Patents by Inventor Udi Eyal Fima

Udi Eyal Fima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING SAME
    Publication number: 20180186852
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Application
    Filed: February 16, 2018
    Publication date: July 5, 2018
    Applicant: Opko Biologics Ltd.
    Inventors: Fuad FARES, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9975938
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: May 22, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20180087042
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: April 11, 2017
    Publication date: March 29, 2018
    Inventors: Udi Eyal FIMA, Gili HART
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9908924
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also discarded.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: March 6, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • PEGYLATED OXM VARIANTS
    Publication number: 20180050113
    Abstract: A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.
    Type: Application
    Filed: November 2, 2017
    Publication date: February 22, 2018
    Applicant: OPKO Biologics Ltd.
    Inventors: Udi Eyal Fima, Oren Hershkovitz
  • Long-acting polypeptides and methods of producing same
    Patent number: 9896494
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: February 20, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9884901
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: February 6, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9828417
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: November 28, 2017
    Assignee: OPKO Biologics Ltd.
    Inventors: Udi Eyal Fima, Gili Hart
  • Pegylated OXM variants
    Patent number: 9821070
    Abstract: A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: November 21, 2017
    Assignee: OPKO Biologics Ltd.
    Inventors: Udi Eyal Fima, Oren Hershkovitz
  • Long-acting coagulation factors and methods of producing same
    Patent number: 9663778
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: May 30, 2017
    Assignee: OPKO Biologies Ltd.
    Inventors: Udi Eyal Fima, Gili Hart
  • LONG-ACTING OXYNTOMODULIN VARIANTS AND METHODS OF PRODUCING SAME
    Publication number: 20170088598
    Abstract: This invention is directed to a chorionic gonadotrophin carboxy terminal peptide (CTP)-modified dual GLP-1/Glucagon receptor agonist, and methods of producing and using the same.
    Type: Application
    Filed: October 5, 2016
    Publication date: March 30, 2017
    Applicant: OPKO BIOLOGICS LTD.
    Inventors: Udi Eyal FIMA, Oren HERSHKOVITZ
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
    Publication number: 20160310576
    Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
    Type: Application
    Filed: July 1, 2016
    Publication date: October 27, 2016
    Applicant: OPKO Biologics Ltd.
    Inventors: Fuad FARES, Udi Eyal Fima
  • Long-acting coagulation factors and methods of producing same
    Patent number: 9458444
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: October 4, 2016
    Assignee: OPKO BIOLOGICS LTD.
    Inventors: Udi Eyal Fima, Gili Hart
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20160250301
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: May 19, 2016
    Publication date: September 1, 2016
    Applicant: OPKO Biologics Ltd.
    Inventors: Udi Eyal FIMA, Gili HART
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20160076018
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: November 23, 2015
    Publication date: March 17, 2016
    Applicant: OPKO Biologics Ltd.
    Inventors: Udi Eyal FIMA, Gili Hart
  • Long-acting coagulation factors and methods of producing same
    Patent number: 9249407
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: February 2, 2016
    Assignee: OPKO BIOLOGICS LTD.
    Inventors: Udi Eyal Fima, Gili Hart
  • LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME
    Publication number: 20150368630
    Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
    Type: Application
    Filed: February 5, 2013
    Publication date: December 24, 2015
    Applicant: PROLOR BIOTECH INC.
    Inventors: Udi Eyal FIMA, Gili Hart
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING SAME
    Publication number: 20150203558
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Application
    Filed: December 10, 2014
    Publication date: July 23, 2015
    Inventors: FUAD FARES, UDI EYAL FIMA
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
    Publication number: 20150158926
    Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
    Type: Application
    Filed: November 26, 2014
    Publication date: June 11, 2015
    Inventors: FUAD FARES, UDI EYAL FIMA
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING SAME
    Publication number: 20150152155
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Application
    Filed: November 21, 2014
    Publication date: June 4, 2015
    Inventors: Fuad FARES, Udi Eyal Fima