Patents by Inventor Ulrich Niewohner

Ulrich Niewohner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isoxazolo pyrimidinones and the use thereof
    Publication number: 20030149033
    Abstract: The invention relates to novel isoxazolo pyrimidinones of general formula (I), a method for producing the same and the pharmaceutical use thereof.
    Type: Application
    Filed: October 22, 2002
    Publication date: August 7, 2003
    Inventors: Ulrich Niewohner, Helmut Haning, Thomas Lampe, Mazen Es-Sayed, Gunter Schmidt, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn, Karl-Heinz Schlemmer
  • Novel heterocycles 3
    Publication number: 20030139415
    Abstract: The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
    Type: Application
    Filed: May 30, 2002
    Publication date: July 24, 2003
    Inventors: Cristina Alonso-Alija, Heike Gielen, Martin Hendrix, Ulrich Niewohner, Dagmar Schauss, Hilmar Bischoff, Nils Burkhardt, Volker Geiss, Karl-Heinz Schlemmer, Nigel J. Cuthbert, Mary F. Fitzgerald, Graham Sturton
  • Substituted imidazotriazinones
    Patent number: 6573263
    Abstract: The present invention relates to new substituted imidazotriazinones, processes for their preparation, and their use for the production of medicaments, in particular for improving perception, concentration power, learning power and/or memory power.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: June 3, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Dagmar Schauss, Martin Hendrix, Gerhard König, Frank-Gerhard Böss, Franz-Josef Van Der Staay, Rudy Schreiber, Karl-Heinz Schlemmer, Rolf Grosser
  • 2-phenyl substituted imidatriazinones as phosphodiesterase inhibitors
    Patent number: 6566360
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: May 20, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jörg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
  • Substituted imidazotriazinones
    Publication number: 20020198377
    Abstract: The present invention relates to new substituted imidazotriazinones, processes for their preparation, and their use for the production of medicaments, in particular for improving perception, concentration power, learning power and/or memory power.
    Type: Application
    Filed: December 21, 2001
    Publication date: December 26, 2002
    Inventors: Ulrich Niewohner, Dagmar Schauss, Martin Hendrix, Gerhard Konig, Frank-Gerhard Boss, Franz-Josef Van Der Staay, Rudy Schreiber, Karl-Heinz Schlemmer, Rolf Grosser
  • 7-alkyl- and cycloalkyl-substituted imidazotriazinones
    Patent number: 6476029
    Abstract: The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: November 5, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn
  • Heterocyclylmethyl-substituted pyrazole derivatives
    Patent number: 6462068
    Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: October 8, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Fürstner, Ulrich Niewöhner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky, Dieter Arlt
  • Dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-one
    Patent number: 6458796
    Abstract: The present invention relates to novel dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-one, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: October 1, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Helmut Haning, Ulrich Niewöhner, Ulrich Rosentreter, Thomas Schenke, Erwin Bischoff, Karl-Heinz Schlemmer
  • Selective PDE 2 inhibitors as pharmaceuticals for improving perception
    Publication number: 20020132754
    Abstract: The invention relates to the use of selective phosphodiesterase 2 (PDE 2) inhibitors for producing pharmaceuticals for improving perception, concentration, learning and/or memory.
    Type: Application
    Filed: July 23, 2001
    Publication date: September 19, 2002
    Inventors: Frank-Gerhard Boss, Martin Hendrix, Gerhard Konig, Ulrich Niewohner, Karl-Heinz Schlemmer, Rudy Schreiber, Franz-Josef Van Der Staay, Dagmar Schauss
  • Heterocyclylmethyl-substituted pyrazol derivatives
    Patent number: 6414009
    Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: July 2, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Fürstner, Ulrich Niewöhner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky, Dieter Arlt
  • Medicaments for viral diseases
    Publication number: 20020082264
    Abstract: Chromanone derivatives are highly active antiviral agents. Combinations of chromanones and/or chromanols with HBV polymerase inhibitors, HBV DNA inhibitors or HBV core protein inhibitors and/or isoxazoles and, where appropriate, interferon inhibit the replication of HBV viruses better than agents disclosed previously.
    Type: Application
    Filed: August 30, 2001
    Publication date: June 27, 2002
    Inventors: Susanne Nikolic, Stephan Bartel, Michael Brands, Ulrich Niewohner, Arnold Paessens, Erwin Graef, Karl-Heinz Schlemmer, Kerstin Henninger, Rainer Endermann, Olaf Weber, Diana Koletzki
  • Heterocyclylmethyl-substituted pyrazol derivatives
    Patent number: 6410740
    Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: June 25, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Fürstner, Ulrich Niewöhner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky, Dieter Arlt
  • Heterocyclylmethyl-substituted pyrazole derivatives
    Patent number: 6387940
    Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: May 14, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Fürstner, Ulrich Niewöhner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hütter, Klaus Dembowsky, Dieter Arlt
  • 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
    Patent number: 6362178
    Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: March 26, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jörg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
  • Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special diseases of the cardiovascular and the central nervous systems
    Patent number: 6180656
    Abstract: The present invention relates to the new use of 1-benzyl-3-(substituted hetaryl)-fused pyrazole derivatives, some of which are known, of the general formula (I) in which R1 to R4 have the meaning indicated in the description, as medicaments, and to new active compounds, in particular to their use as vasodilators, if appropriate in combination with organic nitrates and NO donors and if appropriate in combination with compounds which inhibit the degradation of cGMP.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: January 30, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Chantal F{umlaut over (u)}rstner, Alexander Straub, Ulrich Niewöhner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim H{umlaut over (u)}tter, Klaus Dembowsky
  • 1,5-dihydro-pyrazolo[34-D]-pyrimidinone derivatives
    Patent number: 6174884
    Abstract: The 1,5-dihydro-pyrazolo[3,4-d]-pyrimidinone derivatives are prepared by fusing the pyrimidone heterocycle with the suitably substituted pyrazoles. The compounds are suitable as active compounds in medicaments, in particular in medicaments for the treatment of cardiovascular and cerebrovascular diseases, diseases of the peripheral blood vessels and diseases of the urogenital tract.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: January 16, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Helmut Haning, Ulrich Niewöhner, Ulrich Rosentreter, Thomas Schenke, Jörg Keldenich, Erwin Bischoff, Karl-Heinz Schlemmer, Helmuth Sch{umlaut over (u)}tz, G{umlaut over (u)}nter Thomas
  • Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases
    Patent number: 6166027
    Abstract: The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: December 26, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Straub, Chantal Furstner, Ulrich Niewohner, Thomas Jaetsch, Achim Feurer, Raimund Kast, Johannes-Peter Stasch, Elisabeth Perzborn, Joachim Hutter, Klaus Dembowsky, Dieter Arlt
  • 9-substituted 2-(2-n-alkoxyphenyl)-purin-6-ones
    Patent number: 5866571
    Abstract: 9-Substituted 2-(2-n-alkoxyphenyl)purin-6-ones are prepared by cyclizing correspondingly substituted imidazoles and derivatizing the purines thus obtained. The 9-substituted .sup.2 -(2-n-alkoxyphenyl)purin-6-ones can be employed as active compounds in medicaments, in particular in medicarnents for treatment of inflammations, thromboembolic diseases and cardiovascular diseases.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: February 2, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Erwin Bischoff, Helmuth Schutz, Elisabeth Perzborn, Matthias Schramm
  • 2,9-disubstituted purin-6-ones
    Patent number: 5861404
    Abstract: 2,9-Disubstituted purin-6-ones are prepared by acylating correspondingly substituted aminoimidazoles in a first step and then cyclizing the product to the purine. The new 2,9-disubstituted purin-6-ones can be employed as active compounds in medicaments, in particular for the treatment of inflammations, thromboembolic and cardiovascular diseases and diseases of the urogenital system.
    Type: Grant
    Filed: January 12, 1996
    Date of Patent: January 19, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Erwin Bischoff, Helmuth Schutz, Elisabeth Perzborn, Matthias Schramm
  • Purin-6-one derivatives
    Patent number: 5861396
    Abstract: Purin-6-one derivatives are prepared by acylating appropriately substituted imidazole carboxamides and then cyclizing to give the purines. The purin-6-one derivatives are suitable as active compounds in medicaments, in particular for the treatment of cardiovascular disorders, disorders of the vascular system and of the urogenital system.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: January 19, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Erwin Bischoff, Joachim Hutter, Elisabeth Perzborn, Helmuth Schutz