Abstract: A method of operating a multi-beam particle beam system includes: generating a multiplicity of particle beams such that they each pass through multipole elements that are either intact or defective; focusing the particle beams in a predetermined plane; determining excitations for the deflection elements of the multipole elements; exciting the deflection elements of the multipole elements that are intact with the determined excitations; modifying the determined excitations for the deflection elements of the multipole elements that are defective; and exciting the deflection elements of the defective multipole elements with the modified excitations. Modifying the determined excitations includes adding corrective excitations to the determined excitations. The corrective excitations are the same for all deflection elements of the defective multipole element.

Abstract: The present application relates to a combination of 5-amino-2,3-dihydro-1,4-phthalazinedione or one of its pharmaceutically acceptable salts and a 6?-methoxycinchonan-9-ol or a pharmaceutically acceptable salt thereof for use in the prevention or treatment of coronaviral infections. In particular, the invention relates to a combination of 5-amino-2,3-dihydro-1,4-phthalazinedione sodium salt and quinine or quinidine for said purposes. Pharmaceutical compositions and advantageous formulation techniques are disclosed.

Abstract: The present invention relates to an elderberry extract for use in a method of preventing or treating a SARS-CoV-2 infection, wherein said elderberry extract is an ultrafiltrated elderberry extract. The present invention further relates to a composition, preferably pharmaceutical composition, comprising an elderberry extract. Furthermore, the present invention relates to a method of preparing an ultrafiltrated elderberry extract.

Abstract: The invention relates to a method for determining the physicochemical properties of a nanoscale system (NSS) using analytical ultracentrifugation), comprising the steps of generating a multi-dimensional sedimentation analysis map associated with the NSS of interest; selecting sample-dependent parameters; determining sedimentation coefficient value/parameter in the sample; inserting sample sedimentation coefficient values onto the multi-dimensional sedimentation analysis map to obtain a NSS sample map value; and inferring from the NSS sample map value the physicochemical properties of the NSS sample. Furthermore, the invention relates to a system for performing the method, a computer program product and a computer readable storage medium.

Abstract: The present application relates to the use of a phthalazinedione in the prevention or treatment of coronaviral infections. Pharmaceutical compositions, combinations and advantageous formulation techniques are disclosed.

Abstract: The present application relates to 6?-methoxycinchonan-9-ols for use in the prevention or treatment of a coronaviral infection. Pharmaceutical compositions, combinations with antiviral agents, advantageous formulation techniques and a method of treatment are disclosed. Compositions of dietary supplements containing quinine are provided.

Abstract: The present invention relates to the use of 5-amino-2,3-dihydro-1,4-phthalazinedione or one of its pharmaceutically acceptable salts in the prevention or treatment of acute lung injury. The invention in particular relates to the use of 5-amino-2, 3-dihydro-1,4-phthalazinedione sodium salt for said purposes.

Abstract: The present application relates to small molecule inhibitors of human deubiquitinases for use in the prevention or treatment of a coronaviral infection. It relates in particular to small molecule inhibitors of USP7 and USP47. Pharmaceutical compositions, respective advantageous formulation techniques and a method of treatment are disclosed.

Abstract: The invention relates to a method for determining the physicochemical properties of a nanoscale system (NSS) using analytical ultracentrifugation), comprising the steps of generating a multi-dimensional sedimentation analysis map associated with the NSS of interest; selecting sample-dependent parameters; determining sedimentation coefficient value/parameter in the sample; inserting sample sedimentation coefficient values onto the multi-dimensional sedimentation analysis map to obtain a NSS sample map value; and inferring from the NSS sample map value the physicochemical properties of the NSS sample. Furthermore, the invention relates to a system for performing the method, a computer program product and a computer readable storage medium.

Abstract: The present invention relates to polymers and to the use thereof in the form of active electrode material or in an electrode slurry as electrical charge storage means, the electrical charge storage means especially being secondary batteries. These secondary batteries are especially notable for high cell voltages, and simple and scalable processing and production methods (for example by means of screen printing).

Abstract: A method of creating customized beverage products includes providing a multiple stream filing system suited for producing an array of beverage products. The method also includes receiving an order for a customized beverage product from the array of beverage products. The order indicates at least one characteristic of the customized beverage product. The at least one characteristic comprises one or more of the following: a beverage formulation, a beverage additive, a package size, a package shape, or label content. The method further includes instructing the multiple stream filling system to produce the customized beverage product. The multiple stream filing system produces the customized beverage product without performing an operation to reduce contamination of the customized beverage product with ingredients from a previously produced beverage product.

Abstract: The present invention relates to polymers and to the use thereof in the form of active electrode material or in an electrode slurry as electrical charge storage means, the electrical charge storage means especially being secondary batteries. The secondary batteries are especially notable for high cell voltages, a small drop in capacity even on undergoing several charging and discharging cycles, and simple and scalable processing and production methods (for example by means of screen printing).

Abstract: The present invention relates to the use of a thianthrene-containing polymer as redox-active electrode material, for example as an electrode slurry, for electrical charge storage means, especially secondary batteries. It additionally also relates to the electrode material comprising the polymer, and to an electrode and an electrical charge storage means comprising the polymer.

Abstract: The invention relates to pyridine-3,5-bis-thiocyanates which are new active substances for the treatment and prevention of retroviral infections and secondary diseases thereof, in particular HIV infections and AIDS, from the group of deubiquitinase inhibitors. Administration of the compounds of the invention increases the immunogenicity of viral proteins and thus the antiviral response.

Abstract: Systems and methods for blending low solubility ingredients are provided. In one embodiment, a method of blending a low solubility ingredient into a beverage solution includes dissolving the low solubility ingredient in a preselected solvent to provide a first solution. In one embodiment, the preselected solvent is preheated. The method also includes mixing various ingredients from one or more pre-blend batches to form a beverage syrup and mixing the first solution with the beverage syrup to form the beverage solution.

Abstract: The present invention relates to the use of a thianthrene-containing polymer as redox-active electrode material, for example as an electrode slurry, for electrical charge storage means, especially secondary batteries, It additionally also relates to the electrode material comprising the polymer, and to an electrode and an electrical charge storage means comprising the polymer,

Abstract: The problem addressed was that of providing novel polymers which are preparable with a low level of complexity, with the possibility of controlled influence on the physicochemical properties thereof within wide limits in the course of synthesis, and which are usable as active media in electrical charge storage elements for high storage capacity, long lifetime and stable charging/discharging plateaus. 9,10-Bis(1,3-dithiol-2-ylidene)-9,10-dihydroanthracene polymers consisting of an oligomeric or polymeric compound of the general formula I have been found.

Abstract: Disclosed is an oligomeric or polymeric compound comprising at least two structural units of formula (I) wherein Ar is a carbocyclic aromatic radical or a heterocyclic aromatic radical with the two carbonyl carbon atoms being attached to two ring carbon atoms of the Ar group forming together with the imide-nitrogen atom a five-membered or a six-membered ring X is a divalent group selected from —CR1R2—, —CO—, —SiR3R4—, —P(O)R5—, —P(O)(OR6)—, —PR7—, —P(OR8)—, —S(O)— or —S(O)2—.

Abstract: A method of creating customized beverage products includes providing a multiple stream filing system suited for producing an array of beverage products. The method also includes receiving an order for a customized beverage product from the array of beverage products. The order indicates at least one characteristic of the customized beverage product. The at least one characteristic comprises one or more of the following: a beverage formulation, a beverage additive, a package size, a package shape, or label content. The method further includes instructing the multiple stream filling system to produce the customized beverage product. The multiple stream filing system produces the customized beverage product without performing an operation to reduce contamination of the customized beverage product with ingredients from a previously produced beverage product.

Abstract: The present invention relates to polymers and to the use thereof in the form of active electrode material or in an electrode slurry as electrical charge storage means, the electrical charge storage means especially being secondary batteries. These secondary batteries are especially notable for high cell voltages, and simple and scalable processing and production methods (for example by means of screen printing).