Abstract: Embodiments are provided for suggesting topics in a messaging system. A set of queries is received from a chat transcript history, where the set of queries includes a set of unhandled queries, and each unhandled query comprises a query for which a bot did not identify a corresponding topic (e.g., queries that did not trigger selection of a topic by the bot). A vector representation is generated for each unhandled query in the set of unhandled queries. The vector representations for the set of unhandled queries are clustered to generate one or more clusters of vector representations, each cluster corresponding to a group of unhandled queries. A corresponding suggested topic is generated for each cluster and provided to an authoring tool that comprises one or more interactive elements to enable an author to select at least one of the suggested topics for implementation in the bot.

Abstract: The present invention relates to a multi-source bi-directional onboard charger. The bi-directional onboard charger comprises input relays, an AC/DC converter, a staged circuit, and a DC/DC converter. The charger can either charge a battery by a power supplier or supply power to external loads by discharging the battery. The input relays are configured to accommodate multiple power sources including single-phase AC, three-phase AC, and DC power sources. Using relays and means for controlling the AC/DC converter with the staged circuit, the staged circuit is configured to perform various functions including a power decoupling circuit to replace electrolytic capacitor. The magnet of the DC/DC converter is optionally configured to be a 4-winding coupled inductor.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: Embodiments are provided for detecting overlapping topics in a messaging system. In an example system, a plurality of trigger phrases is received, where each trigger phrase is configured to trigger a bot that receives the trigger phrase to select a corresponding topic for conversation. For each trigger phrase, a vector representation is generated. Measures of similarity are generated based at least on the vector representations, where each measure of similarity represents a degree of similarity between a respective pair of vector representations. A topic overlap is detected based on a pair of vector representations having a measure of similarity above a similarity threshold, where the topic overlap indicates two trigger phrases that are overlapping. The topic overlap is provided to an authoring tool that comprises one or more interactive elements to enable a user to change at least one of the two trigger phrases that are overlapping.

Abstract: An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized clamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: System and method for adjusting side mirrors capture, by a primary camera, a facial image of a driver; estimate a 3D eye location with respect to a 3D coordinate of the primary camera based on the captured facial image; map the estimated 3D eye location to a respective set of pitch and yaw of the side mirror based on a look up table; and rotate the side mirror to a target position in accordance with the respective set of pitch and yaw. The lookup table includes a plurality of rows, each containing a pair of a key and a set of values. The key is a set of three parameters of 3D line of locations where the driver can observe an optimal view behind the vehicle, and the set of values includes a set of pitch and yaw of the side mirror corresponding to the 3D line of locations.

Abstract: A method for adjusting a side mirror of a vehicle includes capturing, by a primary camera provided in front of a driver of the vehicle, a facial image of the driver; estimating a 3D eye location with respect to a 3D coordinate of the primary camera based on the captured facial image; mapping the estimated 3D eye location to a respective set of pitch and yaw angles of the side mirror based on a lookup table; and rotating the side mirror to a target position in accordance with the respective set of pitch and yaw angles. The lookup table includes a plurality of rows, each row containing a pair of a key and a set of values. The key is a 3D eye location, and the set of values includes a set of pitch and yaw angles of the side mirror corresponding to the 3D eye location.

Abstract: A smart medical device includes a structure configured to be at least partially implanted in a body, and an electronics cartridge that is configured to be inserted into the structure after the structure is implanted in the body. The structure may be a cannulated screw for use in treating bone fractures. The medical device includes an impedance sensor for monitoring and reporting on the healing state of bone fractures. The sensor includes components of the electronics cartridge and electrodes that are either associated with the cannulated screw or with the insertable electronics cartridge.

Abstract: Embodiments are provided for detecting overlapping topics in a messaging system. In an example system, a plurality of trigger phrases is received, where each trigger phrase is configured to trigger a bot that receives the trigger phrase to select a corresponding topic for conversation. For each trigger phrase, a vector representation is generated. Measures of similarity are generated based at least on the vector representations, where each measure of similarity represents a degree of similarity between a respective pair of vector representations. A topic overlap is detected based on a pair of vector representations having a measure of similarity above a similarity threshold, where the topic overlap indicates two trigger phrases that are overlapping. The topic overlap is provided to an authoring tool that comprises one or more interactive elements to enable a user to change at least one of the two trigger phrases that are overlapping.

Abstract: Embodiments are provided for suggesting topics in a messaging system. A set of queries is received from a chat transcript history, where the set of queries includes a set of unhandled queries, and each unhandled query comprises a query for which a bot did not identify a corresponding topic (e.g., queries that did not trigger selection of a topic by the bot). A vector representation is generated for each unhandled query in the set of unhandled queries. The vector representations for the set of unhandled queries are clustered to generate one or more clusters of vector representations, each cluster corresponding to a group of unhandled queries. A corresponding suggested topic is generated for each cluster and provided to an authoring tool that comprises one or more interactive elements to enable an author to select at least one of the suggested topics for implementation in the bot.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: Embodiments are provided for detecting overlapping topics in a messaging system. In an example system, a plurality of trigger phrases is received, where each trigger phrase is configured to trigger a bot that receives the trigger phrase to select a corresponding topic for conversation. For each trigger phrase, a vector representation is generated. Measures of similarity are generated based at least on the vector representations, where each measure of similarity represents a degree of similarity between a respective pair of vector representations. A topic overlap is detected based on a pair of vector representations having a measure of similarity above a similarity threshold, where the topic overlap indicates two trigger phrases that are overlapping. The topic overlap is provided to an authoring tool that comprises one or more interactive elements to enable a user to change at least one of the two trigger phrases that are overlapping.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: This disclosure features methods and devices for treating diseases with orally-delivered biotherapeutics.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: A method of treating a disease or condition in a subject in need thereof is disclosed. The method comprising: trans-epithelially administering a dispensable substance to the gastrointestinal (GI) tract of the subject by orally administering an ingestible device comprising the dispensable substance to the subject. The ingestible device is configured for trans-epithelial delivery of the dispensable substance to the GI tract of the subject and the dispensable substance comprises a pharmaceutical formulation comprising a therapeutically effective amount of a glucagon receptor agonist or a glucagon-like peptide-1 (GLP-1) receptor agonist. The ingestible device releases the dispensable substance as at least one jet to a desired location of the GI tract of the subject.

Abstract: This disclosure features methods and devices for treating diseases with orally-delivered biotherapeutics.

Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.

Abstract: An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.