect to a liver and used for alleviating the toxicity of an acetaminophen (APAP) medicament to the liver. The compound composition comprises (a) a pharmaceutically effective amount of acetaminophen and (b) a frequently-used safe and pharmaceutically acceptable excipient that can be combined with one or more than two medicaments that can reduce the toxicity of a drug via liver enzyme CYP2E1 metabolism to the liver.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: December 27, 2022
    Assignee: NATIONAL DEFENSE EDUCATION AND RESEARCH FOUNDATION
    Inventors: Oliver Yoa-Pu Hu, Tung-Yuan Shih
  • Publication number: 20220265587
    Abstract: The present invention relates to compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof. The present compound is represented by Formula (II), which has the formula: R1—O—X—(CH2)m—X—O—R2, wherein: each X is —C(?O)—; R1 is a C1-C18 alkyl polyol; R2 is a saccharide group of formula (G)p; G is a monosaccharide residue, where (i) at least one of the —OH groups in (G)p is substituted by a halogen atom, and (ii) the saccharide group of formula (G)p is linked to —O— through a —CH2 group; p is 1 or 2; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.
    Type: Application
    Filed: March 3, 2022
    Publication date: August 25, 2022
    Applicant: SINEW PHARMA INC.
    Inventors: Oliver Yoa-Pu HU, Tung-Yuan SHIH, Cheng-Huei HSIONG, Hsin-Tien HO
  • Patent number: 11285123
    Abstract: The present invention relates to compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof. The present compound is represented by Formula (II), which has the formula: R1—O—X—(CH2)m—X—O—R2, wherein: each X is —C(?O)—; R1 is a C1-C18 alkyl polyol: R2 is a saccharide group of formula (G)p; G is a monosaccharide residue, where (i) at least one of the —OH groups in (G)p is substituted by a halogen atom, and (ii) the saccharide group of formula (G)p is linked to —O— through a —CH2 group; p is 1 or 2; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: March 29, 2022
    Assignee: SINEW PHARMA INC.
    Inventors: Oliver Yoa-Pu Hu, Tung-Yuan Shih, Cheng-Huei Hsiong, Hsin-Tien Ho
  • Publication number: 20210008101
    Abstract: The present invention relates to methods and compositions for preventing, reducing or eradicating toxicity caused by acetaminophen (APAP). Specifically, the toxicity is nephrotoxicity and/or hepatotoxicity.
    Type: Application
    Filed: February 14, 2019
    Publication date: January 14, 2021
    Applicant: SINEW PHARMA INC.
    Inventors: Oliver Yoa-Pu HU, Tung-Yuan SHIH, Cheng-Huei HSIONG, Hsin-Tien HO, Kai-Min CHU
  • Publication number: 20200009097
    Abstract: The present invention relates to compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof. The present compound is represented by Formula (II), which has the formula: R1—O—X—(CH2)m—X—O—R2, wherein: each X is —C(?O)—; R1 is a C1-C18 alkyl polyol: R2 is a saccharide group of formula (G)p; G is a monosaccharide residue, where (i) at least one of the —OH groups in (G)p is substituted by a halogen atom, and (ii) the saccharide group of formula (G)p is linked to —O— through a —CH2 group; p is 1 or 2; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.
    Type: Application
    Filed: September 17, 2019
    Publication date: January 9, 2020
    Applicant: SINEW PHARMA INC.
    Inventors: Oliver Yoa-Pu HU, Tung-Yuan SHIH, Cheng-Huei HSIONG, Hsin-Tien HO
  • Patent number: 10456371
    Abstract: The present invention relates to compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof. The present compound is represented by Formula (II), which has the formula: R1—O—X—(CH2)m—X—O—R2, wherein: each X is —C(?O)—; R1 is a C1-C18 alkyl polyol; R2 is a saccharide group of formula (G)p; G is a monosaccharide residue, where (i) at least one of the —OH groups in (G)p is substituted by a halogen atom, and (ii) the saccharide group of formula (G)p is linked to —O— through a CH2 group; p is 1 or 2; and m is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: October 29, 2019
    Assignee: SINEW PHARMA INC.
    Inventors: Oliver Yoa-Pu Hu, Tung-Yuan Shih, Cheng-Huei Hsiong, Hsin-Tien Ho
  • Patent number: 10420737
    Abstract: A new compound composition that is free of a side effect to a liver and used for alleviating the toxicity of an acetaminophen (APAP) medicament to the liver. The compound composition comprises (a) a pharmaceutically effective amount of acetaminophen and (b) a frequently-used safe and pharmaceutically acceptable excipient that can be combined with one or more than two medicaments that can reduce the toxicity of a drug via liver enzyme CYP2E1 metabolism to the liver.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: September 24, 2019
    Assignee: NATIONAL DEFENSE EDUCATION AND RESEARCH FOUNDATION
    Inventors: Oliver Yao-Pu Hu, Tung-Yuan Shih
  • Publication number: 20190262289
    Abstract: A new compound composition that is free of a side effect to a liver and used for alleviating the toxicity of an acetaminophen (APAP) medicament to the liver. The compound composition comprises (a) a pharmaceutically effective amount of acetaminophen and (b) a frequently-used safe and pharmaceutically acceptable excipient that can be combined with one or more than two medicaments that can reduce the toxicity of a drug via liver enzyme CYP2E1 metabolism to the liver.
    Type: Application
    Filed: May 14, 2019
    Publication date: August 29, 2019
    Applicant: NATIONAL DEFENSE EDUCATION AND RESEARCH FOUNDATION
    Inventors: Oliver Yoa-Pu HU, Tung-Yuan SHIH
  • Publication number: 20180256526
    Abstract: The present invention relates to compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof.
    Type: Application
    Filed: September 26, 2016
    Publication date: September 13, 2018
    Applicant: SINEW PHARMA INC.
    Inventors: Oliver Yoa-Pu HU, Tung-Yuan SHIH, Cheng-Huei HSIONG, Hsin-Tien HO
  • Publication number: 20170172950
    Abstract: A new compound composition that is free of a side effect to a liver and used for alleviating the toxicity of an acetaminophen (APAP) medicament to the liver. The compound composition comprises (a) a pharmaceutically effective amount of acetaminophen and (b) a frequently-used safe and pharmaceutically acceptable excipient that can be combined with one or more than two medicaments that can reduce the toxicity of a drug via liver enzyme CYP2E1 metabolism to the liver.
    Type: Application
    Filed: November 13, 2013
    Publication date: June 22, 2017
    Applicant: NATIONAL DEFENSE EDUCATION AND RESEARCH FOUNDATION
    Inventors: Oliver Yao-Pu Hu, Tung-Yuan Shih
  • Publication number: 20170101678
    Abstract: Present invention provides a method for screening drug-induced toxicity and screening for drug-induced toxicity by using the NAT2, CYP2E1 and Xanthine Oxidase genes, in particular, provides a method for screening TB drug-induced hepatotoxicity. The method of present invention includes providing test specimen, detection of at least one type of SNPs of the NAT2, CYP2E1 and Xanthine Oxidase genes from the DNA of said test specimen; presence of the SNP genotype indicates the test specimen has a risk for developing anti-TB drug-induced toxicity; said SNP genotype is selected from at least one of the following groups or their combinations thereof: rs1041983, rs1112005, rs1495741, rs1799930, rs1799931, rs1801280, rs1961456, rs2087852, rs11996129, rs2031920, rs2249695, rs3813865, rs3813867, rs1884725, rs2295475 and rs17011368.
    Type: Application
    Filed: January 27, 2014
    Publication date: April 13, 2017
    Applicant: RESEARCH CENTER FOR BIOTECHNOLOGY AND MEDICINE POLICY
    Inventors: Oliver Yao-Pu HU, Cheng-Huei HSIONG, Hsin-Tien HO, Tung-Yuan SHIH
  • Publication number: 20090315367
    Abstract: A lounge comprises a seat frame, a back frame, a left frame and a right frame; the seat frame and the back frame being installed between the left frame and the right frame; a top of the left frame having a left handle and a top of the right frame having a right handle; at least one of the left frame and right frame having a liftable inner tube and an openable table plate for being positioned horizontally for adjusting a height of the lounge and for supporting objects upon the table plate. Thus the lounge has the functions of liftability and placing objects. The lounge provides the table plate so that the user can work conveniently without needing a further table. These functions can not be achieved by the prior art.
    Type: Application
    Filed: June 18, 2008
    Publication date: December 24, 2009
    Inventor: Tung-Yuan SHIH
  • Publication number: 20090205129
    Abstract: A lie-able sofa comprises a seat having a seat frame; in side the seat frame of the seat having at least one an oblong frame and at least one short frame; a hollow space being formed between the oblong frame and the short frame; a back frame uprightly installed to a backside of the seat; each bridge unit being formed by two connecting sheets being arranged at an upper side and a lower side; a nut and a stud serving to lock the two connecting sheets together; each connecting sheet having two cambered sheets at two sides thereof; as the two connecting sheets are combined, the cambered sheets of different connecting sheets being formed with a space for receiving the main support tube. By above structure, the oblong frame and the short frames are retained to the seat.
    Type: Application
    Filed: February 17, 2008
    Publication date: August 20, 2009
    Inventor: Tung-Yuan Shih
  • Patent number: 6872147
    Abstract: A billiard table includes a table top, two pairs of brackets secured to the table top and each having one or more openings, two pairs of bars each having one or more ears easily and quickly hooking to the openings of the brackets, for easily and quickly hooking and securing the bars to the table top, and for allowing the billiard table to be assembled by the users. A number of angles are secured between the bars for securing the bars together and to the table top. A bottom plate may be secured to the bars, and a support device may be secured to the bottom plate.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: March 29, 2005
    Inventor: Tung Yuan Shih
  • Publication number: 20040192454
    Abstract: A ball member for billiard and bocce games includes an inner core member made of cheaper or heavier materials and having an outer peripheral portion, and an outer covering member engaged onto the outer peripheral portion of the inner core member, the outer covering member may be made of poly resin or synthetic materials having a smooth outer surface. The inner core member may be made or waste or recycled materials, and may include different weights from that of the outer covering member, to determine or adjust the ball member to the required weight.
    Type: Application
    Filed: March 27, 2003
    Publication date: September 30, 2004
    Inventor: Tung Yuan Shih
  • Publication number: 20040026853
    Abstract: A game table includes a housing having two side panels each of which has a number of recesses formed in the upper portion. A number of glider bars each has two gaskets received in the recesses of the side panels, and each has one or more cushioning rings and one or more players. Two beams are engaged onto the side panels and the gaskets for retaining the gaskets between the side panels and the beams. The cushioning rings and the players may be easily assembled onto the glider bars before the glider bars are assembled onto the side panels of the housing with the beams.
    Type: Application
    Filed: August 12, 2002
    Publication date: February 12, 2004
    Inventor: Tung Yuan Shih
  • Publication number: 20040029644
    Abstract: A billiard table includes a table top, two pairs of brackets secured to the table top and each having one or more openings, two pairs of bars each having one or more ears easily and quickly hooking to the openings of the brackets, for easily and quickly hooking and securing the bars to the table top, and for allowing the billiard table to be assembled by the users. A number of angles are secured between the bars for securing the bars together and to the table top. A bottom plate may be secured to the bars, and a support device may be secured to the bottom plate.
    Type: Application
    Filed: August 12, 2002
    Publication date: February 12, 2004
    Inventor: Tung Yuan Shih
  • Patent number: D505464
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: May 24, 2005
    Inventor: Tung-Yuan Shih
  • Patent number: D495387
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: August 31, 2004
    Inventor: Tung-Yuan Shih